scholarly journals Cambios y riesgos asociados a la adolescencia

2017 ◽  
Vol 7 (2) ◽  
pp. 109 ◽  
Author(s):  
Carmen Viejo ◽  
Rosario Ortega-Ruiz
Keyword(s):  
School Violence ◽  
Social Dynamics ◽  
Pubertal Development ◽  
Social Changes ◽  
Functional Changes ◽  
Problem Behaviours ◽  
Potential Benefits ◽  
Potential Risks ◽  
Consumo De Sustancias ◽  
The Brain

Resumen: La adolescencia es un periodo crítico de cambios biológicos, comportamentales y sociales continuos. Estos cambios pueden ser fuente tanto de crecimiento como de obstáculos para el desarrollo en años posteriores. El desarrollo puberal, los cambios morfológicos y funcionales a nivel cerebral, y la ampliación del contexto social y las dinámicas de relación que en él se desarrollan, pueden suponer para los adolescentes un factor de riesgo para la implicación en diversas conductas problema. Este monográfico presenta algunos de los últimos trabajos desarrollados en torno al consumo de sustancias, la violencia escolar, bullying, ciberbullying o cibercortejo.Risks and changes related to the adolescenceAbstract: The adolescence is a critical period time: biological, behavioural and social changes occur continuously. Those changes could be understood as potential benefits for the development along the adolescence and afterwards, but also as potential risks for this period. The pubertal development; the morphological and functional changes in the brain; and the wider social context where the adolescents stablish new and more complex social dynamics, could be acting as risk factors for several problem behaviours. This Special Issue presents some of the latest papers developed about consumption, school violence, bullying, cyberbullying and cyberdating.

Electromagnetic field in Alzheimer’s disease: a literature review of recent preclinical and clinical studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Reem Habib Mohamad Ali Ahmad ◽  
Marc Fakhoury ◽  
Nada Lawand
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorder ◽  
In Vivo Studies ◽  
Key Factors ◽  
Potential Benefits ◽  
Preclinical And Clinical Studies ◽  
The Brain

: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive loss of neurons leading to cognitive and memory decay. The main signs of AD include the irregular extracellular accumulation of amyloidbeta (Aβ) protein in the brain and the hyper-phosphorylation of tau protein inside neurons. Changes in Aβ expression or aggregation are considered key factors in the pathophysiology of sporadic and early-onset AD and correlate with the cognitive decline seen in patients with AD. Despite decades of research, current approaches in the treatment of AD are only symptomatic in nature and are not effective in slowing or reversing the course of the disease. Encouragingly, recent evidence revealed that exposure to electromagnetic fields (EMF) can delay the development of AD and improve memory. This review paper discusses findings from in vitro and in vivo studies that investigate the link between EMF and AD at the cellular and behavioural level, and highlights the potential benefits of EMF as an innovative approach for the treatment of AD.

281 Can We Developmentally Program the Epigenome to Improve Traits Relevant to Production in Cattle?

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 20-20
Author(s):  
Robert A Cushman ◽  
Alexandria Snider ◽  
Matthew S Crouse
Keyword(s):  
Ovarian Reserve ◽  
Equal Opportunity ◽  
Production Systems ◽  
Pubertal Development ◽  
Transcript Abundance ◽  
Developmental Programming ◽  
Production Traits ◽  
Female Progeny ◽  
Primordial Follicles ◽  
Functional Changes

Abstract While sequence variation can be informative to associate regions of the genome with specific traits and improve genetic selection, the epigenome may provide a more powerful tool to manage cattle. Identifying practices that are producer friendly and effectively control epigenetic function within animals is crucial to translating developmental programming to a production setting. Initial studies of developmental programming investigated how environmental or nutritional stresses during fetal and peri-natal development impacted performance of animals later in life. These studies demonstrated changes in methylation, alterations in transcript abundance, and negative impacts on physiology, but they also suggested that we may be able to beneficially impact the epigenome and developmentally program animals to excel in their niche in the production system. Maternal nutritional status during the third trimester influenced date of conception of female progeny in several studies but failed to do so in other studies. Transcriptomic analyses provided evidence that nutritional treatments alter mRNA abundance in brain, liver, muscle, and ovary, but does not conclusively demonstrate that this is due to functional changes in the epigenome. If developmental programming is to be applied in production systems, responses must be consistent and beneficial. Reducing nutrient intake in heifers during peri-pubertal development increased number of primordial follicles in the ovaries and reproductive longevity. While nutritional programming of the ovarian reserve in peri-pubertal heifers appears to occur consistently across locations and studies, it does not ensure that subsequent environmental stressors will not induce changes in the ovarian reserve that will negate beneficial effects. These studies demonstrate that it is possible to developmentally program the epigenome in cattle in ways that will improve production traits; however, there remains a need for studies to improve the consistency of response and to determine best practices that fit into production systems. USDA is an equal opportunity provider and employer.

Effects of long-term oral administration of silver nanoparticles on the cognitive functions of mammals

2021 ◽  
Vol 29 (6) ◽  
pp. 33-38
Author(s):  
Anna Alexandrovna Antsiferova ◽  
Marina Yurievna Kopaeva ◽  
Vyacheslav Nikolaevich Kochkin ◽  
Pavel Konstantinovich Kashkarov
Keyword(s):  
Silver Nanoparticles ◽  
Oral Administration ◽  
Dietary Supplement ◽  
Cognitive Functions ◽  
High Demand ◽  
Gastrointestinal Infections ◽  
Impaired Cognitive Function ◽  
Potential Risks ◽  
The Brain

Introduction. Since the beginning of the XXI century, silver nanoparticles have been widely used in various industries, medicine and pharmaceuticals due to their pronounced antibacterial, antiviral and fungicidal properties. In connection with such a high demand for the use of silver nanoparticles, it is very important to understand the associated potential risks from their use. Materials and methods. In the course of the work, there has been a study of the effects of the long-term oral administration of a commercially produced dietary supplement based on silver nanoparticles with a size of 34 nm and stabilized with polyvinylpyrrolidone in an amount of 50 μg/day/animal on the cognitive functions of C57Bl/6 mice, as well as their accumulation in the brain by the method of instrumental neutron activation analysis. The dietary supplement used is recommended for people as a treatment for gastrointestinal infections. Results. It was found that after 180 days of administration, silver nanoparticles impair long-term contextual memory, and over time, the content of silver in the brain increases. Conclusion. Presumably impaired cognitive function with accumulation of silver in the brains of mice. This poses the risk of prolonged oral use of the silver nanoparticles.

scholarly journals Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Alessio Molfino ◽  
Gianfranco Gioia ◽  
Filippo Rossi Fanelli ◽  
Alessandro Laviano
Keyword(s):  
Adipose Tissue ◽  
Food Intake ◽  
Proinflammatory Cytokines ◽  
Adaptive Response ◽  
Energy Homeostasis ◽  
Cancer Cachexia ◽  
Behavioral Changes ◽  
Brain Areas ◽  
Functional Changes ◽  
The Brain

Inflammation characterizes the course of acute and chronic diseases and is largely responsible for the metabolic and behavioral changes occurring during the clinical journey of patients. Robust data indicate that, during cancer, functional modifications within brain areas regulating energy homeostasis contribute to the onset of anorexia, reduced food intake, and increased catabolism of muscle mass and adipose tissue. In particular, functional changes are associated with increased hypothalamic concentration of proinflammatory cytokines, which suggests that neuroinflammation may represent the adaptive response of the brain to peripheral challenges, including tumor growth. Within this conceptual framework, the vagus nerve appears to be involved in conveying alert signals to the hypothalamus, whereas hypothalamic serotonin appears to contribute to triggering catabolic signals.

scholarly journals Perubahan Sosial, Ijtihad dan Dinamika Hukum Islam

2018 ◽  
Vol 4 (1) ◽  
pp. 63-76
Author(s):  
Salamah Eka Susanti
Keyword(s):  
Social Change ◽  
Social System ◽  
Social Dynamics ◽  
Islamic Law ◽  
Social Changes ◽  
Cultural Objects ◽  
The Road ◽  
The Social ◽  
Rapid Changes ◽  
The Law

The Qur'an contains only a small number of detailed laws, while the sunna is limited to the cases that occurred in its time, so to solve new problems, ijtihad is required. In such a connection for a Muslim, new problems arising from the progress of science and technology, should not be confronted with confrontational passages, but must be solved by ijtihadi.Karena reality often occurs, that the development of society and public opinion faster the pace of the road from on the development of the law itself. The dynamics of people's lives are characteristic of change. Through the power of intention, power, and creativity, humans create cultural objects as a result of their creations. Changes that occur in society when observed can occur in various There are slow changes (evolution) and there are rapid changes (revolution). The social changes that occur in a society, directly or indirectly, affect institutions in various fields, such as government, economics, education, religion and so on. The continuation of an impact on the social system changes. When the law is faced with social change, it occupies one of its functions, which can function as a means of social control, and the law can serve as a means of social change. the characteristics of the law above is due to the inconsistency of social dynamics and the dynamics of law in the life of society. Unequaled dynamics of society and law, usually will bring social lag. From here, then comes a question whether Islamic law as a norm of God's determination can experience changes in accordance with the needs of the community? Ijtihad is an important factor for the development and development of Islamic law.Ijtihad done to answer the problems that arise in society that is not yet known legal status.ijtihad has a wide scope, the issues are not regulated explicitly dala m al-Qur'an and sunna can be done ijtihad. In order for humans to have breadth in determining its activities according to its ability, needs and environment. Therefore ijtihad in the field of Islamic law in anticipating the dynamics of society and social changes concerning the values, behavior patterns, and social system of a society is a concern in establishing Islamic law. Thus ijtihad is the third source in the development of Islamic law. Keywords: Social Change, Ijtihad, Law, Islamic.

scholarly journals Analysis of the Results of the Pedagogical Research and Eeg in the Aspect of Effective Modern Teaching Aids in the Technical Education

2015 ◽  
Vol 4 ◽  
pp. 480
Author(s):  
Tomasz Prauzner
Keyword(s):  
Computer Technology ◽  
Medical Equipment ◽  
Modern Technology ◽  
Social Changes ◽  
Teaching Aids ◽  
Modern Media ◽  
Research Findings ◽  
General Pedagogy ◽  
Pedagogical Research ◽  
The Brain

<p class="IATED-Affiliation">The development of computer technology is reflected in among other things, the development of modern didactics. Current pedagogy and media education, as a fast developing discipline of general pedagogy, is a topic of a number of studies. Applying the modern multimedia aids at various stages and in various types of education is considered as an indispensable element of modern didactics, due to new opportunities the modern media offers. The paper deals with didactic innovations based on research conducted within pedagogy on the observable social changes induced by development in information technology. The main objective of the paper is to address the issue how to apply modern technology and research findings on the functioning of the brain in order to improve the effectiveness of the learning process. The paper presents only the results of a pilot study, which can be used as a basis for further research using medical equipment for analyzing EEG brain waves for didactic purposes.</p><p> </p>

scholarly journals Patients’ perception about the outcomes of prosthetic treatment in Southern Brazil

2020 ◽  
Vol 19 ◽  
pp. e209398
Author(s):  
Giseli Sauer Benetti ◽  
Lara Dotto ◽  
Angélica Maroli ◽  
Fabíola Barbon ◽  
Alfonso Sanchez-Ayala ◽  
...  
Keyword(s):  
Significant Influence ◽  
Education Level ◽  
Prior Treatment ◽  
Southern Brazil ◽  
Negative Perception ◽  
Sociodemographic Data ◽  
Initial Appointment ◽  
Potential Benefits ◽  
Potential Risks ◽  
The City

Aim: this study assessed the patients’ perception of the outcomes of prosthetic treatment in a University of Southern Brazil. Methods: patients seeking for prosthetic treatment were invited to answer a questionnaire with 41 items about the potential risks, benefits, and consequences of no treatment. Answers were obtained according to a five-item Likert-scale varying from 1 (completely disagree) to 5 (completely agree). Sociodemographic data was included in the comparison. Mann-Whitney or Kruskal-Wallis (95%) compared data depending on the variable. Results: two-hundred twenty-five patients answered the questionnaire. Median age of participants was 45-54 years. The potential benefits were similar among participants irrespective of the variable adopted. The perception of risks was significant influenced by variables gender, age, education level, type of edentulous space, prior treatment with prosthodontics, type of prosthodontics, and prosthodontics usage in years. Consequences of no treatment were affected by age, prior treatment with prosthodontics, and prosthodontics usage in years. Conclusions: the study showed the fundamental importance of correct elucidation about the potential risks (negative perception) in the initial appointment for the studied population. Elucidation about the consequences of no treatment are relevant because some differences were seen into the variables. Prosthodontics patients from the city of Passo Fundo seem well informed about the benefits of the prosthetic treatment, besides the significant influence of some sociodemographic and prosthetic conditions. 

scholarly journals Interdisciplinary consensus statement on indication and application of a hydrogel spacer for prostate radiotherapy based on experience in more than 250 patients

2016 ◽  
Vol 50 (3) ◽  
pp. 329-336 ◽  
Author(s):  
Arndt-Christian Müller ◽  
Johannes Mischinger ◽  
Theodor Klotz ◽  
Bernd Gagel ◽  
Gregor Habl ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Rectal Wall ◽  
Locally Advanced ◽  
Transrectal Ultrasound ◽  
Serious Adverse Event ◽  
Prostate Radiotherapy ◽  
Risk Prostate Cancer ◽  
Potential Benefits ◽  
Potential Risks ◽  
Current Experience

Abstract Background The aim of the study was to reach a consensus on indication and application of a hydrogel spacer based on multicentre experience and give new users important information to shorten the learning curve for this innovative technique. Methods The interdisciplinary meeting was attended by radiation oncologists and urologists, each with experience of 23 – 138 hydrogel injections (SpaceOAR®) in prostate cancer patients before dose-escalated radiotherapy. User experience was discussed and questions were defined to comprise practical information relevant for successful hydrogel injection and treatment. Answers to the defined key questions were generated. Hydrogel-associated side effects were collected to estimate the percentage, treatment and prognosis of potential risks. Results The main indication for hydrogel application was dose-escalated radiotherapy for histologically confirmed low or intermediate risk prostate cancer. It was not recommended in locally advanced prostate cancer. The injection or implantation was performed under transrectal ultrasound guidance via the transperineal approach after prior hydrodissection. The rate of injection-related G2-toxicity was 2% (n = 5) in a total of 258 hydrogel applications. The most frequent complication (n = 4) was rectal wall penetration, diagnosed at different intervals after hydrogel injection and treated conservatively. Conclusions A consensus was reached on the application of a hydrogel spacer. Current experience demonstrated feasibility, which could promote initiation of this method in more centres to reduce radiation-related gastrointestinal toxicity of dose-escalated IGRT. However, a very low rate of a potential serious adverse event could not be excluded. Therefore, the application should carefully be discussed with the patient and be balanced against potential benefits.

Economics & Practical Applications for Applied Trauma Theory

2013 ◽  
Vol 2 (2) ◽  
pp. 41-55 ◽  
Author(s):  
David S. Bathory
Keyword(s):  
World Wide ◽  
Rural Tourism ◽  
Clinical Population ◽  
Intergenerational Effects ◽  
Mass Trauma ◽  
Practical Applications ◽  
Functional Changes ◽  
The World ◽  
South Eastern Europe ◽  
The Brain

The effects of global warming are becoming apparent throughout the world. Europe has begun to experience more severe winters and increased rain (Steffen, 2011). Massive flooding in South Eastern Europe has devastated communities and repeatedly strains the economy of these regions resulting in mass trauma to the residents of multiple countries. Intergenerational effects of trauma (Kaitz, Levy, Ebstein, Faraone, & Mankuta, 2009) have been noted to be an increasing world-wide concern. These traumatic effects are not only psychologically based but result in structural and functional changes within the brain and body (van der Kolk, Roth, Pelcovitz, Sunday, & Spinazzola, 2005; Bathory, 2011; Bathory, 2012a; Bathory, 2012b). This paper explores the application of sustainable energy and rural tourism to assist mass victims of natural disaster flooding. The author provides the cultural precedents for marketing, as well as the psychoneurobiological rationale and application for an intervention to a large non-clinical population.

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