scholarly journals UJI EFEKTIVITAS EKSTRAK BIJI KETUMBAR (CORIANDRUM SATIVUM L.) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS HIPERKOLESTEROLEMIA DIABETES

2020 ◽  
Vol 4 (2) ◽  
pp. 357
Author(s):  
Syarifah Nazira ◽  
Maria Selvester Thadeus ◽  
Niniek Hardini
Keyword(s):  
Oxidative Stress ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Seed Extract ◽  
Coriandrum Sativum ◽  
Blood Cholesterol ◽  
Glomerular Hypertrophy ◽  
Blood Cholesterol Level ◽  
High Fat ◽  
Coriander Seed

Diabetes Mellitus (DM) is metabolic disease characterized hyperglicemia caused by abnormalities of insulin secretion, insulin sensitivity, or both of them.  Persistent hyperglicemia can trigger the production of oxidative stress. Oxidative stress can cause  glomerular hypertrophy. Coriander seed extract has the potential to overcome oxidative stress. This study aims to determine the effect of coriander seed extract to kidney histopathological examination, blood cholesterol, and blood sugar level in hypercholestrolemia diabetic rats. Samples consist of 30 males wistar rats were divided into five treatments i.e: (K1) standard feed and aquades, (K2) high-fat feed, alloxan, and  glibenclamid 0,045 mg/day, (K3) high-fat feed, alloxan, and coriander seed extract 300 mg/kgBW/day, (K4) high-fat feed, alloxan, and coriander seed extract 500mg/kgBW/day, (K5) high-fat feed, alloxan, and  coriander seed extract 700mg/kgBW/day. Coriander seed extract was given for 28 days. The result of Wilcoxon test showed that coriander seed extract can reduce blood cholesterol level in diabetic hypercholesterolemia, meanwhile the result of paired T-test showed that it can reduce blood sugar level. Measurement of kidney’s histopathological structure as glomerular area was analyzed by Kruskal Wallis test (p=0,001) and continued with Mann-Whitney test. Group K4 can reduce glomerular area significantly compared with group K3 and K5. In conclussion, coriander seed extract can reduce blood cholesterol, blood sugar level and effectively reduce glomerular hypertrophy at dose of 500mg/kgBW/day. Keyword : Coriandrum sativum L.; coriander seed extract; glomerular hypertrophy; blood cholesterol level; blood  glucose level ABSTRAK Diabetes Melitus (DM) merupakan suatu penyakit metabolik dengan karakteristik  hiperglikemi yang terjadi karena kelainan sekresi insulin, kerja insulin atau kedua-duanya. Hiperglikemi persisten dapat memicu produksi stres oksidatif. Stres oksidatif dapat menyebabkan terjadinya hipertrofi glomerulus. Ekstrak biji ketumbar (Coriandrum sativum L.) berpotensi mengatasi stres oksidatif. Penelitian ini bertujuan untuk mengetahui efek pemberian esktrak biji ketumbar (Coriandrum sativum L.) terhadap gambaran histopatologi ginjal, kadar kolesterol darah, dan kadar gula darah tikus model hiperkolesterolemia diabetes. Sebanyak 30 ekor tikus putih jantan galur wistar, dikelompokkan menjadi lima kelompok dengan perlakuan berbeda yaitu: (K1) pakan standar dan aquades, (K2) pakan tinggi lemak, aloksan, dan glibenklamid 0,045mg/hari, (K3) pakan tinggi lemak, aloksan dan ekstrak biji ketumbar 300mg/kgBB/hari, K4) pakan tinggi lemak, aloksan dan ekstrak biji ketumbar 500mg/kgBB/hari, (K5) pakan tinggi lemak, aloksan, dan ekstrak biji ketumbar 700mg/kgBB/hari. Ekstrak biji ketumbar diberikan selama 28 hari. Hasil uji Wilcoxon menunjukkan ekstrak biji ketumbar dapat menurunkan kadar kolesterol darah, sedangkan hasil uji T berpasangan menunjukkan ekstrak biji ketumbar dapat menurunkan kadar guka darah sewaktu pada tikus model hiperkolesterolemia diabetes. Histopatologi ginjal dianalisis menggunakan uji Kruskal Wallis didapatkan (p=0,001) dan dilanjutkan dengan uji Mann-Whitney. Pada kelompok K4 terdapat penurunan luas glomerulus yang signifikan dibanding kelompok K3 dan K5. Kesimpulannya, esktrak biji ketumbar dapat menurunkan kadar kolesterol darah, kadar gula darah, dan pada dosis 500mg/kgBB/hari paling efektif untuk menurunkan hipertrofi gomerulus. 

scholarly journals Açaí (Euterpe oleracea Mart.) seed extract protects against hepatic steatosis and fibrosis in high-fat diet-fed mice: Role of local renin-angiotensin system, oxidative stress and inflammation

2020 ◽  
Vol 65 ◽  
pp. 103726 ◽  
Author(s):  
Matheus Henrique Romão ◽  
Graziele Freitas de Bem ◽  
Izabelle Barcellos Santos ◽  
Ricardo de Andrade Soares ◽  
Dayane Teixeira Ognibene ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepatic Steatosis ◽  
High Fat Diet ◽  
Renin Angiotensin System ◽  
Seed Extract ◽  
Euterpe Oleracea ◽  
High Fat ◽  
Angiotensin System ◽  
Euterpe Oleracea Mart

scholarly journals Pengaruh Ekstrak Biji Ketumbar (Coriandrum Sativum) Terhadap Kadar Trigliserida Dan Gambaran Histologi Hati Tikus (Rattus Novergicus) Yang Diinduksi Oleh Pakan Tinggi Lemak

2020 ◽  
Vol 9 (1) ◽  
pp. 47-54
Author(s):  
Liah Kodariah ◽  
Aziz Ansori Wahid
Keyword(s):  
Fatty Liver ◽  
Triglyceride Level ◽  
Serum Triglyceride ◽  
Seed Extract ◽  
Serum Triglyceride Level ◽  
High Fat ◽  
Rat Serum ◽  
Histological Picture ◽  
White Rats ◽  
Coriander Seed

AbstrakHiperlipidemia merupakan salah satu penyebab penyakit jantung koroner yang ditandai dengan adanya penumpukan lemak yang disebabkan oleh kadar trigliserida tinggi. Hiperlipidemia dapat mengakibatkan perlemakan hati (fatty-liver) sehingga hepatosit mengalami kerusakan dan peningkatan aktivitas enzim trans-aminase. Hati memiliki peran penting untuk metabolisme lipid karena lipid diangkut di dalam darah sebagai lipoprotein yang dibentuk di dalam hati. Tujuan penelitian ini adalah untuk mempelajari pengaruh ekstrak biji ketumbar terhadap kadar trigliserida serum darah dan gambaran histologi hati tikus putih yang diinduksi pakan tinggi lemak. Penelitian menggunakan metode eksperimen, sampel sebanyak 24 ekor tikus putih galur Wistar dikelompokkan kedalam 6 kelompok, yaitu: K1 (tikus diberi pakan normal dan diberi akuades), K2 (tikus hanya diberi pakan tinggi lemak), K3 (tikus diberi pakan tinggi lemak dan simvastatin dosis 0,18 mg/kg BB/hari), K4, K5, dan K6 (tikus diberi pakan diet tinggi lemak dan diberikan ekstrak biji ketumbar dengan dosis masing-masing 5,4 mg/kg BB/hari, 10,8 mg/kg BB/hari, dan 21,6 mg/kg BB/hari). Hasil penelitian menunjukkan adanya penurunan kadar trigliserida serum darah tikus sebelum dan setelah diberikan ekstrak biji ketumbar. Pada gambaran histologi K1, K3, K4, K5, dan K6 didapatkan gambaran histologi hati yang normal, sedangkan pada K2 ditemukan sel kariolisis (nekrosis). Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak biji ketumbar berpengaruh terhadap penurunan kadar trigliserida serum darah tikus dan adanya perubahan histologi hati pada kelompok tikus yang diberikan ekstrak biji ketumbar dengan kelompok yang tidak diterapi.Kata kunci: biji ketumbar, trigliserida, histologi, hati, hiperlipidemia.AbstractHyperlipidemia is one of the causes of coronary heart disease marked by the accumulation of fat caused by high triglyceride levels. Hyperlipidemia can cause fatty liver so that hepatocytes experience damage and increase the activity of the transaminase enzyme. The liver has an important role in lipid metabolism because lipids are transported in the blood as lipoproteins formed in the liver. The purpose of this study is to investigate the effect of coriander seed extract on blood serum triglyceride levels and the histological picture of white rat liver induced by high-fat feed. The study used an experimental method in which a sample of 24 white rats were grouped into 6 groups, K1 (rats were given normal feed and given aqua dest), K2 (rats were only given high-fat feed), K3 (rats were given high-fat feed and simvastatin dose 0. 18 mg/kg/day), while K4, K5, and K6 (rats were fed a diet high in fat and given coriander seed extract at a dose of 5.4 mg/kg/day, 10.8 mg/kg/day, and 21.6 mg/kg/day respectively). The results showed a decrease in rat serum triglyceride level before and after coriander seed extract was given. In the histological features of K1, K3, K4, K5, and K6, a normal histological picture of the liver was found, while karyolysis cells (necrosis) were observed in K2 group. Based on the results of the study, the coriander seed extract might affect the reduction in rat serum triglyceride level as well as the histological changes of liver in rats treated with coriander seed extract as compared to the untreated group.Keywords: coriander seed, triglyceride, histology, liver, hyperlipidemia

scholarly journals Açaí seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet–fed mice

2020 ◽  
Vol 79 ◽  
pp. 35-49 ◽  
Author(s):  
Izabelle Barcellos Santos ◽  
Graziele Freitas de Bem ◽  
Cristiane Aguiar da Costa ◽  
Lenize Costa Reis Marins de Carvalho ◽  
Amanda Faria de Medeiros ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
White Adipose Tissue ◽  
High Fat Diet ◽  
Renin Angiotensin System ◽  
Seed Extract ◽  
High Fat ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
System Activation

Modulatory Effect of Whole Flour and Hydroalcoholic Extract of Finger Millet (Elusine coracana) on the Abnormalities Associated with Metabolic Syndrome in Hyperlipidemic Diabetic Rats

2021 ◽  
Vol 1 (30) ◽  
pp. 39-48
Author(s):  
Upma Bhandari *Mamta F Singh
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Blood Sugar ◽  
High Fat Diet ◽  
Blood Sugar Level ◽  
Finger Millet ◽  
Diabetic Rats ◽  
Fasting Blood Sugar ◽  
High Fat ◽  
Hydroalcoholic Extract

Abstract- The present study was designed to evaluate the effect of whole flour and hydroalcoholic extract of finger millet (Elusine coracana) in high fat diet (HFD) and streptozotocin induced metabolic syndrome in rats. The HFD was fed to the rats for a period of 45 days to induce hyperlipidemia. Diabetes was induced by single intraperitoneal injection of streptozotocin (65mg/kg i.p) in 0.1M citrate buffer pH 4.5. Animals with fasting blood sugar level of 250 mg/dl were considered as hyperlipidemic diabetic rats (HDR) and were selected for the study. The HDR were divided into five groups with six animals in each group and one group of normal animals. The HDR received whole flour and hydroalcoholic extract of Elusine coracana at a dose of 100, 200 and 400 mg/kg for a period of 21 days. Body weight, body mass index, fasting blood sugar level, lipid profile and the level of oxidative stress was measured in animals after the treatment. All treatments significantly decreased body weight, BMI, fasting blood sugar and also improved lipid profile in HDR as compared to the toxicant control. The treatments significantly reduced the level of lipid peroxidation and improved superoxide dismutase and reduced glutathione in the pancreas of HDR. Whole flour and hydroalcoholic extract of Elusine coracana at a dose of 200 and 400 mg/kg caused significant alleviation of the abnormalities of metabolic syndrome in rats. Keywords: Finger millet, High fat diet, Hyperlipidemic diabetic rats, Metabolic syndrome.

scholarly journals Grape seed extract attenuates oxidative stress induced by high fat/carbohydrate meal in metabolic syndrome patients

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Ravi Kiran Tadapaneni ◽  
Sandhya Krishnankutty ◽  
Lourdes Alandete ◽  
Jody M. Randolph ◽  
Mandeep Cheema ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
High Fat ◽  
Carbohydrate Meal

Hydroalcoholic Seed Extract of Coriandrum sativum (Coriander) Alleviates Lead-Induced Oxidative Stress in Different Regions of Rat Brain

2014 ◽  
Vol 159 (1-3) ◽  
pp. 351-363 ◽  
Author(s):  
Manoj Kumar Velaga ◽  
Prabhakara Rao Yallapragada ◽  
Dale Williams ◽  
Sharada Rajanna ◽  
Rajanna Bettaiya
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Seed Extract ◽  
Coriandrum Sativum

scholarly journals EFEKTIVITAS PEMBERIAN EKSTRAK BIJI KETUMBAR TERHADAP GAMBARAN SEL BUSA ATEROSKLEROSIS AORTA ABDOMINALIS TIKUS HIPERKOLESTEROLEMIA DIABETES

2020 ◽  
Vol 4 (2) ◽  
pp. 369
Author(s):  
Kusvandita Giopratiwi ◽  
Maria Selvester Thadeus ◽  
Retno Yulianti
Keyword(s):  
Treatment Group ◽  
High Fat Diet ◽  
Foam Cell ◽  
Seed Extract ◽  
Foam Cell Formation ◽  
Control Group ◽  
P Value ◽  
High Fat ◽  
Aorta Abdominalis ◽  
Coriander Seed

Coriander Seed Extract (CSE) is thought to have the potential to repair foam cell formation process which is part of atherosclerotic lesion. The aim of this study is to identify the effects of coriander seed extract on histopathological features of atherosclerotic foam cells abdominal aorta in rats hypercholesterolemia diabetes model. The study was conducted for 63 days. 30 Wistar outbred rats were grouped into five groups, each group consist of 6 rats. Negative control group (standar feed), positive control group (high fat diet and alloxan + glibenclamide 0.045 mg), treatment group 1 (high fat diet and alloxan + CSE 300 mg/kgBB/day), treatment group 2 (high fat diet and alloxan + CSE 500 mg/kgBB/day), treatment group 3 (high fat diet and alloxan + CSE 700 mg/kgBB/day). After the treatment were given to each group, the next procedure were dissection, extraction of the aorta abdominal organ, and histopathological examination of foam cell. Data were analyzed with One Way ANOVA test and Post Hoc Bonferoni test show there are significant difference (P value = 0.049) between positive control group and treatment group 3. In conclusion, CSE 700 mg/kgBB dose can reduce foam cell formation. Keywords: atherosclerosis; coriander seed extract; foam cell; hypercholesterolemia. ABSTRAK Ekstrak biji ketumbar (EBJ) diduga memiliki potensi untuk memperbaiki proses pembentukan sel busa lesi aterosklerosis. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian ekstrak biji ketumbar terhadap gambaran histopatologi sel busa aterosklerosis aorta abdominalis tikus model hiperkolesterolemia diabetes. Penelitian dilakukan selama 63 hari. Sebanyak 30 ekor tikus Galur Wistar outbred dibagi ke dalam 5 kelompok, masing-masing kelompok terdiri dari 6 ekor. Kelompok kontrol negatif (pakan standar), kelompok kontrol positif (pakan tinggi lemak dan aloksan + glibenklamid 0.045 mg), kelompok perlakuan 1 (pakan tinggi lemak dan aloksan + EBJ 300 mg/kgBB/hari), kelompok perlakuan 2 (pakan tinggi lemak dan aloksan + EBJ 500 mg/kgBB/hari), dan kelompok perlakuan 3 (pakan tinggi lemak dan aloksan + EBJ 700 mg/kgBB/hari). Setelah perlakuan, dilakukan pembedahan dan pengambilan organ aorta abdominalis lalu dibuat preparat untuk menilai gambaran sel busa. Analisis statistika dengan Uji One Way ANOVA dan uji Post Hoc Bonferoni menunjukkan ada perbedaan signifikan (P Value=0.049) antara kelompok kontrol positif dengan kelompok perlakuan 3. Kesimpulannya, EBJ dosis 700 mg/kgBB/hari memiliki efektivitas untuk menurunkan pembentukan sel busa dalam proses aterosklerosis.

scholarly journals Hypercholesterolemia risk associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol level in human and mouse

2020 ◽  
Author(s):  
Fangfang Han ◽  
Xiao Liu ◽  
Chuanfang Chen ◽  
Yinan Liu ◽  
Mingkun Du ◽  
...  
Keyword(s):  
Cholesterol Level ◽  
G Protein ◽  
Association Studies ◽  
Blood Cholesterol ◽  
Genome Wide Association Studies ◽  
Blood Cholesterol Level ◽  
High Fat ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Human And Mouse

Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with dyslipidemia. However, about 95% of of these variants are located in genome noncoding regions and cluster in different loci. The disease-causing variant for each locus and underline mechanism remain largely unknown. We systematically analyzed these noncoding variants and found that rs1997243 is the disease-causing variant in locus 7p22, which is strongly associated with hypercholesterolemia. The rs1997243 risk allele is associated with increased expression of GPR146 in human and targeted activation of the rs1997243 site specifically up regulates GPR146 expression in cultured cells. GPR146 is an orphan G-protein coupled receptor that is located on plasma membrane and responses to stimulation of heat-inactivated serum. Disrupting gpr146 specifically in the liver decreases the blood cholesterol level and prevents high-fat or high-fat high-cholesterol diets induced hypercholesterolemia in mice. Thus we uncovered a novel G-protein coupled receptor that regulates blood cholesterol level in both human and mouse. Our results also suggest that antagonizing GPR146 function will be an effective strategy to treat hypercholesterolemia.

STUDY OF CORIANDER SEED OIL (Coriandrum sativum L.)

2010 ◽  
Vol 13 (3) ◽  
pp. 29-38
Author(s):  
Ha Bich Phan ◽  
Thach Ngoc Le
Keyword(s):  
Biological Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Seed Oil ◽  
Coriandrum Sativum ◽  
Conventional Heating ◽  
Geranyl Acetate ◽  
Physical And Chemical ◽  
Coriander Seed Oil ◽  
Coriander Seed

Coriandrum sativum L. belongs to the Apiaceae family, which is cultivated in Dong Nai province, in this paper its seed oil of was studied. The essential oil was extracted by hydrodistillation. We used two methods for activating of hydrodistillation: conventional heating and microwave irradiating. Its physical and chemical indexes were measured. The chemical composition of this oil was identified by GC/MS and quantified by GC/FID. Linalool (75.51-77.21 %), and geranyl acetate (15.64-12.79 %) were the main constituents of the oil which were obtained in 0,32-0.39 % yield. The biological activity of this oil was reported.

PENGARUH SENAM KAKI TERHADAP KADAR GULA DARAH PADA PASIEN DENGAN DIABETES MELITUS

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Niken Sukesi
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Disease ◽  
Blood Sugar ◽  
Research Design ◽  
Blood Circulation ◽  
Blood Sugar Level ◽  
Consecutive Sampling ◽  
Post Test ◽  
The One ◽  
Diabetes Melitus

Penyakit Diabetes Melitus dapat menyebabkan komplikasi yang sangat berat. Komplikasi dari Diabetes Melitus ini meliputi jantung iskemik, serebrovaskuler, gagal ginjal, ulkus pada kaki, gangguan penglihatan. Komplikasi yang paling sering terjadi adanya perubahan patologis pada anggota gerak bawah yang disebut kaki diabetik. Salah satu jenis olahraga yang dianjurkan dengan diabetes mellitus adalah senam kaki. Senam kaki merupakan latihan yang dilakukan bagi penderita DM atau bukan penderita untuk mencegah terjadinya luka dan membantu melancarkan peredaran darah bagian kaki. Penelitian ini bertujuan untuk menganalisis pengaruh senam kaki terhadap kadar gula darah pasien diabetes mellitus. Desain dalam penelitian ini adalah Quasy Eksperiment dengan rancangan Pre and Post Test Without Control. Teknik pengambilan sampel menggunakan Consecutive sampling. Alat pengumpul data yang digunakan instrument observasi senam kaki untuk menilai senam kaki, dan alat menilai kadar gula darah yaitu glucometer, kapas dan jarum. Rata-rata kadar gula darah sebelum dan setelah dilakukan senam kaki mengalami penurunan dan ada pengaruh kadar gula darah sebelum dengan sesudah dilakukan senam kaki pada pasien diabetes melitusKata Kunci: Senam Kaki, Kadar Gula Darah THE EFFECT OF GYMNASTIC FEET TOWARD THE BLOOD SUGAR LEVEL FOR THE DIABETICSDiabetes Mellitus causes the complication case. It concludes the heart iskemik, serebrovaskuler, cronic kidney disease, ulcus on the feet, and the impairment of sight. The complication often causes the changing of pathological in certain place such as feet. The one of recommended sport for diabetics is gymnastic feet. Gymnastic feet is an experience for diabetics or not in order to prevent the wound and launch the blood circulation. The research objective is to analyze the effect of gymnastic feet to blood sugar level for diabetics. The research design is using experiment quasy with pre and post test without control. It is using consecutive sampling as the sample of collecting technique, and using observation of gymnastic feet as the collecting data technique to assess the blood sugar level, those are glucometer, cotton, and needle. The average of blood sugar level is decrease after doing the gymnastic feet. Moreover, there is differences between after and before doing the gymnastic feet for diabetics.Key Words : Gymnastic Feet, Blood sugar level

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