scholarly journals Epic Formulas with a Matrix Construction: from Stability in Structure to Reference in Consciousness (Image of a Hero in the Yakut Olonkho)

2020 ◽  
Vol 1 (10) ◽  
pp. 213-230
Author(s):  
Yu. P. Borisov
Keyword(s):  
Gender Differences ◽  
Material Property ◽  
Background Knowledge ◽  
Comprehensive Analysis ◽  
Human Speech ◽  
Reference Models ◽  
Complex Processes ◽  
Short Time ◽  
Matrix Construction ◽  
First Time

The complex processes involved in the generation of the image of the hero by the narrator and the perception of this image by the epic audience are studied. A comprehensive analysis of epic formulas with a matrix construction is carried out in order to identify their reference models. The novelty of the work lies in the fact that for the first time the problems of human speech-thinking activity on the basis of the epic formulas of the Yakut olonkho are considered. As a result of the research, the author comes to the conclusion that when revealing the image of the hero, the narrator uses the parallels as a referent: property of the material / property of the image. It is noted that, in turn, the recipients decipher these constructions thanks to the background knowledge about the referent, in particular, about the property of the described material, which is mentally brought under the image of a hero. According to the author, the very structure of the organization of matrix structures does not allow the olonkhosut to completely replace the components that form the referent. Moreover, it is stated that the structure of the analyzed constructions ignores even gender differences in describing the image of heroic women. It is pointed out that the described processes, when the narrator recites certain analyzed epic formulas, occur in a very short time.

scholarly journals Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lan N. Truong ◽  
Brayden D. Whitlock
Keyword(s):  
Sodium Chloride ◽  
Improved Method ◽  
Candida Auris ◽  
Antimicrobial Surfaces ◽  
E Coli ◽  
Route Of Transmission ◽  
The World ◽  
Short Time ◽  
First Time ◽  
Time Point

AbstractControlling infections has become one of the biggest problems in the world, whether measured in lives lost or money spent. This is worsening as pathogens continue becoming resistant to therapeutics. Antimicrobial surfaces are one strategy being investigated in an attempt to decrease the spread of infections through the most common route of transmission: surfaces, including hands. Regulators have chosen two hours as the time point at which efficacy should be measured. The objectives of this study were to characterize the new antimicrobial surface compressed sodium chloride (CSC) so that its action may be understood at timepoints more relevant to real-time infection control, under two minutes; to develop a sensitive method to test efficacy at short time points; and to investigate antifungal properties for the first time. E. coli and Candida auris are added to surfaces, and the surfaces are monitored by contact plate, or by washing into collection vats. An improved method of testing antimicrobial efficacy is reported. Antimicrobial CSC achieves at least 99.9% reduction of E. coli in the first two minutes of contact, and at least 99% reduction of C. auris in one minute.

scholarly journals Bactericidal activity of three different antiseptic ophthalmic preparations as surgical prophylaxis

2021 ◽  
Author(s):  
Daniele Tognetto ◽  
Marco R. Pastore ◽  
Gian Marco Guerin ◽  
Giuliana Decorti ◽  
Martina Franzin ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Povidone Iodine ◽  
Bacterial Load ◽  
Viable Cells ◽  
Polyethylene Glycol 1000 ◽  
Oil Concentration ◽  
Short Time ◽  
First Time ◽  
Antiseptic Solutions

Abstract Purpose In the era of antibiotic resistance, there is an increased interest in antiseptic solutions that might represent a reliable option for ocular surface disinfection. The objective of this study is to compare for the first time three different antiseptic ophthalmic preparations to assess their in vitro antimicrobial activity. Methods The antiseptic activity of three commercial ophthalmic solutions, IODIM (povidone-iodine 0.6% in hyaluronic acid vehicle—Medivis, Catania, Italy), OZODROP (nanoemulsion with ozonated oil—concentration not specified—FBVision, Ophthalmic Pharmaceuticals, Rome, Italy), and DROPSEPT (chlorhexidine 0.02% and vitamin E 0.5% Tocopherol Polyethylene Glycol 1000 Succinate—TPGS, Sooft Italia, Montegiorgio, Italy), was tested in vitro on six reference strains by time-killing assays. Viable cells were evaluated after 1, 15, 30 min; 2, 6, and 24 h exposure by seeding 100 µl of the suspension (or appropriate dilutions) on LB agar or Sabouraud-dextrose agar. All plates were incubated at 37 °C for 24 h and evaluated by manually counting the colonies. Results IODIM solution showed a very rapid microbicidal activity: the number of viable cells for all the tested strains was under the detection limit (less than 10 CFU/ml) already after 1 min exposure, and this result was maintained at every incubation time. The rapid antimicrobial activity of povidone-iodine was not replicated when testing the other two antiseptics. Conclusions The study reports the great efficacy in reducing bacterial load in a very short time of povidone-iodine 0.6% compared with other antiseptic preparations.

Generalized eruptive keratoacanthomas of Grzybowski (case report)

2021 ◽  
Author(s):  
И.А. Куклин ◽  
Н.П. Малишевская ◽  
М.М. Кохан ◽  
Г.Д. Сафонова ◽  
О.Г. Римар ◽  
...  
Keyword(s):  
Clinical Care ◽  
Clinical Manifestations ◽  
Review Of The Literature ◽  
Trunk Limbs ◽  
The Face ◽  
Spontaneous Involution ◽  
Atrophic Scars ◽  
Short Time ◽  
First Time ◽  
Aromatic Retinoids

В статье представлен краткий обзор литературы о клинических проявлениях, современных методах диагностики и лечения чрезвычайно редкого заболевания – множественной эруптивной кератоакантомы типа Гржебовски. Заболевание характеризуется возникновением сотен или тысяч генерализованных зудящих узелков на коже лица, туловища, конечностей, половых органов, слизистой полости рта и гортани в течение короткого времени. Заболевание развивается в возрасте старше 40 лет, имеет рецидивирующее течение, возможна спонтанная инволюция отдельных элементов с формированием участков депигментации или атрофических рубцов. Авторы приводят случай собственного клинического наблюдения множественной эруптивной кератоакантомы типа Гржебовски у пациента 50 лет, который обратился на консультацию к дерматовенерологу в клинику Уральского НИИ дерматовенерологии и иммунопатологии. Длительность болезни на момент обращения составляла 2,5 года, ее возникновению предшествовало неоднократное посещение больным стран с избыточной инсоляцией, что может рассматриваться в качестве этиологического фактора развития заболевания. Диагноз впервые был заподозрен на консилиуме дерматовенерологов на основании клинической картины заболевания и в дальнейшем верифицирован данными патоморфологического исследования биоптата пораженной кожи. Показана эффективность применения ароматических ретиноидов в лечении множественной эруптивной кератоакантомы типа Гржебовски и приведены побочные эффекты, которые развились у больного при самостоятельном увеличении дозы ацитретина до 70 мг/сутки. В статье констатируется чрезвычайно редкая встречаемость данного заболевания, о чем свидетельствует приведенный клинический случай, диагностируемый впервые более чем за 90-летнюю историю существования института. Подчеркивается важность консолидации клинического опыта нескольких ведущих дерматовенерологов для диагностики множественной эруптивной кератоакантомы типа Гржебовски. The article presents a brief review of the literature about clinical manifestations, modern methods of diagnosticsand treatment of an extremely rare disease – generalized eruptive keratoacanthomas of Grzybowski. The disease is characterized by the appearance of hundreds or thousands of generalized itchy nodules on the skin of the face, trunk, limbs, genitals, oral mucosa and larynx within a short time. The disease develops at the age of over 40, has a recurrent course, spontaneous involution of individual elements with the formation of areas of depigmentation or atrophic scars is possible. The authors describe a case of their own clinical care of generalized eruptive keratoacanthomas of Grzybowski in a 50-year-old patient who consulted a dermatovenerologist at the clinic of the Ural Research Institute of Dermatovenerology and Immunopathology.The duration of the disease at the time of visit to a doctor was 2,5 years, its occurrence was preceded by repeated visits to countries with excessive insolation, which can be considered as an etiological factor in the development of the disease. The diagnosis was first suspected at a boarddermatovenerologists based on the clinical picture of the disease and subsequently verified by the data of a pathomorphological examination of the biopsy of the affected skin.The effectiveness of the use of aromatic retinoids in the treatment of generalized eruptive keratoacanthomas of Grzybowski is shown and the side effects that developed in the patient with an independent increase in the dose of acitretin to 70 mg/day are given. The article states the extremely rare occurrence of this disease, as evidenced by the above clinical case, diagnosed for the first time in more than 90 years of the institute's existence. The importance of consolidating the clinical experience of several leading dermatovenerologists for the diagnostics of generalized eruptive keratoacanthomas of Grzybowski is emphasized.

An Effective Synthesis of N,N-Diphenyl Carbazolium Salts

Synlett ◽  
2017 ◽  
Vol 29 (10) ◽  
pp. 1314-1318 ◽  
Author(s):  
Charles Diesendruck ◽  
Sinai Aharonovich ◽  
Nansi Gjineci ◽  
Dario Dekel
Keyword(s):  
Positive Charge ◽  
Quaternary Ammonium Salts ◽  
Simple Approach ◽  
Ammonium Salts ◽  
State Structure ◽  
Pi Systems ◽  
Effective Synthesis ◽  
Short Time ◽  
First Time ◽  
General Method

Tetraaryl ammonium salts are a synthetic challenge, since there is no general method for the arylation of triaryl amines. Contrary to other quaternary ammonium salts, tetraaryl ammonium salts should be very chemically stable. The ipso carbons are not very electrophilic, since the positive charge is distributed throughout the pi systems and they have no acidic β hydrogens. Here we demonstrate a simple approach to N,N-diphenyl carbazolium salts using only three synthetic steps, allowing for an easy production of these salts in large amounts and in a relatively short time. In addition, we study the Cu(I) catalyzed multi-arylation of 2,2’-diaminobiphenyl, focusing on the regioselectivity of each step. Finally, we characterize, for the first time, the solid state structure of a tetraaryl ammonium salt.

scholarly journals Swedish baron G.M. Sprengtporten in Russian service, 1786-1809

2021 ◽  
Vol 20 (4) ◽  
pp. 480-492
Author(s):  
Vladimir N. Shaidurov ◽  
Valentina A. Veremenko
Keyword(s):  
19Th Century ◽  
Russian Empire ◽  
Early 19Th Century ◽  
Independent State ◽  
Russian Army ◽  
Historical Figures ◽  
The Russian Empire ◽  
Short Time ◽  
First Time ◽  
Swedish Citizen

General of the Infantry Count G.M. Sprengtporten (1740-1819) is one of the less known historical figures of the last quarter of the 18th and of the early 19th century. As a Swedish citizen, he hatched plans to turn Finland into an independent state. In the mid-1780s he saw in Catherine II a potential ally who could implement his ideas. After accepting the invitation to enter Russian service, Sprengtporten did not blend either in the Highest Court or in the Russian army. Not having shown any significant military feats during the wars of the late 18th and early 19th centuries, he distinguished himself in the diplomatic and lawmaking field. An important event was his mission to Europe (1800-1801), which resulted in the return of more than six thousand Russian prisoners to Russia. The draft Regulations on the Establishment of the Main Administration in New Finland, developed by Sprengtporten with some changes made by Emperor Aleksander I, became the cornerstone of Finnish autonomy within the Russian Empire over the next century. Occupying for a short time the post of Governor General, he became a link between Finland and Russia. The scientific novelty of the article lies in the comprehensive presentation of the Russian service of G.M. Sprengtporten. The article is written on the basis of published sources and unpublished documents from some central archives, which are introduced into scientific circulation for the first time.

LÉTI’S TWO STEP APPROACH IN THE DOMAIN OF 3D INTEGRATION

2011 ◽  
Vol 2011 (1) ◽  
pp. 000169-000172
Author(s):  
André Rouzaud ◽  
Nicolas Sillon ◽  
Mark Scannell ◽  
David Henry ◽  
T. Mourier
Keyword(s):  
Product Development ◽  
Laboratory Scale ◽  
Integration Scheme ◽  
3D Integration ◽  
Time To Market ◽  
Dual Approach ◽  
Technological Means ◽  
Short Time ◽  
First Time ◽  
Mature Process

In a first time confined to labs and then R&D centers, 3D integration technologies have now gained maturity and are now penetrating the industrial world. More and more, R&D centers are approached to back the industrial developments with associated constraints of swift product development, prototyping, and short time-to- market. To face this paradigm, Léti has developed a specific two-step approach in the field of 3D integration, including both a very advanced R&D part focused on the most promising technologies and integration flows, and the industrial validation of the most mature process flows already assessed at the laboratory scale or on specific industrial themes. This talk aims to detail the two aspects of this dual approach:-In the first part, we will give an overview of the innovative R&D performed on the still nascent and most promising integration flows, as well as the associated technological means.-in the second part, we will present the prototyping activities that Léti is now offering. Based on a limited number of mature and already validated process steps (bonding and thinning, TSV, bumping, stacking) this generic integration scheme allows industrial customers to assess on their own wafers the benefits of an innovative 3D integration.

N-Methylated 1,8-Diaminonaphthalenes as Bifunctional Nucleo­philes in Reactions with α,ω-Dihalogenoalkanes: A Facile Route to Heterocyclic and Double Proton Sponges

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3427-3438
Author(s):  
Valery A. Ozeryanskii ◽  
Ekaterina V. Kolupaeva ◽  
Alexander F. Pozharskii
Keyword(s):  
Nitrogen Atom ◽  
Starting Material ◽  
One Pot ◽  
Heterocyclization Reaction ◽  
New Type ◽  
Organic Receptor ◽  
Proton Sponges ◽  
Short Time ◽  
First Time ◽  
Facile Route

The reaction of 1-dimethylamino-8-(methylamino)naphthalene with 1,3-dibromopropane chemoselectively leads to the product of N,N′-heterocyclization, while in the case of 1,4-dibromobutane and 1,2-bis(bromomethyl)benzene the process results in heterocyclization onto the same nitrogen atom with the formation of previously unknown 1-dimethylamino-8-pyrrolidino- and 1-dimethylamino-8-isoindolino-naphthalenes. The same reactions conducted without adding any auxiliary base lead to the formation of N,N′-linked double proton sponges as a new type of polynitrogen organic receptor. Proceeding as a sequence of quaternization–demethylation–cyclization steps, this heterocyclization process can also be used to construct six-membered rings (piperidino, morpholino), albeit in lower yields. The ability of 1,2-dibromoethane to brominate N-alkylated 1,8-diaminonaphthalenes is also described. It is shown for the first time that a commercially available 1,8-bis(dimethylamino)naphthalene (DMAN) can be used as a starting material in a heterocyclization reaction, which via a one-pot approach and in a short time can be converted into 1,5-dimethylnaphtho[1,8-bc]-1,5-diazacyclooctane or 1-dimethylamino-8-(pyrrolidin-1-yl)naphthalene.

scholarly journals Phenolic Profiling of Flax Highlights Contrasting Patterns in Winter and Spring Varieties

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4303 ◽  
Author(s):  
Job Tchoumtchoua ◽  
David Mathiron ◽  
Nicole Pontarin ◽  
David Gagneul ◽  
Anne-Isaline van Bohemen ◽  
...  
Keyword(s):  
Linum Usitatissimum ◽  
Comprehensive Analysis ◽  
Coniferyl Alcohol ◽  
Preparative Hplc ◽  
Omega 3 ◽  
Standard Analysis ◽  
Plant Grown ◽  
First Time

Flax (Linum usitatissimum) is a plant grown in temperate regions either for its fiber or for its seeds, which are rich in the essential fatty acid omega-3. It is also well known as a source of medicinal compounds. The chemical composition of its leaves is currently poorly described. In order to fill this gap, we have conducted a comprehensive analysis of flax leaf metabolome. The exploration of the metabolome allowed the characterization of compounds isolated for the first time in flax leaves. These molecules were isolated by preparative HPLC and then characterized by NMR, LC-MS and standard analysis. This work extended our picture of C-glycosyl-flavonoids and coniferyl alcohol derivatives accumulated in flax. The follow-up of the content of these different metabolites via UPLC-MS revealed significant accumulation differences in spring and winter flax leaves. In particular, two methylated C-glycosylflavonoids (swertisin and swertiajaponin) were the most abundant phenolic compounds in winter flax whereas they were not detected in spring flax. This result suggests that these 2 compounds are involved in cold stress tolerance in flax.

scholarly journals Optical Short-Time Variations in GK Persei during the 1983 Outburst

1987 ◽  
Vol 93 ◽  
pp. 485-485
Author(s):  
H. Steinle ◽  
W. Pietsck
Keyword(s):  
Accretion Disk ◽  
Time Resolution ◽  
X Rays ◽  
X Ray ◽  
Time Variations ◽  
Short Time ◽  
First Time ◽  
Calar Alto

AbstractDuring the August 1983 outburst of the old nova GK Persei observations with EXOSAT showed for the first time a 351 second periodicity in X-rays.Our fast photometry (U(B)V with 25 sec time resolution) was made at the end of the outburst in the nights of September 29 , and October 1–3 , using the 2.2 meter telescope at Calar Alto (Spain).Optical variations up to 10% in U and 4% in V with periodicities in the range 350 to 360 seconds were found, lasting only for few cycles.A comparison with the extrapolated prediction of the X-ray maxima did not show a coincidence, but rather an anticoincidence in several cases. This supports a model of reprocessed X-rays at the inner edge of an accretion disk.

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