scholarly journals The ABRF Metabolomics Research Group 2016 Exploratory Study: Investigation of Data Analysis Methods for Untargeted Metabolomics

Metabolites ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 128
Author(s):  
Christoph W. Turck ◽  
Tytus D Mak ◽  
Maryam Goudarzi ◽  
Reza M Salek ◽  
Amrita K Cheema

Lack of standardized applications of bioinformatics and statistical approaches for pre- and postprocessing of global metabolomic profiling data sets collected using high-resolution mass spectrometry platforms remains an inadequately addressed issue in the field. Several publications now recognize that data analysis outcome variability is caused by different data treatment approaches. Yet, there is a lack of interlaboratory reproducibility studies that have looked at the contribution of data analysis techniques toward variability/overlap of results. The goal of our study was to identify the contribution of data pre- and postprocessing methods on metabolomics analysis results. We performed urinary metabolomics from samples obtained from mice exposed to 5 Gray of external beam gamma rays and those exposed to sham irradiation (control group). The data files were made available to study participants for comparative analysis using commonly used bioinformatics and/or biostatistics approaches in their laboratories. The participants were asked to report back the top 50 metabolites/features contributing significantly to the group differences. Herein we describe the outcome of this study which suggests that data preprocessing is critical in defining the outcome of untargeted metabolomic studies.

2020 ◽  
Vol 12 (1) ◽  
pp. 41-54
Author(s):  
Agustiarini Eka Dheasari

The purpose of this research is to develop bigbook folklore media to improve the empathy and storytelling ability of early childhood, especially age 5-6 years. This research is research and development (R&D) using ADDIE development model (Analyze, Design, Develop, Implementation, and Evaluate). Collecting data used interview guides, validation, observation sheets and teacher questionnaires. Data analysis techniques in this study used Independent t-test with a significance level of 0.05. Based on the results of the assessment experts showed that the product developed "very good". This shows that the bigbook media is appropriate to be used to increase empathy and storytelling skills of children aged 5-6 years. Based on the results of the study, there was a difference improvement of storytelling and empathy skills in the final outcomes between post treatment of the control group without bigbook media and post treatment of experimental group using bigbook media. The sig (2-tailed) value of the storytelling is 0,000 (very good) and empathy children received a sig (2-tailed) value of  0,000 (very good). The result of this study that the bigbook media based on folklore is effectively used to increase empathy and storytelling skills of children aged 5-6 years.


2020 ◽  
Vol 4 (3) ◽  
pp. 337
Author(s):  
Ni Putu Sawitri Ekayani ◽  
I Made Suarjana ◽  
I Nyoman Laba Jayanta

This research aimed to analyze the effect of the Two Stay Two Stray (TSTS) learning model assisted with mind mapping media toward social studies learning outcomes in Grade V. The type of this research was a quasi-experimental research design with nonequivalent post-test only controls group design. The population of this research was all of the fifth-grade elementary schools in Cluster I Bangli District, which totaled 7 classes with 138 students. The samples were determined using a simple random sampling technique, totaling 20 students as the experimental group and 30 students as the control group. Data analysis techniques in this research used descriptive statistical analysis techniques and data analysis prerequisite tests. Hypothesis analysis used the t-test polled variance test. The results of the calculation of the average social studies learning outcomes of the experimental group students were 23.15 included in the very high category, while students in the control group had an average value of 17.23 including the moderate category. Based on calculations with the t-test obtained a t-count of 4.89 is greater than the t-table value of 2.010 with a dk of 48, at a significance level of 5%. From the results of the analysis, it can be concluded that the Two Stay Two Stray (TSTS) learning model assisted with mind mapping media has a significant effect on social studies learning outcomes for fifth-grade elementary school students. Therefore, the TSTS learning model assisted with mind mapping media is suitable to be applied to improve students' social studies learning outcomes


Author(s):  
Arisman Arisman

This research starts from the low endurance possessed by SAC athletes, therefore researchers are interested in exploring further and trying to contribute in the form of exercises namely square exercises to increase the aerobic endurance of athletes. This type of research was an experimental design with pretest-posttest control group design. The sample is 30 people. divided into two groups, namely (experimental group and control group, 15 people each). the experimental group was given treatment in the form of square exercise. The data collection technique is using the 12-minute run test with data analysis techniques using the t-test (different test). Based on the results of the study data analysis found tcount (11.12)> t table (1.75) and the value of sig. (p) 0,000 <of 0,05. Conclusion, square exercises can increase the aerobic endurance of athletes in the club's archery significantly. Keywords : Square Exercise, Aerobic Endurance


Author(s):  
John A. Hunt

Spectrum-imaging is a useful technique for comparing different processing methods on very large data sets which are identical for each method. This paper is concerned with comparing methods of electron energy-loss spectroscopy (EELS) quantitative analysis on the Al-Li system. The spectrum-image analyzed here was obtained from an Al-10at%Li foil aged to produce δ' precipitates that can span the foil thickness. Two 1024 channel EELS spectra offset in energy by 1 eV were recorded and stored at each pixel in the 80x80 spectrum-image (25 Mbytes). An energy range of 39-89eV (20 channels/eV) are represented. During processing the spectra are either subtracted to create an artifact corrected difference spectrum, or the energy offset is numerically removed and the spectra are added to create a normal spectrum. The spectrum-images are processed into 2D floating-point images using methods and software described in [1].


2010 ◽  
Vol 41 (01) ◽  
Author(s):  
HP Müller ◽  
A Unrath ◽  
A Riecker ◽  
AC Ludolph ◽  
J Kassubek

2019 ◽  
Vol 3 (1) ◽  
pp. 31-41
Author(s):  
Sri Sudiarti

The objectives of this research are to know and to analyze about the effect of Continuous Improvement on the performance of employees at PT. Rentang Buana Niagamakmur (PT.RBN) Tasikmalaya. Research method which applied in this research is survey research method, while data collecting technique is done by through questionaire. Sampling technique applies sample is accidental sampling technique and the size sample is 55 respondents. Data analysis techniques used in the study is simple regression technique, analysis of the coefficient of determination  and t test. The results showed that the Continuous Improvement  including both criteria, including employee performance criteria, as well as Continuous Improvement  has a positive influence on employee performance of 76,4% in PT . Rentang Buana Niagamakmur (PT.RBN) Tasikmalaya.


Author(s):  
Niken Setyaningrum ◽  
Andri Setyorini ◽  
Fachruddin Tri Fitrianta

ABSTRACTBackground: Hypertension is one of the most common diseases, because this disease is suffered byboth men and women, as well as adults and young people. Treatment of hypertension does not onlyrely on medications from the doctor or regulate diet alone, but it is also important to make our bodyalways relaxed. Laughter can help to control blood pressure by reducing endocrine stress andcreating a relaxed condition to deal with relaxation.Objective: The general objective of the study was to determine the effect of laughter therapy ondecreasing elderly blood pressure in UPT Panti Wredha Budhi Dharma Yogyakarta.Methods: The design used in this study is a pre-experimental design study with one group pre-posttestresearch design where there is no control group (comparison). The population in this study wereelderly aged over> 60 years at 55 UPT Panti Wredha Budhi Dharma Yogyakarta. The method oftaking in this study uses total sampling. The sample in this study were 55 elderly. Data analysis wasused to determine the difference in blood pressure before and after laughing therapy with a ratio datascale that was using Pairs T-TestResult: There is an effect of laughing therapy on blood pressure in the elderly at UPT Panti WredhaBudhi Dharma Yogyakarta marked with a significant value of 0.000 (P <0.05)


Author(s):  
Siti Mariana Ulfa

AbstractHumans on earth need social interaction with others. Humans can use more than one language in communication. Thus, the impact that arises when the use of one or more languages is the contact between languages. One obvious form of contact between languages is interference. Interference can occur at all levels of life. As in this study, namely Indonesian Language Interference in Learning PPL Basic Thailand Unhasy Students. This study contains the form of interference that occurs in Thai students who are conducting teaching practices in the classroom. This type of research is descriptive qualitative research that seeks to describe any interference that occurs in the speech of Thai students when teaching practice. Data collection methods in this study are (1) observation techniques, (2) audio-visual recording techniques using CCTV and (3) recording techniques, by recording all data that has been obtained. Whereas the data wetness uses, (1) data triangulation, (2) improvement in perseverance and (3) peer review through discussion. Data analysis techniques in this study are (1) data collection, (2) data reduction, (3) data presentation and (4) conclusions. It can be seen that the interference that occurs includes (1) interference in phonological systems, (2) interference in morphological systems and (3) interference in syntactic systems. 


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