scholarly journals Recent Development in Nanomaterial-Based Electrochemical Sensors for Cholesterol Detection

Chemosensors ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 98
Author(s):  
Hemraj Mahipati Yadav ◽  
Jong-Deok Park ◽  
Hyeong-Cheol Kang ◽  
Jae-Joon Lee
Keyword(s):  
Electrochemical Sensors ◽  
Electrochemical Sensing ◽  
Environmental Stability ◽  
Functional Nanomaterials ◽  
Sensing Properties ◽  
Research Fields ◽  
Cholesterol Detection ◽  
Significant Attention ◽  
Remarkable Progress ◽  
Made In

Functional nanomaterials have attracted significant attention in a variety of research fields (in particular, in the healthcare system) because of the easily controllable morphology, their high chemical and environmental stability, biocompatibility, and unique optoelectronic and sensing properties. The sensing properties of nanomaterials can be used to detect biomolecules such as cholesterol. Over the past few decades, remarkable progress has been made in the production of cholesterol biosensors that contain nanomaterials as the key component. In this article, various nanomaterials for the electrochemical sensing of cholesterol were reviewed. Cholesterol biosensors are recognized tools in the clinical diagnosis of cardiovascular diseases (CVDs). The function of nanomaterials in cholesterol biosensors were thoroughly discussed. In this study, different pathways for the sensing of cholesterol with functional nanomaterials were investigated.

Electrochemical Sensors Based on Architectural Diversity of the ?-Conjugated Structure: Recent Advancements from Conducting Polymers and Carbon Nanotubes

2007 ◽  
Vol 60 (7) ◽  
pp. 472 ◽  
Author(s):  
Liming Dai
Keyword(s):  
Carbon Nanotubes ◽  
Conducting Polymers ◽  
Electrochemical Sensors ◽  
Functional Materials ◽  
High Sensitivity ◽  
Electrochemical Sensing ◽  
Environmental Stability ◽  
Carbon Fibres ◽  
Recent Developments

Conjugated conducting polymers and carbon nanotubes, both of which possess a conjugated structure of alternating carbon–carbon single and double bonds for the delocalization of π-electrons, are two important classes of electrochemical sensing materials. The combination of carbon nanotubes with conducting polymers or other functional materials (e.g., DNA chains, proteins, metal nanoparticles, carbon fibres) was found to create synergetic effects, that provide the basis for the development of numerous novel sensors with a high sensitivity, good selectivity, excellent environmental stability, and low power consumption. This article reviews recent developments in this exciting new area of electrochemical sensing by presenting the rational strategy of the author’s group in the design and characterization of these new electrochemical sensors based on architectural diversity of the π-conjugated structure.

scholarly journals Utilising Commercially Fabricated Printed Circuit Boards as an Electrochemical Biosensing Platform

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 793
Author(s):  
Uroš Zupančič ◽  
Joshua Rainbow ◽  
Pedro Estrela ◽  
Despina Moschou
Keyword(s):  
Printed Circuit Boards ◽  
Electrochemical Sensors ◽  
Cost Effective ◽  
Electrochemical Sensing ◽  
Label Free ◽  
Circuit Boards ◽  
Printed Circuit ◽  
Sensing Applications ◽  
Electrochemical Biosensing ◽  
Pre Treatment

Printed circuit boards (PCBs) offer a promising platform for the development of electronics-assisted biomedical diagnostic sensors and microsystems. The long-standing industrial basis offers distinctive advantages for cost-effective, reproducible, and easily integrated sample-in-answer-out diagnostic microsystems. Nonetheless, the commercial techniques used in the fabrication of PCBs produce various contaminants potentially degrading severely their stability and repeatability in electrochemical sensing applications. Herein, we analyse for the first time such critical technological considerations, allowing the exploitation of commercial PCB platforms as reliable electrochemical sensing platforms. The presented electrochemical and physical characterisation data reveal clear evidence of both organic and inorganic sensing electrode surface contaminants, which can be removed using various pre-cleaning techniques. We demonstrate that, following such pre-treatment rules, PCB-based electrodes can be reliably fabricated for sensitive electrochemical biosensors. Herein, we demonstrate the applicability of the methodology both for labelled protein (procalcitonin) and label-free nucleic acid (E. coli-specific DNA) biomarker quantification, with observed limits of detection (LoD) of 2 pM and 110 pM, respectively. The proposed optimisation of surface pre-treatment is critical in the development of robust and sensitive PCB-based electrochemical sensors for both clinical and environmental diagnostics and monitoring applications.

scholarly journals Diagnosis and Therapeutic Management of Liver Fibrosis by microRNA

2021 ◽  
Vol 22 (15) ◽  
pp. 8139
Author(s):  
Tomoko Tadokoro ◽  
Asahiro Morishita ◽  
Tsutomu Masaki
Keyword(s):  
Liver Fibrosis ◽  
Viral Infections ◽  
Primary Biliary Cholangitis ◽  
Medical Need ◽  
Key Factor ◽  
Complications Of Cirrhosis ◽  
And Control ◽  
Functional Rnas ◽  
Remarkable Progress ◽  
Made In

Remarkable progress has been made in the treatment and control of hepatitis B and C viral infections. However, fundamental treatments for diseases in which liver fibrosis is a key factor, such as cirrhosis, alcoholic/nonalcoholic steatohepatitis, autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis, are still under development and remain an unmet medical need. To solve this problem, it is essential to elucidate the pathogenesis of liver fibrosis in detail from a molecular and cellular perspective and to develop targeted therapeutic agents based on this information. Recently, microRNAs (miRNAs), functional RNAs of 22 nucleotides, have been shown to be involved in the pathogenesis of liver fibrosis. In addition, extracellular vesicles called “exosomes” have been attracting attention, and research is being conducted to establish noninvasive and extremely sensitive biomarkers using miRNAs in exosomes. In this review, we summarize miRNAs directly involved in liver fibrosis, miRNAs associated with diseases leading to liver fibrosis, and miRNAs related to complications of cirrhosis. We will also discuss the efficacy of each miRNA as a biomarker of liver fibrosis and pathology, and its potential application as a therapeutic agent.

scholarly journals Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4607
Author(s):  
Dounia Elfadil ◽  
Abderrahman Lamaoui ◽  
Flavio Della Pelle ◽  
Aziz Amine ◽  
Dario Compagnone
Keyword(s):  
Food Safety ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Electrochemical Analysis ◽  
Ease Of Use ◽  
Electrochemical Sensing ◽  
Food Contaminants ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

scholarly journals Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Coatings ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 204
Author(s):  
Yuhao Zhou ◽  
Bowen Ji ◽  
Minghao Wang ◽  
Kai Zhang ◽  
Shuaiqi Huangfu ◽  
...  
Keyword(s):  
Thin Film ◽  
High Resolution ◽  
Future Research ◽  
Nano Fabrication ◽  
Computer Interfaces ◽  
Continuous Progress ◽  
Open Mesh ◽  
Remarkable Progress ◽  
Thin Film Devices ◽  
Made In

Remarkable progress has been made in the high resolution, biocompatibility, durability and stretchability for the implantable brain-computer interface (BCI) in the last decades. Due to the inevitable damage of brain tissue caused by traditional rigid devices, the thin film devices are developing rapidly and attracting considerable attention, with continuous progress in flexible materials and non-silicon micro/nano fabrication methods. Therefore, it is necessary to systematically summarize the recent development of implantable thin film devices for acquiring brain information. This brief review subdivides the flexible thin film devices into the following four categories: planar, open-mesh, probe, and micro-wire layouts. In addition, an overview of the fabrication approaches is also presented. Traditional lithography and state-of-the-art processing methods are discussed for the key issue of high-resolution. Special substrates and interconnects are also highlighted with varied materials and fabrication routines. In conclusion, a discussion of the remaining obstacles and directions for future research is provided.

scholarly journals Fundamentals, achievements and challenges in the electrochemical sensing of pathogens

The Analyst ◽  
2015 ◽  
Vol 140 (21) ◽  
pp. 7116-7128 ◽  
Author(s):  
Javier Monzó ◽  
Ignacio Insua ◽  
Francisco Fernandez-Trillo ◽  
Paramaconi Rodriguez
Keyword(s):  
Electrochemical Sensors ◽  
Electrochemical Sensing ◽  
Medical Applications

Electrochemical sensors are powerful tools widely used in industrial, environmental and medical applications.

Smooth Muscle Contraction: Recent Advances

1994 ◽  
Vol 72 (11) ◽  
pp. 1317-1319
Author(s):  
Newman L. Stephens
Keyword(s):  
Smooth Muscle ◽  
Muscle Contraction ◽  
Myosin Light Chain ◽  
Kinase Activity ◽  
Smooth Muscle Contraction ◽  
Recent Advances ◽  
Regulation Of Contraction ◽  
Muscle Biochemistry ◽  
Remarkable Progress ◽  
Made In

Research in smooth muscle contraction has shown remarkable progress over the last 5 years. Striking advances have been made in the areas of biochemical regulation of contraction, centering on myosin light chain kinase activity, and of biophysical delineation of the contractile process at the actomyosin level by use of the newly developed motility assay. The purpose of the symposium held at Minaki, Ont., was to obtain a comprehensive reporting of the recent advances made in the area of smooth muscle contraction. Specifically, advances in the areas of biophysics of contraction, energetics, and contractile and regulator proteins (including the interesting newcomers caldesmon and calponin) and the changes that occur in pathophysiological entities such as asthma, hypertension, anaphylactic shock, high-altitude hypoxia, and persistent pulmonary hypertension of the newborn were presented.Key words: smooth muscle biophysics, smooth muscle biochemistry, energetics of smooth muscle, pathophysiology of smooth muscle.

scholarly journals Paving the way for transgenic schistosomes

Parasitology ◽  
2011 ◽  
Vol 139 (5) ◽  
pp. 651-668 ◽  
Author(s):  
S. BECKMANN ◽  
C. G. GREVELDING
Keyword(s):  
Rna Interference ◽  
Initial Phase ◽  
Functional Characterization ◽  
Reporter Genes ◽  
Significant Progress ◽  
Gene Insertion ◽  
Remarkable Progress ◽  
Made In ◽  
Silence Gene

SUMMARYIn parasitological research, significant progress has been made with respect to genomics and transcriptomics but transgenic systems for functional gene analyses are mainly restricted to the protozoan field. Gene insertion and knockout strategies can be applied to parasitic protozoa as well as gene silencing by RNA interference (RNAi). By contrast, research on parasitic helminthes still lags behind. Along with the major advances in genome and transcriptome analyses e.g. for schistosomes, methods for the functional characterization of genes of interest are still in their initial phase and have to be elaborated now, at the beginning of the post-genomic era. In this review we will summarize attempts made in the last decade regarding the establishment of protocols to transiently and stably transform or transfect schistosomes. Besides approaches using particle bombardment, electroporation or virus-based infection strateies to introduce DNA constructs into adult and larval schistosome stages to express reporter genes, first approaches have also been made in establishing protocols based on soaking, lipofection, and/or electroporation for RNA interference to silence gene activity. Although in these cases remarkable progress can be seen, the schistosome community eagerly awaits major breakthroughs especially with respect to stable transformation, but also for silencing or knock-down strategies for every schistosome gene of interest.

Development of Au-Pd@UiO-66-on-ZIF-L/CC as a self-supported electrochemical sensor for in situ monitoring of cellular hydrogen peroxide

2021 ◽  
Author(s):  
Jilin Zheng ◽  
Peng Zhao ◽  
Shiying Zhou ◽  
Sha Chen ◽  
Yi Liang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Electrochemical Sensor ◽  
Noble Metals ◽  
Electrochemical Sensors ◽  
Metal Organic Frameworks ◽  
Electrochemical Sensing ◽  
In Situ Monitoring ◽  
Metal Organic

Integrating metal-organic frameworks (MOFs) of different components or structures together and exploiting them as electrochemical sensors for electrochemical sensing have aroused great interest. And the incorporation of noble metals with...

Nanowire Modification to Enhance the Performance of Neurotransmitter Sensors

2010 ◽  
Vol 1 (4) ◽  
Author(s):  
Hung Cao ◽  
J.-C. Chiao
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Electrochemical Sensors ◽  
Electrochemical Sensing ◽  
Human Central Nervous System ◽  
Excitatory Neurotransmitter ◽  
Modification Method ◽  
Solid Liquid ◽  
Scanning Electron ◽  
Si Wafer

In this work, we have developed a method to modify the platinum (Pt) working electrode with nanowires using vapor-solid-liquid (VLS) mechanism in order to increase the sensitivity of our microelectrochemical neurotransmitter sensors. Our sensor probes were manufactured from a 300 μm thick silicon (Si) wafer with several electrode designs for implantation in various locations of the human central nervous system. The surfaces of electrodes were observed and characterized by scanning electron microscopy (SEM) and cyclic voltammetry (CV). The complete devices were made and used to demonstrate the enhancement in performance contributed by nanowires in the enzyme-based electrochemical sensing of L-glutamate, which is the most abundant excitatory neurotransmitter. Comparison between electrodes with and without nanowire modification was conducted, showing that the modification method is a good option to improve the performance of electrochemical sensors.

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