Irizin: a new myokine and its effect on metabolism

2021 ◽  
pp. 17-28
Author(s):  
V. A. Prylutska ◽  
A. V. Solntsаva ◽  
T. A. Piskun
Keyword(s):  
Protective Factor ◽  
Metabolic Diseases ◽  
Protective Role ◽  
Impaired Glucose Metabolism ◽  
Oncological Diseases ◽  
Relationship Of ◽  
The Relationship ◽  
Positive Effect

Muscles release hormones (myokines) into the bloodstream, which affect the production of cytokines and their metabolism in various organs and tissues. One of them is irisin, a new adipokine with important autocrine and endocrine functions. It is produced not only by muscle tissue, but also by lymphoid organs, adipose and nervous tissue. It has been proven that this myokine can play a role in the pathogenesis of metabolic and oncological diseases, inflammation, aging and neurogenesis. The content of irisin in the blood is regulated not only by physical activity, but also by diet, changes in body weight, and drugs. The increased interest in studying the relationship of irisin with metabolic diseases is due to the search for a potentially new point of application for overcoming type 2 diabetes mellitus and insulin resistance. Irisin plays a major role in the interaction of the muscle­adiposetissue­bone­brain axis. It has been found that exercise has a positive effect on the functioning of the nervous system. Irisin has an anabolic effect on the skeleton and plays a significant role in bone metabolism. It has been established that exercise is a protective factor in people with cancer, reduces the toxicity of chemotherapy and improves the quality of life of patients, although the mechanisms of this phenomenon require further study. The relationship between circulating irisin levels and impaired glucose metabolism in children is discussed. It is proposed to use irisin as one of the predictors of childhood obesity. Its protective role in pregnancy and in newborns is being studied. A decrease in serum irisin levels is considered a marker of gestational diabetes. It has been suggested that cord blood irisin levels may be a reliable predictor of obesity in the future. Further research is needed to better understand the mechanism of action of this myokine in various diseases in children and to identify the relationship between circulating irisin levels and the amount of brownadipose tissue in newborns of different gestational age and with different birth weights.

scholarly journals Omics-based biomarkers in the diagnosis of diabetes

2019 ◽  
Vol 31 (2) ◽  
Author(s):  
Wei Zien Gan ◽  
Valsala Ramachandran ◽  
Crystale Siew Ying Lim ◽  
Rhun Yian Koh
Keyword(s):  
Metabolic Diseases ◽  
Early Screening ◽  
Glucose Levels ◽  
Non Invasive ◽  
Life Threatening ◽  
Autoantibody Detection ◽  
Relationship Of ◽  
The Relationship

AbstractDiabetes mellitus (DM) is a group of metabolic diseases related to the dysfunction of insulin, causing hyperglycaemia and life-threatening complications. Current early screening and diagnostic tests for DM are based on changes in glucose levels and autoantibody detection. This review evaluates recent studies on biomarker candidates in diagnosing type 1, type 2 and gestational DM based on omics classification, whilst highlighting the relationship of these biomarkers with the development of diabetes, diagnostic accuracy, challenges and future prospects. In addition, it also focuses on possible non-invasive biomarker candidates besides common blood biomarkers.

scholarly journals Pengaruh Kualitas Sistem Mobile Banking terhadap Laba Bersih dengan Penggunaan Sebagai Variabel Intervening

2020 ◽  
Vol 15 (2) ◽  
pp. 1-8
Author(s):  
Taufan Adi Kurniawan ◽  
Dewi Kusuma Wardani ◽  
Ely Jupita Lestari
Keyword(s):  
Primary Data ◽  
Mobile Banking ◽  
System Quality ◽  
Banking Services ◽  
Software Application ◽  
Net Benefits ◽  
Relationship Of ◽  
The Relationship ◽  
Positive Effect

The main objective of this study is to determine whether the quality of the system can affect the net benefits of using mobile banking both directly and through the variable of mobile banking usage. The type of data used is primary data. The data is taken from distributed questionnaire to BRI bank customers in Yogyakarta using mobile banking services. The sampling method used is convenience sampling. Data were analyzed using Partial Least Squares (PLS) available in SmartPLS 3.0 software application. the results of this study indicate that the quality of the system has a positive effect on usage. System benefits have a direct positive effect on net benefits. Usage is not an intervening variable in the relationship of system quality to net benefits.

scholarly journals Surveying the relationship between Gly1057Asp polymorphism of IRS-2 gene and susceptibility to type 2 diabetes; a systematic review and meta-analysis study

2019 ◽  
Vol 8 (4) ◽  
pp. 263-270
Author(s):  
Faezeh Kiani ◽  
Fatemeh Sayehmiri ◽  
Ali Hasanpour Dehkordi ◽  
Morteza Motedayen
Keyword(s):  
Type 2 Diabetes ◽  
Confidence Interval ◽  
Significant Relationship ◽  
Meta Analysis ◽  
Protective Role ◽  
Increase Risk ◽  
Genetic And Environmental Factors ◽  
Relationship Of ◽  
The Relationship

Type 2 diabetes mellitus (T2DM) is a multi-factorial disease in which influenced by several genetic and environmental factors. Insulin receptor substrate 2 (IRS 2) is the main mediator of insulin in the liver which controls insulin sensitivity. Gly1057Asp polymorphism is one of the candidates to increase risk of T2DM. The present study is an attempt to study the relationship of Gly1057Asp polymorphism of IRS-2 and T2DM by a meta-analysis. A systemic search was conducted in English and Persian databases such as Scopus, PubMed, Google Scholar, SID, and other academic databases for studies that have investigated the relationship of Gly1057Asp polymorphism of IRS-2 and T2DM. This association was determined using odds ratios (ORs) with a confidence interval of 95% (CIs). Heterogeneity of the studies was examined by I2 index. Funnel plots and Egger tests were used to determine bias or publication bias. The collected data was analyzed in STATA through meta-analysis. Nine articles were selected as eligible for further analysis, which represented 3,196 patients with T2DM and 3409 controls subjects without T2DM. The present meta-analysis showed a significant relationship between GA genotype of Gly1057Asp polymorphism and T2DM (OR=0.88; 95% confidence interval, 0.79-0.98), whereas no significant relationship between GG and AA genotype with T2DM was seen; OR for GG and AA genotypes were 1.10 (95% CI, 0.99 -1.22) and 1.13 (95% CI, 0.95- 1.33), respectively. The results of our study show that genotype GA of Gly1057Asp polymorphism of IRS-2 gene plays a protective role and may decrease the risk of T2DM, whereas GG and AA genotypes are considered as a risk factor and related to development of T2DM to some extents.

scholarly journals Neophilia dan Dampaknya Bagi Kualitas Pengalaman Penikmat Makanan Lokal Kota Kebumen

2020 ◽  
Vol 19 (1) ◽  
pp. 65-75
Author(s):  
Sigit Wibawanto
Keyword(s):  
Quality Of Experience ◽  
Food Preferences ◽  
Descriptive Research ◽  
Quality Of Food ◽  
Pass Through ◽  
Relationship Of ◽  
The Relationship ◽  
The City ◽  
Positive Effect

This study is limited to the discussion of food consumption which is explored from the dimensions of local food preferences in destinations. This study has three objectives: to establish the neophilic tendency of foods to determine the consumption of new foods; how is the quality of food experiences with neophilia personalities; and how tourist food experiences are moderated by travel motives for new experiences about food in the places visited. This study illustrates a descriptive research scheme, tested on travelers who happen to pass through the city of Kebumen who enjoy "Ambal" satay food by 100 respondents. The study used a partial statistical test (t-test) and Moderated Regretion Analysis (MRA) to look for the effect of variable X on the Y variable. The results showed neophilia personality had a positive effect on the quality of experience. Travel motives that moderate the neophilia personality are not able to moderate the relationship of the neophilia personality to the quality of experience. The conclusions of the study show the higher the neophilia personality and travel motives, the more it can affect the quality of the experience but not with moderation.

scholarly journals The relationship of visceral obesity and cardio-ankle vascular index with impaired glucose metabolism according to the ESSE-RF study in West Siberian region.

2018 ◽  
Vol 96 (2) ◽  
pp. 137-146
Author(s):  
Alexei N. Sumin ◽  
N. A. Bezdenezhnykh ◽  
N. V. Fedorova ◽  
A. V. Bezdenezhnykh ◽  
E. V. Indukaeva ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Glucose Metabolism ◽  
Visceral Obesity ◽  
Impaired Glucose Metabolism ◽  
Population Sampling ◽  
Patients With Diabetes ◽  
Relationship Of ◽  
The Relationship

Aim. To study the relationship of cardio-ankle vascular index (CAVI) and the factors of cardiovascular risk (including visceral obesity) with impaired glucose metabolism in a population sampling. Material and methods. Cross-sectional study was performed within the framework of multicentre epidemiological study ESSE-RF from March to October 2013. The study subject was a random population sampling of male and female adult population in the age of 25-64 years old in the Kemerovo region. Standard research protocol ESSE-RF is extended with additional research of peripheral arteries' stiffness at VaSeraVS-1000 apparatus (Fukuda Denshi, Japan) with automatic estimation of cardio-ankle vascular index. A sample of 1619 subjects was formed in several stages, 2 subjects with T1DM were excluded from it. The rest 1617 subjects were divided into three groups: group 1 - subjects with type 2 diabetes mellitus (T2DM) (n = 272), group 2 - subjects with pre-diabetes - impaired fasting glucose, impaired glucose tolerance or a combination of them (n = 44), group 3 - subjects without any confirmed impaired glucose metabolism (n = 1301). Results. This type 2 diabetes was diagnosed in 16.6% patients, pre-diabetes - in 2.7%. When comparing the clinical and medical history and laboratory characteristics to the following trend is noteworthy: patients with diabetes and prediabetes were comparable for most indicators, but significantly different from patients without disorders of carbohydrate metabolism. The prevalence of coronary heart disease, hypertension, obesity, stroke, kidney disease, dyslipidemia was higher among diabetic and pre-diabetic persons. The incidence of pathologic CAVI (> 9.0) was higher among patients with diabetes and prediabetes (15.9% and 16.8%) compared with those with normoglycaemia (9.0%, p < 0.001 for trend). In the total sample CAVI positively correlated with age (r = 0.526, р < 0.001), T2DM (r = 0.128, р < 0.001), pre-diabetes (r = 0.071, р = 0.002), waist circumference (r = 0.125, р < 0.001), visceral obesity (r = 0.097, р < 0.001), but not with BMI (r = 0.042, р = 0.132). According to the result of the regression analysis CAVI values were associated with the presence of diabetes (odds ratio (OR) 1.185 with an increase in the CAVI for each unit, 95% confidence interval (CI) 1.100-1.276; p < 0.001), and pre-diabetes (OR 1.179, 95% CI 1.008-1.380; p = 0.044). Visceral obesity was associated with T2DM (OR 2.893, 95% CI 2.093-3.999, р < 0.001) and pre-diabetes (OR 2.350, 95% CI 1.119-4.935, р < 0.001). Conclusion. Prediabetic and diabetic patients have similar prevalence of cardiovascular risk factors, including increased stiffness of arteries and visceral obesity. In a community sample of West Siberia increase in CAVI was associated with both type 2 diabetes and prediabetes.

Using the alveograph in developing requirements for the quality of flour for wafer sheet production

2020 ◽  
Vol 29 (12) ◽  
pp. 52-58
Author(s):  
E.P. Meleshkina ◽  
◽  
S.N. Kolomiets ◽  
A.S. Cheskidova ◽  
◽  
...  
Keyword(s):  
Rheological Properties ◽  
Quality Indicators ◽  
Wheat Flour ◽  
Mathematical Statistics ◽  
Intended Purpose ◽  
The Future ◽  
Relationship Of ◽  
The Relationship

Objectively and reliably determined indicators of rheological properties of the dough were identified using the alveograph device to create a system of classifications of wheat and flour from it for the intended purpose in the future. The analysis of the relationship of standardized quality indicators, as well as newly developed indicators for identifying them, differentiating the quality of wheat flour for the intended purpose, i.e. for finished products. To do this, we use mathematical statistics methods.

Management of Economics and State "Bottom"

2020 ◽  
Vol 17 (6) ◽  
pp. 76-91
Author(s):  
E. D. Solozhentsev
Keyword(s):  
Quality Of Life ◽  
Artificial Intelligence ◽  
Probabilistic Models ◽  
Human Life ◽  
Special Software ◽  
Human Quality ◽  
Relationship Of ◽  
The Relationship

The scientific problem of economics “Managing the quality of human life” is formulated on the basis of artificial intelligence, algebra of logic and logical-probabilistic calculus. Managing the quality of human life is represented by managing the processes of his treatment, training and decision making. Events in these processes and the corresponding logical variables relate to the behavior of a person, other persons and infrastructure. The processes of the quality of human life are modeled, analyzed and managed with the participation of the person himself. Scenarios and structural, logical and probabilistic models of managing the quality of human life are given. Special software for quality management is described. The relationship of human quality of life and the digital economy is examined. We consider the role of public opinion in the management of the “bottom” based on the synthesis of many studies on the management of the economics and the state. The bottom management is also feedback from the top management.

DIAGNOSING QUALITY OF FRICTION SYSTEMS OF MECHANISMS OF DEVICES

2019 ◽  
Vol 1 (7) ◽  
pp. 10-13
Author(s):  
D. Yu. Ershov ◽  
I. N. Lukyanenko ◽  
E. E. Aman
Keyword(s):  
Surface Defects ◽  
Diagnostic Methods ◽  
Design Parameters ◽  
Diagnostic Model ◽  
Mechanical Assemblies ◽  
Local Defects ◽  
Relationship Of ◽  
The Relationship ◽  
Production And Operation

The article shows the need to develop diagnostic methods for monitoring the quality of lubrication systems, which makes it possible to study the dynamic processes of contacting elements of the friction systems of instrument mechanisms, taking into account roughness parameters, the presence of local surface defects of elements and the bearing capacity of a lubricant. In the present article, a modern diagnostic model has been developed to control the quality of the processes of production and operation of friction systems of instrument assemblies. With the help of the developed model, it becomes possible to establish the relationship of diagnostic and design parameters of the mechanical system, as well as the appearance of possible local defects and lubricant state, which characterize the quality of friction systems used in many mechanical assemblies of the mechanisms of devices. The research results are shown in the form of nomograms to assess the defects of the elements of friction mechanisms of the mechanisms of the devices.

Sign in / Sign up

Export Citation Format

Share Document