scholarly journals Hepatoprotective Effect of Corrigiola telephiifolia Pourr. Root Methanolic Extracts against CCl4-Induced Hepatic Damage in Mice

2021 ◽  
Vol 12 (2) ◽  
pp. 2489-2502
Keyword(s):  
Biochemical Parameters ◽  
Methanolic Extract ◽  
Hepatoprotective Activity ◽  
Hepatic Damage ◽  
Hepatoprotective Effect ◽  
Histopathological Analysis ◽  
Medicinal And Aromatic Plants ◽  
Bioactive Substances ◽  
Methanolic Extracts ◽  
Hepatic Cells

Liver disease is a dysfunction that affects all or part of the liver and can lead to death. While the use of medicinal and aromatic plants has been a source of bioactive substances with hepatoprotective properties. This study aims to evaluate the hepatoprotective effect of the methanolic extract of Corrigiola telephiifolia roots on hepatic damage induced by carbon tetrachloride (CCl4) in mice. Animals were treated daily with C. telephiifolia methanolic extract (CTME) at doses of 5 and 10 mg/kg b.w for 60 days. In addition, CCl4 was injected (1 mL/kg, i.p.) for its hepatotoxic effects. At the end of the experiment, the blood of all animals was collected to evaluate biochemical parameters and the liver for histopathological analysis. The administration of CTME showed significant hepatoprotective activity by improving the biochemical parameters and the histological appearance of hepatic cells induced by CCl4. Consequently, C. telephiifolia could be used in the prevention and/or treatment of liver intoxication.

scholarly journals Evaluation of Hepatoprotective Activity of Caralluma europaea Stem Extract against CCl4-Induced Hepatic Damage in Wistar Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hayat Ouassou ◽  
Mohamed Bouhrim ◽  
Nour Elhouda Daoudi ◽  
Hassane Mekhfi ◽  
Abderrahim Ziyyat ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Experimental Period ◽  
Hepatoprotective Activity ◽  
Hepatic Damage ◽  
Hepatoprotective Effect ◽  
Low Density

The present study aims to evaluate the hepatoprotective activity of stem aqueous extract of Caralluma europaea (AECe) on carbon tetrachloride- (CCl4-) induced hepatic damage in Wistar rats. The animals were daily treated with the aqueous extract of C. europaea at a dose of 250 mg/kg body weight for 14 days. CCl4 was injected (1 ml/kg, i.p.) two times, on the 7th and 14th days. At the end of the experimental period, all rats were anesthetized to collect blood for the assessment of biochemical parameters and then sacrificed to collect the liver for weighing. Hepatotoxicity was evaluated by measuring the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin (total and direct), malondialdehyde (MDA), total protein (TP), triglycerides (TG), total cholesterol, very low-density lipoprotein (VLDL-c ), low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c), urea, creatinine, and uric acid. Based on the results obtained in this study, the administration of C. europaea before exposure to the administration of CCl4 conferred favorable hepatoprotective effect in rats. The treatment with AECe (250 mg/kg) exhibits a significant hepatoprotective effect by ameliorating CCl4-induced alterations of these biochemical parameters. Hence, C. europaea could be a potential medicinal herb that can be used in the future to prevent liver intoxication.

scholarly journals Comparative Nephroprotective Effects of Extracts of Buchholzia coriacea on some Biochemical Parameters in Carbon Tetrachloride-induced Toxicity in Rattus novergicus

2018 ◽  
Vol 17 (2) ◽  
pp. 227-235
Author(s):  
Godwin C. Ugwu ◽  
Chinagorom L. Okanya ◽  
Jude V. Egbuji ◽  
Jude I. Okwo ◽  
Emmanuel I. Nnamonu ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Uric Acid ◽  
Carbon Tetrachloride ◽  
Medicinal Plant ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Methanolic Extract ◽  
Rat Kidney ◽  
Aqueous Extracts ◽  
Methanolic Extracts

Buchholzia coriacea (wonderful kola) is a medicinal plant that has been used worldwide as an alternative medication to promote human health. Comparative nephroprotective effects of crude seed powder, aqueous and methanolic extracts of B. coriacea in hepatotoxic rats was investigated for 56 days. The crude powder (BCCP), aqueous extract (BCAE) and methanolic extract (BCME) significantly reduced (p<0.05) the levels of creatinine and uric acid and decreased minimally throughout the treatment periods. Total protein increased significantly (p<0.05). Significant decrease (p<0.05) were observed with 200 mg/kg BCAE and BCCP respectively in urea and BUN levels. Noticeable nephroprotective effects may be attributed to the presence of phytochemicals like flavonoids and tannins which act as antioxidants. This study has demonstrated that B. coriacea crude seed powder, methanolic and aqueous extracts caused no adverse effect on the rat kidney and may be recommended for the management of nephrotoxicity Dhaka Univ. J. Pharm. Sci. 17(2): 227-235, 2018 (December)

Hepatoprotective effect of methanolic extracts of Phyllanthus virgatus against carbon tetrachloride-induced liver injury in rats

2016 ◽  
Vol 2 (1) ◽  
pp. 1-7
Author(s):  
Chattu Maheswara Rao
Keyword(s):  
Carbon Tetrachloride ◽  
Serum Level ◽  
Total Protein ◽  
Liver Enzymes ◽  
Methanolic Extract ◽  
Hepatocellular Injury ◽  
Significant Extent ◽  
Methanolic Extracts ◽  
Hepatic Cells ◽  
Glutamate Pyruvate

In this study, the methanolic extract of Phyllanthus virgatus was evaluated against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. The results of this study indicated that Phyllanthus virgatus exhibited moderate protective effect at a dose of 100-200 mg/kg by lowering serum level of liver enzymes such as alanine amino transferees (ALT), glutamate pyruvate transaminases (SGPT), aspartate aminotransferase (AST), glutamate oxaloacetate transaminases (SGOT), and total protein to a significant extent. Further, no significant effects were seen on blood serum level at a dose of 100-200 mg/kg body weight. The highest activity was observed at a dose of 200 mg/kg with a reduction of serum concentration of ALT, AST, total bilirubin and total protein. The methanolic extract of P. virgatus showed significant decrease in the levels of liver enzymes, indicating the protection of hepatic cells thereby protecting against CCl4 induced hepatocellular injury.

scholarly journals Hepatoprotective Effect of Pretreatment withThymus vulgarisEssential Oil in Experimental Model of Acetaminophen-Induced Injury

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Renata Grespan ◽  
Rafael Pazinatto Aguiar ◽  
Frederico Nunes Giubilei ◽  
Rafael Rocco Fuso ◽  
Marcio José Damião ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Essential Oil ◽  
Radical Scavenging ◽  
Clinical Problem ◽  
Hepatoprotective Activity ◽  
Hepatoprotective Effect ◽  
Thymus Vulgaris ◽  
Histopathological Analysis

Acute liver damage caused by acetaminophen overdose is a significant clinical problem and could benefit from new therapeutic strategies.Objective. This study investigated the hepatoprotective effect ofThymus vulgarisessential oil (TEO), which is used popularly for various beneficial effects, such as its antiseptic, carminative, and antimicrobial effects. The hepatoprotective activity of TEO was determined by assessing serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in mice. Their livers were then used to determine myeloperoxidase (MPO) enzyme activity and subjected to histological analysis. In vitro antioxidant activity was evaluated by assessing the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH•)-scavenging effects of TEO and TEO-induced lipid peroxidation. TEO reduced the levels of the serum marker enzymes AST, ALT, and ALP and MPO activity. The histopathological analysis indicated that TEO prevented acetaminophen-induced necrosis. The essential oil also exhibited antioxidant activity, reflected by its DPPH radical-scavenging effects and in the lipid peroxidation assay. These results suggest that TEO has hepatoprotective effects on acetaminophen-induced hepatic damage in mice.

scholarly journals Antioxidant and Hepatoprotective Studies on Methanolic Extract of Caryopses of Echinochloa frumentacea Link

2017 ◽  
Vol 9 (10) ◽  
Author(s):  
Swaroopa Rani Vanapatla ◽  
Sana Syed ◽  
Praneetha Pallerla ◽  
Ravi Kumar Bobbala
Keyword(s):  
Antioxidant Activity ◽  
Methanolic Extract ◽  
Reducing Power ◽  
Hepatoprotective Activity ◽  
Hepatic Damage ◽  
Altered Level ◽  
Phenolic Contents ◽  
Antihepatotoxic Activity ◽  
Echinochloa Frumentacea

Background: The present study was aimed to evaluate the methanolic extract of caryopses of Echinochloa frumentacea (EFME) for its in-vitro antioxidant activity and in-vivo hepatoprotective activity against paracetamol and antihepatotoxic activity against D-Galactosamine induced hepatic damage in rats. Materials and Methods: The flavonoid and phenolic contents, of EFME were estimated and the antioxidant studies were conducted for the extract, EFME using various methods such as DPPH, superoxide, nitric oxide, hydroxyl radical, hydrogen peroxide scavenging activities and reducing power assay. Liver damage was induced by administering paracetamol (3g/Kg) and the hepatoprotective activity of the extract was assessed on the basis of improvement in the altered level of various serum biochemical parameters and in the changes occurred in the histology of liver of the rats taking Silymarin (100mg/kg) as the standard. Among the three test doses of EFME, 100 mg/kg was found to be the effective. Hence, EFME 100 mg/kg was selected to assess its antihepatotoxic activity against D-Galactosamine (400 mg/kg) induced hepatic damage in rats. Results: The flavonoid and phenolic contents of the extract, EFME were found to be 7.56±1.29mg and 138.53±2.11mg of rutin and gallic acid equivalents per gram of extract respectively. The extract exhibited antioxidant activity and significant (p less than 0.01) hepatoprotective activity. Conclusion: The study revealed that the extract EFME at 100 mg/kg has shown significant hepatoprotective and antihepatotoxic activity against paracetamol and D-Galactosamine induced hepatic damage in rats respectively.

scholarly journals Hepatoprotective Activity of Licorice Water Extract against Cadmium-Induced Toxicity in Rats

2009 ◽  
Vol 6 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Jong Rok Lee ◽  
Sook Jahr Park ◽  
Hyeung-Sik Lee ◽  
Seon Young Jee ◽  
Jungcheol Seo ◽  
...  
Keyword(s):  
Liver Toxicity ◽  
Protein Translocation ◽  
Single Injection ◽  
Water Extract ◽  
Hepatoprotective Activity ◽  
Histopathological Analysis ◽  
Hepatic Cells ◽  
Bh3 Domain ◽  
Vehicle Treatment ◽  
Digestive Disorders

Licorice is commonly used as a cure for digestive disorders and as a detoxification agent in East Asia. This study investigated the protective effect of licorice water extract against cadmium (CdCl2, Cd)-induced liver toxicity in rats. To induce acute toxicity, Cd (4 mg/kg body weight) was dissolved in normal saline and intravenously (i.v.) injected into rats. The rats then received either a vehicle or licorice water extract (50, 100 mg/kg/day) for 3 days, and were subsequently exposed to a single injection of Cd 24 h after the last licorice/vehicle treatment. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were significantly increased by Cd treatment. In contrast, pretreatment with licorice reduced ALT, AST and LDH. In histopathological analysis, licorice decreased the central necrosis around central veins, the peripheral hemorrhage around portal triads, the percentage of degenerative hepatic regions (%/mm2hepatic parenchyma) and the number of degenerative hepatic cells (N/100 hepatic cells). Licorice also inhibited the increment of Bad (a BH3 domain-containing protein) translocation by Cd in liver cells. These results demonstrate that licorice could have a hepatoprotective effect by inhibiting the translocation of Bad to the mitochondria in Cd-intoxificated rats.

scholarly journals Smilax zeylanica: A Promising Antilipidemix and Antiobesity Agent

2021 ◽  
pp. 342-362
Author(s):  
Rosaline Mishra ◽  
Divya Juyal ◽  
S. Sadish Kumar
Keyword(s):  
Biochemical Parameters ◽  
Methanolic Extract ◽  
Ethyl Acetate Extract ◽  
Plasma Samples ◽  
Methanolic Extracts ◽  
Naturally Occurring ◽  
Function Test ◽  
Established Fact ◽  
Pharmacological Potential ◽  
Pharmacological Screening

Background: It is well established fact that obesity has now said to be a disease status.The phytochemicals have always been looked for their enormous stored potential. Similax zeylanica is a naturally occurring flavonoid known for its pharmacological potential. In this study it was aimed to determine the antiobesity and antilipidemic effect of various Similax zeylanica extract. Materials and Methods: The pharmacological screening of Cyclohexane extract of Smilax zeylanica (SZH), ethyl acetate extract Smilax zeylanica (SZE) and methanolic extract of Smilax zeylanica (SZM) was performed. The acute toxicity studies were performed on various animal groups. Obesity was diet induced.The plasma samples were investigated for various biochemical parameters such as glucose, lipid profile (Cholesterol, TG, HDL, LDL and VLDL), Liver function test (SGPT, SGOT). Results and Conclusion: The various parameters studied showed that the methanolic extracts of Similax zeylanica showed enormous antiobesity potential and concluded for the supplementation for antilipidemic effect.

scholarly journals Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats

2007 ◽  
Vol 57 (2) ◽  
pp. 241-248 ◽  
Author(s):  
Tatjana Panovska ◽  
Svetlana Kulevanova ◽  
Icko Gjorgoski ◽  
Mirjana Bogdanova ◽  
Gordana Petrushevska
Keyword(s):  
Ethyl Acetate ◽  
Biochemical Parameters ◽  
Hepatic Injury ◽  
Ethyl Acetate Extract ◽  
Liver Homogenate ◽  
Thiobarbituric Acid ◽  
Hepatoprotective Activity ◽  
Hepatoprotective Effect ◽  
Antioxidative Status ◽  
Teucrium Polium

Hepatoprotective effect of the ethyl acetate extract ofTeucrium poliumL. against carbontetrachloride-induced hepatic injury in ratsHepatoprotective activity of the ethyl acetate extract ofTeucrium poliumL. was investigated using rats with CCl4--induced liver damage. Specific biochemical parameters (glutathione peroxidase, superoxide dismutase, reduced glutathione and total antioxidative status) were estimated in blood and in liver homogenate. Lipid peroxidation in CCl4--intoxicated rats was evidenced by a marked increment in the levels of thiobarbituric acid reactive substances. Histopatological examinations of the liver were undertaken to monitor the liver status. Silymarin was used as a standard to compare the hepatoprotective activity of the extract. Some biochemical parameters in groups treated with theTeucrium poliumextract at a dose of 25 mg kg-1, showed significantly different values than that of the CCl4--treated group. The liver biopsy of all experimental rat groups treated with theTeucrium poliumethyl acetate extract showed significant restoration of the normal histomorphological pattern of liver cells. The study substantiates the potential hepatoprotective activity of the ethyl acetate extract ofTeucrium poliumL.

scholarly journals Hepatoprotective Activity of Tectona grandis Against CCl4-Induced Hepatic Damage in Rats

2019 ◽  
Vol 9 (1) ◽  
pp. 5-11
Author(s):  
Geeta Deswal ◽  
Kumar Guarve ◽  
Priyanka Kriplani ◽  
Ashwani K. Dhingra ◽  
Bhawna Chopra ◽  
...  
Keyword(s):  
Liver Damage ◽  
Serum Bilirubin ◽  
Tectona Grandis ◽  
Treated Group ◽  
Hepatoprotective Activity ◽  
Hepatic Damage ◽  
Control Group ◽  
Standard Drug ◽  
Methanolic Extracts ◽  
Serum Glutamate

Background: Literature reports numerous causes for liver damage, which mainly include viral hepatitis (most commonly hepatitis B), cirrhosis, cell stress, hepatic damage by NSAIDs or alcohol. In the present study, methanolic extracts of Tectona grandis leaves were evaluated for hepatoprotective activity against CCl4 induced liver damage in rats. Methods: Hepatic injury in rats was carried out using the CCl4-induced hepatotoxic model. Methanolic extracts of Tectona grandis were administered orally at two different doses (200mg/kg & 400mg/kg) daily. The biochemical parameters (SGOT, SGPT, ALP, and serum bilirubin) were estimated using Reitman and Frankel's method in addition Kind King’s method. Results: The preliminary phytochemical studies confirmed the existence of saponins, carbohydrates, tannins, and flavonoids. CCl4 treated group boost the concentrations of Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphate (ALP) and serum bilirubin as compared to control group (rats treated with vehicle). The methanolic extract of plant (200 mg/kg & 400 mg/kg) and standard drug silymarin (100 mg/kg) produced a significant decrease in raised levels of these enzymes as compared to control. Conclusion: The results clearly indicate that Tectona grandis leaves have notable hepatoprotective activity in rats hepatic damage induced by CCl4.

scholarly journals Hepatoprotective activity of methanolic extract of young shoots of Bambusa arundinaceae in thioacetamide induced liver injury in rats

2017 ◽  
Vol 6 (2) ◽  
pp. 140-148
Author(s):  
Kajal N Chauhan ◽  
◽  
Bhavini Shah ◽  
Manish Nivsarkar ◽  
◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Liver Injury ◽  
Cell Viability ◽  
Biochemical Parameters ◽  
Methanolic Extract ◽  
Reducing Power ◽  
Tumor Cell Line ◽  
Hepatoprotective Activity

Background: Whole plant of Bambusa arundinaceae (Bamboo) belonging to family (Graminae) is used in number of disease including liver ailments in various parts of India. The present study is done to evaluate antioxidant and Hepatoprotective activity of methanolic extract of young shoots of Bambusa arundinaceae in Thioacetamide induced liver injury in rats. Material and method: Antioxidant activity of methanolic extract was evaluated by DPPH, Ferric reducing power assay and Lipid peroxidation. In vitro hepatoprotective activity of methanolic extracts (25, 50, 100, 200 and 400 µg/ml) against thioacetamide (100mM) induced cytotoxicity was assessed by monitoring cell viability in HepG2 and Hep3b tumor cell line and also in primary hepatocytes. In vivo hepatoprotective activity of methanolic extract (50, 100, 200 mg/kg p.o.) was observed againt thioacetamide (100 mg/kg s.c.) induced liver injury in rat by measuring biochemical parameters viz, Aspartate Transaminase, Alanine Transaminase, Alkaline Phosphatase, Total and Direct Bilirubin. The histopathological studies were also performed. Results: Methanolic extract of young shoots showed good antioxidant activity. Thioacetamide caused significant reduction in cell viability in in vitro studies. Treatment with methanolic extract caused significant increase in cell viability. In vivo studies showed that Thioacetamide induced elevation of biochemical parameters in rats were significantly (p<0.0001) decreased with methanolic extract treatment in rats. Histopathology studies also supported the protective effect of methanolic extract. Conclusion: The current study reveals that the methanolic extract of Bambusa arundinaceae has hepatoprotective activity which may be due to its antioxidant activity.

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