scholarly journals Cytokine profile and antibodies to neurotransmitters during comorbid depression and alcohol dependence in women

2020 ◽  
pp. 5-11
Author(s):  
Т.И. Невидимова ◽  
Л.А. Ветрилэ ◽  
Т.В. Давыдова ◽  
И.А. Захарова ◽  
Д.Н. Савочкина ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Blood Serum ◽  
Depressive Episode ◽  
Rating Scale ◽  
Dysthymic Disorder ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mild Depression ◽  
Addictive Disorders ◽  
Moderate Depression ◽  
Anti Inflammatory

Цель исследования - сравнительный анализ содержания про- и противовоспалительных цитокинов и аутоантител к нейромедиаторам дофамину, норадреналину, серотонину, глутамату и ГАМК в сыворотке крови пациенток с алкогольной зависимостью и депрессией разной степени тяжести. Методика. Клиническое обследование и создание банка биологического материала выполнены на базе отделений аффективных расстройств и аддиктивных состояний и лаборатории клинической психонейроиммунологии и нейробиологии НИИ психического здоровья Томского НИМЦ РАН. Исследована сыворотка крови 52 женщин в возрасте 40-55 лет: 17 условно здоровых лиц, и 35 пациенток с аффективными и аддиктивными расстройствами. В соответствии с МКБ-10 у 6 пациенток диагностирован синдром зависимости от алкоголя (F10.2). У 29 пациенток диагностирована депрессия разной степени тяжести. В подгруппу легкой депрессии (сумма баллов по шкале Гамильтона HDRS до 16 баллов включительно) вошли 13 пациенток: 5 с депрессивным эпизодом легкой степени F32.0 и 8 с дистимией F34.1. В подгруппу умеренной депрессии (сумма баллов по шкале Гамильтона выше 16 баллов) вошли 16 пациенток: 7 с депрессивным эпизодом средней степени F32.1 и 9 с рекуррентной депрессией F33.1. Антитела к нейромедиаторам дофамину, норадреналину, серотонину, глутамату и ГАМК в сыворотке крови определяли методом твердофазного иммуноферментного анализа на полистироловых планшетах, активированных соответствующими тест-антигенами. Интерлейкины в сыворотке крови определяли методом иммуноферментного анализа с использованием тест-систем производства ООО Цитокин (Санкт-Петербург). Определяли баланс провоспалительных цитокинов - интерлейкинов (ИЛ 1β, ИЛ 6) и противовоспалительных - ИЛ 10. Результаты. Уровень аутоантител к нейромедиаторам связан с тяжестью депрессии. При легкой депрессии отличия от контрольного уровня незначительны. При умеренной депрессии повышен уровень антител к серотонину, глутамату и ГАМК. Спектр антител при алкоголизме сходен с таковым при умеренной депрессии. Можно предполагать, что данные паттерны отражают коморбидное течение депрессии и аддикции. Соотношение содержания провоспалительного (ИЛ 6) и противовоспалительного (ИЛ 10) цитокинов в сыворотке крови при алкоголизме незначительно отличалось от контрольного уровня, в то время как при отягощении депрессии это соотношение существенно повышалось и у 20% обследованных в явной форме указывало на преобладание воспаления над компенсаторными процессами. Заключение. Феномен нейровоспаления не является достаточным для понимания нейроиммунных механизмов коморбидной патологии. Иммунорегуляция нейромедиаторного обмена является новым источником информации о нейроиммунном дисбалансе при сочетанных расстройствах. Aim. Comparative analysis of concentrations of pro- and anti-inflammatory cytokines and autoantibodies to the neurotransmitters dopamine, norepinephrine, 5-hydroxytryptamine, glutamate, and GABA in the blood serum of female patients with alcohol dependence and depression of different severity. Methods. Clinical examination and creation of a bank of biological material were performed at the Departments of Affective Disorders and Addictive Conditions and the Laboratory of Clinical Psychoneuroimmunology and Neurobiology of the Mental Health Institute, Tomsk Scientific Research Center of the Russian Academy of Sciences. Blood serum of 52 women aged 40-55 years was studied, including 17 conditionally healthy individuals, and 35 patients with affective and addictive disorders. In accordance with ICD-10, 6 patients were diagnosed with alcohol dependence syndrome (F10.2), and 29 patients were diagnosed with depression of different severity. The subgroup of mild depression with a Hamilton Depression Rating Scale (HDRS) score <16 included 13 patients (5 with a mild depressive episode F32.0 and 8 with dysthymic disorder F34.1). The subgroup of moderate depression with a total HDRS score >16 included 16 patients (7 with a moderate depressive episode F32.1 and 9 with recurrent depression F33.1). Serum antibodies to the neurotransmitters dopamine (DA), norepinephrine (NA), 5-hydroxytryptamine (5-HT), glutamate (GLU), and GABA were determined by enzyme-linked immunosorbent assay (ELISA) on polystyrene plates activated with the respective test antigens. Serum interleukins (IL) were measured using ELISA test systems. The balance of pro-inflammatory (IL 1β and IL 6) and anti-inflammatory (IL 10) cytokines was determined. Statistical analysis was performed with the φ Fisher criteria, and data were graphically presented as mean values. Results. Concentrations of autoantibodies to neurotransmitters were related with the severity of depression. In mild depression, differences from the control values were negligible. In moderate depression, levels of antibodies to 5-hydroxytryptamine, glutamate, and GABA were increased. In alcohol dependence, the array of antibodies was similar to that in moderate depression. These patterns apparently reflect the comorbid course of depression and addiction. The ratio of pro-inflammatory (IL 6) to anti-inflammatory (IL 10) cytokine serum concentrations in alcohol dependence was slightly different from the control ratio. At the same time in more severe depression, this ratio significantly increased and clearly indicated prevalence of inflammation over compensatory processes in 20% of the patients. Conclusion. The phenomenon of neuroinflammation is not sufficient to understand neuroimmune mechanisms of the comorbid pathology. Immunoregulation of neurotransmitter metabolism is a new source of information about neuroimmune imbalance in combined disorders.

scholarly journals Prevalence of Depression Among Post-Graduate Medical Trainees: A Multi-Centre Survey

2014 ◽  
Vol 4 (1) ◽  
pp. 18-21 ◽  
Author(s):  
S Zaman ◽  
MA Rahim ◽  
AH Khan ◽  
SH Habib ◽  
MM Rahman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Low Income ◽  
Rating Scale ◽  
Mild Depression ◽  
Cross Sectional Survey ◽  
Post Graduate ◽  
Graduate Medical ◽  
Medical Trainees ◽  
Moderate Depression ◽  
Prevalence Of Depression

Objectives: To describe the prevalence of depression among post-graduate medical students and to evaluate some related risk factors. Methodology: This cross-sectional survey was done in three post-graduate medical teaching institutes in Dhaka, Bangladesh in February 2013. A preformed questionnaire including some demographic, socio-economic and work related variables was used for the purpose and depression was diagnosed and severity assessed by using Hamilton Rating Scale for Depression (HAM-D). Results: A total of 100 post-graduate medical trainees were given a preformed questionnaire. Among them 53 students filled it up properly and sent back in given time (response rate was 53%). Mean age of the respondents was 31.6 years, male and females were almost equally distributed. Depression was present in 21 (39.6%) respondents. Among them 17 (80.9%) had mild depression and 4 (19.1%) had moderate depression. None of the respondents had severe or very severe depression. Increased age, low income, marital status, living away from family, smoking, long working hours and inadequate time for study appeared as important risk factors. Conclusion: Two-fifth of post-graduate medical trainees suffered from mild to moderate depression. This issue should be properly addressed because of its possible impact on training outcome. DOI: http://dx.doi.org/10.3329/birdem.v4i1.18548 Birdem Med J 2014; 4(1): 18-21

scholarly journals Comparative evaluation of cytokine and acute-phase protein concentrations in sera of dairy cows with subclinical and clinical ketosis as a different view of the causes of the disease

2021 ◽  
pp. 1572-1578
Author(s):  
Piotr Brodzki ◽  
Jan Marczuk ◽  
Urszula Lisiecka ◽  
Marek Szczubiał ◽  
Adam Brodzki ◽  
...  
Keyword(s):  
Blood Serum ◽  
Dairy Cows ◽  
Inflammatory Cytokines ◽  
Acute Phase ◽  
Assay Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Common Disease ◽  
Amyloid A ◽  
Tnf Α ◽  
Anti Inflammatory

Background and Aim: Ketosis is a common disease occurring during the first stage of lactation in highly productive dairy cows. The aim of the present study was the comparative assessment of selected pro-inflammatory cytokines (including tumor necrosis factor-α [TNF-α] and interleukin 6 [IL-6]), anti-inflammatory cytokines (including IL-10), and acute-phase proteins (APPs) (including haptoglobin [Hp] and serum amyloid A [SAA]), in the sera of cows with subclinical ketosis (SCK), in those with clinical ketosis (CK), and in healthy cows. Materials and Methods: Thirty dairy cows of Holstein-Friesian breed were investigated. The cows were divided into three groups depending on the serum β-hydroxybutyric acid (BHBA) level. The control, SCK, and CK groups included healthy cows, cows with SCK, and cows with CK, respectively. BHBA concentration in blood serum was determined using colorimetric method. The blood serum was used for proper tests. Cytokine (TNF-α, IL-6, and IL-10) and APPs (SAA and Hp) concentrations in the investigated samples were determined by enzyme-linked immunosorbent assay method. Results: The SCK group had significantly higher TNF-α, IL-6; IL-10, and SAA values than had the CK group (p<0.01). The SCK group had a lower Hp concentration than had the CK group (p<0.05). Conclusion: This study showed that the inflammation intensity is higher in the initial phase of the disease and decreases during the advancement, probably due to active anti-inflammatory mechanisms (an increase of IL-10 concentration), which protect animal organism from self-destruction. On the basis of our study, it can be assumed that ketosis development in dairy cows was preceded by the systemic inflammation that may influence the progress of this disease.

scholarly journals A COMPARATIVE STUDY TO ASSESS THE LEVEL OF DEPRESSION BETWEEN ELDERLY LIVING AT OLD AGE HOME AND LIVING WITH FAMILIES IN HARYANA

2020 ◽  
pp. 102-106
Author(s):  
Sonia Devi ◽  
Suman ◽  
Dr. Santosh Gurjar
Keyword(s):  
Comparative Study ◽  
Old Age ◽  
Health Problem ◽  
Rating Scale ◽  
Severe Depression ◽  
Cluster Sampling ◽  
Human Beings ◽  
Mild Depression ◽  
Moderate Depression ◽  
Elderly Living

Background and aim: Depression has always been a health problem for human beings. Historical documents written by healers, philosophers, writers, throughout the age point to the longstanding existence of depression as a health problem, and the continuous and sometime ingenious struggle people have made to find effective ways to treat this illness. In the study the aim to assess the level of depression between elderly living at old age home and living with families in Haryana. Materials and Methods: A comparative study to assess the depression between elderly living at old age home and living with families in selected Haryana. 100samples were selected by cluster sampling technique in each stratum have 50 samples. Data was collected with the help of Hamilton depression rating scale. Data analyzed by Descriptive (Mean, Median, Mode, Standard Deviation) and inferential technique. Results: Level of depression among elderly living in old age home 2% having normal level of depression, 34% mild depression, 46% moderate depression, 4% severe depression, 14% very severe depression and Level of depression among elderly living with family members 46% having normal depression, 44% having mild depression, 08% having moderate depression, 2% having severe depression. Conclusion: The study shown that assess the level of depression between elderly living at old age home and living with families in Haryana. KEY WORDS: Comparative, Knowledge, Elderly, Depression, Old age Home

scholarly journals AGE-DEPENDENT INDEXES OF IMMUNITY IN THE PATIENTS WITH PSORIATIC ARTHRITIS

2019 ◽  
Vol 21 (1) ◽  
pp. 69-76 ◽  
Author(s):  
A. A. Barilo ◽  
S. V. Smirnova ◽  
M. V. Smolnikova
Keyword(s):  
Psoriatic Arthritis ◽  
Blood Serum ◽  
Inflammatory Cytokines ◽  
Peripheral Blood ◽  
Clinical Course ◽  
Adult Patients ◽  
Enzyme Linked Immunosorbent Assay ◽  
Systemic Inflammatory Disease ◽  
Age Dependent ◽  
Anti Inflammatory

Psoriatic arthritis is a chronic progressive systemic inflammatory disease of joints and spine, which leads to the development of erosive arthritis, bone resorbtion, multiple enthesitis and spondylitis. Severe clinical course, resistance to therapy, high prevalence of disability, increased mortality of patients determine a need for further study of the disease. Psoriatic arthritis is a multifactorial disease including immune pathogenic factors representing a complex process of interaction between cellular and humoral components of immune system. The most important way of activating epidermal cells and synovial membrane proliferation in psoriatic arthritis is an imbalance of proinflammatory and anti-inflammatory cytokines. It is noted that the features of clinical course in psoriasis are age-dependent. The study of immune response indices in different age groups allows to reveal distinct progression features of the psoriatic pathology.The purpose of this study was to compare concentrations of proinflammatory and anti-inflammatory cytokines, cellular and humoral immunity, and to conduct a comparative analysis in young and adult patients with psoriatic arthritis.The study included a group of patients with psoriatic arthritis (n = 101) who were divided by their age: group 1, from 18 to 44 years (n = 43); group 2, over 44 years (n = 58). The control groups (3 and 4) included virtually healthy people (n = 103) matched for sex and age with the patients. Populational and subpopulation profiling of blood lymphocytes was performed by flow-cytometry using monoclonal antibodies to CD3, CD4, CD8, CD16, CD19 (LLC “Sorbent”, Moscow, Russia). Phagocytic activity of peripheral blood neutrophils was assessed microscopically by uptake of latex particles. Concentrations of IgA, IgM, and IgG immunoglobulins, circulating immune complexes, cytokines (IL-4, IL-6, IL-10, TNFα) in blood serum was determined by enzyme-linked immunosorbent assay. Statistical evaluation of the results obtained was performed using applied “Statistica 6.0” software.In all the age subgroups of patients with psoriatic arthritis, we have revealedstatistically significant differences against controls, i.e., increased relative and absolute number of CD3-CD16+lymphocytes in peripheral blood, higher concentration of CIC-C1q, with decreased concentrations of IgA, IgM, IgG in blood serum. The analysis of the main cellular and humoral indicators of immunity in psoriatic arthritis patients revealed a statistically significant differences for psoriatic arthritis in young and adulthood. E.g., the serum concentration of IL- 10 was statistically significantly lower in psoriatic arthritis at a young age in comparison with adult psoriatic arthritis. Phagocytic number and IgG concentration in serum were statistically significantly lower in adults with psoriatic arthritis adulthood than in young patients.In conclusion, The revealed changes in immunological indices in psoriatic arthritis in young and adult patients indicate to differences against healthy controls, as well as intergroup differences. Previous studies have not revealed statistically any significant differences in immunological parameters between young and adult patients with psoriatic arthritis in, thus suggesting a presence of immune disorders associated with psoriatic pathology, but not with the age of patients. However, changes of immunological reactivity are observed with increasing age of patients with psoriatic arthritis and development of severe clinical forms, and they can be considered as markers of psoriatic disease progression, such as increased concentrations of IL-10 and lower IgG amounts in blood serum, a decreased phagocytic number.

Effect of Chondroitin Sulfate on Blood Serum Cytokine Profile during Carrageenan-induced Edema and Monoiodoacetate-induced Osteoarthritis in Rats

2019 ◽  
Vol 14 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Oleksandr Korotkyi ◽  
Andrii Vovk ◽  
Oksana Blokhina ◽  
Kateryna Dvorshchenko ◽  
Tetyana Falalyeyeva ◽  
...  
Keyword(s):  
Knee Joint ◽  
Blood Serum ◽  
Chondroitin Sulfate ◽  
Transforming Growth Factor ◽  
Experimental Models ◽  
Cytokine Profile ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Cytokines ◽  
Anti Inflammatory ◽  
Therapeutic Administration

Background: Blood cytokines affect the development of inflammatory processes in both normal and pathological states. We have studied changes in the concentration of interleukins (ILs) - 1&#946;, IL-4, IL-10, IL-12B p40, transforming growth factor &#946; (TGF &#946;), tumor necrosis factor (TNF-&#945;) in acute carrageenan-induced inflammation and degenerative-dystrophic changes of knee joint caused by monoiodoacetate-induced Osteoarthritis (OA) in experimental models on rats. We also investigated the change in the cytokine profile during prophylactic and therapeutic administration of chondroitin sulfate to animals under experimental conditions. </P><P> Methods: The concentration of the cytokines was measured in blood serum by enzyme-linked immunosorbent assay. Results: The manifestation of articular lesions was characterized by a disturbance in the balance between proinflammatory (IL-1&#946;, IL-12B p40, TNF-&#945;) and anti-inflammatory (IL-4, IL-10, TGF -&#946;) cytokines. Conclusion: A reduction in the concentration of proinflammatory cytokines in blood serum after prophylactic and therapeutic administration of chondroitin sulfate to the rat with experimental models of acute inflammation of the hind limb and degenerative-dystrophic changes in the knee joint with OA is associated with anti-inflammatory and regenerative properties of the drug.

scholarly journals Core Depressive Symptoms In Depressed Cancer OutpatientsB

2011 ◽  
Vol 7 (1) ◽  
pp. 178-181 ◽  
Author(s):  
Massimo Pasquini ◽  
Isabella Berardelli ◽  
Ambra Cabra ◽  
Annalisa Maraone ◽  
Gabriella Matteucci ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Cancer Patients ◽  
Depressed Mood ◽  
Rating Scale ◽  
Depression Scale ◽  
Well Being ◽  
Mild Depression ◽  
Self Assessment ◽  
Moderate Depression ◽  
Severity Of Depression

Objective: This study aimed to estimate the prevalence of core depressive symptoms among cancer outpatients diagnosed with depressive or adjustment disorders with depressed mood. We also aimed to detect potential differences between patient self-assessment and psychiatrist evaluation in classifying the severity of depression. Methods: Fifty-two outpatients diagnosed with solid tumor malignancy and depressive or adjustment disorder with depressed mood were assessed using the Hamilton Depression Rating Scale (HAMD-17) (and its shortened version the HAMD-7) and the Zung Self-Rating Depression Scale (ZSDS) (and its shortened version BZSDS). Results: Based on HAMD-7 results, the prevalence of moderate depression was low (7.7%); using the BZSDS moderate depression was absent. Mild depression was identified in 82.3% and 73% of our subjects using the HAMD-7 and the BZSDS, respectively. The strength of agreement between psychiatrist and patients’ self-evaluation for mild depression was “slight”, employing the original and the abbreviated versions of both scales. Conclusion: Our findings suggest that the prevalence of core depressive symptoms is very low in cancer patients diagnosed with depressive disorder. The lack of a strong agreement between psychiatrist and patient in classifying the severity of depression highlights the importance of factors such as well-being and functional status among depressed cancer patients in their self assessment of depression.

scholarly journals Effect of galanin on severity of tremor in Parkinson's disease

2021 ◽  
Vol 38 (5) ◽  
pp. 55-60
Author(s):  
N. V. Selyanina ◽  
O. V. Khegai ◽  
Yu. V. Karakulova
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Serum ◽  
Movement Disorders ◽  
Rating Scale ◽  
Statistical Processing ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Parkinsonian Tremor ◽  
Quantitative Content

Objective. To study the effect of galanin on the severity of tremor in Parkinson's disease. Materials and methods. A comprehensive examination of 73 patients with Parkinson's disease and 16 apparently healthy individuals (control group) was carried out. We used the clinical-anamnestic method, the Hen-Yar scale of movement disorders in Parkinson's disease (PD), the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Serum galanin content was determined by enzyme immunoassay. Serum galanin was determined by enzyme-linked immunosorbent assay using an ELISA Kit for Galanin (USA). Statistical processing of the material was carried out using the Statistica 10.0 program. Results. Tremor is one of the main complaints of PD patients. In the main group, the average severity of the disease, subjective and objective manifestations of movement disorders were determined. In patients with PD, a decrease in the quantitative content of blood serum galanin (6.0 [4.3; 10.2] ng / ml) was determined in comparison with the control group (16.9 [9.8; 18.1] ng/ml, p = 0.001). A negative correlation dependence of the galanin content with motor manifestations was revealed in the first (R = 0.8; p = 0, 0001) and second (R = 0.53; p = 0.000002) parts of the MDS-UPDRS, as well as with the severity of resting tremor in the hand (R = 0.81; p = 0.000000) and leg (R = 0.76; p = 0.000001). The dependence of serum galanin on the form of the disease was not obtained in the study. Conclusions. In Parkinson's disease, there is a decrease in the quantitative content of the neuropeptide galanin in the blood serum, which is negatively associated with motor manifestations of the disease and is associated with the severity of parkinsonian tremor.

scholarly journals EFFECTIVENESS OF ACETYLSALICYLIC ACID IN CORRECTION OF POST-STROKE FATIGUE DURING ACUTE CEREBROVASCULAR EVENTS

2019 ◽  
Vol 23 (1-2) ◽  
pp. 8-12 ◽  
Author(s):  
I.I. Delva
Keyword(s):  
Acetylsalicylic Acid ◽  
Blood Serum ◽  
Hemorrhagic Stroke ◽  
Clinical Course ◽  
Medical Rehabilitation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cerebrovascular Event ◽  
Inflammatory Reactions ◽  
Post Stroke ◽  
Anti Inflammatory

Post-stroke fatigue (PSF) is a common and often debilitating sequela of strokes that affects more than one third of stroke patients. Recent investigations revealed etiologic and pathogenetic heterogeneity of PSF depending on the time after acute cerebrovascular event (ACE). PSF that occur during acute stroke is associated predominantly with biological factors, including stroke-inducing immune and inflammatory reactions. In particular, we found significant associations between clinical features of PSF and certain regularities of C-reactive protein (CRP) and interleukin (IL)-1β levels in blood serum during the first 3 months after ACE occurrence. Given that there is not a clearly defined etiology for PSF, there are no rationally informed interventions. Іf dysregulation of the immune response isan important contributing factor to PSF, interventions that lessen inflammation would be appropriate treatment strategies. Іt would be reasonable to consider ASA, albeit at a higher dose than is normally used for secondary stroke prevention, as a treatment for PSF. Thus, it is advisable to study effects of ASA at the anti-inflammatory dose (300 mg a day) on markers of system inflammation an don PSF clinical course during the first 3 months after ACE occurrence. Objective: to study effectiveness of ASA at the anti-inflammatory dose (300 mg a day) on PSF clinical course and ASA effects on markers of system inflammation during the first 3 months after acute cerebrovascular event (ACE) occurrence. We recruited in the study 39 in hospital patients with ischemic strokes and transient ischemic attacks (TIA) who needed to take acetylsalicylic acid (ASA). All patients had been diagnosed with PSF within the first 3 days after ACE onset. PSF was diagnosed by use of questionnaire – Fatigue Assessment Scale (FAS). We formed two groups of patients. The first group (control PSF group) consisted of 24 patients who used ASA according to «Unified clinical protocol for medical care. Ischemic stroke (emergency, primary, secondary (specialized) medical aid, medical rehabilitation)» - after excluding hemorrhagic stroke by neuroimaging it was started ASA intake in the doses of 150-300 mg a day enterally during hospital stay with subsequent intake of 75-150 mg a day (prophylactic dose) continuously after hospital discharge. The second group (ASA PSF group) had 15 patients who started to use ASA just after excluding hemorrhagic stroke in the dosage of 300 mg a day for 3 months with subsequent dose reduction to 75-150 mg a day (prophylactic dosage) continuously. Diagnosis of PSF presence/absence, measurement of PSF severity and simultaneous measurement of systemic inflammatory markers in blood serum were carried out at the certain time points after ACE onset: at the first 3 days, at 1 month and at 3 months. Concentrations of СRP, IL-1β andIL-6 in blood serum were measured by enzyme-linked immunosorbent assay. The use of ASA in the dose of 300 mg a day during 3 months in patients who had been diagnosed with PSF within the first days after ACE occurrence is associated with significant decreasing of PSF intensity due to FAS in comparison with using of preventive ASA doses. The use of ASA in the dose of 300 mg a day during 3 months after ACE occurrence is associated with significant modification of post-stroke inflammatory response in form of CRP and IL-1β blood level changes.

Efficacy of hypericum extract Ws® 5570 compared with paroxetine in patients with a moderate major depressive episode–a subgroup analysis

2017 ◽  
Vol 41 (S1) ◽  
pp. S529-S530
Author(s):  
E. Holsboer-Trachsler ◽  
E. Seifritz ◽  
M. Hatzinger
Keyword(s):  
Subgroup Analysis ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Rating Scale ◽  
Randomised Trial ◽  
Major Depressive ◽  
Double Blind ◽  
Moderate Depression ◽  
Symptom Intensity ◽  
Remission Rates

IntroductionVarious studies showed the efficacy and tolerability of WS® 5570 (Hyperiplant® Rx, Dr. Willmar Schwabe GmbH & Co. KG) for the treatment of acute mild-to moderate depression. Beneficial effects of WS® 5570 have been also shown in patients with moderate-to-severe depression.Objectives/aimsWe present a subgroup analysis of a double blind, randomised trial to compare the therapeutic efficacy of WS® 5570 with paroxetine in patients suffering from a major depressive episode with moderate symptom intensity. This analysis on moderately depressed patients treated with WS® 5570 tries to support the hypothesis that WS® 5570 is an effective remedy in patients with major depression and moderate symptom intensity.MethodsModerate depression was defined by a baseline Hamilton Depression Rating Scale (HAM-D) total score between 22 and 25. Sixty-four patients received, after a single blind placebo run-in phase of 3–7 days, either 3 × 300 mg/day WS® 5570 or 20 mg/day paroxetine for six weeks. The change of the HAM-D total score was used to describe the efficacy of WS® 5570 compared with paroxetine in the subgroup of patients with moderate depression.ResultsThe reduction of the HAM-D total score was significantly more pronounced in patients treated with 3 × 300 mg/day WS® 5570 compared to 20 mg/day paroxetine. After six weeks, responder (87.1%) and remission rates (60.6%) to WS® 5570 were significantly higher than to paroxetine (71%/42.4%).ConclusionsAfter six weeks, patients treated with WS® 5570 showed a higher reduction in depression severity score and yielded greater response and remission rates compared with patients treated with paroxetine.Disclosure of interestSupported by Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany

scholarly journals Depression in Patients with Diabetes Mellitus-an Analytical Study in Rajshahi

2021 ◽  
Vol 34 (1) ◽  
pp. 47-54
Author(s):  
Md Aminul Hasan ◽  
Md Azizul Hoque ◽  
AA Mamun Hossain ◽  
Md Amzad Hossain Sardar ◽  
Md Ruhul Amin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Rating Scale ◽  
Blood Glucose Control ◽  
Severe Depression ◽  
Mild Depression ◽  
College Hospital ◽  
Moderate Depression ◽  
Dsm V ◽  
Healthy Control

Background: Depression is one of the most common comorbid psychiatric disorders associated with diabetes mellitus (DM), and it impacts glycemic control. Optimal management of depression may lead to better control of glucose levels in DM. Objectives: The aim of this study was to assess depression in patients with DM and to compare it with healthy control and to determine the association of depression with glycemic control and socio-demographic profile in patients with DM and healthy control. Patients and methods: This cross-sectional comparative study was conducted among 140 patients with DM attending Rajshahi Medical College Hospital and Diabetic Association Hospital, Rajshahi, from July 2014 to June 2016. Subsequently, 140 age-matched healthy controls were included in this study. The DSM-V criteria were used to diagnose depression and the severity of depression was assessed by the Hamilton rating scale for depression. Blood glucose control was assessed by measuring HbA1c and categorized as: good glycemic control <7%, fair glycaemic control 7-8% and > 8% considered as poor glycemic control.  Results: The proportion of depression was significantly higher in the patient (51, 36,4%) than in the control (20,14.3%) (X2= 18.256, df= 2, p <0.001). Among patients 13 (9.28%) had mild depression, 23 (16.42%) had moderate depression and 15 (10.70%) had severe depression. But among control 11 (7.87%) had mild depression, 7 (5%) had moderate depression and 2 (1.43%) had severe depression. Depression was more in patients aged 40-60 years (45,42.1%) than in those aged 18-39 years (6,18.2%) which was statistically significant (t = - 3.947, p < 0.001). Both mild, moderate and severe depression were more common among singles, obese, Type 2 DM & patients who were taking both insulin & OHA. Statistically significant depression were observed in poorly controlled DM (HbA1c>8%) compared to fair control (HbA1c 7-8%) (p <0.001, 95% CI = 2.29 to 3.82) and good control (HbA1c < 7%) (p <0.001, 95% CI = 4.25 to 5.98).The likelihood of depression was not significantly associated with different occupation, level of education, residence and duration of DM. Significant positive correlation was observed between DSM-V score and age (r = 0.295, p<0.001),BMI (r = 0.473, p<0.001), duration of DM and HbA1c (r = 0.734, p<0.001) in patients with DM. Conclusion: Our findings demonstrate that there is a higher proportion of depression in patients with DM, which is almost thrice than healthy control. Since patients with DM are at higher risk of developing depression, assessment of depression should be part of the initial and ongoing evaluation of these patients to improve their quality of life. TAJ 2021; 34: No-1: 47-54

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