scholarly journals A short communication nutritional observation study

2020 ◽  
Vol 3 (2) ◽  
pp. 01-04
Author(s):  
Asmaa Hamouda
Keyword(s):  
Vitamin B12 ◽  
Short Communication ◽  
Low Density Lipoprotein ◽  
Negative Relationship ◽  
Density Lipoprotein ◽  
Vitamin B ◽  
Observation Study ◽  
Anthropometric Measures ◽  
Liver And Kidney ◽  
The Relationship

Obesity is the most prevalent nutritional dysfunction in society and the vital risk determinant for several relevant disorders. The first step of obesity assessment is calculated anthropometric measures and, secondly, measure biological and nutritional profiles. The current purpose is to investigate the relationship between BMI with biochemical profile, Vitamin B12, Fe, and cortisol in the volunteer’s population. There is an appositively connection between body mass index (BMI) with cortisol, liver and kidney profile, fasting blood sugar (FBS), Cholesterol, triglyceride, and low-density lipoprotein (LDL) and negative relationship between BMI and Vitamin B12, Fe, and high-density lipoprotein (HDL) in the present study. There is a significant elevation of cortisol, lipid profile, FBS, liver, and kidney function with BMI in the current work in females more than males compared to a reference range, and a significant decrease in Fe and vitamin B that can be due to diet habits, BMI, malabsorption in obesity condition, hormones affect or genetic variations between male and female. That will need further investigation.

scholarly journals Korelasi Kontrol Glikemik dengan HDL dan Small-Dense LDL pada Penderita Diabetes Melitus dengan Komplikasi Jantung Koroner di RSUP Dr. Kariadi Semarang, Jawa Tengah

2019 ◽  
Vol 8 (1) ◽  
pp. 67-75
Author(s):  
Srilaning Driyah ◽  
Lisyani BS ◽  
Kusmiyati DK
Keyword(s):  
Blood Glucose ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Negative Relationship ◽  
Density Lipoprotein ◽  
Low Density ◽  
Apo B ◽  
Small Dense Ldl ◽  
The Relationship ◽  
Diabetes Melitus

Abstract Blood glucose level could be measured before 2-3 months using glycated haemoglobin (HbA1c). In diabetes mellitus (DM) the size of low-density lipoprotein (LDL-K) often changes to a small size, called small dense LDL-K sdLDL) which is atherogenic and low high-density lipoprotein (HDL) level. High HbA1c indicates uncontrolled glucose levels and often cause complications of coronary heart disease (CHD). This is a further investigation from the previous one about ”The Relationship between HbA1c with LDL and Apo B in DM patients with cardiac complications." This study used analytical, cross-sectional design. Thirty patients DM with CHD complications were examined for HbA1C levels via the Exchange-HPLC ion methods, HDL-K and LDL-K by enzymatic colourimetric methods and apo B by the immunoturbidimetry methods. The relationship between variables was analyzed by the Pearson correlation test.The mean level of HbA1c was 8.72%, male HDL was 35.67 mg / dl, female was 39.57 mg / dl, LDL-K was 110.64 mg / dl, apo B was 111.88 mg / dl and sd-LDL was 1, 02. A strong negative relationship between HbA1c and HDL levels for both men and women with r = - 0.647; r = - 0.675 with significance level p = 0.017; p = 0.008. Whereas HbA1c with sd-LDL has a weak negative relationship, but not significant (r = -0.352; p = 0.057). Hence, lipid profile measurement can be considered to monitor risk of cardiovacular diseases, particularly in those with abnormal blood glucose metabolism. AbstrakPemantauan kadar gula 2-3 bulan sebelumnya dapat diukur menggunakan glycated hemoglobin (HbA1c). Pada diabetes melitus (DM) ukuran low density lipoprotein (LDL-K) sering berubah menjadi kecil, yang dinamakan small dence LDL-K (sd-LDL) yang bersifat aterogenik, dan kadar high density lipoprotein (HDL) sering rendah. HbA1c yang tinggi menandakan kadar glukosa tidak terkontrol dan sering menyebabkan salah satu komplikasi ke penyakit jantung koroner (PJK). Penelitian ini merupakan penelitian lanjutan dari penelitian berjudul “ Hubungan HbA1c dengan trigliserida dan Apo B pada penderita DM dengan komplikasi penyakit jantung” Studi ini menggunakan desain analitik potong lintang. Tiga puluh pasien DM dengan komplikasi PJK diperiksa kadar HbA1c melalui metoda ion-Exchange HPLC, HDL-K dan LDL-K dengan metoda kolometrik enzimatik dan apo B dengan metoda imunoturbidimetri. Hubungan antar variabel dianalisis dengan uji korelasi Pearson.Hasil penelitian didapatkan laki laki 16 dan perempuan 14 pasien. Kadar rerata HbA1c 8,72%, HDL laki laki 35,67 mg/dl, perempuan 39,57 mg/dl, LDL-K 110,64 mg/dl, apo B 111,88 mg/dl dan sd-LDL 1,02. Hubungan negatif kuat antara kadar HbA1c dan HDL baik laki laki maupun perempuan dengan r = - 0,647 ; r = - 0,675 dengan tingkat kemaknaan p = 0,017; p = 0,008. Sedangkan HbA1c dengan sd-LDL terdapat hubungan negatif lemah, tetapi tidak bermakna (r=-0,352 ; p = 0,057). Karena itu, pemeriksaan profil lipid dapat dipertimbangkan untuk memantau risiko penyakit kardiovaskular khususnya bagi mereka dengan gangguan metabolisme gula darah

scholarly journals The relationship of the serum endocan level with the CHA2DS2-VASc score in patients with paroxysmal atrial fibrillation

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Gökhan Ceyhun
Keyword(s):  
Atrial Fibrillation ◽  
Paroxysmal Atrial Fibrillation ◽  
Stroke Risk ◽  
Low Density Lipoprotein ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Roc Curve Analysis ◽  
Reactive Protein ◽  
Relationship Of ◽  
The Relationship

Abstract Background In this study considering the relationship between serum endocan and CHA2DS2-VASc score, we assumed that endocan level could be a new biomarker for stroke risk in patients with paroxysmal atrial fibrillation (PAF). It was examined that endocan could be an alternative to determine the risk of stroke and anticoagulation strategy in patients with PAF. The CHA2DS2-VASc scores were calculated for 192 patients with PAF, and their serum endocan levels were measured. The patients were divided into two groups as those with low to moderate (0-1) and those with high (≥ 2) CHA2DS2-VASc scores, and the endocan levels were compared between these two groups. Results The serum endocan level was significantly higher in the high CHA2DS2-VASc score group (p < 0.001). In the multivariate logistic regression analysis, endocan, C-reactive protein, and low-density lipoprotein were found to be independent determinants of the CHA2DS2-VASc score. The predictive value of endocan was analyzed using the ROC curve analysis, which revealed that endocan predicted a high stroke risk (CHA2DS2-VASc ≥ 2) at 82.5% sensitivity and 71.2% specificity at the cutoff value of 1.342. Conclusion This study indicates that endocan is significantly associated with CHA2DS2-VASc score. We demonstrated that endocan could be a new biomarker for the prediction of a high stroke risk among patients diagnosed with PAF.

scholarly journals Subclinical Hypothyroidism and Indices for Metabolic Syndrome in Japanese Women: One-Year Follow-Up Study

2013 ◽  
Vol 98 (8) ◽  
pp. 3280-3287 ◽  
Author(s):  
Yasuyo Nakajima ◽  
Masanobu Yamada ◽  
Masako Akuzawa ◽  
Sumiyasu Ishii ◽  
Yasuhiro Masamura ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Odds Ratio ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Free T4 ◽  
The Relationship

Context: Subclinical hypothyroidism (SCH) and metabolic syndrome (MetS) increase with age; however, their relationship remains unclear. Objective: Our objective was to investigate the relationship between SCH and indices of metabolic syndrome and follow up subjects for 1 year. Design: Cross-sectional and longitudinal follow-up studies of cases were collected from Takasaki Hidaka Hospital between 2003 and 2007. Participants: Overall, 11 498 participants of health checkups were analyzed. The mean age was 48 ± 9 years. Main Outcome Measures: The relationship between SCH and indices of MetS were examined. Results: Serum free T4 levels were lower in women than men in most of the age groups, and the prevalence of SCH, 6.3% in women vs 3.4% in men, increased with age, reaching 14.6% in 70-year-old women. Multivariate logistic-regression analyses revealed that waist circumference and the serum triglyceride and low-density lipoprotein-cholesterol levels were significantly higher in subjects with SCH than without among women. Reflecting these findings, the adjusted odds ratio of MetS in patients with SCH was higher than in the euthyroid subjects in women with an odds ratio of 2.7 (95% confidence interval 1.1–5.6; P = .017) but not in men. Furthermore, progression from euthyroid into SCH resulted in a significant increase in the serum triglyceride levels but not low-density lipoprotein-cholesterol in women. Conclusion: Japanese women exhibited a high prevalence of SCH associated with low free T4 levels. There was a strong association between SCH and several indices of metabolic syndrome in women. SCH may affect serum triglyceride levels and be a risk factor for metabolic syndrome.

scholarly journals In vivo and in silico investigations of the toxicological and analgesic properties of unprocessed Aloe vera gel in experimental rat models

2018 ◽  
Vol 70 (4) ◽  
pp. 727-735 ◽  
Author(s):  
Subhashis Paul ◽  
Arnab Chakraborty ◽  
Debabrata Modak ◽  
Arnab Sen ◽  
Soumen Bhattacharjee
Keyword(s):  
Side Effects ◽  
Low Density Lipoprotein ◽  
Aloe Vera ◽  
Density Lipoprotein ◽  
Bioactive Molecules ◽  
Complementary Medicines ◽  
Aloe Vera Gel ◽  
Liver And Kidney ◽  
Aloe Gel

Aloe vera is a commonly used plant in both food and medicine industry. The potential toxicological side-effects of prolonged intake of Aloe extract have not been evaluated in detail. This work presents an in-depth toxicological study of the crude unprocessed A. vera gel in experimental rats. Acute and sub-chronic toxicity was evaluated in a 1 to 28-day long feeding schedule of the aqueous homogenized gel material. Hemoglobin, total protein, high density lipoprotein (HDL), low density lipoprotein (LDL), cholesterol, triglyceride, serum creatinine, serum alanine transaminase (SGPT), aspartate transaminase (SGOT) and alkaline phosphatase were examined and kidney and liver histology was performed. In the acute toxicity test, the behavioral aspects were also considered. A molecular docking assay was performed to investigate the binding affinities of pure A. vera compounds with liver and kidney toxicological marker enzymes, in order to assess the probable mode of action of selected Aloe constituents. Solubility factors for the active constituents were also studied to determine their possible miscibility with body fluids. The results from in vivo tests provided no major toxicological indications. Crude Aloe gel consumption up to 4 g/kg body weight (b.w.) showed no toxicological side effects. From the structural standpoint, Aloe-based bioactive molecules, such as Aloe-emodin, acetophenone, ?-sitosterol, cholestenol and squalene showed promising binding affinity to qualify as alternative and complementary medicines. The synergistic roles of all A. vera constituents remain to be validated in human disease models.

scholarly journals A Mobile-Based Comprehensive Weight Reduction Program for the Workplace (Health-On): Development and Pilot Study (Preprint)

2018 ◽  
Author(s):  
Min Kyu Han ◽  
Belong Cho ◽  
Hyuktae Kwon ◽  
Ki Young Son ◽  
Hyejin Lee ◽  
...  
Keyword(s):  
Mobile Technology ◽  
Weight Reduction ◽  
Weight Control ◽  
Glycosylated Hemoglobin ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Program ◽  
Metabolic Profiles ◽  
Anthropometric Measures ◽  
Periodic Feedback

BACKGROUND There is a growing interest in mobile technology for obesity management. Despite the known effectiveness of workplace-based weight loss programs, there are few studies on mobile phone–delivered interventions. OBJECTIVE This study aimed to develop and verify an integrated and personalized mobile technology–based weight control program, named Health-On, optimized for workplaces. METHODS A weight reduction algorithm was developed for calorie prescription, continuous monitoring, periodic feedback and reevaluation, goal resetting, and offline intervention with behavior-changing strategies. A total of 30 obese volunteers (body mass index ≥25 kg/m<sup>2</sup>) participated in the 12-week Health-On pilot program. The primary outcome was weight reduction, and secondary outcomes were improved anthropometric measures, metabolic profiles, and fat computed tomography measures, all assessed pre- and postintervention. RESULTS Health-On incorporated proprietary algorithms and several strategies intended to maximize adherence, using compatible online and offline interventions. The mean weight of 30 participants decreased by 5.8%, and median weight also decreased from 81.3 kg (interquartile range [IQR] 77.1-87.8) before intervention to 76.6 kg (IQR 70.8-79.5) after the 12-week intervention period (<italic>P</italic>&lt;.001). The metabolic profiles and fat measures (blood pressure, glycosylated hemoglobin, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, alanine aminotransferase, and visceral and subcutaneous adipose tissue; <italic>P</italic>&lt;.05) also improved significantly. CONCLUSIONS In this single-group evaluation of 30 participants before and after the Health-On program, body weight decreased and metabolic profiles and fat measures improved. Follow-up studies are needed to assess effectiveness and long-term adherence.

scholarly journals ANALISIS HUBUNGAN KADAR GULA DARAH PUASA DENGAN KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN (HDL) PADA PASIEN DIABETES MELLITUS TIPE 2 DI RSUP SANGLAH

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Nyoman Jirna
Keyword(s):  
Blood Sugar ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Fasting Blood Sugar ◽  
Cholesterol Levels ◽  
Sugar Levels ◽  
Dm Type 2 ◽  
The Relationship

Abstract Diabetes mellitus (DM) is a group of metabolic diseases with characteristic hyperglycemia that happen by abnormal secretions of insulin, insulin action, or both. The condition of insulin resistance in DM type 2 cause abnormal lipid metabolism that indicated by increase or decrease levels of lipid fraction in plasma, include increase levels of Very Low Density Lipoprotein (VLDL) or triglycerides, decrease levels of High Density Lipoprotein (HDL), and formed small dense Low Density Lipoprotein (LDL). The purpose of this study is to determine the relationship between the fasting blood sugar levels with HDL cholesterol levels in patients with DM type 2. The method use an analytical study with cross sectional design. Sampling examined as many as 35 samples by purposive sampling. The relationship between fasting blood sugar levels with HDL cholesterol levels is analyzed by Pearson Product Moment Correlation test. Based on the result concluded that there is a relationship between fasting blood sugar levels with HDL cholesterol levels in patients with DM type 2 in RSUP Sanglah with significant value sig=0,030 (sig

scholarly journals Sea Buckthorn and Grape Antioxidant Effects in Hyperlipidemic Rats: Relationship with the Atorvastatin Therapy

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Erieg A. Mohamed ◽  
Despina M. Bordean ◽  
Isidora Radulov ◽  
Răzvan F. Moruzi ◽  
Călin I. Hulea ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Sea Buckthorn ◽  
Cellular Damage ◽  
Tissue Samples ◽  
Grape Extract ◽  
Atorvastatin Therapy ◽  
Liver And Kidney ◽  
And Control

Background. Medications to reduce oxidative stress are preventing cellular damage associated with hyperlipidemia. In this regard, statins (e.g., atorvastatin) act primarily by decrease in low-density lipoprotein-c but, in the last decade, hepatotoxicity, associated with liver injuries in the next months after treatments’ initiation, was reported. In this case, associated phytotherapy can be a solution. Purpose. To investigate the antioxidant potential and response to free radicals, in the case of hyperlipidemic rats treated with atorvastatin. Sea buckthorn (Hippophae rhamnoides) and a grape extract (antioxivita) efficiency in the oxidative stress were investigated, also being ascertained the rats’ organs cytoarchitecture. Methods. Eighty-four hyperlipidemic Wistar rats were divided into seven groups and orally treated as follows: ATS, atorvastatin (20 mg/kg·bw); ATS + Hr, atorvastatin + H. rhamnoides; ATS + Aox, atorvastatin + grape extract; Hr, H. rhamnoides; and Aox, grape extract (both as 100 mg/kg·bw). HFD and Control received high fat diet and normal fodder only. After two and six months, respectively, rats were euthanized and the heart, liver, and kidneys were gathered. The tissue samples were prepared by homogenization of 0.5 g tissue, in ethanol, kept for 48 hours at 4°C–10°C and then filtered, in order to assess organs’ cytoarchitecture and the TAC’s values (by using cupric ion reducing antioxidant capacity (CUPRAC) assay). The test tubes were incubated, at room temperature, for 30 minutes, and then analyzed using a spectrophotometer at 450–650 nm. Results. The statistics (ANOVA) revealed that sea buckthorn diminished notably (p<0.001) the oxidative stress in the heart, liver, and kidney. After six months, the TAC’s reduced levels for the heart were significant (p<0.001) in ATS + Aox. In the case of histology, the liver’s cytoarchitecture in ATS revealed abnormal cytoarchitecture. In ATS + Hr, ATS + Aox, Hr, and Aox, cell regeneration improved in different stages, especially for ATS + Hr and ATS + Aox, in comparison with HFD, which exhibited fat degeneration. Kidney’s cytoarchitecture revealed cellular healing, especially in ATS + Hr and ATS + Aox.

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