scholarly journals Impact of post- amputation pain syndrome on the results of bone stump formation

Morphologia ◽  
2021 ◽  
Vol 15 (3) ◽  
pp. 50-56
Author(s):  
Y.O. Bezsmertnyi ◽  
V.I. Shevchuk ◽  
Y. Jiang ◽  
H.V. Bezsmertna ◽  
O.Yu. Bezsmertnyi
Keyword(s):  
Pain Syndrome ◽  
Medullary Canal ◽  
High Rate ◽  
Cylindrical Shape ◽  
Residual Limb ◽  
Support Element ◽  
In Series ◽  
Reparative Process ◽  
Postamputation Pain ◽  
The Impact

Background. To the present day, a high rate of unsatisfactory amputation results still exists. The healing of the bone residual limb, the main support element of the residual limb, is of particular importance. Objective. To study the impact of postamputation pain syndrome on the nature of reparative processes in the bone residual limb. Methods. Three series of experiments were performed on 45 rabbits, 15 in each with mid-third thigh amputation and muscular plasty. In series 1 and 2, a perineural catheter was attached to the sciatic nerve stump during amputation, and mechanical irritation of the nerve was performed daily for 20 minutes in series 1 for 20 days. In series 2, 0.3 ml of 1% lidocaine was injected through the catheter into the circumference of the nerve twice daily for 20 days. Animals of series 3 served as a control. The follow-up periods were 1, 3, 6 months. The study method was histological with infusion of the vessels with ink-gelatin mixture. Results. In series 1, there was a sharp disturbance of the reparative process, which consisted in shape changes, resorption of the cortical diaphyseal plate, stump deformity, absence of bone closure plate formation, and microcirculatory disturbances. In most experiments of the 2nd series, organotypic stumps were formed with normalized microcirculation. In series 3, the results of the residual limb formation were better than in series 1, but worse than in series 2. Conclusion. In the absence of pain syndrome, the bone stump after amputation at the diaphysis level over a period of 1, 3, 6 months retains its cylindrical shape, the structure of the cortical diaphyseal plate, the content of the medullary canal with normal microcirculation, the formation of the bone closure plate, and the completion of the reparative process. The presence of postamputation pain syndrome in the stump distorts the course of the reparative process with the development of pathological remodeling of bone tissue.

scholarly journals Bone stump formation against the background of post-amputation pain syndrome

2021 ◽  
Author(s):  
Yurii Oleksiiovych Bezsmertnyi ◽  
Viktor Ivanovych Shevchuk ◽  
Yankai Jiang ◽  
Halyna Victorіvna Bezsmertna ◽  
Oleksandr Yuriiovych Bezsmertnyi
Keyword(s):  
Pain Syndrome ◽  
Structure Characteristic ◽  
Residual Limb ◽  
In Series ◽  
Perineural Catheter ◽  
Microcirculatory Disturbances ◽  
Reparative Process ◽  
Series Of Experiments ◽  
The Impact

Introduction: Bone is the basis of the stump. Aim: To study the impact of post-amputation pain syndrome on the nature of reparative processes in the bone residual limb. Material and methods: Three series of experiments were performed on 45 rabbits, 15 in each with mid-third thigh amputation and muscular plasty. In series 1, 2, a perineural catheter was attached to the sciatic nerve stump during amputation, and mechanical irritation of the nerve was performed daily for 20 minutes in series 1 for 20 days. In series 2, 0.3 mL of lidocaine (1%) was injected through the catheter into the circumference of the nerve twice daily for 20 days. Series 3 is a control. The follow-up periods were 1, 3, 6 months. The study method was histological with infusion of the vessels with ink-gelatin mixture. Results and discussion: In series 1, there was a sharp disturbance of the reparative process, which consisted in shape changes, resorption of the cortical diaphyseal plate, fractures, stump deformity, absence of bone closure plate formation, and microcirculatory disturbances. In the overall majority of experiments of series 2, the stumps retained the shape and structure characteristic of diaphysis with normalization of microcirculation. In series 3, the results of the residual limb formation were better than in series1, but worse than in series 2. Conclusions: When the pain syndrome is resolved within 20 days after amputation, a bone stump is formed with an organotypic shape and structure characteristic of the diaphysis, the formation of a compact closure plate of mature bone tissue, normalization of the medullary tissues and blood circulation. In post-amputation pain syndrome, organotypic formation of the residual limb does not occur.

scholarly journals REPARATIVE REGENERATION AT THE END OF BONE FILING AFTER OSTOPLASTIC AMPUTATION

2021 ◽  
Vol 74 (3) ◽  
pp. 413-417
Author(s):  
Viktor I. Shevchuk ◽  
Yurii O. Bezsmertnyi ◽  
Halyna V. Bezsmertna ◽  
Tetyana V. Dovgalyuk ◽  
Yankai Jiang
Keyword(s):  
Bone Structure ◽  
Compact Bone ◽  
Cortical Plate ◽  
Cylindrical Shape ◽  
Marrow Cavity ◽  
In Series ◽  
Reparative Process ◽  
Microcirculatory Disorders ◽  
Series Of Experiments ◽  
Incomplete Closure

The aim: To study the role and place of bone grafting in the formation of bone stump after amputation. Materials and methods: 3 series of experiments were carried out on 44 rabbits with amputation of the thigh in the middle third and stump grafting using osteoplastic hermetic closure of the canal with a thin cortical plate (series I), closure of the canal with a spongy bone (series II), and loose closure of the canal with a cortical graft located at the entrance to the canal at an angle of 30° (ІІІ series). Observation period: 1, 3, 6 months. Histological examination method with vascular filling with 10% mascara-gelatin mixture. Results: In series I, in the majority of observations, a stump of a cylindrical shape with a bone locking plate of an osteon-beam structure and normalization of intraosseous microcirculation was formed. A slight displacement of the graft caused a violation of microcirculation. In series II, organotypic stumps were formed in all observations. In series III, incomplete closure of the bone marrow cavity led to sharp microcirculatory disorders and the course of the reparative process with pathological bone remodeling. Conclusions: The parameters of the favorable course of the reparative process and the formation of the organotypic bone stump are the safety of its cylindrical shape, the presence of a compact bone structure, normalization of intraosseous microcirculation.

Others' participation rate influences an individual's charitable behavior: Others' similarity as a moderator

2017 ◽  
Vol 45 (10) ◽  
pp. 1607-1618 ◽  
Author(s):  
Seung Yun Lee ◽  
Sunho Jung ◽  
Sangdo Oh ◽  
Seong Hoon Park
Keyword(s):  
Undergraduate Students ◽  
Participation Rate ◽  
High Rate ◽  
Charitable Behavior ◽  
High Participation ◽  
Negative Effect ◽  
The Impact ◽  
And Diffusion ◽  
High Participation Rate ◽  
Diffusion Of Responsibility

We proposed that a moderator, others' similarity, would determine the impact of high participation rates of others on an individual's charitable behavior, and aimed to show that this moderator would work through the diffusion of responsibility motive. Participants (N = 152 undergraduate students) completed measures of charitable behavior and diffusion of responsibility, after being assigned to 1 of 2 conditions where a set percentage of other students (manipulated as either similar undergraduate students or dissimilar graduate students) were stated to have already donated to a charitable campaign (high contribution condition = 70% participation, low contribution condition = 30% participation). Our results showed that the high participation rate of others increased an individual's charitable behavior when the others in question were similar to that individual, but not when the others were dissimilar. In addition, the high rate of participation by others increased the diffusion of responsibility motive when the others in question were dissimilar to that individual, leading to a negative effect on that individual's charitable behavior.

scholarly journals Peculiarities of Neurostimulation by Intense Nanosecond Pulsed Electric Fields: How to Avoid Firing in Peripheral Nerve Fibers

2021 ◽  
Vol 22 (13) ◽  
pp. 7051
Author(s):  
Vitalii Kim ◽  
Emily Gudvangen ◽  
Oleg Kondratiev ◽  
Luis Redondo ◽  
Shu Xiao ◽  
...  
Keyword(s):  
Side Effects ◽  
Electric Fields ◽  
Pulsed Electric Fields ◽  
Opposite Polarity ◽  
Nerve Fibers ◽  
High Rate ◽  
Excitation Threshold ◽  
Compound Action Potentials ◽  
Supramaximal Stimulation ◽  
The Impact

Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects of PEF therapies are strong involuntary muscle contractions and pain. Nanosecond-range PEF (nsPEF) are less efficient at neurostimulation and can be employed to minimize such side effects. We quantified the impact of the electrode configuration, PEF strength (up to 20 kV/cm), repetition rate (up to 3 MHz), bi- and triphasic pulse shapes, and pulse duration (down to 10 ns) on eliciting compound action potentials (CAPs) in nerve fibers. The excitation thresholds for single unipolar but not bipolar stimuli followed the classic strength–duration dependence. The addition of the opposite polarity phase for nsPEF increased the excitation threshold, with symmetrical bipolar nsPEF being the least efficient. Stimulation by nsPEF bursts decreased the excitation threshold as a power function above a critical duty cycle of 0.1%. The threshold reduction was much weaker for symmetrical bipolar nsPEF. Supramaximal stimulation by high-rate nsPEF bursts elicited only a single CAP as long as the burst duration did not exceed the nerve refractory period. Such brief bursts of bipolar nsPEF could be the best choice to minimize neuromuscular stimulation in ablation therapies.

scholarly journals The High-Rate Sealed MRPC to Promote Pollutant Exchange in Gas Gaps: Status on the Development and Observations

2021 ◽  
Vol 11 (11) ◽  
pp. 4722
Author(s):  
Botan Wang ◽  
Xiaolong Chen ◽  
Yi Wang ◽  
Dong Han ◽  
Baohong Guo ◽  
...  
Keyword(s):  
Gas Flow ◽  
High Rate ◽  
Stable Operation ◽  
Beam Test ◽  
High Luminosity ◽  
Rate Test ◽  
3D Printed ◽  
Resistive Plate Chambers ◽  
The Impact ◽  
Current Behavior

This work reports the latest observations on the behavior of two Multigap Resistive Plate Chambers (MRPC) under wide high-luminosity exposures, which motivate the development and in-beam test of the sealed MRPC prototype assembled with low-resistive glass. The operation currently being monitored, together with previous simulation results, shows the impact of gas pollution caused by avalanches in gas gaps, and the necessity to shrink the gas-streaming volume. With the lateral edge of the detector sealed by a 3D-printed frame, a reduced gas-streaming volume of ~170 mL has been achieved for a direct gas flow to the active area. A high-rate test of the sealed MRPC prototype shows that, ensuring a 97% efficiency and 70 ps time resolution, the sealed design results in a stable operation current behavior at a counting rate of 3–5 kHz/cm2. The sealed MRPC will become a potential solution for future high luminosity applications.

scholarly journals The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series

Vaccines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 407
Author(s):  
Ana Luiza Bierrenbach ◽  
Yoonyoung Choi ◽  
Paula de Mendonça Batista ◽  
Fernando Brandão Serra ◽  
Cintia Irene Parellada ◽  
...  
Keyword(s):  
Time Series ◽  
Time Series Analysis ◽  
Hepatitis A ◽  
National Level ◽  
Age Groups ◽  
High Rate ◽  
Series Analysis ◽  
Annual Reduction ◽  
The Impact ◽  
Vaccination Period

Background: In 2014, a recommended one-dose of inactivated hepatitis A vaccine was included in the Brazilian National Immunization Program targeting children 12–24 months. This decision addressed the low to intermediate endemicity status of hepatitis A across Brazil and the high rate of infection in children and adolescents between 5 and 19 years old. The aim of the study was to conduct a time-series analysis on hepatitis A incidence across age groups and to assess the hepatitis A distribution throughout Brazilian geographic regions. Methods: An interrupted time-series analysis was performed to assess hepatitis A incidence rates before (2010–2013) and after (2015–2018) hepatitis A vaccine program implementation. The time-series analysis was stratified by age groups while a secondary analysis examined geographic distribution of hepatitis A cases. Results: Overall incidence of hepatitis A decreased from 3.19/100.000 in the pre-vaccine period to 0.87/100.000 (p = 0.022) post-vaccine introduction. Incidence rate reduction was higher among children aged 1-4 years old, with an annual reduction of 67.6% in the post-vaccination period against a 7.7% annual reduction in the pre-vaccination period (p < 0.001). Between 2015 and 2018, the vaccination program prevented 14,468 hepatitis A cases. Conclusion: Our study highlighted the positive impact of a recommended one-dose inactivated hepatitis A vaccine for 1–4-years-old in controlling hepatitis A at national level.

The Temperature-Phased Anaerobic Biofilter Process

1994 ◽  
Vol 29 (9) ◽  
pp. 213-223 ◽  
Author(s):  
Sandra K. Kaiser ◽  
Richard R. Dague
Keyword(s):  
System Performance ◽  
Anaerobic Treatment ◽  
Size Ratio ◽  
High Rate ◽  
Phase System ◽  
Optimum Size ◽  
Treatment Technology ◽  
Two Phase ◽  
In Series ◽  
Two Temperature

The “temperature-phased anaerobic biofilter” or TPAB process (U.S. Patent pending), is a new high-rate anaerobic treatment system that includes a thermophilic (56°C) biofilter connected in series with a mesophilic (35°C) biofilter providing for two-temperature, two-phase treatment. Three TPAB systems of different thermophilic:mesophilic reactor size ratios were operated at system HRTs of 24 hrs, 36 hrs, and 48 hrs to characterize performance and to determine if an optimum size ratio exists between the thermophilic and mesophilic phases. The three TPAB systems achieved SCOD reductions in excess of 97% and TCOD reductions in excess of 90% for a synthetic milk substrate over a range of system COD loadings from 2 g COD/L/day to 16 g COD/L/day. There was little difference in performance between the three TPAB systems based on COD reduction and methane production. The 1:7 ratio of thermophilic:mesophilic phase TPAB system performed as well as the 1:3 and 1:1 size ratio TPAB systems. In applications of the process, a relatively small thermophilic first-phase can be used without sacrificing overall two-phase system performance. The TPAB process is a promising new anaerobic treatment technology with the ability to achieve higher efficiencies of organic removals than is generally possible for single-stage anaerobic filter systems operated at equivalent HRTs and organic loadings.

scholarly journals Exploring the effectiveness of a COVID-19 contact tracing app using an agent-based model

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jonatan Almagor ◽  
Stefano Picascia
Keyword(s):  
High Rate ◽  
Contact Tracing ◽  
Agent Based Model ◽  
Agent Based ◽  
The Social ◽  
Behavioural Factors ◽  
The Impact ◽  
Different Levels ◽  
User Rate

AbstractA contact-tracing strategy has been deemed necessary to contain the spread of COVID-19 following the relaxation of lockdown measures. Using an agent-based model, we explore one of the technology-based strategies proposed, a contact-tracing smartphone app. The model simulates the spread of COVID-19 in a population of agents on an urban scale. Agents are heterogeneous in their characteristics and are linked in a multi-layered network representing the social structure—including households, friendships, employment and schools. We explore the interplay of various adoption rates of the contact-tracing app, different levels of testing capacity, and behavioural factors to assess the impact on the epidemic. Results suggest that a contact tracing app can contribute substantially to reducing infection rates in the population when accompanied by a sufficient testing capacity or when the testing policy prioritises symptomatic cases. As user rate increases, prevalence of infection decreases. With that, when symptomatic cases are not prioritised for testing, a high rate of app users can generate an extensive increase in the demand for testing, which, if not met with adequate supply, may render the app counterproductive. This points to the crucial role of an efficient testing policy and the necessity to upscale testing capacity.

Efficacy of a password-protected pill-dispensing device to enhance disposal of unused opioids after cancer surgery.

2021 ◽  
Vol 39 (28_suppl) ◽  
pp. 264-264
Author(s):  
Jacob Cogan ◽  
Melissa Kate Accordino ◽  
Melissa Parsons Beauchemin ◽  
Sophie Ulene ◽  
Elena B. Elkin ◽  
...  
Keyword(s):  
Pain Control ◽  
Cancer Surgery ◽  
High Rate ◽  
Smartphone App ◽  
Opioid Use ◽  
Structured Interviews ◽  
Health Crisis ◽  
Patient Reported ◽  
After Cancer ◽  
The Impact

264 Background: Opioid misuse is a public health crisis. Initial opioid exposures often occur post-operatively, and 10% of opioid-naïve patients who undergo cancer surgery subsequently become long-term opioid users. It has been shown that 70% of opioids prescribed post-operatively go unused, but only 9% of unused pills are disposed appropriately, which increases the risk of unintended use. We evaluated the impact of an inexpensive, password-protected dispensing device with mail return capacity on retrieval of unused pills after cancer surgery. Methods: Adult patients scheduled for major cancer-related surgery were eligible. Enrolled patients received opioid prescriptions in a password-protected, pill-dispensing device (Addinex) from a specialty pharmacy. The mechanical device links to a smartphone app, which provides passwords on a prescriber-defined schedule. Patients request a password when they are in pain, enter the password into the device and receive a pill if the prescribed time has elapsed. The smartphone app provides clinical guidance based on patient-reported pain levels, and suggests tapering strategies. Patients are instructed to return the device in a DEA-approved mailer when opioid use is no longer required for pain control. Unused pills are destroyed upon receipt. The primary objective was to determine the feasibility of device return, defined as > 50% of patients with device return. We also explored patterns of device use, patient reported outcomes, and device satisfaction via surveys and semi-structured interviews. Results: Between October, 2020 and April, 2021, 13 patients completed the study; 4 patients are currently enrolled. Among the initial 13 patients, 7 underwent abdominal hysterectomy, 4 underwent mastectomy and 2 underwent cutaneous tumor resections. The majority of these patients (n = 10, 77%) returned the device, and more than half (n = 7, 54%) returned the device within 6 weeks of surgery. Only a minority of patients (n = 5, 38%) used the device to obtain opioids; most (n = 8, 62%) used no opioids at home, and all of these patients returned the device and the unused pills. Of 11 patients who participated in semi-structured interviews, most (n = 7, 64%) said they felt safer having opioids in the device instead of a regular pill bottle. Among device users, the majority (n = 4, 80%) reported an overall positive experience. All non-users reported having no opioid requirement for pain control. Conclusions: Our early findings suggest that use of an inexpensive, password-protected, pill-dispensing device to assist with opioid dispensing and return is feasible, with a high rate of device and unused opioid return to the pharmacy. This strategy may be effective for reducing opioid diversion. Analyses and recruitment are ongoing to evaluate the benefits of reducing post-operative opioid consumption.

Influence of Various Basin Types on Performance of Passive Solar Still: A Review

2021 ◽  
Vol 10 (4) ◽  
pp. 789-802
Author(s):  
Tri Hieu Le ◽  
Minh Tuan Pham ◽  
H Hadiyanto ◽  
Van Viet Pham ◽  
Anh Tuan Hoang
Keyword(s):  
Water Depth ◽  
Thermal Efficiency ◽  
Tracking System ◽  
Design Parameters ◽  
Cylindrical Shape ◽  
Solar Still ◽  
Practical Utilization ◽  
Passive Solar Still ◽  
Passive Solar ◽  
The Impact

Passive solar still is the simplest design for distilling seawater by harnessing solar energy. Although it is undeniable that solar still is a promising device to provide an additional freshwater source for global increasing water demand, low thermal efficiency along with daily distillate yield are its major disadvantages. A conventional solar still can produced 2 to 5 L/m2day. Various studies have been carried out to improve passive solar stills in terms of daily productivity, thermal efficiency, and economic effectiveness. Most of the researches that relate to the daily output improvement of passive solar still concentrates on enhancing evaporation or/and condensation processes. While the condensation process is influenced by wind velocity and characteristics of the condensed surface, the evaporation process is mainly affected by the temperature of basin water. Different parameters affect the brackish water temperature such as solar radiation, design parameters (for example water depth, insulators, basin liner absorptivity, reflectors, sun tracking system, etc). The inclined angle of the top cover is suggested to equal the latitude of the experimental place. Moreover, the decrease of water depth was obtained as a good operational parameter, however, the shallow water depth is required additional feed water for ensuring no dry spot existence. Reflectors and sun-tracking systems help solar still absorb as much solar intensity as possible. The internal reflector can enhance daily yield and efficiency of stepped solar still up to 75% and 56% respectively, whereas, passive solar still with the support of a sun-tracking system improved daily yield up to 22%. Despite large efforts to investigate the impact of the different parameters on passive solar distillation, the effect of the basin liner (including appropriate shapes and type of material), needs to be analyzed for improvement in practical utilization. The present work has reviewed the investigation of the solar still performance with various types of basin liner. The review of solar stills has been conducted critically with rectangular basin, fins basin, corrugated basin, wick type, steps shape, and cylindrical shape basin with variety of top cover shapes. The findings from this work conclude that the basin liner with a cylindrical shape had better performance in comparison with other metal types and provides higher freshwater output. Stepped type, inclined, fin absorber, and corrugated shapes had the efficient performance.  Further exploration revealed that copper is the best-used material for the productivity of passive solar still.

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