CYCLODEXTRIN IN DRUG DELIVERY APPLICATION: A REVIEW

2019 ◽  
Vol 7 (4) ◽  
Author(s):  
Rajveer Bhaskar ◽  
Monika Ola ◽  
Rahul Patel ◽  
Dr. S. S. Chalikwar
Keyword(s):  
Drug Delivery ◽  
High Performance ◽  
Pulmonary Delivery ◽  
Drug Carriers ◽  
Review Article ◽  
Complexing Agents ◽  
Nasal Drug Delivery ◽  
Drug Molecules ◽  
Pharmaceutical Application ◽  
Wide Range

The cyclodextrins have a wide range of applications in various areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most popular pharmaceutical application of cyclodextrin is to increase the solubility, stability, safety and bioavailability of drug molecules. The idea of this review article is to solve and study any of the findings and application of cyclodextrin (CD) and their derivatives in different areas of drug delivery. This review article introduce the molecular structure, properties like complexation, solubility etc. of cyclodextrins and targeted on its use for parenteral, oral, ophthalmic and nasal drug delivery. Other routes including dermal, rectal, sublingual and pulmonary delivery are again briefly addressed. The aim of this contribution is to focus on the potential application of chemically altared cyclodextrins as high-performance drug carriers in drug delivery systems with emphasis on the other recent developments. Thus cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems associated with the delivery of different other novel drugs through different delivery routes. Keywords: Cyclodextrin, complexing agents, bioavailability, industrial application

scholarly journals Functional Nanofibrous Biomaterials of Tailored Structures for Drug Delivery—A Critical Review

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 522
Author(s):  
Zhen Li ◽  
Shunqi Mei ◽  
Yajie Dong ◽  
Fenghua She ◽  
Yongzhen Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Extracellular Matrix ◽  
Critical Review ◽  
Polymeric Materials ◽  
Structural Features ◽  
Advantages And Disadvantages ◽  
Drug Molecules ◽  
Wide Range ◽  
Polymeric Nanofibers ◽  
Insight Into

Nanofibrous biomaterials have huge potential for drug delivery, due to their structural features and functions that are similar to the native extracellular matrix (ECM). A wide range of natural and polymeric materials can be employed to produce nanofibrous biomaterials. This review introduces the major natural and synthetic biomaterials for production of nanofibers that are biocompatible and biodegradable. Different technologies and their corresponding advantages and disadvantages for manufacturing nanofibrous biomaterials for drug delivery were also reported. The morphologies and structures of nanofibers can be tailor-designed and processed by carefully selecting suitable biomaterials and fabrication methods, while the functionality of nanofibrous biomaterials can be improved by modifying the surface. The loading and releasing of drug molecules, which play a significant role in the effectiveness of drug delivery, are also surveyed. This review provides insight into the fabrication of functional polymeric nanofibers for drug delivery.

scholarly journals Advanced characterizations of nanoparticles for drug delivery: investigating their properties through the techniques used in their evaluations

2017 ◽  
Vol 6 (4) ◽  
pp. 355-372 ◽  
Author(s):  
Syed Mahmood ◽  
Uttam Kumar Mandal ◽  
Bappaditya Chatterjee ◽  
Muhammad Taher
Keyword(s):  
Drug Delivery ◽  
Advanced Characterization ◽  
Data Interpretation ◽  
Review Article ◽  
The Body ◽  
Drug Molecule ◽  
Drug Molecules ◽  
Preparation Techniques

AbstractNanomedicine has achieved a huge success in delivering a wide variety of drug molecules into the target site of the body. In this respect, the characterization of nanoformulation is very important to investigate the drug molecule together with its carrier as a nanoform during formulation, storage, and in vivo transport through the body. This review article summarizes important advanced characterization techniques of nanoformulation with respect to their theories, use of required instrumental parameters, sample preparation techniques, data interpretation, etc., to exploit them for the best possible results. This review article also sheds a glimpse to the shortcomings of these techniques together with further advancements required in future.

scholarly journals PROPERTIES, PHARMACEUTICAL APPLICATION AND VARIOUS TECHNIQUE OF CHEMICAL MODIFICATION IN NATIVE STARCH: A DESCRIPTIVE REVIEW

2019 ◽  
pp. 54-59
Author(s):  
BISHAL JYOTI BORDOLOI ◽  
BHUPEN KALITA ◽  
DIBYENDU SHIL
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
The Body ◽  
Gelling Agent ◽  
Intrinsic Properties ◽  
Pharmaceutical Application ◽  
Conventional Drug ◽  
Wide Range ◽  
Thickening Power ◽  
And Storage

Starch is one important natural polymer that finds application in the formulation of dosage forms as the binder, disintegrates, diluents, gelling agent etc. Starch is drawing the attention in drug delivery as it is cheap, non-toxic, renewable, biodegradable and compatible with many other materials for industrial application. Starch has vital intrinsic properties that have made its pharmaceutical applications possible. It has also been used for a wide range of particular drug delivery applications, such as the delivery of challenging molecules and targeting to specific sites in the body. Starches are integrally unsuitable for most applications such as loss of viscosity and thickening power upon cooking and storage, retrogradation characteristics and absence of certain groups responsible for a particular function etc. So, in order to reduce its limitations and improve its applications, modification of starch is necessary. It can be modified by several ways like chemical modification, physical modification and genetic modification but the most important one is the chemical modification. This review summarizes the properties and application of native starchin conventional drug delivery systems within a world of dynamic drug production technology. It also describes the chemical modification like cross-linking, esterification, etherification and dual modification of starch.

scholarly journals Erythrocytes and Nanoparticles: New Therapeutic Systems

2021 ◽  
Vol 11 (5) ◽  
pp. 2173
Author(s):  
Clara Guido ◽  
Gabriele Maiorano ◽  
Carmen Gutiérrez-Millán ◽  
Barbara Cortese ◽  
Adriana Trapani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Hybrid Approach ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Target Cells ◽  
Preparation Methods ◽  
Medical Practitioners ◽  
Surface Receptors ◽  
Wide Range

Nano-delivery systems represent one of the most studied fields, thanks to the associated improvement in the treatment of human diseases. The functionality of nanostructures is a crucial point, which the effectiveness of nanodrugs depends on. A hybrid approach strategy using synthetic nanoparticles (NPs) and erythrocytes offers an optimal blend of natural and synthetic materials. This, in turn, allows medical practitioners to exploit the combined advantages of erythrocytes and NPs. Erythrocyte-based drug delivery systems have been investigated for their biocompatibility, as well as the long circulation time allowed by specific surface receptors that inhibit immune clearance. In this review, we will discuss several methods—whole erythrocytes as drug carriers, red blood cell membrane-camouflaged nanoparticles and nano-erythrosomes (NERs)—while paying attention to their application and specific preparation methods. The ability to target cells makes erythrocytes excellent drug delivery systems. They can carry a wide range of therapeutic molecules while also acting as bioreactors; thus, they have many applications in therapy and in the diagnosis of many diseases.

scholarly journals Nanocomposite Hydrogels: A Promising Approach for Developing Stimuli-responsive Platforms and their Application in Targeted Drug Delivery

2021 ◽  
Author(s):  
Amirmasoud Samadi ◽  
Fatemeh Yazdian ◽  
Mona Navaei-Nigjeh ◽  
Hamid Rashedi
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Carriers ◽  
Wound Complications ◽  
Inadequate Response ◽  
Hydrophobic Drugs ◽  
Natural Polymers ◽  
Smart Systems ◽  
Nanocomposite Hydrogels ◽  
Wide Range

Introduction: With the development of hydrogels from half a century ago, their application in various medical fields, including drug delivery has been widely expanded. Hydrogels used in this field are produced with synthetic polymers such as polyvinylpyrrolidone, polyvinyl alcohol, or natural polymers like chitosan, agarose, and hyaluronic acid to develop biocompatible, biodegradable, and non-immunogenic drug carriers. However, limitations such as inadequate response to stimulation, low homogeneity, and poor loading capacity for hydrophobic drugs have limited the use of hydrogels for drug delivery due to the hydrophilic nature of the hydrogel. The use of nanoparticles in the structure of hydrogels to produce hydrogel nanocomposites leads to more diverse interactions such as hydrogen and electrostatic bonds in addition to covalent interactions between hydrogel polymers. In addition to enhancing the mechanical properties of the hydrogel and further homogeneity, these interactions lead to the formation of platforms responsive to various stimuli, attaining sustained release, and ameliorating the poor loading of hydrophobic drugs used in cancer treatment and wound dressing. Conclusion: A review of a research conducted in the last 20 years represents that the application of nanocomposite hydrogels in drug delivery includes a wide range of production methods, nanoparticles to create various stimulation mechanisms, and therapeutic applications. Indeed, research has been focused on developing smart systems for controlled release with stimuli to reduce side effects of conventional cancer treatment methods, such as chemotherapy, by targeting drug delivery and reducing drug administration frequency and mitigating chronic wound complications by the release of growth factors.

scholarly journals Peptide Nanomaterials for Drug Delivery Applications

2020 ◽  
Vol 21 (4) ◽  
pp. 401-412 ◽  
Author(s):  
Sreekanth Pentlavalli ◽  
Sophie Coulter ◽  
Garry Laverty
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Diverse Range ◽  
Drug Molecules ◽  
Sustained Drug Delivery ◽  
Self Assembling ◽  
Wide Range ◽  
Methods Of Synthesis ◽  
Self Assembled

Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of enzymes or light, it is possible to trigger self-assembly and design a host of different self-assembled nanostructures. The resulting nanostructures include nanotubes, nanofibers, hydrogels and nanovesicles which all display a diverse range of physico-chemical and mechanical properties. Depending on their design, peptide self-assembling nanostructures can be manufactured with improved biocompatibility and in vivo stability and the ability to encapsulate drugs with the capacity for sustained drug delivery. These molecules can act as carriers for drug molecules to ferry cargo intracellularly and respond to stimuli changes for both hydrophilic and hydrophobic drugs. This review explores the types of self-assembling nanostructures, the effects of external stimuli on and the mechanisms behind the assembly process, and applications for such technology in drug delivery.

Biomacromolecule-mediated pulmonary delivery of siRNA and anti-sense oligos: challenges and possible solutions

2021 ◽  
Vol 23 ◽  
Author(s):  
Yaseen Hussain ◽  
Jing-Hao Cui ◽  
Haroon Khan ◽  
Pooyan Makvandi ◽  
Waqas Alam
Keyword(s):  
Pulmonary Delivery ◽  
Drug Carriers ◽  
Systemic Circulation ◽  
Biochemical Properties ◽  
Manufacturing Facility ◽  
Synthetic Materials ◽  
Wide Range ◽  
Recent Developments ◽  
Antisense Oligos ◽  
Reticulo Endothelial System

Biomacromolecules have gained much attention as biomedicine carriers in recent years due to their remarkable biophysical and biochemical properties including sustainability, non-toxicity, biocompatibility, biodegradability, long systemic circulation time and ability to target. Recent developments in a variety of biological functions of biomacromolecules and progress in the study of biological drug carriers suggest that these carriers may have advantages over carriers of synthetic materials in terms of half-life, durability, protection and manufacturing facility. Despite the full pledge advancements in the applications of biomacromolecules, its clinical use is hindered by certain factors that allow the pre-mature release of loaded cargos before reaching the target site. The delivery therapeutics are degraded by systemic nucleases, cleared by reticulo-endothelial system, cleared by pulmonary mucus cilia or engulfed by lysosome during cellular uptake that has led to the failure of clinical therapy. It clearly indicates that there is a wide range of gaps in the results of experimental work and clinical applications of biomacromolecules. This review focuses mainly on the barriers (intracellular/extracellular) and hurdles to the delivery of biomacromolecules with special emphasis on siRNA as well as the delivery of antisense oligos in multiple pulmonary diseases, particularly focusing on lung cancer. Also, the challenges posed to such delivery and possible solutions have been highlighted.

Methods for Determining the Parameters of Receptor-Ligand Interactions on the Model of Concanavalin A and Mannosylated Chitosans Promising Carriers for Drug Delivery to Alveolar Macrophages

2021 ◽  
Vol 37 (5) ◽  
pp. 28-40
Author(s):  
D.A. Vanichkin ◽  
E.V. Kudryashova
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Fluorescence Quenching ◽  
Concanavalin A ◽  
Uv Spectroscopy ◽  
Isothermal Calorimetry ◽  
Mannose Receptor ◽  
Drug Carriers ◽  
Wide Range ◽  
Ligand Interactions

Abstract-The search for mannosylated molecules forming strong complexes with the model mannose receptor, concanavalin A (ConA), is an important step for the creation of targeted drug carriers. The goal of this work was to develop an accurate and reproducible method for determining the parameters of lectin-ligand interactions to assess the affinity of concanavalin A to chitosan and its mannosylated derivatives. It was shown that the use of UV spectroscopy, as well as fluorescence quenching, makes it possible to determine the parameters of ligand-receptor complexation at reagent concentrations 1-2 orders of magnitude lower than those described in the literature and obtained, including by isothermal calorimetry. UV spectroscopy also opens up the possibility of analyzing a wide range of ligands and makes the process less laborious. Comparative characteristics of the above methods are given. It was proposed to use chitosans as carriers for drug delivery to macrophages due to their biocompatibility, mucoadhesiveness, as well as the ability to reduce the toxicity of antibacterial agents and enhance their absorption by macrophages. Unmodified chitosans bind to ConA relatively weakly (Kd ≈ 10-4 M). With an increase in the molecular weight, the degree of modification of chitosans with mannose, as well as with the introduction of a spermidine spacer into their molecule, the strength of complexation of the carrier with the model mannosylated receptor ConA increases significantly; Kd values are in the range of 10-6-10-7 M, which is almost an order of magnitude lower than for the natural ligand, trimannoside. The effect is achieved due to the high clustering of mannose residues (Man). Taking into account such criteria of drugs as safety and immunogenicity, we believe that among the studied chitosan molecules, a spacer-containing high-mannosylated chitosan polymer with a molecular weight of 5 kDa should be considered the optimal carrier for drug delivery to macrophages. Key words: mannose receptors, chitosan, concanavalin A, UV spectroscopy, fluorescence quenching, dissociation constant, macrophages

Nanocellulose-based Hydrogels for Biomedical Applications

2019 ◽  
Vol 15 (4) ◽  
pp. 371-381 ◽  
Author(s):  
Amalnath John ◽  
Wen Zhong
Keyword(s):  
Biomedical Applications ◽  
High Performance ◽  
Polymer Networks ◽  
Three Dimensional ◽  
Drug Carriers ◽  
Wound Dressings ◽  
Self Healing ◽  
Natural Polymers ◽  
Wide Range ◽  
Materials Used

Hydrogels are three-dimensional polymer networks capable of absorbing and holding a large amount of water. They have a wide range of biomedical applications including drug carriers, biosensors, tissue scaffolds and wound dressings owning to their innate resemblance to the living tissue. Recently biodegradable and renewable natural polymers, especially nanocellulose, have gained immense attention in the development of hydrogels for biomedical applications. This review provides a brief analysis of the various nanocellulosic materials used in the fabrication of hydrogels for various biomedical applications. Recent developments in high performance hydrogels based on nanocellulose, including self-healing, highly tough and/or stretchable and 3D printable hydrogels will also be covered in this review.

scholarly journals AN UPDATED REVIEW ON THE APPLICATION OF DENDRIMERS AS SUCCESSFUL NANOCARRIERS FOR BRAIN DELIVERY OF THERAPEUTIC MOIETIES

2021 ◽  
pp. 1-9
Author(s):  
SARANYA SASI ◽  
SHARON KUNNATH JOSEPH ◽  
ARYA MANGALATH ARIAN ◽  
SACHIN THOMAS ◽  
AMRUTHA V. U. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Genetic Material ◽  
Review Article ◽  
Wide Range ◽  
The Central Nervous System ◽  
Systemic Side Effects ◽  
High Degree ◽  
Novel Drug ◽  
Physical And Chemical ◽  
The Brain

It’s been nearly 100 y of effort to study the organization and role of the blood brain-barrier and still, we strive to find better techniques to overcome this barrier to deliver the drugs to the brain effectively with reduced systemic side effects. The advances in nanotechnology have given newer horizons in achieving this goal since the nano-scaled systems can modify an existing drug to have a high degree of sensitivity to the physiological conditions and specificity to reach the target organ. Among the various nanocarriers, dendrimers owing to their unique physical and chemical characteristics, represent a potential therapeutic tool in biomedical and pharmaceutical science. Dendrimers, an established polymeric nanocarrier system of the time, can deliver both drugs and genetic material and are being extensively studied to target the brain. The surface modification of dendrimers can reduce their innate toxicity problems and increase the therapeutic efficacy of brain disorders. This review article is an attempt to update on the potential of dendrimers explored in the past five years as a drug delivery avenue that can be considered as a promising solution in the management of a wide range of disorders affecting the central nervous system, including neoplastic, degenerative, and ischemic conditions. The following search criteria were used to expand the review article with the keywords dendrimers, novel drug delivery, nanoparticles, site-specific drug delivery etc.

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