scholarly journals Genome sequence for the blue-flowered Andean shrub Iochroma cyaneum reveals extensive discordance across the berry clade of Solanaceae

2021 ◽  
Author(s):  
Adrian F. Powell ◽  
Jing Zhang ◽  
Duncan Hauser ◽  
Julianne Vilela ◽  
Alice Hu ◽  
...  
Keyword(s):  
Wild Species ◽  
Strong Support ◽  
Basic Research ◽  
Nicotiana Attenuata ◽  
Gene Trees ◽  
Wide Range ◽  
Reference Quality ◽  
Morphological Transitions ◽  
Research Questions ◽  
Model Clade

The tomato family, Solanaceae, is a model clade for a wide range of applied and basic research questions. Currently, reference-quality genomes are available for over 30 species from seven genera, and these include numerous crops as well as wild species (e.g., Jaltomata sinuosa and Nicotiana attenuata). Here we present the genome of the showy-flowered Andean shrub Iochroma cyaneum, a woody lineage from the tomatillo subfamily Physalideae. The assembled size of the genome (2.7Gb) is more similar in size to chilipepper (2.6Gb) than to other sequenced diploid members of the berry clade of Solanaceae (e.g., potato, tomato, and Jaltomata). Our assembly recovers 92% of the conserved orthologous set, suggesting a nearly complete genome for this species. Most of the genomic content is repetitive (69%), with gyspy elements alone accounting for 52% of the genome. Despite the large amount of repetitive content, most of the 12 Iochroma chromosomes are highly syntenic with tomato. Bayesian concordance analysis provides strong support for the berry clade, including Iochroma, but reveals extensive discordance along the backbone, with placement of pepper and Jaltomata being highly variable across gene trees. The Iochroma genome contributes to a growing wealth of genomic resources in Solanaceae and underscores the need for expanded sampling of diverse berry genomes to dissect major morphological transitions.

scholarly journals Sharing SRP data to reduce environmentally associated disease and promote transdisciplinary research

2020 ◽  
Vol 35 (2) ◽  
pp. 111-122
Author(s):  
Michelle L. Heacock ◽  
Sara M. Amolegbe ◽  
Lesley A. Skalla ◽  
Brittany A. Trottier ◽  
Danielle J. Carlin ◽  
...  
Keyword(s):  
Environmental Health ◽  
Data Sharing ◽  
Data Streams ◽  
Basic Research ◽  
Research Projects ◽  
Engineering Research ◽  
Environmental Health Sciences ◽  
Wide Range ◽  
Comprehensive Picture ◽  
Research Questions

AbstractThe National Institute of Environmental Health Sciences (NIEHS) Superfund Basic Research and Training Program (SRP) funds a wide range of projects that span biomedical, environmental sciences, and engineering research and generate a wealth of data resulting from hypothesis-driven research projects. Combining or integrating these diverse data offers an opportunity to uncover new scientific connections that can be used to gain a more comprehensive understanding of the interplay between exposures and health. Integrating and reusing data generated from individual research projects within the program requires harmonization of data workflows, ensuring consistent and robust practices in data stewardship, and embracing data sharing from the onset of data collection and analysis. We describe opportunities to leverage data within the SRP and current SRP efforts to advance data sharing and reuse, including by developing an SRP dataset library and fostering data integration through Data Management and Analysis Cores. We also discuss opportunities to improve public health by identifying parallels in the data captured from health and engineering research, layering data streams for a more comprehensive picture of exposures and disease, and using existing SRP research infrastructure to facilitate and foster data sharing. Importantly, we point out that while the SRP is in a unique position to exploit these opportunities, they can be employed across environmental health research. SRP research teams, which comprise cross-disciplinary scientists focused on similar research questions, are well positioned to use data to leverage previous findings and accelerate the pace of research. Incorporating data streams from different disciplines addressing similar questions can provide a broader understanding and uncover the answers to complex and discrete research questions.

scholarly journals Twitter in Marketing Practice of the Religious Media. An Empirical Study on Catholic Weeklies in Poland

Religions ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 421
Author(s):  
Iwona Leonowicz-Bukała ◽  
Andrzej Adamski ◽  
Anna Jupowicz-Ginalska
Keyword(s):  
Communication Channel ◽  
Basic Research ◽  
Marketing Practice ◽  
Religious Media ◽  
The Social ◽  
Social Media Platforms ◽  
Twitter Account ◽  
Research Questions ◽  
Marketing Tool

This article presents the partial conclusion of the research project devoted to marketing activity of Polish Catholic opinion-forming weeklies on the social media platforms. The main aim of this article is to present the results of the study on the use of Twitter as a marketing tool by Polish nationwide Catholic opinion-forming weeklies. The basic research questions concerned the extent of utilizing the platform by the magazines’ editors to create and distribute the content of their media product, maintain and develop brand communication and self-promotion. The case studies and the content analysis of the accounts of the three magazines—Gość Niedzielny, Tygodnik Katolicki Niedziela and Przewodnik Katolicki—show that there are three different ways in how the editors of the magazines understand the role of the Twitter account of the title they represent—as an ‘active communicator’, ‘active communicator and community supporter’ or ‘community supporter’. The conclusions show that the studied media fairly efficiently use the visual and distributional potential of the platform as well as some of its features, at the same time missing the chance to build a brand-loyal community. They also limit the role of Twitter to that of a supplement for the main communication channel, which is the printed weekly and its website.

scholarly journals Role of Insulin in Health and Disease: An Update

2021 ◽  
Vol 22 (12) ◽  
pp. 6403
Author(s):  
Md Saidur Rahman ◽  
Khandkar Shaharina Hossain ◽  
Sharnali Das ◽  
Sushmita Kundu ◽  
Elikanah Olusayo Adegoke ◽  
...  
Keyword(s):  
Insulin Signaling ◽  
Basic Research ◽  
Future Research ◽  
Protective Effects ◽  
Glucose Levels ◽  
Physiological Processes ◽  
Blood Glucose Levels ◽  
Wide Range ◽  
Health And Disease

Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose levels; insulin acts via an anabolic pathway, while glucagon performs catabolic functions. Insulin regulates glucose levels in the bloodstream and induces glucose storage in the liver, muscles, and adipose tissue, resulting in overall weight gain. The modulation of a wide range of physiological processes by insulin makes its synthesis and levels critical in the onset and progression of several chronic diseases. Although clinical and basic research has made significant progress in understanding the role of insulin in several pathophysiological processes, many aspects of these functions have yet to be elucidated. This review provides an update on insulin secretion and regulation, and its physiological roles and functions in different organs and cells, and implications to overall health. We cast light on recent advances in insulin-signaling targeted therapies, the protective effects of insulin signaling activators against disease, and recommendations and directions for future research.

scholarly journals Detecting cybersecurity attacks across different network features and learners

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Joffrey L. Leevy ◽  
John Hancock ◽  
Richard Zuech ◽  
Taghi M. Khoshgoftaar
Keyword(s):  
Feature Selection ◽  
Intrusion Detection ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Machine Learning Algorithms ◽  
Feature Selection Technique ◽  
Impact Performance ◽  
Detection Model ◽  
Wide Range ◽  
Research Questions

AbstractMachine learning algorithms efficiently trained on intrusion detection datasets can detect network traffic capable of jeopardizing an information system. In this study, we use the CSE-CIC-IDS2018 dataset to investigate ensemble feature selection on the performance of seven classifiers. CSE-CIC-IDS2018 is big data (about 16,000,000 instances), publicly available, modern, and covers a wide range of realistic attack types. Our contribution is centered around answers to three research questions. The first question is, “Does feature selection impact performance of classifiers in terms of Area Under the Receiver Operating Characteristic Curve (AUC) and F1-score?” The second question is, “Does including the Destination_Port categorical feature significantly impact performance of LightGBM and Catboost in terms of AUC and F1-score?” The third question is, “Does the choice of classifier: Decision Tree (DT), Random Forest (RF), Naive Bayes (NB), Logistic Regression (LR), Catboost, LightGBM, or XGBoost, significantly impact performance in terms of AUC and F1-score?” These research questions are all answered in the affirmative and provide valuable, practical information for the development of an efficient intrusion detection model. To the best of our knowledge, we are the first to use an ensemble feature selection technique with the CSE-CIC-IDS2018 dataset.

scholarly journals Technology-enhanced and game based learning for children with special needs: a systematic mapping study

2021 ◽  
Author(s):  
Jose A. Gallud ◽  
Monica Carreño ◽  
Ricardo Tesoriero ◽  
Andrés Sandoval ◽  
María D. Lozano ◽  
...  
Keyword(s):  
Special Needs ◽  
State Of The Art ◽  
Research Community ◽  
Systematic Mapping Study ◽  
Children With Special Needs ◽  
Game Based Learning ◽  
Mapping Study ◽  
Systematic Mapping ◽  
Wide Range ◽  
Research Questions

AbstractTechnology-based education of children with special needs has become the focus of many research works in recent years. The wide range of different disabilities that are encompassed by the term “special needs”, together with the educational requirements of the children affected, represent an enormous multidisciplinary challenge for the research community. In this article, we present a systematic literature review of technology-enhanced and game-based learning systems and methods applied on children with special needs. The article analyzes the state-of-the-art of the research in this field by selecting a group of primary studies and answering a set of research questions. Although there are some previous systematic reviews, it is still not clear what the best tools, games or academic subjects (with technology-enhanced, game-based learning) are, out of those that have obtained good results with children with special needs. The 18 articles selected (carefully filtered out of 614 contributions) have been used to reveal the most frequent disabilities, the different technologies used in the prototypes, the number of learning subjects, and the kind of learning games used. The article also summarizes research opportunities identified in the primary studies.

Emphatic Sentences: A Comparative-Translational Study of Formal-Functional Relations in English and Romanian

Transilvania ◽  
2021 ◽  
pp. 75-84
Author(s):  
Mona Arhire
Keyword(s):  
Target Language ◽  
Original Text ◽  
John Fowles ◽  
Translational Study ◽  
Form And Function ◽  
Functional Relations ◽  
Wide Range ◽  
Research Questions ◽  
And Function ◽  
Stylistic Device

Emphasis, a well-acknowledged stylistic device, is a carrier of a considerable load of emotional content in the fictional dialogue. Its manifestation can take sundry forms and can be attached to a wide range of feelings and can take different degrees of intensity, all of which determines the creation of the atmosphere and impacts the reception by the readership. This paper reports on the investigation of the occurrence of emphasis embedded in the dialogic utterances of John Fowles’ novel Mantissa. The focus lies on the relation between the formal construction of emphatic sentences and the functional values deriving therefrom. The study entails a comparative analysis of emphatic utterances depicted from the English original text and its translation into Romanian. The three research questions refer to the comparative-contrastive realization of emphatic sentences in the two languages, to the extent to which the functional component succeeds in being transferred to the target language and to possible means of compensation when structural differences pose translational problems. The analysis is structured along a typology of sentences adapted to the nature of the text under scrutiny and to the aims of this study. The findings and conclusions ultimately indicate the importance of establishing a relation between form and function in matter of emphasis in the literary dialogue as an act of communication depending on linguistic devices for its effectiveness.

Epigenetics and Applied Anthropology

2021 ◽  
Author(s):  
Charles H. Klein
Keyword(s):  
Social Inequalities ◽  
Homo Sapiens ◽  
Single Gene ◽  
Molecular Genetic ◽  
Healthcare Providers ◽  
Basic Research ◽  
Sufficient Information ◽  
Theoretical Frameworks ◽  
Noncoding Dna ◽  
Wide Range

Since Francis Crick and James D. Watson’s discovery of DNA in 1953, researchers, policymakers, and the general public have sought to understand the ways in which genetics shapes human lives. A milestone in these efforts was the completion of the Human Genome Project’s (HGP) sequencing of Homo sapiens’ nearly three million base pairs in 2003. Yet, despite the excitement surrounding the HGP and the discovery of the structural genetic underpinnings of several debilitating diseases, the vast majority of human health outcomes have not been linked to a single gene. Moreover, even when genes have been associated with particular diseases (e.g., breast and colon cancer), it is not well understood why certain genetically predisposed individuals become ill and others do not. Nor has the HGP’s map provided sufficient information to understand the actual functioning of the human genetic code, including the role of noncoding DNA (“junk DNA”) in regulating molecular genetic processes. In response, a growing number of scientists have shifted their attention from structural genetics to epigenetics, the study of how genes express themselves in particular situations and environments. Anthropologists play roles in these applications of epigenetics to real-world settings. Their new theoretical frameworks unsettle the nature-versus-nurture binary and support biocultural anthropological research demonstrating how race becomes biology and embodies social inequalities and health disparities across generations. Ethnographically grounded case studies further highlight the diverse epigenetic logics held by healthcare providers, researchers, and patient communities and how these translations of scientific knowledge shape medical practice and basic research. The growing field of environmental epigenetics also offers a wide range of options for students and practitioners interested in applying the anthropological toolkit in epigenetics-related work.

scholarly journals Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle

2011 ◽  
Vol 437 (2) ◽  
pp. 215-222 ◽  
Author(s):  
Christopher G. R. Perry ◽  
Daniel A. Kane ◽  
Chien-Te Lin ◽  
Rachel Kozy ◽  
Brook L. Cathey ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Dynamic Range ◽  
Energy Charge ◽  
Respiratory Control ◽  
Basic Research ◽  
Dependent Manner ◽  
Atpase Inhibitor ◽  
Wide Range ◽  
The Impact

Assessment of mitochondrial ADP-stimulated respiratory kinetics in PmFBs (permeabilized fibre bundles) is increasingly used in clinical diagnostic and basic research settings. However, estimates of the Km for ADP vary considerably (~20–300 μM) and tend to overestimate respiration at rest. Noting that PmFBs spontaneously contract during respiration experiments, we systematically determined the impact of contraction, temperature and oxygenation on ADP-stimulated respiratory kinetics. BLEB (blebbistatin), a myosin II ATPase inhibitor, blocked contraction under all conditions and yielded high Km values for ADP of >~250 and ~80 μM in red and white rat PmFBs respectively. In the absence of BLEB, PmFBs contracted and the Km for ADP decreased ~2–10-fold in a temperature-dependent manner. PmFBs were sensitive to hyperoxia (increased Km) in the absence of BLEB (contracted) at 30 °C but not 37 °C. In PmFBs from humans, contraction elicited high sensitivity to ADP (Km<100 μM), whereas blocking contraction (+BLEB) and including a phosphocreatine/creatine ratio of 2:1 to mimic the resting energetic state yielded a Km for ADP of ~1560 μM, consistent with estimates of in vivo resting respiratory rates of <1% maximum. These results demonstrate that the sensitivity of muscle to ADP varies over a wide range in relation to contractile state and cellular energy charge, providing evidence that enzymatic coupling of energy transfer within skeletal muscle becomes more efficient in the working state.

scholarly journals Serbian theolinguistics today: Research issues and results

2016 ◽  
Vol 72 (1-2) ◽  
pp. 159-186
Author(s):  
Ksenija Koncarevic ◽  
Srdjan Petrovic
Keyword(s):  
Basic Research ◽  
Discourse Theory ◽  
Scientific Journals ◽  
Research Directions ◽  
Research Issues ◽  
Methodological Basis ◽  
Wide Range ◽  
The Republic ◽  
General Linguistics ◽  
Slavic Studies

The essay gives a survey of basic research directions in Serbian theolinguistics (in the fields of general linguistics, Serbian studies, Slavic studies and foreign philology), and presents the most important achievements in the fundamental and applicative fields of the study of the sacral language (from the synchronic perspective) which are presented in monographs, papers published in thematic anthologies, proceedings of scientific conferences and scientific journals in Serbia, Montenegro and the Republic of Srpska (with bibliographic references for the 2000-2013 period). Serbian theolinguistics, although in the stage of scientific constitution, potentially has a wide range of fundamental areas of study (some of the main issues from 2000 to 2013 were theoretical and methodological basis of theolinguistics, modern functioning of liturgical languages, confessional markedness of language levels, functional stylistics, genology and stylistics of resources, discourse theory) and spheres of application (lexicography, traductology, linguodidactics). Its perspective in the forthcoming period lies in strengthening the ties with leading centres of theolinguistics in the Slavic world and the integration of researchers of philological and theological profiles in order to further its development.

scholarly journals The use of ceramics as an aesthetic element in Durban architecture (1914-2012)

2013 ◽  
Author(s):  
◽  
Raksha Padaruth
Keyword(s):  
Historical Background ◽  
Art Practice ◽  
Local Identity ◽  
Architectural Elements ◽  
Architectural Element ◽  
Wide Range ◽  
Research Questions ◽  
Contemporary Practice ◽  
Insight Into

This paper documents and evaluates the use of ceramics as an aesthetic architectural element in Durban from 1914-2012 with special reference to James Hall (1916-2006), Andrew Walford (b.1942) and Jane du Rand (b.1969). These artists were selected because their work demonstrates a wide range of the use of decorative tiles and mosaics as aesthetic elements in Durban architecture over a period of more than fifty years. Reference is made to the historical use of tiles and mosaics as aesthetic architectural elements in Durban from 1914-1955 in order to provide a context to an investigation and evaluation of the contribution of Hall, Walford and du Rand to the use of tiles and mosaics as an aesthetic architectural element in Durban. The paper begins by highlighting the importance of this study, discusses the role of ceramic architectural adornment and defines terminology for the purpose of this research. In addition an explanation of the research methodology used, research questions and literature review is provided. The study is contextualised through an overview of the historical background of the use of ceramics (tiles and mosaics) as an aesthetic element in architecture. The importance of the use of ceramic elements in relation to architecture, as well as the different techniques and methods of production, are highlighted and related to contemporary practice. The overview provides insight into how the use of ceramic elements in the past has influenced the approach of contemporary practice. My contribution to the use of mosaics as an aesthetic architectural element in Durban and my art practice, in the form of an installation titled passage is discussed and evaluated. The paper concludes by noting that the historical use of tiles and mosaics as aesthetic elements in architecture persists in contemporary art practice. However, the methods of tiled mosaic production and tiled mosaic techniques have been revolutionised extensively. It is evident that, the use of ceramics as an aesthetic element in Durban architecture reflects, both a strong European design influence and a distinctive local identity.

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