scholarly journals Coronavirus: Penyakit Lama, Virus Lama, Kemasan Baru

2020 ◽  
Vol 2 (1) ◽  
pp. 43
Author(s):  
Heru Wijono
Keyword(s):  
Middle East ◽  
Incubation Period ◽  
Respiratory Disease ◽  
Virus Strain ◽  
Severe Pneumonia ◽  
Middle East Respiratory Syndrome ◽  
Advanced Age ◽  
Acute Respiratory Disease

Abstract— Covid -19, a virus strain and a member of family with known member as Severe Acute Respiratory Disease (SARS) or Middle East Respiratory Syndrome (MERS), but having a potentially lethal differences in not readily recognized by our immunity. Classified as betacoronavirus, with incubation period up to 14 days, the sign and symptoms can be highly variable, from asymptomatic to mild to criticalin the form of severe pneumonia. Almost half the persons infected did not show any symptoms, but in cases of people with comorbidities such as advanced age, pregnancy, obesity or other certain diseases, could increase the likelihood of morbidity and even potentially fatal. Covid-19 has spread globally, including Indonesia, with a potentially increased number of cases, prevention in covid-19 protocol is a necessity. Keywords: Covid-19, SARS, symptoms, variable, prevention Abstrak— Covid-19, yang sebelumnya dikenal sebagai virus strain dari kelompok family yang sama dengan Severe Acute Respiratory Disease (SARS) atau Middle East Respiratory Syndrome (MERS), tapi memiliki fatalitas yang secara potensial lebih tinggi, karena bersiafat novel bagi sistem imunitas kita. Termasuk betacoronavirus, dengan masa inkubasi sampai dengan 14 hari, tanda dan gejala penyakit bisa sangat bervariasi, mulai dari asimtomatik, ringan sampai berat, dalam bentuk pneumonia berat. Hamper separuh penderita yang terinfeksi tidak menunjukkan gejala sama sekali, tapi pada penderita dengan komorbiditas seperti usia lanjut, kehamilan, obesitas atau penyakit kronis tertentu, resiko moribiditas dan mortalitas dapat meningkat. Covid-19 saat ini sudah menyebar ke seluruh dunia, termasuk Indonesia, dengan adanya potensi kenaikan kasus lebih banyak, pencegahan dalam bentuk protocol covid-19 bersifat mutlak diperlukan. Kata kunci: Covid-19, SARS, gejala, bervariasi, pencegahan

scholarly journals Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Seropositive Camel Handlers in Kenya

Viruses ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 396 ◽  
Author(s):  
Alice N. Kiyong’a ◽  
Elizabeth A. J. Cook ◽  
Nisreen M. A. Okba ◽  
Velma Kivali ◽  
Chantal Reusken ◽  
...  
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
High Risk ◽  
Middle East ◽  
Respiratory Disease ◽  
Risk Groups ◽  
Middle East Respiratory Syndrome ◽  
Limited Evidence ◽  
Dromedary Camels ◽  
Associated Risk Factors

Middle East respiratory syndrome (MERS) is a respiratory disease caused by a zoonotic coronavirus (MERS-CoV). Camel handlers, including slaughterhouse workers and herders, are at risk of acquiring MERS-CoV infections. However, there is limited evidence of infections among camel handlers in Africa. The purpose of this study was to determine the presence of antibodies to MERS-CoV in high-risk groups in Kenya. Sera collected from 93 camel handlers, 58 slaughterhouse workers and 35 camel herders, were screened for MERS-CoV antibodies using ELISA and PRNT. We found four seropositive slaughterhouse workers by PRNT. Risk factors amongst the slaughterhouse workers included being the slaughterman (the person who cuts the throat of the camel) and drinking camel blood. Further research is required to understand the epidemiology of MERS-CoV in Africa in relation to occupational risk, with a need for additional studies on the transmission of MERS-CoV from dromedary camels to humans, seroprevalence and associated risk factors.

scholarly journals The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling

2014 ◽  
Vol 95 (4) ◽  
pp. 874-882 ◽  
Author(s):  
Krystal L. Matthews ◽  
Christopher M. Coleman ◽  
Yvonne van der Meer ◽  
Eric J. Snijder ◽  
Matthew B. Frieman
Keyword(s):  
Middle East ◽  
Severe Pneumonia ◽  
Cell Types ◽  
Innate Immune ◽  
Middle East Respiratory Syndrome ◽  
Signalling Pathways ◽  
Type I ◽  
Accessory Proteins ◽  
Type I Ifn

The recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV), a betacoronavirus, is associated with severe pneumonia and renal failure. The environmental origin of MERS-CoV is as yet unknown; however, its genome sequence is closely related to those of two bat coronaviruses, named BtCoV-HKU4 and BtCoV-HKU5, which were derived from Chinese bat samples. A hallmark of highly pathogenic respiratory viruses is their ability to evade the innate immune response of the host. CoV accessory proteins, for example those from severe acute respiratory syndrome CoV (SARS-CoV), have been shown to block innate antiviral signalling pathways. MERS-CoV, similar to SARS-CoV, has been shown to inhibit type I IFN induction in a variety of cell types in vitro. We therefore hypothesized that MERS-CoV and the phylogenetically related BtCoV-HKU4 and BtCoV-HKU5 may encode proteins with similar capabilities. In this study, we have demonstrated that the ORF4b-encoded accessory protein (p4b) of MERS-CoV, BtCoV-HKU4 and BtCoV-HKU5 may indeed facilitate innate immune evasion by inhibiting the type I IFN and NF-κB signalling pathways. We also analysed the subcellular localization of p4b from MERS-CoV, BtCoV-HKU4 and BtCoV-HKU5 and demonstrated that all are localized to the nucleus.

scholarly journals High Secretion of Interferons by Human Plasmacytoid Dendritic Cells upon Recognition of Middle East Respiratory Syndrome Coronavirus

2015 ◽  
Vol 89 (7) ◽  
pp. 3859-3869 ◽  
Author(s):  
Vivian A. Scheuplein ◽  
Janna Seifried ◽  
Anna H. Malczyk ◽  
Lilija Miller ◽  
Lena Höcker ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Middle East ◽  
Respiratory Disease ◽  
Immune Cell ◽  
Critical Role ◽  
Plasmacytoid Dendritic Cells ◽  
Middle East Respiratory Syndrome ◽  
Early Gene ◽  
Type I ◽  
Endosomal Uptake

ABSTRACTThe Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as the causative agent of a severe respiratory disease with a fatality rate of approximately 30%. The high virulence and mortality rate prompted us to analyze aspects of MERS-CoV pathogenesis, especially its interaction with innate immune cells such as antigen-presenting cells (APCs). Particularly, we analyzed secretion of type I and type III interferons (IFNs) by APCs, i.e., B cells, macrophages, monocyte-derived/myeloid dendritic cells (MDDCs/mDCs), and by plasmacytoid dendritic cells (pDCs) of human and murine origin after inoculation with MERS-CoV. Production of large amounts of type I and III IFNs was induced exclusively in human pDCs, which were significantly higher than IFN induction by severe acute respiratory syndrome (SARS)-CoV. Of note, IFNs were secreted in the absence of productive replication. However, receptor binding, endosomal uptake, and probably signaling via Toll-like receptor 7 (TLR7) were critical for sensing of MERS-CoV by pDCs. Furthermore, active transcription of MERS-CoV N RNA and subsequent N protein expression were evident in infected pDCs, indicating abortive infection. Taken together, our results point toward dipeptidyl peptidase 4 (DPP4)-dependent endosomal uptake and subsequent infection of human pDCs by MERS-CoV. However, the replication cycle is stopped after early gene expression. In parallel, human pDCs are potent IFN-producing cells upon MERS-CoV infection. Knowledge of such IFN responses supports our understanding of MERS-CoV pathogenesis and is critical for the choice of treatment options.IMPORTANCEMERS-CoV causes a severe respiratory disease with high fatality rates in human patients. Recently, confirmed human cases have increased dramatically in both number and geographic distribution. Understanding the pathogenesis of this highly pathogenic CoV is crucial for developing successful treatment strategies. This study elucidates the interaction of MERS-CoV with APCs and pDCs, particularly the induction of type I and III IFN secretion. Human pDCs are the immune cell population sensing MERS-CoV but secrete significantly larger amounts of IFNs, especially IFN-α, than in response to SARS-CoV. A model for molecular virus-host interactions is presented outlining IFN induction in pDCs. The massive IFN secretion upon contact suggests a critical role of this mechanism for the high degree of immune activation observed during MERS-CoV infection.

scholarly journals Protein Intrinsic Disorder and Evolvability of MERS-CoV

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 608
Author(s):  
Vladimir N. Uversky ◽  
Elrashdy M. Redwan ◽  
Abdullah A. Aljadawi
Keyword(s):  
Middle East ◽  
Respiratory Disease ◽  
Intrinsic Disorder ◽  
Middle East Respiratory Syndrome ◽  
Protein Intrinsic Disorder ◽  
Human Coronaviruses ◽  
Viral Respiratory

Middle East Respiratory Syndrome (MERS) is a viral respiratory disease caused by one of the human coronaviruses, MERS-CoV [...]

Obstetric Management in Maternal with Covid-19

2021 ◽  
Vol 1 (6) ◽  
pp. 130-134
Author(s):  
Asoly Giovano
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Pregnant Women ◽  
Respiratory Disease ◽  
Short Duration ◽  
Cellular Immunity ◽  
Severe Pneumonia ◽  
Physiological Changes ◽  
The World ◽  
Obstetric Management

Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS- CoV-2). Covid-19 pandemic began in the end of 2019 and spread all over the world in a short duration of time. Like two other notable beta coronaviruses, severe acute respiratory syndrome coronavirus-1 (SARS-CoV-1) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 can lead to severe contagious respiratory disease. Due to impaired cellular immunity and physiological changes, pregnant women are susceptible to respiratory disease and are more likely to develop severe pneumonia.  

scholarly journals A New-fangled Corona virus coupled with Human Respiratory and AI in COVID-19 Discovery

2021 ◽  
Vol 12 (1S) ◽  
pp. 13-22
Author(s):  
V. A. Kotkar, Et. al.
Keyword(s):  
Middle East ◽  
Respiratory Disease ◽  
Hubei Province ◽  
Middle East Respiratory Syndrome ◽  
Corona Virus ◽  
Positive Sense ◽  
Corona Viruses

Recently a very strange time to fight with invisible enemy. The Corona virus ailment 2019 also known as COVID-19 outburst, which emerged from Wuhan, the Hubei Province, China, had broaden to all the regions of China and 28 additional countries. Corona viruses are a group of viruses with non segmented, single stranded and positive–sense RNA genomes. Corona viruses is also popular to contaminate human hosts and effect respiratory disease like brutal SARS-CoV (Acute Respiratory Syndrome Corona virus) and MERS-CoV (Middle East Respiratory Syndrome Corona virus). In this paper we discussed on detail analysis of COVID-19 disease.

scholarly journals Middle East Respiratory Syndrome Coronavirus and Severe Acute Respiratory Syndrome Coronavirus

2020 ◽  
Vol 41 (04) ◽  
pp. 568-578 ◽  
Author(s):  
Jaffar A. Al-Tawfiq ◽  
Ziad A. Memish
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Emerging Infectious Diseases ◽  
Case Fatality ◽  
Severe Pneumonia ◽  
Middle East Respiratory Syndrome ◽  
Zoonotic Pathogen ◽  
Clinical Presentations ◽  
The World ◽  
Novel Coronavirus

AbstractEmerging infectious diseases continue to be of a significant importance worldwide with the potential to cause major outbreaks and global pandemics. In 2002, the world had witnessed the appearance of the severe acute respiratory syndrome coronavirus in China which disappeared abruptly within 6 months. About a decade later, a new and emerging novel coronavirus named the Middle East respiratory syndrome coronavirus (MERS-CoV) was described in a patient from Saudi Arabia. These two coronaviruses shared multiple similarities in the epidemiology, clinical presentations, and posed challenges in its prevention and management. Seven years since its discovery, MERS-CoV continues to be a lethal zoonotic pathogen capable of causing severe pneumonia with high case fatality rates and the ability to cause large health care-associated outbreaks.

Sign in / Sign up

Export Citation Format

Share Document