scholarly journals Nanoemulgel: a Promising Nanolipoidal-Emulsion Based Drug Delivery System in Managing Psoriasis

2021 ◽  
Vol 20 (2) ◽  
pp. 235-246
Author(s):  
Snigdha Bhardwaj ◽  
Ashutosh Tiwari
Keyword(s):  
Oral Delivery ◽  
Chronic Inflammatory Disease ◽  
Lipophilic Drugs ◽  
Drug Candidates ◽  
Potential System ◽  
Hydrogel Matrix ◽  
Systemic Side Effects ◽  
The Stability ◽  
Novel Concept ◽  
Near Future

Nanomedicine, a novel concept, bears much hope in delivering drug candidates having low solubility and bioavailability. Nano-emulgel, one of the emerging tools, is considered as ideal carriers for the topical delivery of lipophilic drugs to overcome these challenges in the management of psoriasis and related skin problems. Psoriasis is an auto-immune and chronic inflammatory disease affecting 2-3% population of the world. Current available treatment of psoriasis has limitations such as systemic side effects and low percutaneous permeation, which evokes a dire need to develop an alternative lipoidal nanocarrier system. Nano-emulgel is basically formed by admixing nanoemulsion system with a hydrogel matrix using both high and low energy methods. Various literatures have been reported for lipoidal nanocarriers in topical treatment suggesting reduced dose, improved percutaneous absorption and better bioavailability of lipophilic drugs with nano-emulgel delivery via topical route. Several approved marketed preparations are available that strongly support the stability of these nanocarriers in respect to its efficacy and safety. This supports the fact of using topical nano-emulgel system to deliver lipophilic drugs to overcome the sufferings from oral delivery and improved patient compliance. Therefore, it is suggested as a potential system that can be used for an effective management of psoriasis via topical route in near future. Dhaka Univ. J. Pharm. Sci. 20(2): 235-246, 2021 (December)

scholarly journals Polymer-Drug Conjugates as Nanotheranostic Agents

2021 ◽  
Vol 2 (1) ◽  
pp. 63-81
Author(s):  
Sajana Manandhar ◽  
Erica Sjöholm ◽  
Johan Bobacka ◽  
Jessica M. Rosenholm ◽  
Kuldeep K. Bansal
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Treatment Options ◽  
The Body ◽  
Drug Conjugates ◽  
Imaging Characteristics ◽  
Wide Range ◽  
Systemic Side Effects ◽  
Theranostic Agents ◽  
The Stability

Since the last decade, the polymer-drug conjugate (PDC) approach has emerged as one of the most promising drug-delivery technologies owing to several benefits like circumventing premature drug release, offering controlled and targeted drug delivery, improving the stability, safety, and kinetics of conjugated drugs, and so forth. In recent years, PDC technology has advanced with the objective to further enhance the treatment outcomes by integrating nanotechnology and multifunctional characteristics into these systems. One such development is the ability of PDCs to act as theranostic agents, permitting simultaneous diagnosis and treatment options. Theranostic nanocarriers offer the opportunity to track the distribution of PDCs within the body and help to localize the diseased site. This characteristic is of particular interest, especially among those therapeutic approaches where external stimuli are supposed to be applied for abrupt drug release at the target site for localized delivery to avoid systemic side effects (e.g., Visudyne®). Thus, with the help of this review article, we are presenting the most recent updates in the domain of PDCs as nanotheranostic agents. Different methodologies utilized to design PDCs along with imaging characteristics and their applicability in a wide range of diseases, have been summarized in this article.

scholarly journals Treatment of Rheumatoid Arthritis with Traditional Chinese Medicine

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Wen-Yuan Lee ◽  
Hsin-Yi Chen ◽  
Kuan-Chung Chen ◽  
Calvin Yu-Chian Chen
Keyword(s):  
Rheumatoid Arthritis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Protein Complex ◽  
Chronic Inflammatory Disease ◽  
Dynamics Simulation ◽  
Current Therapy ◽  
Potential Candidate ◽  
Interleukin 6 Receptor ◽  
The Stability

Rheumatoid arthritis (RA) is a chronic inflammatory disease that will affect quality of life and, working efficiency, and produce negative thoughts for patients. Current therapy of RA is treated with disease-modifying antirheumatic drugs (DMARDs). Although most of these treatment methods are effective, most patients still have a pleasant experience either due to poor efficacy or side effects or both. Interleukin-6 receptor (IL6R) is important in the pathogenesis of RA. In this study, we would like to detect the potential candidates which inhibit IL6R against RA from traditional Chinese medicine (TCM). We use TCM compounds from the TCM Database@Taiwan for virtually screening the potential IL6R inhibitors. The TCM candidate compound, calycosin, has potent binding affinity with IL6R protein. The molecular dynamics simulation was employed to validate the stability of interaction in the protein complex with calycosin. The analysis indicates that protein complex with calycosin is more stable. In addition, calycosin is known to be one of the components ofAngelica sinensis, which has been indicated to have an important role in the treatment of rheumatoid arthritis. Therefore, calycosin is a potential candidate as lead compounds for further study in drug development process with IL6R protein against rheumatoid arthritis.

scholarly journals ENERGY-BASED PHARMACOPHORE MODELING, VIRTUAL SCREENING, AND MOLECULAR DYNAMICS TO IDENTIFY POTENTIAL INHIBITORS FOR GLYCOGEN SYNTHASE KINASE 3 BETA

2018 ◽  
Vol 11 (2) ◽  
pp. 181
Author(s):  
Sheema Jb ◽  
Waheeta Hopper
Keyword(s):  
Molecular Dynamics ◽  
Wound Healing ◽  
Glycogen Synthase ◽  
Pharmacophore Model ◽  
Pharmacophore Modeling ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Systemic Side Effects ◽  
The Stability ◽  
Potential Inhibitors

  Objective: Glycogen synthase kinase 3 beta (GSK3β) is one of the main targets for wound healing activity. Our objective is to identify novel inhibitors for GSK3β using in silico approach.Methods: Grid-based molecular docking, energy-based pharmacophore (e-pharmacophore) modeling, and molecular dynamics (MD) studies were performed for phytocompounds with GSK3β and compared with standard drugs using Schrodinger software.Results: The glide scores and the molecular interactions of the phytocompounds were well comparable to the standard drugs. The MD was performed for the target bound to the best scoring ligand, entagenic acid. The pharmacophore features of this docked complex were modeled as e-pharmacophore. The constructed e-pharmacophore model was screened against phytocompounds retrieved from literature to identify the ligands with similar pharmacophore features.Conclusion: The glide scores of fukinolic acid, cimicifugic acid, and linarin were −10.99, −8.28, and −7.25 kcal/mol, respectively. The further 50 nanoseconds MD study determined the stability of GSK3β-linarin complex. Nitrofurazone and sulfathiazole drugs can lead to systemic side effects. Hence, it is concluded that linarin could be a potent wound healing compound against GSK3β.

scholarly journals Mineralogical response of the Mediterranean crustose coralline alga <i>Lithophyllum cabiochae</i> to near-future ocean acidification and warming

2016 ◽  
Author(s):  
Merinda C. Nash ◽  
Sophie Martin ◽  
Jean-Pierre Gattuso
Keyword(s):  
Ocean Acidification ◽  
Crustose Coralline Alga ◽  
Coralline Algae ◽  
Coralline Alga ◽  
Magnesium Calcite ◽  
The Mediterranean ◽  
One Year ◽  
The Stability ◽  
Strong Control ◽  
Near Future

Abstract. Red calcareous coralline algae are thought to be among organisms the most vulnerable to ocean acidification due to the high solubility of their magnesium calcite skeleton. Although, skeletal mineralogy is proposed to change as CO2 and temperature continues rising, there is currently very little information available on the response of coralline algal carbonate mineralogy to near-future changes in pCO2 and temperature. Here we present results from a one-year controlled laboratory experiment to test mineralogical responses to pCO2 and temperature in the Mediterranean crustose coralline alga (CCA) Lithophyllum cabiochae. Our results show that Mg incorporation is mainly constrained by temperature (+1 mol% MgCO3 for an increase of 3 °C) and there was no response to pCO2. This suggests that L. cabiochae thalli have the ability to buffer calcifying medium against ocean acidification, enabling them to continue to deposit Mg-calcite with a significant mol% MgCO3 under elevated pCO2. Analyses of CCA dissolution chips showed a decrease in Mg content after 1 year for all treatments but this was not affected by pCO2 nor by temperature. Our findings suggest that biological processes exert a strong control on calcification on Mg-calcite and that CCA may be more resilient under rising CO2 than previously thought. However, previously demonstrated increased skeletal dissolution with ocean acidification will still have major consequences for the stability and maintenance of Mediterranean coralligenous habitats.

A Review of Preparation and Tribological Applications of Pickering Emulsion

2021 ◽  
pp. 1-27
Author(s):  
Yichen Bao ◽  
Kai Liu ◽  
Quan Zheng ◽  
Lulu Yao ◽  
Yufu Xu
Keyword(s):  
Pickering Emulsion ◽  
Solid Particles ◽  
Preparation Methods ◽  
Factors Affecting ◽  
Long Term Stability ◽  
New Strategy ◽  
New Type ◽  
The Stability ◽  
Near Future

Abstract Pickering emulsion is a new type of stable emulsion made by ultra-fine solid particles instead of traditional surfactants as stabilizers, which has received widespread attention in recent years. The preparation methods of stator-rotor homogenization, high-pressure homogenization, and ultrasonic emulsification were compared with others in this work. The main factors affecting the stability of Pickering emulsion are the surface humidity of the solid particles, the polarity of the oil phase, and the oil-water ratio. These factors could affect the nature of the solid particles, the preparation process of Pickering emulsion and the external environment. Consequently, the long-term stability of Pickering emulsion is still a challenge. The tribological investigations of Pickering emulsion were summarized, and the multifunctional Pickering emulsion shows superior prospects for tribological applications. Moreover, the latest development of Pickering emulsion offers a new strategy for smart lubrication in the near future.

scholarly journals A Precise and GNSS-Free Landing System on Moving Platforms for Rotary-Wing UAVs

Sensors ◽  
2019 ◽  
Vol 19 (4) ◽  
pp. 886 ◽  
Author(s):  
Francisco Alarcón ◽  
Manuel García ◽  
Ivan Maza ◽  
Antidio Viguria ◽  
Aníbal Ollero
Keyword(s):  
Relative Position ◽  
Unmanned Helicopter ◽  
Landing Position ◽  
Moving Platforms ◽  
Landing Platform ◽  
Aerial Vehicle ◽  
The Stability ◽  
Novel Concept ◽  
High Level ◽  
Rotary Wing

This article presents a precise landing system that allows rotary-wing UAVs to approach and land safely on moving platforms, without using GNSS at any stage of the landing maneuver, and with a centimeter level accuracy and high level of robustness. This system implements a novel concept where the relative position and velocity between the aerial vehicle and the landing platform are calculated from the angles of a cable that physically connects the UAV and the landing platform. The use of a cable also incorporates a number of extra benefits, such as increasing the precision in the control of the UAV altitude. It also facilitates centering the UAV right on top of the expected landing position, and increases the stability of the UAV just after contacting the landing platform. The system was implemented in an unmanned helicopter and many tests were carried out under different conditions for measuring the accuracy and the robustness of the proposed solution. Results show that the developed system allowed landing with centimeter accuracy by using only local sensors and that the helicopter could follow the landing platform in multiple trajectories at different velocities.

scholarly journals Impact of non-proteinogenic amino acids in the discovery and development of peptide therapeutics

Amino Acids ◽  
2020 ◽  
Vol 52 (9) ◽  
pp. 1207-1226
Author(s):  
Yun Ding ◽  
Joey Paolo Ting ◽  
Jinsha Liu ◽  
Shams Al-Azzam ◽  
Priyanka Pandya ◽  
...  
Keyword(s):  
Amino Acids ◽  
Its Sequence ◽  
Peptide Therapeutics ◽  
Large Proteins ◽  
Drug Candidates ◽  
Ongoing Development ◽  
The Stability ◽  
Natural Amino Acids ◽  
The Impact ◽  
As Toxicity

Abstract With the development of modern chemistry and biology, non-proteinogenic amino acids (NPAAs) have become a powerful tool for developing peptide-based drug candidates. Drug-like properties of peptidic medicines, due to the smaller size and simpler structure compared to large proteins, can be changed fundamentally by introducing NPAAs in its sequence. While peptides composed of natural amino acids can be used as drug candidates, the majority have shown to be less stable in biological conditions. The impact of NPAA incorporation can be extremely beneficial in improving the stability, potency, permeability, and bioavailability of peptide-based therapies. Conversely, undesired effects such as toxicity or immunogenicity should also be considered. The impact of NPAAs in the development of peptide-based therapeutics is reviewed in this article. Further, numerous examples of peptides containing NPAAs are presented to highlight the ongoing development in peptide-based therapeutics.

scholarly journals A Deeper Insight on the Stability of Water-Induced Reconstruction of Anatase (001) Surface

2018 ◽  
Vol 8 (12) ◽  
pp. 2522 ◽  
Author(s):  
Giuseppe Zollo ◽  
Eugenio Vitale
Keyword(s):  
Surface Reconstruction ◽  
Density Functional ◽  
Bulk Water ◽  
Surface Reactivity ◽  
Water Dissociation ◽  
Residual Surface Stress ◽  
Self Assembling ◽  
Potential System ◽  
Surface Hydroxyls ◽  
The Stability

TiO 2 anatase (001) surface has been indicated for many years as a potential system for water dissociation and hydrogen production. Surface reconstruction periodicity of TiO 2 anatase (001) in water is revised on the basis of the new water induced reconstruction model that accounts for dissociative water adsorption in the first monolayer and self-assembling of surface hydroxyls. The study has been performed in the context of first principles total energy calculations on the basis of state of the art Density Functional Theory. Different surface periodical structures have been studied and compared in terms of residual surface stress and surface reactivity. While a preference seems to emerge for the (2 × 3) surface reconstruction, there are indications that this configuration might not occur spontaneously in bulk water.

scholarly journals NANOEMULSIONS FOR PROSTRATE CANCER THERAPY: AN OVERVIEW

2017 ◽  
Vol 10 (5) ◽  
pp. 37
Author(s):  
Manikandan P ◽  
Sundara Ganapathy R
Keyword(s):  
Prostate Cancer ◽  
Oral Delivery ◽  
Water Solubility ◽  
Oral Absorption ◽  
Solid Dispersions ◽  
Dose Proportionality ◽  
Permeation Enhancers ◽  
Lipophilic Drugs ◽  
Prostrate Cancer ◽  
Gastric Fluids

The objective of this review is to focus the inferences of low/poor bioavailability and lack of dose proportionality for the oral delivery of drugs in prostatecancer therapy. To overcome such problems, various formulation strategies has been reported including various methods for the use of surfactants,cyclodextrins, solid dispersions, micronization, permeation enhancers, and lipids. Flutamide is an antiandrogen drug and used for the therapy of prostate cancer. The flutamide drug is having limited clinical application due to its poor water solubility and needs enhancement of its dissolution rate in simulated gastric fluids. The lipid-based formulations such as nanoemulsion have been shown to improve the solubility and oral absorption of lipophilic drugs. To conclude, this article emphasizes the various approaches of nanoemulsion based formulation for prostate cancer therapy.Keywords: Nanoemulsion, Prostate cancer, Flutamide, Antiandrogen drug, Lipophilic drugs.

A Theoretical Discussion of a Menisci Micropump Driven by an Electric Field

2006 ◽  
Vol 129 (4) ◽  
pp. 404-411 ◽  
Author(s):  
Alexandru Herescu ◽  
Jeffrey S. Allen
Keyword(s):  
Electric Field ◽  
Fluid Motion ◽  
Liquid Interfaces ◽  
Vapor Bubbles ◽  
Liquid Phases ◽  
The Stability ◽  
Novel Concept ◽  
Enhanced Boiling ◽  
Stability Limits ◽  
Induced Dipoles

The potential for miniaturization of analytical devices made possible by advances in micro-fabrication technology is driving demand for reliable micropumps. A wide variety of micropumps exist with many types of actuating mechanisms. One such mechanism is electrohydrodynamic (EHD) forces which rely upon Coulomb forces on free charges and/or polarization forces on induced dipoles within the liquid to induce fluid motion. EHD has been used to pump liquid phases and to displace gas–liquid interfaces for enhanced boiling heat transfer as well as to displace gas/vapor bubbles. A novel concept for using EHD polarization forces to deflect a stationary meniscus in order to compress and pump a gaseous phase is described. The pumping mechanism consists in alternative compression of two gas volumes by continuous deflection of the two pinned menisci of an entrapped liquid slug in an electric field. Using the Maxwell stress relations, the electric field strength necessary to operate the pump is determined. The operational limits are determined by analyzing the stability limits of the two menisci from inertial and viscous standpoints, corroborated with the natural frequencies of the gas–liquid interfaces.

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