scholarly journals Effects of contaminated feed with Aspergillus flavus on some hematological and biochemical parameters on Cyprinus carpio L. 1758

2018 ◽  
Vol 42 (1) ◽  
pp. 87-91
Author(s):  
Nahla T. Mansoor
Keyword(s):  
Body Weight ◽  
Aspergillus Flavus ◽  
Cyprinus Carpio ◽  
Biochemical Parameters ◽  
Control Group ◽  
Weight Changes ◽  
Group Feeding ◽  
The Common ◽  
Hematological And Biochemical Parameters ◽  
Hb Concentration

     In this investigation the common carp, Cyprinus carpio L. 1758 was exposed to contaminated feed with Aspergillus flavus under laboratory aquarium conditions (glass ponds) for 90 days. Results revealed that the contaminated feed with (A. flavus) has significantly affect in body weight change, blood and biochemical parameters of groups fed on contaminated feed with A. flavus. Body weight changes were decreased in group feeding on contaminated feed with A. flavus in comparison with control group. The results showed decreases in RBCs, PCV% and Hb concentration but WBCs was increased in treatment fish in comparison with the control group. In addition, serum Glutamic pyruvic trans-aminase, Glutamic oxaloacetic trans-aminase and total cholesterol as compared to control showed an increase (P<0.05) in these parameters in contaminated fish but total protein was decreased in same groups. In conclusion, A. flavus is produced toxic compounds that represent a serious source of contamination in foods; this confirms the infection of aquacultures’ fishes with A. flavus. So, one should not store foods for long periods or under poor conditions, fish health problems may arise.

scholarly journals A 90-Day Oral Toxicity of Hydroethanolic Root Extract of Carissa spinarum in Wistar Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Komlan M. Dossou-Yovo ◽  
Aboudoulatif Diallo ◽  
Povi Lawson-Evi ◽  
Yendubé T. Kantati ◽  
Tchin Darré ◽  
...  
Keyword(s):  
Body Weight ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Hematological Parameters ◽  
Relative Weight ◽  
Control Group ◽  
Root Extract ◽  
Weight Changes ◽  
Oral Toxicity ◽  
Significant Difference

Background. Herbal medication is a worldwide and ancient practice, mostly in developing countries, where a large part of the population is involved in this practice. Hence, studies must be conducted to evaluate their safety and efficiency to avoid or prevent toxicological risks due to their usage. In Togo, Carissa spinarum is a medicinal plant belonging to Apocynaceae family, used as an aphrodisiac or to heal some ailments including malaria, sickle cell anemia, hypertension, pain, and asthma. Notwithstanding its several ethnomedicinal benefits, just a few toxicological data associated with its chronic use are available. Objective. Therefore, this study aims to assess the toxicity of an ethanolic root extract of Carissa spinarum in Wistar rats. Methods. The 90-day oral toxicity process following OECD TG 408 guidelines is used. Male Wistar rats received Carissa spinarum root hydroethanolic extract at 500 and 1000 mg/kg for 90 days by oral gavage. Body weight changes, hematological and blood biochemical parameters, organ weight changes, malondialdehyde as a lipoperoxidation marker expressed according to tissue proteins, and histopathology of vital organs were assessed. Results. No signs of toxicity or mortality were observed during the 90 days experiment. Hematological parameters have not shown any treatment-related abnormalities. According to biochemical parameters, an increase in the chloride ion level was observed at 1000 mg/kg p < 0.01 . There was no significant difference between the treated groups and the control group concerning the malondialdehyde concentration, body weight, and organ relative weight. No changes in necropsy and histopathology of vital organs associated with extract treatment were observed. Conclusion. The results indicated that an ethanolic root extract of Carissa spinarum does not cause adverse effects, which can lead to Wistar rats’ death after 90-day oral administration at 500 and 1000 mg.

scholarly journals Effects of Sweet Potato Leaves, Roselle Calyces and Beetroot on Body Weight, Selected Hematological and Biochemical Parameters in Broiler Chicken

2019 ◽  
Vol 10 (2) ◽  
pp. 133
Author(s):  
Gaymary George Bakari ◽  
Robert Arsen Max ◽  
Shedrack Reuben Kitimu ◽  
Shaabani Mshamu ◽  
Benigni Alfred Temba ◽  
...  
Keyword(s):  
Body Weight ◽  
Sweet Potato ◽  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Hemoglobin Concentration ◽  
The Other ◽  
Control Group ◽  
Positive Effects ◽  
Hematological And Biochemical Parameters ◽  
Sweet Potato Leaves

The study was conducted to assess the effects of sweet potato leaves, roselle calyces and beetroot tubers on body weight, selected hematological and biochemical parameters in broiler chickens. Eighty four (84) broiler chickens aged four weeks were randomly assigned into six groups of 14 chickens each. The first group (G0) remained as untreated control while the other groups were the treated groups which received 25% of ground sweet potato leaves (G1), rosella calyces (G2), beetroot tubers (G3) and their mixtures (G4 and G5) for 28 days. Following inclusion of these different vegetables, blood samples were collected and analyzed for selected hematological and biochemical parameters on day 0, 7, 14, 21 and 28. Results showed that consumption of the three vegetables caused significant decreases (p < 0.05) in body weight, serum glucose and cholesterol. On the other hand, hemoglobin concentration, packed cell volume (PCV) and total white blood cell (WBC) counts were shown to increase significantly (p < 0.05) compared to the control group. It is concluded that the hypoglycemic and hypocholesteremic effects in chickens following consumption of the three vegetables together with their positive effects on PCV and WBC counts are important qualities which can be utilized in the management of conditions such as obesity, diabetes mellitus, hyperlipidemia and cardiovascular diseases (atherosclerosis and coronary disease) in humans. Further studies in other animals are recommended.

scholarly journals TOCOSH FLOUR (Solanum tuberosum L.): A Toxicological Assessment of Traditional Peruvian Fermented Potatoes

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 719
Author(s):  
Jonas Roberto Velasco-Chong ◽  
Oscar Herrera-Calderón ◽  
Juan Pedro Rojas-Armas ◽  
Renán Dilton Hañari-Quispe ◽  
Linder Figueroa-Salvador ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Biochemical Parameters ◽  
Solanum Tuberosum L ◽  
Lethal Dose ◽  
Clinical Signs ◽  
Control Group ◽  
Toxicological Assessment ◽  
Hematological And Biochemical Parameters ◽  
Histopathological Studies

Potato tocosh is a naturally processed potato for nutritional and curative purposes from traditional Peruvian medicine. The aim of this study was to investigate the acute and sub-acute toxicity of tocosh flour (TF). For sub-acute toxicity, TF was administered orally to rats daily once a day for 28 days at doses of 1000 mg/kg body weight (BW). Animals were observed for general behaviors, mortality, body weight variations, and histological analysis. At the end of treatment, relative organ weights, histopathology, hematological and biochemical parameters were analyzed. For acute toxicity, TF was administered orally to mice at doses of 2000 and 5000 mg/kg BW at a single dose in both sexes. Body weight, mortality, and clinical signs were observed for 14 days after treatment. The results of acute toxicity showed that the median lethal dose (LD50) value of TF is higher than 2000 g/kg BW but less than 5000 mg/Kg BW in mice. Death and toxicological symptoms were not found during the treatment. For sub-acute toxicity, we found that no-observed-adverse-effect levels (NOAEL) of TF in rats up to 1000 g/kg BW. There were statistically significant differences in body weight, and relative organ weight in the stomach and brain. No differences in hematological and biochemical parameters were observed when compared with the control group. For sub-acute toxicity, histopathological studies revealed minor abnormalities in liver and kidney tissues at doses of 5000 mg/Kg. Based on these results, TF is a traditional Peruvian medicine with high safety at up to 1000 mg/kg BW for 28 days in rats.

scholarly journals The influence of hypothermia prevention by application of skin moisture absorbent on the value of body temperature, body weight and blood parameters in piglets

2021 ◽  
Vol 73 (5) ◽  
pp. 1058-1066
Author(s):  
M. Mirkov ◽  
I. Radović ◽  
M. Cincović ◽  
M. P. Horvatović ◽  
S. Dragin
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Biochemical Parameters ◽  
Blood Parameters ◽  
Economic Losses ◽  
Control Group ◽  
Pig Production ◽  
Hematological And Biochemical Parameters ◽  
Moisture Absorbent ◽  
Skin Moisture

ABSTRACT Reducing the mortality rate is of a great economic importance for pig farming. Therefore, it is necessary to define the conditions in the farrowing unit based on the performance of the piglets, and specific hematological and biochemical parameters. Therefore, the aim of this paper is to examine the importance of using skin moisture absorbent and its influence in preventing hypothermia, which causes great economic losses in pig production. The experiment was set up on a commercial farm in Serbia and included 92 pigs divided into the experimental and control group. Body temperature values, body weight and blood parameters were monitored. The obtained values indicate that there is a significantly positive correlation of body temperature change and body weight values, and body temperature showed a significantly higher increase in the experimental group compared to the control group. The results obtained from hematological and biochemical parameters provide a clearer picture of the metabolic processes in piglets in the farrowing unit and can be used to further improve pig production and as a complement to genetic enhancement.

scholarly journals Effect of silymarin supplementation on some productive and hematological parameters in meat type male Japanese quails

2019 ◽  
pp. 984
Author(s):  
Hristo Lukanov, Ivelina Pavlova ◽  
Veselin Ivanov, Todor Slavov, Yoana Petrova, Nadya Bozakova
Keyword(s):  
Body Weight ◽  
Growth Performance ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Control Group ◽  
Japanese Quails ◽  
Hematological And Biochemical Parameters ◽  
Experimental Group ◽  
Meat Type ◽  
Main Growth

A total of 90 14-day-old meat type male Japanese quails were included in the experiment and equally divided into 3 groups: control group (CG) without treatment, experimental group 1 (EG 0.5%), supplemented with silymarin 0.5% and experimental group 2 (EG 1%), supplemented with silymarin 1%. The aim of the current study was to establish the effect of supplementation with different doses of silymarin extract on the growth performance and some hematological parameters in male Japanese quails. Main growth performance (body weight, feed consumption and weight gain) were examined and FCR was calculated. Some hematological (WBC, RBC, HGB and HTC) and biochemical (triglycerides, AST and ALT) parameters were determined. The highest average body weight was observed in EG 0.5% group at 35-day-old age and the lowest in EG 1%, 239.61±2.96 g and 231.74±2.96 g respectively. The highest values of the weight gain were calculated in EG 0.5% group, 67.02±2.03 g during the first week of fattening and the lowest was observed in EG 1% group at the fifth week after hatching, 23.30±2.03 g respectively. The lowest values of FCR were observed during the first week of the trial, 2.42±0.08 kg/kg to 2.61±0.13 kg/kg in EG 1% and the control group respectively. The supplementation of 0.5% and 1% silymarin did not significantly change the studied hematological and biochemical parameters. A tendency of higher values of triglycerides and lower values of AST and ALT was observed in the groups, supplemented with silymarin compared to the controls. From the obtained results of the present study we can conclude that the silymarin supplementation at higher doses (0.5% and 1%) did not have effect on the main growth performance and some hematological and biochemical parameters of male Japanese quails.

scholarly journals Effect of enzyme, multivitamin and growth promoter on growth performance and hemato-biochemical parameters in broiler chicken

2016 ◽  
pp. 1-4
Author(s):  
MR Das ◽  
MMH Sarker ◽  
MB Rashid ◽  
MA Miah
Keyword(s):  
Body Weight ◽  
Growth Performance ◽  
Biochemical Parameters ◽  
Control Group ◽  
Growth Promoter ◽  
Breast Meat ◽  
Group A ◽  
Combined Supplementation ◽  
Group B ◽  
Hb Concentration

To investigate the effect of exogenous enzymes, multivitamin and growth promoter on growth performance and different hemato-biochemical parameters of broilers, ten days old “Cobb 500” chicks were used and randomly divided into five equal groups (n=10). Group A was considered as control, fed only with commercial ration. Group B, C, D and E were supplemented with enzymes, multivitamin and enzymes plus multivitamin and growth promoter, respectively for the period of 21 days. Results revealed that body weight was increased significantly (p <0.05) in all four treated groups and highest body weight was recorded in group D. Weights of different organs except viscera (liver, spleen, skin, legs, breast meat, leg meat and viscera) were also varied significantly (p <0.05) among the treated groups. TEC increased significantly (p<0.05) in birds of all treated groups except group E whereas Hb concentration increased significantly (p<0.05) in all treated groups (B, C, D and E) as compared to control group A. Highest PCV was also recorded in group C but all the values were more or less similar and statistically insignificant (p>0.05). Biochemical parameters like AST were decreased significantly (p<0.05) in treated groups except group B and C. But, ALT values decreased significantly (p<0.05) in all treated groups in comparison to control group. It is concluded that combined supplementation of enzyme and multivitamin improved better in body weight and different organs weight gain and improves hemato-biochemical profile in broilers.International Journal of Natural Sciences (2014), 4(1) 1-4

scholarly journals Hematological and Biochemical parameters study of female albino rats treated with lamotrigine drug

2019 ◽  
Vol 24 (3) ◽  
pp. 23
Author(s):  
Gawhar Ahmed Shekha ◽  
Kalthum Asaaf Maulood
Keyword(s):  
Body Weight ◽  
Biochemical Parameters ◽  
Haemoglobin Concentration ◽  
Chloride Ion ◽  
Treated Group ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Anti Epileptic Drug ◽  
Hematological And Biochemical Parameters

The present study was aimed to investigate the possible effects of the anti-epileptic drug lamotrigine (LTG) on some haematological and biochemical parameters in adult female rats. Forty-eight female rats were divided into three groups (each group=16). Group one can be considered as a control group, group two and three administrated lamotrigine drugs orally at a dose of 3.57mg/kg body weight and 7.14mg/kg body weight for 7,14,21,28 day and all groups fed with standard rat feed. The results showed that there were significant (P≤0.05) changes in haematological parameters in group two and three when compared with the control group during all period except the mean level of corpuscular haemoglobin concentration (MCHC). The liver enzyme aspartate transaminase (AST) and alanine transaminase (ALT) and serum urea, creatinine with calcium, potassium, sodium and chloride ion showed significant alteration in the treated group, the relative organ weight showed significant changes in group two and three in comparison with control group during 7,14,21 and 28 days. Estradiol level in group three increased at 7, 14 and 21 day and decreased at 28 days of treatment when compared with group two and the control group. This study suggested that treatment of healthy female albino rats with therapeutic doses of lamotrigine drug for 28 days generally affect on included parameters in this study.   http://dx.doi.org/10.25130/tjps.24.2019.044

scholarly journals The effect of a formulation based on maduramycin and nicarbazine on rats and broiler chickens in a subacute experiment

2021 ◽  
pp. 41-48
Author(s):  
Roman Dotsenko ◽  
Maryna Romanko ◽  
Yevheniia Vashchyk ◽  
Andriy Zakhariev ◽  
Andrii Zemlianskyi ◽  
...  
Keyword(s):  
Body Weight ◽  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Clinical Signs ◽  
The Body ◽  
Male Rats ◽  
Control Group ◽  
White Rats ◽  
Group I ◽  
Hematological And Biochemical Parameters

The aim: to determine the effect of a preparative form of an antiemeric agent based on maduramycin and nicarbazine on the body of white rats and broiler chickens under the conditions of a subacute experiment. Materials and methods. The formulation based on maduramycin and nicarbazine was administered to rats and broiler chickens with feed for 28 days. One control and three experimental groups were formed for the experiment: Group I – animals received a complete diet without admixture of the formulation (control group), Group II – animals that were administered the formulation (by the amount of active substances) at a dose of 5.0 mg / kg, III – 25.0 mg / kg and IV – 50.0 mg / kg of feed, respectively. In order to establish the toxic effect of the formulation on the body of experimental birds on 7, 14, 28 days of the experiment and 7 days after discontinuation of the formulation, 5 heads from each group were killed under light ether anesthesia, blood samples were taken for hematological and biochemical studies. Results. During the study of the general clinical condition of rats and broiler chickens of the experimental groups, no significant changes in behavior and appearance were detected, compared with the control. Hematological parameters of broiler chickens it was found that the receipt of the formulation with feed at doses of 5, 25 and 50 mg/kg body weight, causes a decrease in hemoglobin and an increase in hematocrit in broiler chickens on day 7 of the experiment. It was found that the changes are reversible, on the 28th day of the experiment the value of these indicators was within the physiological norm. In the study of hematological and biochemical parameters of rats, it was found that the receipt of the formulation with food in doses of 25.0 and 50.0 mg/kg for 28 days, causes a decrease in hemoglobin and increase hematocrit, total protein, albumin, creatinine and urea in male rats on the 7th day of the experiment. Conclusions. Under conditions of repeated oral administration of the preparation mixture to rats and poultry at doses of 5, 25 and 50 mg/kg body weight in the absence of clinical signs of poisoning, insignificant fluctuations in hematological and biochemical parameters were identified

Influence of increased doses of fenbendazole supramolecular complex on sheep’s organism

2018 ◽  
Vol 12 (2) ◽  
pp. 46-52 ◽  
Author(s):  
A.I. Varlamova
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Biochemical Parameters ◽  
Negative Influence ◽  
Supramolecular Complex ◽  
Control Group ◽  
Blood Cell Count ◽  
Russian Scientific ◽  
Russian Scientific Research Institute ◽  
Hematological And Biochemical Parameters

The purpose of the research: study of the influence of increased doses of fenbendazole supramolecular complex (FSMC) on sheep’s organism. Materials and methods. The experiment was carried out at the Podolsk Department of All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K. I. Skryabin on 20 manorial invasion-free sheep aged 2-3 years old. Animals were divided according to the principle of analogues into 4 groups, 5 heads in each group. Animals of the 1, 2 and 3 group were orally administered with FSMC given as a single dose of 2, 6, 10 mg/kg, respectively, according to the active substance, i.e in therapeutic and in a dose increased by 3 and 5 times. Sheep of the fourth group didn’t receive the drug and they were as control. Study of clinical, hematological and biochemical parameters of animals from all groups was conducted 1 day before and in 1, 3, 5 days after administration of the drug by means of standard methods. Results and discussion. FSMC in therapeutic dose as well as in a dose increased by 3 and 5 times doesn’t have negative influence on clinical, hematological and biochemical parameters of the sheep. State of the sheep, which received the drug in doses of 20, 60, 100 mg/kg, was within the physiologically normal state and didn’t differ from the state before administration of the drug and from the animals of the control group. Drug security index exceeds 5. Red blood cell count, white blood cell count, hemoglobin count, leukogram parameters as well as biochemical parameters of blood: activity of alkaline phosphatase and amylase, bilirubin, creatinine, urea and glucose counts were within normal limits and didn’t differ from the parameters of the control animals.

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