scholarly journals Effect of Tomate Juice On Trigliserida Levels Of Male White Rats Induced by Alloxan

2021 ◽  
Vol 5 (1) ◽  
pp. 20-25
Author(s):  
FITRI HANDAJANI ◽  
Ibrahim Shihatta
Keyword(s):  
Treatment Group ◽  
Solanum Lycopersicum ◽  
Rattus Norvegicus ◽  
Tomato Juice ◽  
Triglyceride Synthesis ◽  
Experimental Animals ◽  
White Rats ◽  
Wistar Strain ◽  
Significant Difference ◽  
The Mean

Background: Tomato juice is believed to affect triglyceride levels in the blood because it contains lycopene. This study aims to determine the effect of tomato juice (Solanum lycopersicum) on blood triglyceride levels in the wistar strain of male Rattus norvegicus induced by alloxan. Methods: 24 were divided into 3 groups, (1) Group K (-) experimental animals without treatment, (2) Group K (+) experimental animals induced by alloxan 150 mg / kgBB, (3) Treatment group K (P) animals tried alloxan induced 150 mg / kg and got 1.75 ml / head of tomato juice. Results: There was a significant difference in mean triglyceride levels between groups K (-) and group K (+). This indicates that the induction of alloxan increases blood triglyceride levels. There were significant differences in the mean triglyceride levels between the K (+) and K (P) groups because tomato juice contained lycopene which could reduce triglyceride synthesis. Conclusions: Tomato juice (solanum lycopersicum) reduced wistar strain male Rattus novergicus triglyceride levels induced by alloxan.  

scholarly journals Effect of Giving Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract to Epithelialization In Incision Wound of White Rats (Rattus Norvegicus)

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Idola Perdana Sulistyoning Suharto
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Male Rats ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
White Rats ◽  
Significant Difference ◽  
Phaleria Macrocarpa ◽  
Incision Wound

The research purpose was to analysis effect of giving mahkota dewa fruits (Phaleria macrocarpa) extract to epithelialization in incision wound of white rats (Rattus norvegicus). The method was randomized posted-only control group design. There were 30 male rats (Rattus norvegicus) grouped on control and treatment group. Control group divided into three groups (KK1, KK2, KK3) and also treatment group divided into three groups (KP1, KP2, KP3). Control group just given CMC 1% peroral without mahkota dewa fruits extract, the treatment group given mahkota dewa fruits extract 22.5 mg/kg body weight. The data was analyzed by Kruskall Wallis. Based on Kruskall Wallis test, obtained result that there was a significant difference (p<0.05) epithelialization variable with p value p = 0.000 between control and treatment group. And based on One-way Anova test, obtained result that there was a significant difference (p<0.05) with p value p =0.000 between control and treatment group. The conclusion of this research was giving mahkota dewa fruits (Phaleria macrocarpa) extract can increase epithelialization in incision wound of white rats (Rattus norvegicus). Keywords : Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract, Epithelialization, Incision Wound 

scholarly journals Effect of Aloe vera Hydrogel Application on Increasing the Number of Fibroblasts in Socket Wounds Post-Tooth Extraction: An In Vivo Study

2021 ◽  
Vol 6 (2) ◽  
pp. 1347-1352
Author(s):  
Silvi Tiara Dewi ◽  
Chandra Susanto
Keyword(s):  
Polymeric Material ◽  
Tooth Extraction ◽  
Aloe Vera ◽  
Response Process ◽  
Experimental Animals ◽  
Ancient Time ◽  
White Rats ◽  
Wistar Strain ◽  
The Mean

Background. Aloe vera has been used as an anti-inflammatory, antimicrobial, and immune-boosting agent since ancient time. Hydrogel is a polymeric material that can retain a significant amount of water component and can last as long as possible in the gingival sulcus because the hydrogel is hydrophilic. This study is the first study that seeks to explore the potential of Aloe vera in healing socket wounds after tooth extraction. Methods. Twenty-five white rats of the Wistar strain were acclimatized for seven days before being included in the study. After acclimatization, the experimental animals were grouped into five groups. Evaluation of fibroblast response process with HE staining. Results. There were differences in the mean number of fibroblasts in all groups. From the results of this study, it can be stated that there is an effect of the application of hydrogel Aloe vera 1%, 2.5%, 5%, 10%, and xylazine on the increase in the number of fibroblasts in socket wounds after tooth extraction in Rattus novergicus. Conclusion. There is an effect of Aloe vera hydrogel application on increasing the number of fibroblasts in socket wounds after tooth extraction in Rattus novergicus.

scholarly journals UJI AKTIVITAS AMARA DARI PRODUK JST TERNAK, PREBIOTIK TERNAK, DAN ASAM AMINO TERNAK TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus L.) GALUR WISTAR

PHARMACON ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 246
Author(s):  
Marsella Sumerah ◽  
Adithya Yudistira ◽  
Karlah L.R Mansauda
Keyword(s):  
Amino Acid ◽  
Treatment Group ◽  
Rattus Norvegicus ◽  
Animal Feed ◽  
Negative Control ◽  
Herbal Products ◽  
White Rats ◽  
Wistar Strain

ABSTRACTLivestock  JST Products, Livestock Prebiotic Products, and Livestock Amino Acid Products, are herbal products that have the potential to be used as animal feed which functions to increase appetite in livestock. This study aims to determine the amara activity of male white rats (Rattus norvegicus L.) Wistar strain. The rats were treated with an idealized treatment for Animal JST Products, Animal Prebiotic Products, and Animal Amino Acid Products, as much as 2 ml, every afternoon for 10 days using an oral sonde device and a 5 cc dispo and the treatment group without giving the product as a negative control, which was only given food cattle in the form of concentrate. The results showed that the administration of Animal JST Products, Animal Prebiotic Products, and Animal Amino Acid Products, affected the appetite of Male White Rats (Rattus norvegicus L.) Wistar strain, which was marked by weight gain.Keywords  :     Animal JST Products, Animal Prebiotic Products, Animal Amino Acid Products,        Rattus norvegicus L. ABSTRAK Produk JST Ternak, Produk Prebiotik Ternak, dan Produk  Asam Amino Ternak, merupakan suatu produk herbal yang berpotensi untuk dimanfaatkan sebagai pakan ternak yang berfungsi dapat meningkatkan nafsu makan pada ternak. Penelitian ini bertujuan untuk mengetahui aktivitas amara terhadap Tikus Putih Jantan (Rattus norvegicus L.) Galur Wistar. Tikus diberi perlakuan dioralkan Produk JST Ternak, Produk Prebiotik Ternak, dan Produk Asam Amino Ternak, sebanyak 2 ml, setiap sore selama 10 hari dengan menggunakan alat sonde oral dan dispo 5 cc dan kelompok perlakuan tanpa pemberian produk sebagai kontrol negatif, yang hanya diberikan pakan ternak berupa konsentrat. Hasil menunjukkan bahwa pemberian Produk JST Ternak, Produk Prebiotik Ternak, dan Produk Asam Amino Ternak, berpengaruh terhadap nafsu makan Tikus Putih Jantan (Rattus norvegicus L.) Galur Wistar, yang ditandai dengan kenaikan berat badan.Kata Kunci  : Produk JST Ternak, Produk Prebiotik Ternak, Produk  Asam Amino Ternak,  Rattus norvegicus L.

scholarly journals The Effectiveness of Purslane Extract Provision on Liver of White Rats (Rattus norvegicus) with High Fat Diet

2021 ◽  
Vol 11 (4) ◽  
pp. 608-613
Author(s):  
Yuli Susana ◽  
Lucia Tri Suwanti ◽  
Lianny Nangoi
Keyword(s):  
Rattus Norvegicus ◽  
High Fat Diet ◽  
Fatty Degeneration ◽  
The Body ◽  
Portulaca Oleracea ◽  
High Fat ◽  
Treatment Groups ◽  
White Rats ◽  
Significant Difference ◽  
The Mean

Most animal owners provide fatty food with high cholesterol level that exceeds the needs of their pets. The pattern of giving a high-fat diet causes interference with the cholesterol synthesis in the body. It can damage the liver by causing fatty degeneration, hepatic cirrhosis, and eventually necrosis of the liver. The purpose of the current study was to determine the effectiveness of Purslane extract (Portulaca oleracea L.) on the liver histopathological image of white rats (Rattus norvegicus) with a high-fat diet. The current study used an experimental method with a completely randomized design on 20 males white mouses (Rattus norvegicus) divided into five treatment groups. There were two control groups, the first group received standard feed (Pellet) and Carboxymethyl Cellulose Sodium 1%, while the second was given standard feed and a high-fat diet. Three treatment groups which included P1, P2, P3 were given standard feed, a high-fat diet, and purslane extract solution with 54 mg/day, 108 mg/day, and 216 mg/day, respectively. Research results from the mean rank of fatty degeneration which was measured using the Kruskal Wallis test presented significant differences, and the results from the mean of fatty degeneration using the Mann Whitney test did not indicate any significant difference. Liver cell necrosis from the two tests presented a significant difference. Purslane extract (Portulaca oleracea L.) was confirmed to be effective in reducing or decreasing hepatocyte cell damage after receiving a high-fat diet.

scholarly journals The differences of glycodelin and uterus NK cell expression in obese and non-obese rats (Rattus norvegicus)

2021 ◽  
Vol 29 (2) ◽  
pp. 63
Author(s):  
Diyah Nofita Ofa Ningtriyas ◽  
Arsana Wiyasa ◽  
Muhammad Nooryanto
Keyword(s):  
Rattus Norvegicus ◽  
Nk Cell ◽  
Female Rats ◽  
White Rats ◽  
Wistar Strain ◽  
Obese Female ◽  
Significant Difference ◽  
Obese Rats ◽  
Cell Expression

HIGHLIGHTS1. Obesity increases the risk of comorbidities especially for the pregnancy.2. The study analyzed glycodelin levels and uterine NK cell expression using Rattus norvegicus as animal model.3. uNK cell expression of the obese rats group was higher as the marker of chronic inflammation for obesity.4. Although there was increasing uNK cells in obese rats group, this result was not followed by the level of gycodelin.ABSTRACTObjectives: To prove the existence of differences in glycodelin levels and uterine NK cell expression in obese and non-obese female white rats of Wistar strain (Rattus norvegicus).Materials and Methods: . This study used a randomized post-test only controlled group design. This in vivo study used two groups of female rats (Rattus norvegicus). Group 1 was treated with the high obese diet for eight weeks, and group 2 was not treated with the high obese diet. After eight weeks, the rats were weighed, the proestrus phase was synchronized, and then the rats were terminated.Results: In this study, there was no significant difference in glycodelin levels between the obese and non-obese groups with a p= 0.821 (p >0.05). Significant differences were found in uterine NK cell expression between obese dan non-obese groups with p=0.001 (p <0.05). The correlation test of glycodelin levels and uterine NK cell expression showed insignificant results with a correlation coefficient of 0.120 and p=0.513. This proved that there was no significant correlation between glycodelin levels and uterine NK cell expression.Conclusion: There was no significant difference between glycodelin levels and uterine NK cell expression in obese and non-obese female white rats of Wistar strain (Rattus norvegicus). 

scholarly journals POTENSI PEMBERIAN EKSTRAK BUAH DELIMA (Punica granatum L) TERHADAP KUALITAS SPERMATOZOA TIKUS PUTIH (Rattus norvegicus) YANG TERPAPAR PANAS

2020 ◽  
Vol 8 (1) ◽  
pp. 5
Author(s):  
Nucifera Fadhillah Santoso ◽  
Budi Utomo ◽  
Mirni Lamid
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Membrane Integrity ◽  
Punica Granatum ◽  
Control Treatment ◽  
Control Group ◽  
White Rats ◽  
Significant Difference ◽  
The Difference

The purpose of this research was to determine the effect of pomegranate (Punica granatul l) fruit extract for spermatozoa quality including the motility, viability and membrane integrity of spermatozoa. The researchused 20 male white rats  (Rattus norvegicus) with 200-300 gram average body weight. P0 as control was given with CMC Na 0.5%.  P1 used 75 mg/kg BW dose of extract,  P2used 150 mg/kg BW dose of extract,  P3 used 300 mg/kg BW dose of extract. The treatment was given perorally for 14 days. The experiment was used completely random design (CRD). The result of this study was analyzed with ANOVA followed by Tukey Test (p<0.05). The result showed that there was significant effect from therapy on the quality of rats spermatozoa. The difference of spermatozoa’s concentration between first treatment group P1 and control treatment group is not significant, while the treatment other result showed between the second treatment group and the control group P0. A significant difference occurs in the percentage of motility, viability and  membrane integrity. The treatment from P2 group showed the best result in maintaining the quality of rats spermatozoa.

scholarly journals Pengaruh Pemberian Hormon Medroxy Progesterone Acetat terhadap Ketebalan Endometrium Rattus Norvegicus Betina Strain Wistar

2020 ◽  
Vol 20 (2) ◽  
pp. 682
Author(s):  
Defi Yulita ◽  
M Biomed
Keyword(s):  
Family Planning ◽  
Treatment Group ◽  
Sample Size ◽  
Rattus Norvegicus ◽  
Endometrial Thickness ◽  
Female Rats ◽  
Control Group ◽  
Childbearing Age ◽  
Wistar Strain ◽  
Significant Difference

Based on the National Population and Family Planning Agency (BKKBN) data in 2013, there were 8,500,247 couples of childbearing age who were new KB (family planning) participants with the total number using injection was 4,128,115 (48.56%). Research Objectives to find out The Effect of The Administration OF Medroxy Progesterone Acetate Hormone to Endometrial Thickness of The Female Rattus Norvegicus Wistar Strain. The design of this research is the post test only control group design by having  white rats species Rattus Norvegicus Wistar Strain as the poplulation, the samples are taken randomly from all populations that met the following sample criteria: female rats, Aged 12-14 weeks, having body weight of 150 - 200 grams. Based on the calculation of the sample size, the sample size / number of animals r = 10 rats was obtained, with a total sample size for both groups of treatment and control were 20 female rats which included: group 1 amounted to 10 rats that were not given Medroxy Progesterone Acetat hormones as a control group where group 2 amounted to 10 rats which given Medroxy Progesterone Acetat as a treatment group. The results showed the average endometrial thickness in the (P1) Medroxy Progesterone Acetate Hormone group was 493.17 µm ± 114.96, this result was lower than the control group 1192.56 µm ± 428.94. From the ANOVA test table, the P value <0.05 means that there is a very significant difference in the average endometrial thickness between the control group and the treatment group. Based on the results of the Post Hoc Bonfferoni Test, it can be seen that the average endometrial thickness between Control and P1 showed a significant difference (P <0.05). The analysis of the result and discussion of the research can be concluded that: the Medroxy Progesterone Acetate hormone affects the endometrial thickness, and there is a difference in the histological picture of endometrial thickness due to the administration of the Medroxy Progesterone Acetate hormone and without the administration of to the administration of the Medroxy Progesterone Acetate hormone.

scholarly journals THE EFFECT OF POLYPROPYLENE PLASTIC RESIDUE ON HEATED PALM OIL AGAINST HISTOPATHOLOGICAL CHANGES OF SMALL INTESTINE ON MALE WHITE RAT (Rattus norvegicus) WISTAR STRAIN

2020 ◽  
Vol 8 (2) ◽  
pp. 76
Author(s):  
Aulia Puspa Amaris ◽  
Lita Rakhma Yustinasari ◽  
Djoko Legowo ◽  
Hani Plumeriastuti ◽  
Chairul Anwar ◽  
...  
Keyword(s):  
Small Intestine ◽  
Palm Oil ◽  
Rattus Norvegicus ◽  
Histopathological Changes ◽  
Scoring Method ◽  
Treatment Groups ◽  
Whitney Test ◽  
White Rats ◽  
Wistar Strain ◽  
Significant Difference

This study was conducted to investigate the effect of polypropylene residue on heated palm oil against histopathological changes of small intestine on male white rat (Rattus norvegicus) wistar strain. Eighteen male white rats divided into three groups and were administered via peroral gavage with different treatments for five weeks. The treatment were Control (84 grams palm oil), P1 (84 grams palm oil with 2.3 grams plastic), and P2 (84 grams palm oil with 6.81 grams plastic). The histopathological changes of small intestine were examined by using Barthel Scoring method was analysed using Kruskal Wallis and continued with Mann-Whitney test. The result showed that were significant difference (p<0.05) between treatment groups. The worse damage of polypropylene plastic residue was 6.81 grams.

scholarly journals Pengaruh Vitamin D3 Terhadap Kadar Hemoglobin Tikus Wistar yang Dipapar Asap Rokok

2019 ◽  
Vol 1 (1) ◽  
pp. 22-28
Author(s):  
Hetti Rusmini ◽  
Dita Fitriani ◽  
Dessy Hermawan ◽  
Diah Adelia Emilda
Keyword(s):  
Cigarette Smoke ◽  
Erythrocyte Membrane ◽  
Vitamin D3 ◽  
Rattus Norvegicus ◽  
Not Given ◽  
White Rats ◽  
Wistar Strain ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

Hemoglobin is a tetrametric erythrocyte protein that carries O2 to the tissues and returns CO2 and protons to the lungs. Cigarette smoke is proven that could reduce hemoglobin levels through oxidative stress which causes the erythrocyte membrane to be easily lysed. The lysis erythrocyte membrane causes hemoglobin levels to be low. Vitamin D is included in natural antioxidants which have a neuroprotective tendency through antioxidative mechanisms. To determine the effect of giving vitamin D3 on hemoglobin levels in white rats (Rattus norvegicus) male Wistar strain after being exposed by cigarette smoke. This type of pure experimental research (tue-experiment) used pre and post with control group design. Samples were white rats (Rattus norvegicus) male Wistar strain aged 10-12 weeks with the weight of around 150-200 grams in a total of 24 individuals. Samples were divided into four groups including K1 which is not exposed by cigarette smoke and not given of vitamin D3, K2 is a group exposed by cigarette smoke but not given of vitamin D3, K3 is a group that is not exposed by cigarette smoke but given of vitamin D3 a dose of 0.2 µgr /head, P1 is a group exposed by cigarette smoke and given a vitamin D3 dose of 0.2 µgr /head. The test of paired t-test showed a significant difference p <0.05 in the K2 group with p = 0.044, the K3 group with p = 0.013, and P1 group with p = 0.037. Whereas in group 1 there was no significant difference p = 0.932. The One-way Anova test obtained results with a value of p = 0.027 (p <0.05) which means that there were significant differences between groups. The Post Hoc LSD test showed a significant difference in group 1 whit group 2 p = 0.025 and in group 2 with group 3 p = 0.012.

The Effect of Yacon Leaf Powder (Smallanthus Sonchifolius) on White Rats (Rattus norvegicus) Blood Glucose Levels with High Sugar Diet

2021 ◽  
Vol 8 (2) ◽  
pp. 217-220
Author(s):  
Thatit Nurmawati ◽  
Sandi Alfa Wiga Arsa ◽  
Nawang Wulandari ◽  
Agus Saparudin
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Carbohydrate Diet ◽  
Glucose Levels ◽  
Smallanthus Sonchifolius ◽  
High Carbohydrate ◽  
White Rats ◽  
Blood Glucose Levels ◽  
Treatment Dose ◽  
Significant Difference

Maintaining a lifestyle can reduce the incidence of DM (diabetes mellitus). DM occurs due to insulin disorders so that blood glucose levels increase, which can lead to various complications. The management of blood glucose levels by activating the insulin function can be done by using natural ingredients such as the Yakon (Smallanthus sonchifolius) plant. Yakon leaves contain phenol which can reduce blood glucose. The design of this study was experimental with a pre-posttest approach with control-group design, using male and healthy white rats (Rattus norvegicus). Rats were divided into 3 groups, treatment dose 1, treatment dose 2 and control. The rats were given a high carbohydrate diet during 9 weeks to make the rats hyperglycemic. In the treatment group, dose 1 was 150 mg/kg BW, dose 2 was 300 mg kg BW, and was given for 3 days. The results showed that the rats in the treatment group dose 1 had decreased in the average blood sugar level of 114.10 mg / dl (p 0.002) and dose 2 was 105.27 mg / dl (p 0.005). This showed that there was an effect of treatments on blood sugar levels. The comparison results showed that there was a significant difference between the dose 1, the dose 2 group and the control (Sig. (2-tailed) = 0.001 (α) = 0.05). There was no significant difference in the treatment group dose 1 and treatment dose 2 (Sig. (2-tailed) = 0.693, (α) = 0.05). Yakon leaves can be used alternative to lower to control blood glucose levels in rats receiving a high-carbohydrate diet

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