scholarly journals Research of safety and toxicity of drug “Biozapin”

2021 ◽  
Vol 23 (103) ◽  
pp. 157-161
Author(s):  
O. Chechet ◽  
V. Kovalenko ◽  
O. Haidei ◽  
O. Krushelnytska
Keyword(s):  
Live Weight ◽  
Animal Husbandry ◽  
Antagonistic Activity ◽  
Control Group ◽  
Intragastric Administration ◽  
Toxicological Studies ◽  
Study Results ◽  
Probiotic Strains ◽  
Pelleted Feed ◽  
Soil Insects

Modern animal husbandry and poultry farming is developing very rapidly compared to the possibilities of previous years. Obtaining high economic indicators is possible with balanced feeding and strict observance of veterinary and sanitary measures. Failure to comply with the technology of cultivation leads to the activation of opportunistic pathogens. During the industrial rearing of animals, microflora accumulates both indoors and in the environment. Fattening animals with pelleted feed indoors and the lack of contact with donors of typical microorganisms available in nature (soil, insects, plants) lead to the intestine's colonization by enterobacteria. As a result, probiotics have become very popular in animal husbandry and poultry to normalize the intestinal microflora and disinfect humus, treat animal housing, and eliminate odors: probiotics – microbial drugs which are stabilized cultures of microorganisms that have antagonistic activity against pathogenic microflora. Today, the sources of probiotic strains are nine species of microorganisms. However, probiotics' antimicrobial and stimulating potential based on safe and effective strains of B. subtilis and B. amyloliquefaciens bacilli is much higher than probiotics based on Lacto- and bifidobacteria. The study aimed to investigate the safety and cute toxicity of the probiotic drug “Biozapin” based on a mixture of probiotic bacteria Bacillus sybtilis, Bacillus amyloliquefaciens and aluminosilicate with a single injection into animals and to establish the maximum therapeutic, toxic and lethal doses. The article presents information on the study results of acute toxicity and safety of the drug “Biozapin”. At intragastric administration of this drug to white mice at a dose of 5000 mg/kg of body weight, it does not cause their death; therefore, it is possible to draw a conclusion that this drug is nontoxic. Dilution of the drug “Biozapin” in various concentrations are harmless to the simplest tetrachimene piriformis. The increase in live weight of one head of mice with forced administration of the drug “Biozapin” intragastrically in different concentrations was: sample № 1 – 11.5 %, sample № 2 – 10.0 %, sample № 3 – 13.5 %, sample № 4 – 11.7 %, sample № 5 – 11.1 %, in the control group – 13.9 %. At pathological autopsy of animals, no visible pathological changes were found. The results of toxicological studies have shown that the drug “Biozapin” is harmless and non-toxic.

The influence of highly dispersed preparations on metabolism and productivity of young cattle

2020 ◽  
pp. 22-33
Author(s):  
E. A. Sizova ◽  
A. M. Makaeva
Keyword(s):  
Trace Elements ◽  
High Surface ◽  
Live Weight ◽  
Animal Husbandry ◽  
Control Group ◽  
Dispersed Particles ◽  
Highly Dispersed ◽  
Young Cattle ◽  
Experimental Group ◽  
Highly Dispersed Particles

Preparations of highly dispersed particles of trace elements are increasingly used in animal husbandry. This is determined by their extraordinary biological properties such as the ability to penetrate into tissues and organs, a high surface area, and so on. One of the promising directions for using highly dispersed particles both in the post-embryonic and embryonic periods of animal development is the use of trace elements as sources. This is determined by the relatively lower toxicity, higher bioavailability of elements from preparations of highly dispersed particles, which reduces the load on the environment and allows you to produce products enriched with minerals. The purpose of the research was to study the effect of highly dispersed drugs on rumen digestion, the composition of the rumen microbiome, metabolism and productivity of young cattle. A comprehensive assessment of the use of highly dispersed SiO2 and FeCo preparations in cattle nutrition has been provided in the paper. The digestibility of feed, metabolism, and productivity of young cattle when feeding highly dispersed particles have been studied. An unusual fact of increasing bacterial biomass when using highly dispersed particles of silicon dioxide in animal feeding has been described. A method for increasing the digestibility of feed components by ruminants through the use of highly dispersed FeCo alloy particles has been proposed. As follows from the data obtained the use of highly dispersed particles allowed to increase the live weight of experimental young animals to 413 kg in the 1st experimental group and 416 kg in the 2nd experimental group, which was by 11 (P ≤ 0,01) and 14 kg (P ≤ 0,01) higher than the control indicator. As follows from the analysis of the data obtained, the profitability of rearing young animals in the 1st and 2nd experimental groups was by 2,4 and 2,2 % higher than the same indicator calculated for the control group.

scholarly journals Effect of probiotic strains of Bacillus subtilis on the growth parameters of broiler chickens and caecal microbiota

2020 ◽  
Vol 222 ◽  
pp. 02054
Author(s):  
Ayslu Mardanova ◽  
Anastasia Nikolaeva ◽  
Guzel Lutfullina ◽  
Aygul Ganeeva ◽  
Margarita Sharipova
Keyword(s):  
Bacillus Subtilis ◽  
Broiler Chickens ◽  
Pathogenic Bacteria ◽  
Growth Parameters ◽  
Live Weight ◽  
Control Group ◽  
Probiotic Properties ◽  
Probiotic Strains ◽  
Opportunistic Pathogenic ◽  
Caecal Microbiota

In this paper, the probiotic properties of Bacillus subtilis GM2 and GM5 strains were studied. It is shown that the use of probiotic additives based on the spores of these bacteria leads to an increase in the live weight gain of broiler chickens by 4.16% and 10.76% relative to the control. Metagenomic analysis showed that representatives of the phylum Firmicutes (54.55%) and Bacteroidetes (30.45%), mainly represented by the families Ruminococcacea and Bacteroidaceae, predominate in the caecal microbiota of broiler chickens on day 42. It was found that a probiotic based on the B. subtilis GM5 strain leads to an increase in the proportion of Firmicutes in caecum by 27% and a decrease in Bacteroidetes by 19%. There was also a significant decrease in the number of representatives of opportunistic pathogenic bacteria of the Enterobacteriaceae family relative to the control group.

scholarly journals Dairy productivity of mixed-aged Holstein cows with prolonged lactation function

2020 ◽  
Vol 8 (4) ◽  
pp. 265-268
Author(s):  
G. S. Gutsulyak
Keyword(s):  
Milk Yield ◽  
Live Weight ◽  
Holstein Cows ◽  
Control Group ◽  
Lactation Period ◽  
Group V ◽  
Productivity Level ◽  
Group I ◽  
Study Results ◽  
High Level

Presented study results of the productivity of mixed-aged cows with prolonged lactation. The formation of experimental groups was carried out according to the principle of analog groups, taking into account breed, live weight, age and physiological condition (lactation):25 animals in groups I, II, III and IV and 10 animals in group V. It was found that with the industrial technology of Holstein cows exploitation, regardless of their age, the duration of the lactation period was almost twice as long as the scientifically substantiated value and ranges from 561.2 to 610.9 days. At the same time, the milk productivity level of the cows in I and IV groups slightly exceeded 13 000 kg of milk per lactation, while in cows if II, III (control), and V groups – this value was higher than 15 000 kg. With prolonged lactation, the milk yield in the experimental groups of animals in terms of 305 days was kept at a fairly high level and there was a definite tendency to an increase in milk yield depending on the age of the animals. The first-calf heifers of group I were characterized by a relatively low milk yield since they gave only 13 291.8 kg of milk for the entire lactation, and in terms of 305 days – 7 944.1 kg, which was 13.57% and compared to III (control) group was 19.54% lower (P < 0.01). Animals of the fifth lactation from group V had the highest milk yield, in which the milk yield per lactation and per 305 days amounted to 15 818.5 kg and 9 716.7 kg of milk, respectively. With intensive exploitation technology and with the increasing age of Holstein cows, complete adaptation occurs, as a result of which their genetic potential for milk production is realized at a high level. This was indicated by the milk yield dynamics in experimental animals of different ages, in which, under the same conditions of feeding and housing, they were gradually increased from the first to the fifth lactation.

Non-traditional feed and probiotics for rearing of goslings

2020 ◽  
pp. 32-41
Author(s):  
N. Lushnikov ◽  
I. Loshkomoynikov
Keyword(s):  
Rapeseed Oil ◽  
Essential Fatty Acids ◽  
Live Weight ◽  
Animal Husbandry ◽  
Essential Amino Acids ◽  
Feed Additives ◽  
Production Costs ◽  
Partial Replacement ◽  
Control Group ◽  
The Cost

Currently, considerable interest is caused by the study of the effect of various feed additives on the productive performance of animals. The ban on the use of antibiotics to stimulate poultry growth in many European countries has increased the interest of researchers and practitioners in the use of probiotics. It is important to study the use of non-traditional feed in animal husbandry. Thus, waste processing of rapeseed (presscake, meal) is the most important sources of essential amino acids (lysine, methionine, tryptophan, etc.), essential fatty acids (linoleic, linolenic, arachidonic, oleic, etc.). The importance of rapeseed seeds and products of its processing has increased after the breeding of varieties with a low content of erucic acid and glucosinolates. The purpose of the research was to study the use of non-traditional feed and probiotics in the rearing of goslings to obtain full-fl edged products when they are grown up to 4 months of age. The possibility of replacing sunflower presscake with rapeseed presscake of Siberian selection and partial replacement of full-fat soy with rapeseed oil has been carried out. It has been found that the treatment of goslings after birth with probiotics “Prolam” and “Monosporin” and their use in feeding the goslings had a positive effect on their growth and development. With an increase in production costs and an increase in the cost of feed, the prime cost of 1 kg of live weight gain has decreased when processing and feeding probiotic “Prolam” by 17,9 %, “Monosporin” by 15,4 %. It has been obtained profits on 1 head more from the use of probiotics by 29,8 and 35 Rubles, respectively, in comparison with the control group. The level of profitability when using probiotics in the 1st experimental group has increased by 29,7 %, in the 2nd group by 24,7 %. The weight of the semi-eviscerated carcass was higher in the experimental groups receiving rapeseed presscake and rapeseed presscake in combination with rapeseed oil, and exceeded the weight of the carcasses of the control group by 286,13 and 388,48 g, respectively. The mass of eviscerated carcasses was also higher in the experimental groups.

THE USE OF BIFID-CONTAINING FEED PROBIOTIC ADDITIVE IN THE FEEDING OF YOUNG CATTLE

2021 ◽  
pp. 3-3
Author(s):  
Р.В. НЕКРАСОВ ◽  
М.Г. ЧАБАЕВ ◽  
Е.Ю. ЦИС ◽  
Б.А. КАРЕТКИН ◽  
Е.А. ТЕРЕШКОВА ◽  
...  
Keyword(s):  
Average Daily Gain ◽  
Live Weight ◽  
Animal Husbandry ◽  
Bifidobacterium Bifidum ◽  
Feed Additive ◽  
Control Group ◽  
Federal Research ◽  
Newborn Calves ◽  
Young Cattle ◽  
The Moment

Для уточнения эффективности скармливания бифидосодержащей кормовой пробиотической добавки молодняку крупного рогатого скота был организован научно-хозяйственный эксперимент в опытно-экспериментальном хозяй- стве Московского региона и в научных подразделениях Федерального государственного бюджетного научного уч- реждения. Новорожденные телята были распределены на 2 группы по 13 голов с учетом живой массы. Изучаемая пробиотическая бифидосодержащая кормовая добавка включала в себя лиофилизированную микробную массу жи- вых антагонистически активных бактерий вида Bifidobacterium bifidum (не менее 1×109 КОЕ/мл бифидобактерий). Скармливание добавки осуществлялось в количестве 10 мл на 1 голову в сутки молодняку опытной группы и спо- собствовало увеличению среднесуточных приростов живой массы на 14,9% по отношению к контрольной группе. Установлено, что с момента рождения до 3-месячного возраста ее использование способствовало 100% сохранности телят, тогда как в контроле этот показатель составил 92,3%. Включение в рацион телят молочного периода про- биотика обеспечило оптимальный гомеостатический и гематологический фон при улучшении морфологических и биохимических показателей крови. Показатели иммунитета, в том числе лизоцимная и бактерицидная активности были выше по отношению к контролю на 11,8 и 4,23% соответственно. Включение в рацион телят бифидодобавки обеспечивало рост лакто- и бифидобактерий в кишечнике животных, соответственно на 10,9 и 8,5%, на фоне по- давления нежелательной микрофлоры. Таким образом, скармливание с первых дней жизни бифидосодержащей добавки телятам способствует повышению у них защитных свойств, профилактирует заболеваемость, что ведет к улучшению зоотехнических показателей производства. To clarify the effectiveness of feeding probiotic bifid-containing feed probiotic additives to young cattle, a scientific and economic experiment was organized in the experimental farm of the Moscow region, and in the scientific divisions of the L.K. Ernst Federal Research Center for Animal Husbandry. Newborn calves were divided into 2 groups of 13 heads, taking into account the live weight. The probiotic bifid-containing feed additive under study contained a lyophilized microbial mass of live antagonistically active bacteria of the Bifidobacterium bifidum species (at least 1×109 CFU / ml of bifidobacteria). Feeding of the supplement was carried out in an amount of 10 ml per 1 head per day to young animals of the experimental group and contributed to an increase in the average daily gain of live weight by 14.9% compared to the control group. It was found that from the moment of birth to 3 months of age, the use contributed to 100% of the safety of calves, while in the control this indicator was 92.3%. The inclusion of probiotic in the diet of calves of the dairy period provided an optimal homeostatic and hematological background while improving the morphological and biochemical parameters of the blood. The indicators of immunity, including lysozyme and bactericidal activity, were higher in relation to the control by 11.8 and 4.23%, respectively. The inclusion of bifid supplements in the calves ' diet ensured the growth of lacto-and bifidobacteria in the intestines of animals, respectively, by 10.9 and 8.5%, against the background of suppression of undesirable microflora. Thus, feeding bifid-containing additives to calves from the first days of life increases their protective properties, prevents morbidity, which leads to an improvement in zootechnical production indicators.

scholarly journals CHLORELLA SUSPENSION AND ITS USAGE IN FINISHING PIGS’ RATIONS

2019 ◽  
Vol 19 (1) ◽  
pp. 46-49 ◽  
Author(s):  
O. KARUNKYI ◽  
T. REZNIK ◽  
Ye KULIDZHANOV
Keyword(s):  
Chemical Composition ◽  
Live Weight ◽  
Animal Husbandry ◽  
Feed Additives ◽  
Farm Animals ◽  
Control Group ◽  
Finishing Pigs ◽  
Feed Conversion ◽  
Special Place ◽  
Experimental Group

The animal husbandry cannot develop successfully without complete balanced feed and optimal forage supply. This article deals with the chemical composition of chlorella suspension. The ration is balanced with seaweeds as well as premixes, vitamins and bio supplement for the last decades. These seaweeds include chlorella - a representative of green microscopic algae. The use of chlorella allows for multi-factor balancing of the diet in accordance with modern feeding standards, which increases the productive effect of feed and significantly increases the transformation of nutrients into livestock products. This is arelevant issue of modern animal husbandry. The chlorella suspension was material for scientific research. It was made on the farm “In Samvel”, Ovidiopol District. According to the result of researches that took place on the farm " In Samvel", Biliayevka District, Odessa Oblast and SERF "Yuzhnyi" OSAGES NAAS, new data concerning chemical composition, the positive influence of investigated chlorella suspension on the growth and development of finishing pigs as well as feed costs by 1 kg of growth were obtained. It has been established that the chemical composition of chlorella suspension takes a special place among all feed additives used in farm animals feeding. It has been established that the additional use of chlorella suspension in the ration of finishing pigs of Large White breeds contribute to the increase of average daily gains by 121.9% against the control group in which chlorella suspensions was not given. Feed conversion to obtain1 kg of pigs live weight gain in the control group was 5.1 kg, in the experimental group - 4.2 kg and feed conversion index in the experimental group was higher by 21.4%. Thus the results of researches indicate the positive effect of investigated chlorella suspension on the growth anddevelopment of finishing pigs. Due to the obtained results, we can state that the chemical composition of the suspension chlorella takes a special place among all feed additives used in farm animals feeding. Chlorella has higher indicators of chemical composition, the amount of protein, vitamins and minerals in comparison with plant fodder and crops of agricultural production.

Efficiency of use in the feeding of first-calf heifers hay and haylage of legume-grass mixtures

2020 ◽  
pp. 3-11
Author(s):  
B. G. Sharifyanov ◽  
F. M. Shagaliev ◽  
G. Kh. Idiyatullin ◽  
E. F. Salikhov ◽  
O. V. Nazarchenko ◽  
...  
Keyword(s):  
Animal Feed ◽  
Live Weight ◽  
Animal Husbandry ◽  
Inorganic Phosphorus ◽  
Control Group ◽  
Steady Increase ◽  
Black And White ◽  
Republic Of Bashkortostan ◽  
White Breed ◽  
The Republic

Increasing the protein nutritional value of rations through the use of legume-grass crops, press-cakes and oil-cakes, complete provision of high-quality animal feed, balanced in protein and other components, is the leading direction of solving the protein problem in animal husbandry and remains an urgent topic for research. The purpose of the research was to study the use of hay and haylage from the mixture of Eastern galega and awnless brome in the rations of first-calf heifers instead of the same feed from the mixture of alfalfa and awnless brome. For carrying out scientific and economic experiments in LLC Kushul in the Dyurtyulinsky district in the Republic of Bashkortostan on the principle of pairs-analogs (breed, live weight, age, level of productivity) four groups of first-calf heifers of Black-and-White breed per 10 heads in each have been selected. The inclusion of 4 kg of hay and 10 kg of haylage in the rations of first-calf heifers of the mixture of Eastern galega and awnless brome has a positive effect on increasing the protein content in milk by 3,1 and 3,4 %, sugar by 0,6 and 0,9 abs.%. There was a steady increase in the milk of cows of the experimental groups: carotene, total calcium and inorganic phosphorus compared to the control group where the animals received 4 kg of hay and 10 kg of haylage of the mixture of alfalfa and awnless brome. Thus, studies have shown that the use in rations of first-calf heifers hay and haylage of mixtures of Eastern galega and awnless brome promotes not only productivity, but also improve milk quality.

scholarly journals Purple wheat as a source of anthocyanins and its effect on the metabolism of rabbits

2019 ◽  
Vol 64 (No. 12) ◽  
pp. 539-546
Author(s):  
O Stastnik ◽  
E Mrkvicova ◽  
L Pavlata ◽  
E Anzenbacherova ◽  
J Prokop ◽  
...  
Keyword(s):  
Wheat Variety ◽  
Live Weight ◽  
Feed Consumption ◽  
Control Group ◽  
Average Weight ◽  
Anthocyanin Content ◽  
Feed Mixture ◽  
Carcass Yield ◽  
Pelleted Feed ◽  
Experimental Group

The effects of feeding rabbits a diet that includes wheat enriched with anthocyanins were examined in this study. In addition to the animal’s performance, the basic carcass yield indicators and the basic indicators of the clinical biochemistry were also evaluated. The experiment was carried out using 18 HYLA female rabbits. The trial was performed at the age of 42 to 103 days. The experimental group (n = 9) received a pelleted feed mixture containing 15% PS Karkulka wheat. The control group (n = 9) received a pelleted feed mixture containing the common wheat variety Vanessa with a minimal anthocyanin content. There were no significant differences (P &gt; 0.05) between the control and experimental group in the live weight on the 103<sup>rd</sup> day. The same trend was found in the average weight gain per trial and in the feed conversion ratio. The average feed consumption was higher (P &lt; 0.05) in the control group compared to the experimental group. There was also a higher (P &lt; 0.05) carcass weight in the control group of the rabbits compared to the experimental group. There were no differences in the percentage carcass yield between the groups. The biochemical indicators and antioxidant activities did not differ between the two groups of rabbits (P &gt; 0.05). Based on these findings, it can be concluded that the use of 15% PS Karkulka wheat in the feed ration for HYLA broiler rabbits was safe and may be fed to broiler rabbits.

MILK PRODUCTIVITY AND REPRODUCTIVE QUALITIES OF FIRST-CALF COWS OF THE SCHWYZ BREED AT DIFFERENT LEVELS OF FEEDING

2020 ◽  
Vol 15 (7) ◽  
pp. 1036-1044
Author(s):  
O.K. Gogaev ◽  
◽  
T.A. Kadieva ◽  
A.R. Demurova ◽  
D.K. Ikoeva ◽  
...  
Keyword(s):  
Milk Fat ◽  
Live Weight ◽  
Animal Husbandry ◽  
Optimal Level ◽  
Control Group ◽  
Lactation Period ◽  
Additional Dose ◽  
North Caucasus ◽  
The North ◽  
The Difference

An important problem in organizing full-fledged feeding of cows is to establish the optimal level of energy nutrition, taking into account productivity, age and lactation period. The studies were carried out in the conditions of the foothill zone of the North Caucasus. 45 first-calf cows of the Schwyz breed were selected, from which three groups (15 heads in each) were formed according to the principle of pairs of analogues, taking into account age, live weight and body condition. The animals of the first group were control animals, and they received a diet that corresponds to the detailed norms (2003) of the All-Russia Institute of Animal Husbandry (ВИЖ). The rations for first-calf cows consisted of leguminous-cereal hay, corn silage, herb haylage, and compound feed. The basic feeds of the diet were given in equal amounts to cows of all groups. The second and third experimental groups during the period of milking received rations in which the level of energy supply was increased by 10 and 20%, respectively. Corn fodder meal was used as additional feeding. In terms of nutritional value, this was 0.92 and 1.84 EFU (0.7 and 1.4 kg), respectively. It was found that the introduction of an additional dose of energy feed (10 and 20% of corn flour) into the feeding ration of experienced first-calf cows contributed to an increase in milk yield in the first 100 days of lactation by 11.5 and 14%, respectively, as well as to some improvement in the quality indicators of milk. For example, in terms of milk fat content, cows from the experimental groups exceeded the control group by 0.06–0.08%, and in terms of milk fat yield, the difference between the groups was 10.9–16.6 kg. The protein content is 0.04–0.08%. The difference in the yield of milk protein is 9.1–14.9 kg. The duration of the interbody period was 6–8 days shorter than in the control group. The introduction of an additional dose of energy feed into the diet reduced the service period by 10–12 days, the frequency of inseminations by 0.3–0.5, and an increase in calf yield by 2–3%.

scholarly journals Development of the Probiotic Feed Supplement Based on Lactobacillus Plantarum to Increase the Broiler Productivity

2019 ◽  
Vol 9 (1) ◽  
pp. 2452-2454
Keyword(s):  
Lactobacillus Plantarum ◽  
Broiler Chickens ◽  
Live Weight ◽  
Scientific Work ◽  
Antagonistic Activity ◽  
Feed Additive ◽  
Control Group ◽  
Feed Supplement ◽  
Growing Period ◽  
Group 2

This article reflects the results of the development of a method for testing a promising feed supplement based on the Lactobacillus plantarum strain, with a high antagonistic activity to campylobacter. To determine the digestibility and use of food nutrients by broilers, a physiological (balance experiment) was conducted on three males from each group at the age of 28 days. By the end of the growing period, there was a clear tendency to increase the live weight of 36-day-old chickens compared with the control group in experimental group 2, which received a feed supplement, including bacteria Lactobacillus plantarum. She was 4.0% higher. As a result of scientific work, it was shown that feeding broiler chickens with a probiotic feed additive based on Lactobacillus plantarum helps to increase their productivity during the entire growing cycle.

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