scholarly journals Immunity Boosting Drugs in Ayurveda – A Review

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 992-996
Author(s):  
Prasad Umakant Wallalwar ◽  
Pradnya Dandekar ◽  
Shweta Dadarao Parwe
Keyword(s):  
Immune System ◽  
Medical Science ◽  
Experimental Studies ◽  
Healthy Person ◽  
Review Article ◽  
Medicinal Herbs ◽  
Immune Modulators ◽  
Diseased Condition ◽  
Immense Potential

The concept of Immunity is mentioned as ‘Vyadhikshamatwa’ in Ayurveda. In Ayurveda numbers of medicinal herbs are described under immunity-enhancing drugs category. The concept of immunity enhancer is explained under the category of Rasayan chikitsa in Ayurveda. These herbs are used in various diseases, especially by modulating the immune system. These herbs are called as Rasayan Dravyas. Ayurveda medical science comprises the herbs which are Rasayana and also which are non-Rasayana in nature. In Samhitas entirely enriched with enormous data of Rasayana medicinal herbs acting as immune modulators. The data of available Samhitas and researches show that these Rasayana herbs have immense potential as immune modulators. Advanced researches have proven that drugs like Guduchi, Haritaki, Ashwagandha, Brahmi, Jyotishmati act as a good immune enhancer. Theses herbs are mentioned in Ayurveda as Rasayana drugs. Experimental studies also have proven the role of Rasayana drugs as antioxidant, adoptogenic and having anti-stress activities. These Rasayana drugs as having immunity enhancer protect the health of a healthy person and protects them from any type of diseased condition. Charakacharya had mentioned Rasayanchikitsa adhyay as the first addhya of their chikitsasthan considering his aim as ‘Swasthasya Swasthya Rakshanam’. This means to protect the health of a healthy person as in priority by using immunity enhancer drugs as Rasayanas. This review article empowers such reviewed data on Rasayan medicinal herbs as a promising future target for immunotherapy.

scholarly journals The Gene Regulatory Roles of Herbal Extracts on the Growth, Immune System, and Reproduction of Fish

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2167
Author(s):  
Ehsan Ahmadifar ◽  
Hamideh Pourmohammadi Fallah ◽  
Morteza Yousefi ◽  
Mahmoud A. O. Dawood ◽  
Seyed Hossein Hoseinifar ◽  
...  
Keyword(s):  
Immune System ◽  
Mode Of Action ◽  
Medicinal Herbs ◽  
Environmental Stressors ◽  
Fish Diet ◽  
Sustainable Aquaculture ◽  
Herbal Supplements ◽  
Aquatic Animals ◽  
Gene Regulatory

The crucial need for safe and healthy aquatic animals obligates researchers in aquaculture to investigate alternative and beneficial additives. Medicinal herbals and their extracts are compromised with diverse effects on the performances of aquatic animals. These compounds can affect growth performance and stimulate the immune system when used in fish diet. In addition, the use of medicinal herbs and their extracts can reduce oxidative stress induced by several stressors during fish culture. Correspondingly, aquatic animals could gain increased resistance against infectious pathogens and environmental stressors. Nevertheless, the exact mode of action where these additives can affect aquatic animals’ performances is still not well documented. Understanding the mechanistic role of herbal supplements and their derivatives is a vital tool to develop further the strategies and application of these additives for feasible and sustainable aquaculture. Gene-related studies have clarified the detailed information on the herbal supplements’ mode of action when administered orally in aquafeed. Several review articles have presented the potential roles of medicinal herbs on the performances of aquatic animals. However, this review article discusses the outputs of studies conducted on aquatic animals fed dietary, medicinal herbs, focusing on the gene expression related to growth and immune performances. Furthermore, a particular focus is directed to the expected influence of herbal supplements on the reproduction of aquatic animals.

PREVENTION AND MANAGEMENT OF HYPERTENSION W. S. R. TO AYURVEDA: REVIEW ARTICLE

2020 ◽  
Vol 8 (06) ◽  
Author(s):  
Dr. Sandip Tawade
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Dietary Habits ◽  
Adult Population ◽  
Medical Science ◽  
Good Health ◽  
Healthy Person ◽  
Review Article ◽  
Unhealthy Lifestyle ◽  
The World

Ayurveda is not only an ancient medical science but it is a complete life science.The main aim of Ayurveda is to maintain the health of a healthy person & to cure the disease of diseased person. From last few decades due to globalisation there is drastic change in working pattern, dietary habits & lifestyle. According to a new research, lifestyle diseases replaced traditional health risk factors resulting in an increase in incidents of diseases & deaths in India in the last two decades. Now most of the diseases & deaths are caused by High Blood Pressure, high cholesterol, obesity, alcohol use and poor diet. Unhealthy lifestyle is the root cause of many diseases broadly termed as lifestyle disorder. Hypertension is the most common lifestyle disease affecting population all over the world. About 26.4% of the world adult population in 2020 had hypertension and 29.2% were projected to have this condition by 2025. India is labeled as global capital of hypertension. The Ayurveda concentrates on achieving the promotion of health, prevention and management of disease for a healthy and happy life in the ailing society. The principals of Ayurveda are focused on maintaining good health by good diet and good lifestyle. Proper dietary habits, proper exercise, Yoga, Meditation along with Ayurveda herbs can be beneficial to balancing of mind, which reduce stress and maintain the blood pressure. The present review article is aimed that the planning of proper herbal medications as per Ayurveda guidelines will definitely control the high blood pressure without any hazardous side effects of drugs.

scholarly journals ROLE OF AMALAKYADI RASAYANA IN LOWERING DOWN THE MORBIDITY RATE IN CHILDREN: A REVIEW

2020 ◽  
Vol 11 (5) ◽  
pp. 121-127
Author(s):  
Ajay Kushwaha ◽  
Nisha Kumari Ojha
Keyword(s):  
Immune System ◽  
Experimental Studies ◽  
Anthelmintic Activity ◽  
The Body ◽  
Morbidity Rate ◽  
Tissue Quality ◽  
Tissue Degeneration ◽  
Age Related

Children are more susceptible to various infections because of underdeveloped immune system as compared to adults. Strengthening the immune system is a natural way to help the body fight against the disease-causing pathogens and immunomodulators can play a major role in this context. Various Ayurveda classics and studies published in journals related to Ayurveda drugs for improving immunity are reviewed and analysed. In Ayurveda, the objective of immune enhancement is achieved through the use of the Amalakyadi Rasayana (an Immunomodulators), as it increases longevity of life, memory, intellect, luxture, complexion, voice, strength of the body functions, strength of all senses and provides the resistance to disease, improves glow and power. Analysis of classical references and various experimental studies show that Amalakyadi Rasayana posse immuno-modulatory, Antioxidant, Anti-inflammatory, Antimicrobial, Anthelmintic activity. Present paper is a review to update knowledge on pharmacological properties, therapeutic actions and possible mode of action of the selected formulation, Amalakyadi rasayana from Yogaratnakara (Rasayanadhikara/17) to enhance the immunity in children. Rasayana is an important part of Ayurvedic therapeutics used to improve the quality of life by strengthening the tissue quality and by reducing the age-related tissue degeneration. This study reveals that Amalakyadi Rasayana have potential to improve or strengthen the immune system in children and thereby can lower down the morbidity rate in children.

The role of the immune system in idiopathic nephrotic syndrome: a review of clinical and experimental studies

2013 ◽  
Vol 63 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Wagner de Fátima Pereira ◽  
Gustavo Eustáquio Alvim Brito-Melo ◽  
Fábio Tadeu Lourenço Guimarães ◽  
Thiago Guimarães Rosa Carvalho ◽  
Elvis Cueva Mateo ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Immune System ◽  
Idiopathic Nephrotic Syndrome ◽  
Experimental Studies

scholarly journals The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19

Biology ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 852
Author(s):  
Yury D. Nechipurenko ◽  
Denis A. Semyonov ◽  
Igor A. Lavrinenko ◽  
Denis A. Lagutkin ◽  
Evgenii A. Generalov ◽  
...  
Keyword(s):  
Immune System ◽  
Conformational Changes ◽  
Review Article ◽  
Potential Importance ◽  
Cytokine Storm ◽  
Vicious Cycle ◽  
Inflammatory Reactions ◽  
Blood Ph ◽  
Protective Antibodies

COVID-19 has specific characteristics that distinguish this disease from many other infections. We suggest that the pathogenesis of severe forms of COVID-19 can be associated with acidosis. This review article discusses several mechanisms potentially linking the damaging effects of COVID-19 with acidosis and shows the existence of a vicious cycle between the development of hypoxia and acidosis in COVID-19 patients. At the early stages of the disease, inflammation, difficulty in gas exchange in the lungs and thrombosis collectively contribute to the onset of acidosis. In accordance with the Verigo-Bohr effect, a decrease in blood pH leads to a decrease in oxygen saturation, which contributes to the exacerbation of acidosis and results in a deterioration of the patient’s condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and thus lead to a decrease in the affinity and avidity of protective antibodies. Hypoxia and acidosis lead to dysregulation of the immune system and multidirectional pro- and anti-inflammatory reactions, resulting in the development of a “cytokine storm”. In this review, we highlight the potential importance of supporting normal blood pH as an approach to COVID-19 therapy.

scholarly journals Effect of immune-modulators (Rasayana Dravya) in Janapadodhwansa WSR to COVID-19

2020 ◽  
Vol 6 (1) ◽  
pp. 26-29
Author(s):  
Vaidya Pratigya Chauhan ◽  
◽  
Bhawna Dutt ◽  
Mahesh Vyas ◽  
S. K. Gupta ◽  
...  
Keyword(s):  
Health Care ◽  
Immune Response ◽  
21St Century ◽  
Preventive Measures ◽  
Experimental Studies ◽  
Collective Actions ◽  
Immune Modulators ◽  
Ancient Science ◽  
The People

Ayurveda provide a basic way of living to the people and mentioned the different “Charyas” to be done by the individuals in day to day life as well as this ancient science garlanded us with the knowledge and code of conducts to conduct different type of studies like experimental studies, survey studies etc. In this sequence, Janapadodhwansa, a chapter describes in Vimana Sthana by Acharya Charaka is considered as the chapter of epidemiological study. Where he explained the whole concept on handling the situation of pandemic state. Now, a days It is evident to notify the Pandemic state of China and different countries due to the virus knows as corona virus, which is responsible and causes pressure on societies and health care system. This is the first pandemic condition of 21st century which requires internationally unified cogent and collective actions by the individuals, communities, commercial bodies etc. Due to the novelty of the virus, there is no treatment known and no vaccination is available. Only social distancing and other preventive measures are tolls used to deal this emergency. And hence, this condition can be correlated with Janapadodhwansa. And Rasayana is one of them, which provide the strength against the viral condition and improve the immune response towards this pandemic disease. This article aims to provide information about role of Rasayana dravyas (Gudhuchi, Amalaki and Haridra) which can be in cooperated in day to day life and act as immune modulators.

scholarly journals Human and Animal Immunomorphology in Norm and Experimental Studies: Contribution of Academician M. R. Sapin to the Development of Immune System Organs Doctrine

2021 ◽  
Vol 9 (4) ◽  
pp. 96-100
Author(s):  
D. B. Nikityuk ◽  
S. V. Klochkova ◽  
N. T. Alexeeva ◽  
A. G. Kvaratskheliya
Keyword(s):  
Immune System ◽  
Ussr Academy ◽  
Experimental Studies ◽  
Scientific Research ◽  
Medical Institute ◽  
Scientific School ◽  
Medical Sciences ◽  
Professional Activities ◽  
Historical Materials

The article provides data on scientific research of the Moscow scientific school of academicians D.A. Zhdanov and M.R. Sapin in the field of morphofunctional organization of the lymphatic and immune systems. The historical materials and scientific research of their students and followers were studied. The biographical milestones in the life and professional activities of Academician of the USSR Academy of Medical Sciences D.A. Zhdanov and his student, academician of the RAS M.R. Sapin within the walls of the I.M. Sechenov First Moscow State Medical Institute (now – Sechenov University). The main scientific direction of D.A. Zhdanov taught about the lymphatic system. As a result of his research, the important role of the organs of the immune system in the formation of the body's response to antigenic effects was shown. Studying the professional and creative activities of M.R. Sapin showed that he was a fairly bright personality in the morphological community. A large number of his students and followers allows the scientific direction of academician M.R. Sapin live and develop today. New scientists-morphologists, using modern research methods, will continue and develop the teachings of M.R. Sapin, as in his time he continued and deepened the scientific direction of his teacher.

Ayurveda and Vyadhikshamatwa (Immunity) During Covid 19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1351-1355
Author(s):  
Jagruti N Chaple
Keyword(s):  
Immune System ◽  
Treatment Protocol ◽  
The Body ◽  
Physical Work ◽  
First Line ◽  
High Quality ◽  
Immune Modulators ◽  
Physical Strength ◽  
Natural Way

COVID-19 which has been declared as pandemic by WHO has harsh impact globally. No treatment protocol has been mentioned yet; main public advice mainly focuses on frequently hand hygiene and social distancing. This concept is mentioned by Acharya Charaka in Janapadodhwansa. Of Rasayana is based upon the immunomodulation. It boosts up the immunity and help to keep the body and mind in the best of its health. Rasayandravya has been first line of defence for Janapadodhwansa (Epidemic Condition). Dhatusarata, balanced state of dosha, health of srotas and agni must be maintained with proper diet and regimen to maintain immunity. This article aims to provide information about the role of Rasayanadravyas (Gudhuchi, Amalaki and Haridra) which can be in cooperated in day to day life and act as immune modulators. Bala is leading factor of all dhatus and its capacity to perform physical work. Physical strength depends on kaphadosha and high-quality dhatus. As ojas is essence of all dhatus, bala ultimately depends on ojas. Modern immunity matches with AyurvedicVyadhiksamata. Capacity to prevents the spread of diseases in the body and capacity of body of blocking the diseases in its primary stage is called as immunity. Ayurveda are significantly helpful in strengthening the immune system and thereby offers a natural way for the prevention of pandemic diseases.

Role of Ayurveda for Poor and Pandemics (Covid19) – A Review article

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 923-927
Author(s):  
Anuradha Kishor Ingale ◽  
Pooja Shrivastav
Keyword(s):  
Immune System ◽  
Sedentary Lifestyle ◽  
Large Population ◽  
Poverty Line ◽  
Review Article ◽  
Poor People ◽  
The People ◽  
Better Than ◽  
Rule Out

The goal of Ayurveda is prevention is better than cure. There are a total of 9152 COVID-19 cases reported in India (till April 13, 2020), 308 people were died because of this disease, and 856 patients were treated successfully in our Country. This virus can easily affect or harm those individuals who have an infection, less immunity and especially who all have been aged more than sixty. Most of the countries are worried only for their people's life (health). In contrast, the developing countries like India that has a large population have to consider about the livelihood for people like Below Poverty Line (BPL) or those living in slum areas, equally with their life. The main aim of the article is to aware the people not only Urban but also among Rural and needy individuals to adopt the Ayurveda lifestyle during Covid19 outbreak. For this to study various methods which are described in Ayurveda for boosting immunity among various individuals. This study is a review type of article. All information and references have been collected and compiled from various available Ayurvedic classics texts. Research articles are also searched from various websites related to Covid19 outbreak and its effect on needy individuals. All matters have been analysed for some discussion, and an attempt has been made to rule out some conclusions. During this lockdown, people are mostly living a sedentary lifestyle which not only weakens their immune system but also make them more susceptible to infections. Hence Ayurveda is a science of life that is mainly focusing on strengthening persons by boosting their immune system through improving our lifestyle by using medicines, diets, meditation and activities like Yoga. This article will give insights about poor people and effective strategy to threat COVID-19 through Ayurveda in India.

scholarly journals Targeting cytokines for treatment of neuropathic pain

2017 ◽  
Vol 17 (1) ◽  
pp. 287-293 ◽  
Author(s):  
Alice L. Hung ◽  
Michael Lim ◽  
Tina L. Doshi
Keyword(s):  
Neuropathic Pain ◽  
Immune System ◽  
Animal Studies ◽  
Large Scale ◽  
Treatment Options ◽  
Immune Modulators ◽  
Tnf Α ◽  
Inflammatory State ◽  
Preclinical And Clinical Studies

AbstractBackgroundNeuropathic pain is a challenging condition often refractory to existing therapies. An increasing number of studies have indicated that the immune system plays a crucial role in the mediation of neuropathic pain. Exploration of the various functions of individual cytokines in neuropathic pain will provide greater insight into the mechanisms of neuropathic pain and suggest potential opportunities to expand the repertoire of treatment options.MethodsA literature review was performed to assess the role of pro-inflammatory and antiinflammatory cytokines in the development of neuropathic pain. Both direct and indirect therapeutic approaches that target various cytokines for pain were reviewed. The current understanding based on preclinical and clinical studies is summarized.Results and conclusionsIn both human and animal studies, neuropathic pain has been associated with a pro-inflammatory state. Analgesic therapies involving direct manipulation of various cytokines and indirect methods to alter the balance of the immune system have been explored, although there have been few large-scale clinical trials evaluating the efficacy of immune modulators in the treatment of neuropathic pain. TNF-α is perhaps the widely studied pro-inflammatory cytokine in the context of neuropathic pain, but other pro-inflammatory (IL-1β, IL-6, and IL-17) and anti-inflammatory (IL-4, IL-10, TGF-β) signaling molecules are garnering increased interest. With better appreciation and understanding of the interaction between the immune system and neuropathic pain, novel therapies may be developed to target this condition.

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