scholarly journals Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods

2020 ◽  
pp. 121-121
Author(s):  
Shirin Parvinroo ◽  
Maede Eslami ◽  
Heshmatollah Ebrahimi-Najafabadi ◽  
Zahra Hesari
Keyword(s):  
Release Rate ◽  
Design Of Experiment ◽  
Xanthan Gum ◽  
Antimicrobial Properties ◽  
Chemical Properties ◽  
P Value ◽  
Release Kinetic ◽  
Natural Polymers ◽  
Sem Images ◽  
Gel Formulations

Background/Aim. Vinegars are of the main international traditional nutraceuticals which have been used as vaginal health protectant due to vagina pH balance maintenance and antimicrobial properties. Since the main used form of vinegar was liquid, it was difficult for vaginal application with low residence time; in this study a vaginal mucoadhesive gel of vinegar was designed. Methods. Xanthan gum (XG) and tragacanth (TG) were utilized as natural gel forming polymers. The effects of Xanthan gum and tragacanth on mucoadhesion strength and drug release of the gel formulations were optimized using a 3 level (32) factorial design. Several physico-chemical properties of the gel formulations including gel viscosity, spreadability, scanning electron microscopy (SEM) images of hydrogel chains, and release kinetic were also investigated. Results. demonstrated that tragacanth possesses a statistically significant effect on release rate control (p-value=0.0027) while both tragacanth and xanthan gum have significant effect (p value= 0.0001 and 0.0017, respectively) on mucoadhesion property. Conclusion. Design of experiment suggested that formulation F7 with 5% xanthan gum and 1% tragacanth (mucoadhesion = 0.4632 N and release rate = 88.8% in 6 hours) can be considered as the optimum formulation with some modifications.

scholarly journals FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOSULPIRIDE BY USING NATURAL POLYMER

2017 ◽  
Vol 10 (5) ◽  
pp. 285
Author(s):  
S Shanmugam
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Xanthan Gum ◽  
Diffusion Mechanism ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Release Kinetic ◽  
Natural Polymers ◽  
In Vitro Drug Release

Objective: The objective of the present study was to develop sustained release matrix tablets of levosulpiride by using natural polymers.Method: The tablets were prepared with different ratios of Chitosan, Xanthan gum and Guar gum by wet granulation technique. The solubility study of the levosulpiride was conducted to select a suitable dissolution media for in vitro drug release studies.Results: Fourier transform infrared (FTIR) study revealed no considerable changes in IR peak of levosulpiride and hence no interaction between drug and the excipients. DSC thermograms showed that no drug interaction occurred during the manufacturing process. In vitro dissolution study was carried out for all the formulation and the results compared with marketed sustained release tablet. The drug release from matrix tablets was found to decrease with increase in polymer ratio of Chitosan, Xanthan gum and Guar gum.Conclusion: Formulation LF3 exhibited almost similar drug release profile in dissolution media as that of marketed tablets. From the results of dissolution data fitted to various drug release kinetic equations, it was observed that highest correlation was found for First order, Higuchi’s and Korsmeyer equation, which indicate that the drug release occurred via diffusion mechanism.  Keywords: Levosulpiride, sustained release tablets, natural polymers, in vitro drug release studies 

scholarly journals Antimicrobial Food Packaging with Biodegradable Polymers and Bacteriocins

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3735
Author(s):  
Małgorzata Gumienna ◽  
Barbara Górna
Keyword(s):  
Food Packaging ◽  
Antimicrobial Properties ◽  
Chemical Properties ◽  
Natural Polymers ◽  
Global Trends ◽  
Wide Range ◽  
Promising Solution ◽  
Food And Drink ◽  
Packaged Food ◽  
Physical And Chemical

Innovations in food and drink packaging result mainly from the needs and requirements of consumers, which are influenced by changing global trends. Antimicrobial and active packaging are at the forefront of current research and development for food packaging. One of the few natural polymers on the market with antimicrobial properties is biodegradable and biocompatible chitosan. It is formed as a result of chitin deacetylation. Due to these properties, the production of chitosan alone or a composite film based on chitosan is of great interest to scientists and industrialists from various fields. Chitosan films have the potential to be used as a packaging material to maintain the quality and microbiological safety of food. In addition, chitosan is widely used in antimicrobial films against a wide range of pathogenic and food spoilage microbes. Polylactic acid (PLA) is considered one of the most promising and environmentally friendly polymers due to its physical and chemical properties, including renewable, biodegradability, biocompatibility, and is considered safe (GRAS). There is great interest among scientists in the study of PLA as an alternative food packaging film with improved properties to increase its usability for food packaging applications. The aim of this review article is to draw attention to the existing possibilities of using various components in combination with chitosan, PLA, or bacteriocins to improve the properties of packaging in new food packaging technologies. Consequently, they can be a promising solution to improve the quality, delay the spoilage of packaged food, as well as increase the safety and shelf life of food.

scholarly journals Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1514
Author(s):  
Ameya Sharma ◽  
Vivek Puri ◽  
Pradeep Kumar ◽  
Inderbir Singh ◽  
Kampanart Huanbutta
Keyword(s):  
Wound Healing ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Antimicrobial Properties ◽  
Entrapment Efficiency ◽  
Tissue Proliferation ◽  
Naturally Occurring ◽  
Reinforcing Material ◽  
Vitro Release

Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (biopolymers) such as sodium alginate, gelatin and xanthan gum, and reinforcing material such as nanoclay was selected. The fabrication of fibers was executed with the aid of extrusion-gelation method. Rifampicin, an antibiotic, has been incorporated into a biopolymeric solution. RF1, RF2, RF3, RF4 and RF5 were coded as various formulation batches of microfibers. The microfibers were further characterized by different techniques such as SEM, DSC, XRD, and FTIR. Mechanical properties and physical evaluations such as entrapment efficiency, water uptake and in vitro release were also carried out to explain the comparative understanding of the formulation developed. The antimicrobial activity and whole blood clotting of fabricated fibers were additionally executed, hence they showed significant results, having excellent antimicrobial properties; they could be prominent carriers for wound healing applications.

Preparation of Ginger Oil in Water Nanoemulsion Using Phase Inversion Composition Technique: Effects of Stirring and Water Addition Rates on their Physico-Chemical Properties and Stability

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Ashraf Farshbaf-Sadigh ◽  
Hoda Jafarizadeh-Malmiri ◽  
Navideh Anarjan ◽  
Yahya Najian
Keyword(s):  
Particle Size ◽  
Phase Inversion ◽  
Antimicrobial Properties ◽  
Chemical Properties ◽  
Water Addition ◽  
Chromatography Method ◽  
Stirring Rate ◽  
Physico Chemical ◽  
Oil In Water ◽  
Addition Rate

Abstract Ginger oil in water (O/W) nanoemulsions, were produced using phase inversion composition method and Tween 80, as emulsifier. Effects of processing parameters namely, stirring rate (100 to1000 rpm) and water addition rate (1–10 mL/min) were evaluated on the physico-chemical, morphological, antioxidant and antimicrobial properties of the prepared O/W nanoemulsions using response surface methodology (RSM). Results indicated that well dispersed and spherical ginger nanodroplets were formed in the nanoemulsions with minimum particle size (8.80 nm) and polydispersity index (PDI, 0.285) and maximum zeta potential value (−9.15 mV), using stirring rate and water addition rate of 736 rpm and 8.18 mL/min, respectively. Insignificant differences between predicted and experimental values of the response variables, indicated suitability of fitted models using RSM. Mean particle size of the prepared nanoemulsion using optimum conditions were changed from 8.81 ± 1 to 9.80 ± 1 nm, during 4 weeks of storage, which revealed high stability of the resulted ginger O/W nanoemulsion. High antioxidant activity (55.4%), bactericidal (against Streptococcus mutans) and fungicidal (against Aspergillus niger) activities of the prepared nanoemulsion could be related to the presence of gingerols and shogaols, a group of phenolic alkanones, in the ginger oil, which those were detected by gas chromatography method.

scholarly journals Screening of mucoadhesive vaginal gel formulations

2014 ◽  
Vol 50 (4) ◽  
pp. 931-941 ◽  
Author(s):  
Ana Ochoa Andrade ◽  
María Emma Parente ◽  
Gastón Ares
Keyword(s):  
Xanthan Gum ◽  
Rational Design ◽  
Point Of View ◽  
Vaginal Fluid ◽  
Multiple Factor Analysis ◽  
Vaginal Drug Delivery ◽  
Rheological Measurements ◽  
Gel Formulations ◽  
Positive Results

Rational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a second polymer (carbomer, guar or xanthan gum). The gels were characterised using in vitroadhesion, spreadability and leakage potential studies, as well as rheological measurements (stress and frequency sweep tests) and the effect of dilution with simulated vaginal fluid (SVF) on spreadability. Results were analysed using analysis of variance and multiple factor analysis. The combination of polymers enhanced adhesion of both primary gelling agents, carbomer and carrageenan. From the rheological point of view all formulations presented a similar behaviour, prevalently elastic and characterised by loss tangent values well below 1. No correlation between rheological and adhesion behaviour was found. Carbomer and carrageenan gels containing the highest percentage of xanthan gum displayed good in vitro mucoadhesion and spreadability, minimal leakage potential and high resistance to dilution. The positive results obtained with carrageenan-xanthan gum-based gels can encourage the use of natural biocompatible adjuvants in the composition of vaginal products, a formulation field that is currently under the synthetic domain.

scholarly journals Pemanfaatan sukun muda untuk peningkatan nilai gizi abon ikan tongkol

2021 ◽  
Vol 2 (2) ◽  
pp. 185
Author(s):  
Eva Fitriyaningsih
Keyword(s):  
Experimental Design ◽  
Nutritional Value ◽  
Economic Value ◽  
Chemical Properties ◽  
Animal Nutrition ◽  
P Value ◽  
Randomized Design ◽  
Study Results ◽  
Completely Randomized Design ◽  
Actual Participation

Background: Using young breadfruit to increase the breadfruit usability and economic value, one of the efforts is through the enrichment of the type of processed breadfruit products, breadfruit provides nutritional value that is beneficial to health, one of the help of breadfruit is increasing breadfruit for shredded products.Objectives: This study aims to find out how to improve young breadfruit 20%, 30%, 40% of the chemical properties (carbohydrate, protein, and fiber) of shredded tuna.Methods: This study used an experimental design with a non-factorial Completely Randomized Design (CRD) with three preparations and three repetitions. Then the chemical tests (carbohydrate, protein, and fiber) at the Laboratory of Animal Nutrition and Feed Technology of the Faculty of Agriculture, Syiah Kuala University, Banda Aceh.Results: The study results showed actual participation in young breadfruit 20%, 30%, and 40% of the chemical properties (carbohydrate, protein, and fiber) in shredded tuna with a p-value < 0.05.Conclusion: Agreeing that 20%, 30%, and 40% of young breadfruit were approved for shredded tuna's chemical properties (carbohydrate, protein, and fiber).

scholarly journals Analisis Pengaruh Kepadatan Debu dan Penggunaan APD Pekerja Pabrik Pakan Ikan Terhadap Gangguan Fungsi Paru Pada Pekerja Pabrik Pakan Ikan di Kecamatan XIII Koto Kampar

2015 ◽  
Vol 2 (2) ◽  
pp. 129
Author(s):  
Indrawati Indrawati ◽  
Zulkarnaini Zulkarnaini ◽  
Suyanto Suyanto
Keyword(s):  
Chemical Properties ◽  
Respiratory Illness ◽  
P Value ◽  
Fish Feed ◽  
Factory Workers ◽  
Cross Sectional ◽  
Function Impairment ◽  
Cross Sectional Design ◽  
Lung Function Impairment ◽  
And Chemical Properties

Cases of pulmonary disorders caused by exposure to dust are found in Indonesia, avariety of factors in the onset of respiratory illness as a result of dust covering the particlesize, shape, concentration, solubility and chemical properties as well as long exposure,several factors of karakteristi workers also can also affect the state including lung, smokinghabit, the habit of wearing personal protective equipment, exercise habits, etc. (karbella2011). The purpose of this study was to determine the effect of the analysis of ambient dustlevels and use of PPE with the incidence of pulmonary function impairment. This study usesobservational study design, with a cross-sectional design that was conducted in May-July2015 in Fish Feed Plant Koto Kampar District XIII. Number of samples 32 people.Measuring instruments used are questionnaires and observation sheets. Analiais data used issimple logistic regression. The results showed that the variables associated with impairedlung function are variable dust density (p value 0.001), use of PPE (p value 0.001), thevariable counfounding; smoking (p value 0.005), and sports (p value 0.014). While mostdominant variable affecting lung function impairment in workers fish feed is variable dustdensity (p value 0.009) and use of PPE (p value 0.023). Advised on factory workers tomaintain the safety of health themselves by using personal protective mill dust densityenvironment experienced during work. 

Antimicrobial Activities of Coriander Seed Essential Oil and Silver Nanoparticles

2021 ◽  
Author(s):  
Kadriye Ozlem saygi ◽  
Birgul Kacmaz ◽  
Serdar Gul
Keyword(s):  
Silver Nanoparticles ◽  
Essential Oil ◽  
Bacterial Infections ◽  
Materials Science ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Elemental Distribution ◽  
Sem Images ◽  
X Ray ◽  
Coriander Seed

Abstract Bacterial infections are one of the most serious health problems all over the world, which cause need for the discovery of new drug. Since antibiotic resistance is a major threat to both humans and the environment, there is a need for studies on the antimicrobial properties of different forms of traditionally used plants. Herein, the seeds of coriander were used to isolate essential oil (EO) and to synthesise silver nanoparticles (C-AgNPs). The major oil constituents were characterized by GC-MS as Linalool (79.12%), Camphor (6.16%), γ-Terpinene (2.82%) and α-Pinene (2.67%). The synthesized AgNPs were characterized by UV-Visible spectrophotometry, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), X-ray difraction (XRD) and Fourier Tranmission Infrared (FTIR). The surface plasmon resonance (SPR) of C-AgNPs at 437 nm was recorded on the UV-Vis spectrometer. The spherical and homogenous of AgNPs was presented in SEM images. EDX showed elemental distribution and confirmed AgNPs. A characteristic intense peak was at 3.0 keV. The antibacterial activities of the essential oil and AgNPs form of coriander seed against Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922 bacteria were investigated by broth microdilution test. AgNPs and essential oil of coriander can be expected to provide future opportunities in nanomedicine and materials science. AgNPs can be displayed synergistic antimicrobial effect when used in combination with essential oil.

Characteristics of Chitosan Nanoparticles for Water and Wastewater Treatment

2017 ◽  
pp. 223-261 ◽  
Author(s):  
Cayla Cook ◽  
Veera Gnaneswar Gude
Keyword(s):  
Wastewater Treatment ◽  
Chitosan Nanoparticles ◽  
Antimicrobial Properties ◽  
Chemical Properties ◽  
Water And Wastewater Treatment ◽  
Coagulation And Flocculation ◽  
Recent Developments ◽  
Water And Wastewater ◽  
Physical And Chemical

Chitosan is a naturally occurring biopolymer originating from several microbial species as well as crustacean species, such as shrimp and lobster. Chitosan has excellent physical and chemical properties that allow its use in various environmental applications especially in water treatment. It is a biodegradable polymer, and it is inexpensive providing an environmentally friendly and economic option for water and wastewater treatment. Chitosan offers a myriad of applications through chemical coagulation and flocculation, antimicrobial properties, adsorption capabilities, and nanofiltration and can provide a sustainable route for water and wastewater treatment. This book chapter elaborates the recent developments in chitosan applications in water and wastewater treatment.

scholarly journals Physically Cross-Linked Gels of PVA with Natural Polymers as Matrices for Manuka Honey Release in Wound-Care Applications

Materials ◽  
2019 ◽  
Vol 12 (4) ◽  
pp. 559 ◽  
Author(s):  
Antonia Neres Santos ◽  
Ana Duarte Moreira ◽  
Carlos Piler Carvalho ◽  
Rosa Luchese ◽  
Edlene Ribeiro ◽  
...  
Keyword(s):  
Weight Loss ◽  
Polyvinyl Alcohol ◽  
Natural Material ◽  
Natural Polymers ◽  
Sodium Carboxymethylcellulose ◽  
Manuka Honey ◽  
Sem Images ◽  
Burn Treatment ◽  
Burn Care ◽  
Capacity Degradation

Manuka honey is a well-known natural material from New Zealand, considered to have properties beneficial for burn treatment. Gels created from polyvinyl alcohol (PVA) blended with natural polymers are potential burn-care dressings, combining biocompatibility with high fluid uptake. Controlled release of manuka honey from such materials is a possible strategy for improving burn healing. This work aimed to produce polyvinyl alcohol (PVA), PVA–sodium carboxymethylcellulose (PVA-CMC), PVA–gelatin (PVA-G), and PVA–starch (PVA-S) cryogels infused with honey and to characterize these materials physicochemically, morphologically, and thermally, followed by in vitro analysis of swelling capacity, degradation/weight loss, honey delivery kinetics, and possible activity against Staphylococcus aureus. The addition of honey to PVA led to many PVA crystals with defects, while PVA–starch–honey and PVA–sodium carboxymethylcellulose–honey (PVA-CMC-H) formed amorphous gels. PVA-CMC presented the highest swelling degree of all. PVA-CMC-H and PVA–gelatin–honey presented the highest swelling capacities of the honey-laden samples. Weight loss/degradation was significantly higher for samples containing honey. Layers submitted to more freeze–thawing cycles were less porous in SEM images. With the honey concentration used, samples did not inhibit S. aureus, but pure manuka honey was bactericidal and dilutions superior to 25% honey were bacteriostatic, indicating the need for higher concentrations to be more effective.

Sign in / Sign up

Export Citation Format

Share Document