scholarly journals Cardiovascular Diseases and Pharmacomicrobiomics: A Perspective on Possible Treatment Relevance

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1338
Author(s):  
Lavinia Curini ◽  
Amedeo Amedei
Keyword(s):  
Cardiovascular Diseases ◽  
Vascular System ◽  
Heart Diseases ◽  
High Serum ◽  
Disease Treatment ◽  
Lipid Disorders ◽  
Male Sex ◽  
The Right ◽  
Rich Countries

Cardiovascular diseases (CVDs), the most common cause of mortality in rich countries, include a wide variety of pathologies of the heart muscle and vascular system that compromise the proper functioning of the heart. Most of the risk factors for cardiovascular diseases are well-known: lipid disorders, high serum LDL cholesterol, hypertension, smoking, obesity, diabetes, male sex and physical inactivity. Currently, much evidence shows that: (i) the human microbiota plays a crucial role in maintaining the organism’s healthy status; and (ii) a link exists between microbiota and cardiovascular function that, if dysregulated, could potentially correlate with CVDs. This scenario led the scientific community to carefully analyze the role of the microbiota in response to drugs, considering this the right path to improve the effectiveness of disease treatment. In this review, we examine heart diseases and highlight how the microbiota actually plays a preponderant role in their development. Finally, we investigate pharmacomicrobiomics—a new interesting field—and the microbiota’s role in modulating the response to drugs, to improve their effectiveness by making their action targeted, focusing particular attention on cardiovascular diseases and on innovative potential treatments.

scholarly journals Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis

2021 ◽  
Vol 8 (2) ◽  
pp. 22
Author(s):  
Rashid Mir ◽  
Imadeldin Elfaki ◽  
Naina Khullar ◽  
Ajaz Ahmad Waza ◽  
Chandan Jha ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Diseases ◽  
Cardiac Dysfunction ◽  
Heart Diseases ◽  
Prognostic Biomarkers ◽  
Apoptotic Bodies ◽  
Artery Disease

Cardiovascular diseases are the leading cause of death worldwide in different cohorts. It is well known that miRNAs have a crucial role in regulating the development of cardiovascular physiology, thus impacting the pathophysiology of heart diseases. MiRNAs also have been reported to be associated with cardiac reactions, leading to myocardial infarction (MCI) and ultimately heart failure (HF). To prevent these heart diseases, proper and timely diagnosis of cardiac dysfunction is pivotal. Though there are many symptoms associated with an irregular heart condition and though there are some biomarkers available that may indicate heart disease, authentic, specific and sensitive markers are the need of the hour. In recent times, miRNAs have proven to be promising candidates in this regard. They are potent biomarkers as they can be easily detected in body fluids (blood, urine, etc.) due to their remarkable stability and presence in apoptotic bodies and exosomes. Existing studies suggest the role of miRNAs as valuable biomarkers. A single biomarker may be insufficient to diagnose coronary artery disease (CAD) or acute myocardial infarction (AMI); thus, a combination of different miRNAs may prove fruitful. Therefore, this review aims to highlight the role of circulating miRNA as diagnostic and prognostic biomarkers in cardiovascular diseases such as coronary artery disease (CAD), myocardial infarction (MI) and atherosclerosis.

scholarly journals Glutathione Participation in the Prevention of Cardiovascular Diseases

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1220
Author(s):  
Deyamira Matuz-Mares ◽  
Héctor Riveros-Rosas ◽  
María Magdalena Vilchis-Landeros ◽  
Héctor Vázquez-Meza
Keyword(s):  
Cardiovascular Diseases ◽  
Superoxide Anion ◽  
Reactive Nitrogen Species ◽  
Hypochlorous Acid ◽  
Reduced Glutathione ◽  
Heart Diseases ◽  
Reactive Species ◽  
Oxygen Species ◽  
Cardiovascular Pathologies

Cardiovascular diseases (CVD) (such as occlusion of the coronary arteries, hypertensive heart diseases and strokes) are diseases that generate thousands of patients with a high mortality rate worldwide. Many of these cardiovascular pathologies, during their development, generate a state of oxidative stress that leads to a deterioration in the patient’s conditions associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Within these reactive species we find superoxide anion (O2•–), hydroxyl radical (•OH), nitric oxide (NO•), as well as other species of non-free radicals such as hydrogen peroxide (H2O2), hypochlorous acid (HClO) and peroxynitrite (ONOO–). A molecule that actively participates in counteracting the oxidizing effect of reactive species is reduced glutathione (GSH), a tripeptide that is present in all tissues and that its synthesis and/or regeneration is very important to be able to respond to the increase in oxidizing agents. In this review, we will address the role of glutathione, its synthesis in both the heart and the liver, and its importance in preventing or reducing deleterious ROS effects in cardiovascular diseases.

scholarly journals The Role of Uridine Adenosine Tetraphosphate in the Vascular System

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Rita C. Tostes ◽  
R. Clinton Webb
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Smooth Muscle Cells ◽  
Vascular Function ◽  
Purinergic Receptors ◽  
Potential Role ◽  
Vascular System

The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

Pivotal Role Of The Interaction Between Herbal Medicines And Gut Microbiota On Disease Treatment

2020 ◽  
Vol 21 ◽  
Author(s):  
Tingting Zhao ◽  
Zhe Wang ◽  
Zhilong Liu ◽  
Youhua Xu
Keyword(s):  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Neurodegenerative Diseases ◽  
Disease Progression ◽  
Herbal Medicines ◽  
Underlying Mechanism ◽  
Disease Treatment ◽  
Endocrine Diseases ◽  
Health And Disease

: With the recognition of the important role of gut microbiota in both health and disease progression, attempts to modulate its composition as well as its co-metabolism with the organism have attracted special attention. Abundant studies have demonstrated that dysfunction or imbalance of gut microbiota is closely with disease including endocrine diseases, neurodegenerative diseases, tumors, cardiovascular diseases, et al. Herbal medicines have been applied for preventing and treating disease worldwide for hundreds of years. Although the underlying mechanism seems to be complex, one of the important one is through modulating gut microbiota. In this review, co-metabolism between herbal medicines and microbiota, as well as the potential pathways are summarized from most recent published papers.

scholarly journals A negatív érzelmek és a szív- és érrendszeri betegségek összefüggései

2018 ◽  
Vol 159 (48) ◽  
pp. 2005-2010
Author(s):  
Piroska Balog
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular Health ◽  
Heart Diseases ◽  
Negative Emotions ◽  
Anger Expression ◽  
Coronary Heart Diseases ◽  
Vital Exhaustion ◽  
Symptoms Of Depression ◽  
European Guidelines

Abstract: With regard to cardiovascular health, the role of negative emotions, particularly that of depression, anxiety, vital exhaustion and hostility has been studied the most widely. Mainly the somatic symptoms of depression and, out of anxiety disorders, generalised anxiety and panic disorder have been linked to cardiovascular diseases. Based on an analysis of interviews of patients having suffered myocardial infarction, it was found that vital exhaustion (a combination of loss of energy, increased irritability, and general demoralization) is a precursor of infarction. Vital exhaustion has proven to contribute to the development of coronary heart diseases, being one of the most important risk factors in both sexes. With regard to hostility, studies show that anger suppression and destructive anger expression (blaming others) are closely linked to a higher incidence of coronary heart diseases. Evidence shows that the relationship between negative emotions and cardiovascular diseases is one of a two-way causality, that is, the presence of a cardiovascular disease may also enhance negative emotions, low heart rate variability playing a crucial role in both diseases. This study also presents interview questions suggested by the European Guidelines (2016) to estimate negative emotions related to coronary heart diseases. Orv Hetil. 2018; 159(48): 2005–2010.

scholarly journals SIRT3: A New Regulator of Cardiovascular Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Wei Sun ◽  
Caixia Liu ◽  
Qiuhui Chen ◽  
Ning Liu ◽  
Youyou Yan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Mitochondrial Function ◽  
Causes Of Death ◽  
Cell Damage ◽  
Heart Diseases ◽  
Tca Cycle ◽  
Metabolic Disturbances ◽  
Glucose And Lipid Metabolism

Cardiovascular diseases (CVDs) are the leading causes of death worldwide, and defects in mitochondrial function contribute largely to the occurrence of CVDs. Recent studies suggest that sirtuin 3 (SIRT3), the mitochondrial NAD+-dependent deacetylase, may regulate mitochondrial function and biosynthetic pathways such as glucose and fatty acid metabolism and the tricarboxylic acid (TCA) cycle, oxidative stress, and apoptosis by reversible protein lysine deacetylation. SIRT3 regulates glucose and lipid metabolism and maintains myocardial ATP levels, which protects the heart from metabolic disturbances. SIRT3 can also protect cardiomyocytes from oxidative stress-mediated cell damage and block the development of cardiac hypertrophy. Recent reports show that SIRT3 is involved in the protection of several heart diseases. This review discusses the progress in SIRT3-related research and the role of SIRT3 in the prevention and treatment of CVDs.

scholarly journals Magnesium and Vascular Changes in Hypertension

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Ana Rosa Cunha ◽  
Bianca Umbelino ◽  
Margarida L. Correia ◽  
Mario Fritsch Neves
Keyword(s):  
Cardiovascular Diseases ◽  
Vascular System ◽  
Serum Magnesium ◽  
Inverse Correlation ◽  
Antiarrhythmic Effect ◽  
The Body ◽  
Vascular Changes ◽  
Sodium Potassium ◽  
Mineral Supplementation

Many factors have been implicated in the pathogenesis of hypertension, including changes in intracellular concentrations of calcium, sodium, potassium, and magnesium. There is a significant inverse correlation between serum magnesium and incidence of cardiovascular diseases. Magnesium is a mineral with important functions in the body such as antiarrhythmic effect, actions in vascular tone, contractility, glucose metabolism, and insulin homeostasis. In addition, lower concentrations of magnesium are associated with oxidative stress, proinflammatory state, endothelial dysfunction, platelet aggregation, insulin resistance, and hyperglycemia. The conflicting results of studies evaluating the effects of magnesium supplements on blood pressure and other cardiovascular outcomes indicate that the action of magnesium in the vascular system is present but not yet established. Therefore, this mineral supplementation is not indicated as part of antihypertensive treatment, and further studies are needed to better clarify the role of magnesium in the prevention and treatment of cardiovascular diseases.

scholarly journals A clinical case of metastatic osteosarcoma in the heart cavity

2018 ◽  
Vol 22 (1) ◽  
pp. 55
Author(s):  
E. I. Iofe ◽  
V. G. Konov ◽  
E. B. Solovyev ◽  
I. I. Bridun
Keyword(s):  
Conflict Of Interest ◽  
Right Atrium ◽  
Clinical Case ◽  
Vascular System ◽  
Heart Diseases ◽  
Clinical Manifestations ◽  
Pericardial Patch ◽  
Metastatic Osteosarcoma ◽  
Malignant Lesions ◽  
The Right

<p>Tumors of the heart are catalogued as a poorly studied area of clinical oncology because of an extreme rarity of this pathology, absence of pathognomonic symptoms, a large variety of clinical manifestations, and diagnostic complexity. In order to achieve diagnostic and therapeutic adequacy, clinicians need to be aware of cancer heart diseases and their frequently atypical clinical manifestations. The report presents a clinical case of tumor spreading through the vascular system and malignant lesions of the right atrium of the heart in a patient with osteosarcoma of the humerus, where osteosarcoma metastases are resected and plasty of the right atrium is performed by using a pericardial patch.</p><p>Received 22 August 2017. Revised 7 December 2017. Accepted 11 December 2017.</p><p><strong>Funding:</strong> The study did not have sponsorship.</p><p><strong>Conflict of interest:</strong> Authors declare no conflict of interest.</p>

scholarly journals Forgiveness and Personality Type among Men and Women Suffering from Cardiovascular Diseases

2014 ◽  
Vol 2 (2) ◽  
pp. 48-52
Author(s):  
Elham Foroozandeh
Keyword(s):  
Cardiovascular Diseases ◽  
Heart Diseases ◽  
Negative Relationship ◽  
Personality Type ◽  
Type A ◽  
Cross Sectional ◽  
Men And Women ◽  
Significant Difference ◽  
Type A Personality

Background: Role of personality and some components of behaviors, traits and emotions as effective factors on coronary heart diseases (CHD) were presented nearly 50 years ago with the concept of “type A” behavior, a compound of hostility, impatience, competitiveness and dominance. Later studies showed crucial role of other traits and behaviors like anger, introversion, depression and forgiveness. Objective: The aim of this study was to compare personality type and forgiveness in the patients suffering from cardiovascular diseases based on gender. Materials and method: The cross sectional study was designed and sample was collected from men and women referred to cardiologists (within the age range of 23-75 years old) from the patients of Shahid Rajaee Heart Hospital of Tehran, Iran from December 2010 to March 2011. Total 87 subjects were selected using random method. The study subjects were given two questionnaires: personality type A (with two factors: TA1, pathologic behaviors of type A personality and TA2, non pathologic behaviors of type A personality) and Interpersonal Forgiveness Inventory (IFI), with three subscales namely reestablishment of relationship, control of revenge and realistic perception. Data were analyzed using SPSS software. Results: Mean(±SD) age of men was 50.5±11.6 years (n=33) and 55.7±14.4 years in women (n=54). Mean duration of suffering from cardiovascular diseases in men was 7.8 years and in women was 9.10 years. The study found high mean scores of type A pathologic but not non pathologic type A among women compared to men (p<0.038) and no statistically significant differences in forgiveness subscales. Conclusion: The study revealed significant difference between women and men suffering from cardiovascular disease in pathologic type A (TA1) and negative relationship between pathologic type A and forgiveness. DOI: http://dx.doi.org/10.3329/dmcj.v2i2.20523 Delta Med Col J. Jul 2014; 2(2): 48-52

scholarly journals The role of serotonergic system in cardiovascular diseases development in children

2015 ◽  
Vol 96 (4) ◽  
pp. 665-669 ◽  
Author(s):  
D I Sadykova ◽  
R R Nigmatullina ◽  
G N Aflyatumova
Keyword(s):  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Heart Development ◽  
Vascular System ◽  
Serotonergic System ◽  
Receptor Subtypes ◽  
Negative Effects ◽  
Blood Pressure Elevation ◽  
Serotonin System

The role of the serotonin system as a link in the pathogenesis of atherosclerosis and arterial hypertension is widely discussed during the recent decades. Serotonin and histamine are part of humoral system of physiological processes regulators and modulators which under pathological conditions are transformed into factors contributing to the disease development. The membrane serotonin transporter has been identified on neurons, platelets, myocardium and smooth muscle cells. The higher is the activity of membrane transporter, the higher is the platelet serotonin concentration, its release into the blood plasma increases thus implementing its negative effects on platelets and wall of the vessels. 5-HT1A, 5-HT2 and 5-HT3 receptor subtypes play a key role in the central mechanisms of regulation of cardiovascular activities while peripheral effects of serotonin on the vascular system are mediated by 5-HT1, 5-HT2, 5-HT3, 5-HT4 and 5-HT7 receptor subtypes. Activation of 5-HT1A receptors causes inhibition of central sympathetic influences and further bradycardia, while 5-HT2 receptors activation - arousal of the sympathetic division, blood pressure elevation, and tachycardia. With the development of anaerobic processes serotonin via 5-HT2 receptors triggers apoptosis of cardiomyocytes leading to the development and progression of heart failure. Participation of 5HT2B receptors in the regulation of heart development during embryogenesis was shown on the mutant mice: cardiomyopathy with ventricular mass loss due to reduction of cardiomyocytes number and size was revealed. The involvement of 5-HT4 receptors in the development of sinus tachycardia and atrial fibrillation; in turn, the use of 5-HT4 receptor antagonists proved to be effective in the treatment of this kind of arrhythmias. Therefore, the study of the serotonergic system role in the development of cardiovascular diseases will allow to open new links in the pathogenesis of arterial hypertension in childhood.

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