scholarly journals Potential Industrial Applications and Commercialization of Microalgae in the Functional Food and Feed Industries: A Short Review

Marine Drugs ◽  
2019 ◽  
Vol 17 (6) ◽  
pp. 312 ◽  
Author(s):  
Franciele Camacho ◽  
Angela Macedo ◽  
Francisco Malcata
Keyword(s):  
Functional Food ◽  
Scientific Evidence ◽  
Scale Up ◽  
Short Review ◽  
Industrial Applications ◽  
Life Extension ◽  
Gastric Ulcers ◽  
Marine Animals ◽  
Microalgal Biomass ◽  
Food And Feed

Bioactive compounds, e.g., protein, polyunsaturated fatty acids, carotenoids, vitamins and minerals, found in commercial form of microalgal biomass (e.g., powder, flour, liquid, oil, tablet, or capsule forms) may play important roles in functional food (e.g., dairy products, desserts, pastas, oil-derivatives, or supplements) or feed (for cattle, poultry, shellfish, and fish) with favorable outcomes upon human health, including antioxidant, anti-inflammatory, antimicrobial, and antiviral effects, as well as prevention of gastric ulcers, constipation, anemia, diabetes, and hypertension. However, scale up remains a major challenge before commercial competitiveness is attained. Notwithstanding the odds, a few companies have already overcome market constraints, and are successfully selling extracts of microalgae as colorant, or supplement for food and feed industries. Strong scientific evidence of probiotic roles of microalgae in humans is still lacking, while scarce studies have concluded on probiotic activity in marine animals upon ingestion. Limitations in culture harvesting and shelf life extension have indeed constrained commercial viability. There are, however, scattered pieces of evidence that microalgae play prebiotic roles, owing to their richness in oligosaccharides—hardly fermented by other members of the intestinal microbiota, or digested throughout the gastrointestinal tract of humans/animals for that matter. However, consistent applications exist only in the dairy industry and aquaculture. Despite the underlying potential in formulation of functional food/feed, extensive research and development efforts are still required before microalgae at large become a commercial reality in food and feed formulation.

scholarly journals Selected Aspects Related to Medicinal and Aromatic Plants as Alternative Sources of Bioactive Compounds

2021 ◽  
Vol 22 (4) ◽  
pp. 1521
Author(s):  
Radu Claudiu Fierascu ◽  
Irina Fierascu ◽  
Anda Maria Baroi ◽  
Alina Ortan
Keyword(s):  
Raw Materials ◽  
Scale Up ◽  
Extraction Methods ◽  
Industrial Applications ◽  
Critical Discussion ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Synthetic Drugs ◽  
Advantages And Disadvantages ◽  
Food And Feed

Natural compounds obtained from different medicinal and aromatic plants have gained respect as alternative treatments to synthetic drugs, as well as raw materials for different applications (cosmetic, food and feed industries, environment protection, and many others). Based on a literature survey on dedicated databases, the aim of the present work is to be a critical discussion of aspects regarding classical extraction versus modern extraction techniques; possibilities to scale up (advantages and disadvantages of different extraction methods usually applied and the influence of extraction parameters); and different medicinal and aromatic plants’ different applications (medical and industrial applications, as well as the potential use in nanotechnology). As nowadays, research studies are directed toward the development of modern, innovative applications of the medicinal and aromatic plants, aspects regarding future perspectives are also discussed.

scholarly journals Microalgal Cell Biofactory—Therapeutic, Nutraceutical and Functional Food Applications

Plants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 836
Author(s):  
Boda Ravi Kiran ◽  
S. Venkata Mohan
Keyword(s):  
Bioactive Compounds ◽  
Well Being ◽  
Human Pathogens ◽  
Microalgal Biomass ◽  
Aquaculture Feed ◽  
Biological Extracts ◽  
Food And Feed ◽  
Food Applications ◽  
Environmental Requirements ◽  
Health And Well Being

Microalgae are multifaceted photosynthetic microorganisms with emerging business potential. They are present ubiquitously in terrestrial and aquatic environments with rich species diversity and are capable of producing significant biomass. Traditionally, microalgal biomass is being used as food and feed in many countries around the globe. The production of microalgal-based bioactive compounds at an industrial scale through biotechnological interventions is gaining interest more recently. The present review provides a detailed overview of the key algal metabolites, which plays a crucial role in nutraceutical, functional foods, and animal/aquaculture feed industries. Bioactive compounds of microalgae known to exhibit antioxidant, antimicrobial, antitumor, and immunomodulatory effects were comprehensively reviewed. The potential microalgal species and biological extracts against human pathogens were also discussed. Further, current technologies involved in upstream and downstream bioprocessing including cultivation, harvesting, and cell disruption were documented. Establishing microalgae as an alternative supplement would complement the sustainable and environmental requirements in the framework of human health and well-being.

scholarly journals Taguchi optimization and scale up of xylanase from Bacillus licheniformis isolated from hot water geyser

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Girisha Malhotra ◽  
Shilpa S. Chapadgaonkar
Keyword(s):  
Process Parameters ◽  
Wheat Bran ◽  
Scale Up ◽  
Industrial Applications ◽  
Hot Water ◽  
Optimization Strategy ◽  
Taguchi Optimization ◽  
Xylanase Production ◽  
Alkali Tolerance ◽  
Optimized Conditions

Abstract Background Xylanase is one of the widely applied industrial enzymes with diverse applications. Thermostability and alkali tolerance are the two most desirable qualities for industrial applications of xylanase. In this paper, we reveal the statistical Taguchi optimization strategy for maximization of xylanase production. The important process parameters pH, temperature, concentration of wheat bran, and concentration of yeast extract were optimized using the Taguchi L8 orthogonal array where the 4 factors were considered at 2 levels (high and low). Results The optimized conditions given by model were obtained as follows: (i) pH 6, (ii) culture temperature 35 °C, (iii) concentration of xylan 2% w/v, (iv) concentration of wheat bran 2.5% w/v. The production was scaled upto 2.5 L bioreactor using optimized process parameters. A high xylanase titer of 400 U/ml could be achieved in less than 60 h of culture in the reactor. Conclusion Optimization was successful in achieving about threefold increase in the yield of xylanase. The optimized conditions resulted in a successful scale up and enhancement of xylanase production.

Application of the Continuous Rheoconversion Process (CRP) to Low Temperature HPDC-Part I: Microstructure

2006 ◽  
Vol 116-117 ◽  
pp. 402-405 ◽  
Author(s):  
Qin Yue Pan ◽  
Stuart Wiesner ◽  
Diran Apelian
Keyword(s):  
Low Temperature ◽  
Scale Up ◽  
Microstructural Characterization ◽  
Industrial Applications ◽  
Primary Phase ◽  
Heat Extraction ◽  
Initial Stage ◽  
Fraction Solid ◽  
Die Castings

The continuous rheoconversion process (CRP) is a novel slurry-on-demand process that was developed at MPI/WPI in 2002. The process is based on a passive liquid mixing technique in which the nucleation and growth of the primary phase are controlled using a specially designed “reactor”. The reactor provides heat extraction, copious nucleation, and forced convection during the initial stage of solidification, thus leading to the formation of globular structures. This paper presents our recent work on the scale-up of the CRP for industrial applications. Specifically, we demonstrate an important application of the CRP to low temperature (low fraction solid) HPDC. In Part I of this paper, we present salient results on microstructural characterization of CRP processed castings vs. conventional die castings.

scholarly journals Effects of Curcumin on Vessel Formation Insight into the Pro- and Antiangiogenesis of Curcumin

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Ting-ye Wang ◽  
Jia-xu Chen
Keyword(s):  
Curcuma Longa ◽  
Scientific Evidence ◽  
Short Review ◽  
Dual Effect ◽  
Scientific Databases ◽  
Wide Range ◽  
Available Information ◽  
Insight Into

Curcumin is a compound extracted from the Curcuma longa L, which possesses a wide range of pharmacological effects. However, few studies have collected scientific evidence on its dual effect on angiogenesis. The present review gathered the fragmented information available in the literature to discuss the dual effect and possible mechanisms of curcumin on angiogenesis. Available information concerning the effect of curcumin on angiogenesis is compiled from scientific databases, including PubMed and Web of Science using the key term (curcumin and angiogenesis). The results were reviewed to identify relevant articles. Related literature demonstrated that curcumin has antiangiogenesis effect via regulating multiple factors, including proangiogenesis factor VEGF, MMPs, and FGF, both in vivo and in vitro, and could promote angiogenesis under certain circumstances via these factors. This paper provided a short review on bidirectional action of curcumin, which should be useful for further study and application of this compound that require further studies.

scholarly journals Industrial applications of laser-induced breakdown spectroscopy: a review

2020 ◽  
Vol 12 (8) ◽  
pp. 1014-1029 ◽  
Author(s):  
S. Legnaioli ◽  
B. Campanella ◽  
F. Poggialini ◽  
S. Pagnotta ◽  
M. A. Harith ◽  
...  
Keyword(s):  
Short Review ◽  
Industrial Applications ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown

A short review on LIBS industrial applications.

scholarly journals Liposomes: From Bangham to Supercritical Fluids

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1022 ◽  
Author(s):  
Paolo Trucillo ◽  
Roberta Campardelli ◽  
Ernesto Reverchon
Keyword(s):  
Encapsulation Efficiency ◽  
Operating Cost ◽  
Scale Up ◽  
Drug Carriers ◽  
Short Review ◽  
Batch Mode ◽  
Advantages And Disadvantages ◽  
Process Scale Up ◽  
Solvent Residue ◽  
Aqueous Core

Liposomes are spherical vesicles made up of an aqueous core surrounded by phospholipids. These delivery systems (DS) are largely employed as drug carriers in several industrial fields, such as pharmaceutical and nutraceutical fields. The aim of this short review is to provide a fast overview on the main fundamentals of liposomes, thought as a compact guide for researchers and students that want to approach this topic for the first time. The mini-review will focus on the definitions, production methods and characterization protocols of the liposomes produced, making a critical comparison of the main conventional and supercritical based manufacturing methods available. The literature was analyzed deeply from the first works by Dr. Bangham in 1965 to the most recent supercritical fluid applications. The advantages and disadvantages of conventional and high-pressure processes will be described in terms of solvent elimination, production at the nanometric (50–300 nm) and micrometric level (1–100 μm) and encapsulation efficiency (20–90%). The first proposed methods were characterized by a low encapsulation efficiency (20–40%), resulting in drug loss, a high solvent residue and high operating cost. The repeatability of conventional processes was also low, due to the prevalent batch mode. Supercritical-assisted methods were developed in semi-continuous layouts, resulting in an easy process scale-up, better control of liposome dimensions (polydispersity index, PDI) and also higher encapsulation efficiencies (up to 90%).

scholarly journals Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast

2015 ◽  
Vol 112 (34) ◽  
pp. E4689-E4696 ◽  
Author(s):  
Mingtao Huang ◽  
Yunpeng Bai ◽  
Staffan L. Sjostrom ◽  
Björn M. Hallström ◽  
Zihe Liu ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Protein Secretion ◽  
Cell Types ◽  
Industrial Applications ◽  
Whole Genome ◽  
Rational Engineering ◽  
Cell Factories ◽  
Food And Feed ◽  
Increasing Demand

There is an increasing demand for biotech-based production of recombinant proteins for use as pharmaceuticals in the food and feed industry and in industrial applications. Yeast Saccharomyces cerevisiae is among preferred cell factories for recombinant protein production, and there is increasing interest in improving its protein secretion capacity. Due to the complexity of the secretory machinery in eukaryotic cells, it is difficult to apply rational engineering for construction of improved strains. Here we used high-throughput microfluidics for the screening of yeast libraries, generated by UV mutagenesis. Several screening and sorting rounds resulted in the selection of eight yeast clones with significantly improved secretion of recombinant α-amylase. Efficient secretion was genetically stable in the selected clones. We performed whole-genome sequencing of the eight clones and identified 330 mutations in total. Gene ontology analysis of mutated genes revealed many biological processes, including some that have not been identified before in the context of protein secretion. Mutated genes identified in this study can be potentially used for reverse metabolic engineering, with the objective to construct efficient cell factories for protein secretion. The combined use of microfluidics screening and whole-genome sequencing to map the mutations associated with the improved phenotype can easily be adapted for other products and cell types to identify novel engineering targets, and this approach could broadly facilitate design of novel cell factories.

Recent Progress in Industrial Applications of CAT-CVD (Hot-Wire Cvd)

2002 ◽  
Vol 715 ◽  
Author(s):  
Atsushi Masuda ◽  
Akira Izumi ◽  
Hironobu Umemoto ◽  
Hideki Matsumura
Keyword(s):  
High Efficiency ◽  
Film Formation ◽  
Industrial Applications ◽  
Life Extension ◽  
Flat Panel Display ◽  
Hot Wire ◽  
Large Area ◽  
Precise Control ◽  
Gaas Devices ◽  
Temperature Deposition

AbstractRapid progresses are achieved in catalytic CVD (Cat-CVD), often called hot-wire CVD, in the past 3-years NEDO national project in Japan. Cat-CVD technology presents many advantages in thin-film formation processes; high-efficiency of gas use, large-area deposition, no ion bombardment and low-temperature deposition even below 200°C. All of the elemental techniques for the industrially applicable Cat-CVD apparatuses, such as the suppression of the metal contamination, the precise control of the substrate temperature, the life extension of the catalyzer, 1-m size uniform deposition and the chamber cleaning, have been completely developed. Sophisticatedly designed substrate holder with electrostatic chuck and showerhead equipped with catalyzers are both key technologies for these achievements. High reproducibility for film properties is also obtained by controlling the reaction between high-density radicals and chamber walls. Prototype mass-production apparatus for SiNx passivation films in GaAs devices has been already developed and this will be probably the first application of Cat-CVD in industry. These recent movements appear to promise the drastic revolution in semiconductor and flat-panel display industries by introducing Cat-CVD in very near future.

scholarly journals Moving from rhetoric to action: how Africa can use scientific evidence to halt the COVID-19 pandemic

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Olushayo Oluseun Olu ◽  
Joy Luba Lomole Waya ◽  
Sylvester Maleghemi ◽  
John Rumunu ◽  
David Ameh ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Preventive Measures ◽  
Negative Impact ◽  
Control Strategies ◽  
Scientific Evidence ◽  
Scale Up ◽  
High Impact ◽  
The Social ◽  
And Control

Abstract The ongoing pandemic of the coronavirus disease 2019 has spread rapidly to all countries of the world. Africa is particularly predisposed to an escalation of the pandemic and its negative impact given its weak economy and health systems. In addition, inadequate access to the social determinants of health such as water and sanitation and socio-cultural attributes may constrain the implementation of critical preventive measures such as hand washing and social distancing on the continent. Given these facts, the continent needs to focus on targeted and high impact prevention and control strategies and interventions which could break the chain of transmission quickly. We conclude that the available body of scientific evidence on the coronavirus disease 2019 holds the key to the development of such strategies and interventions. Going forward, we recommend that the African research community should scale up research to provide scientific evidence for a better characterization of the epidemiology, transmission dynamics, prevention and control of the virus on the continent.

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