scholarly journals Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1927 ◽  
Author(s):  
Alfredo Córdova ◽  
Juan Mielgo-Ayuso ◽  
Enrique Roche ◽  
Alberto Caballero-García ◽  
Diego Fernandez-Lázaro
Keyword(s):  
Muscle Damage ◽  
Alanine Transaminase ◽  
Control Group ◽  
Enzymatic Reactions ◽  
Aspartate Transaminase ◽  
Total Proteins ◽  
Magnesium Supplementation ◽  
Blood Samples ◽  
World Anti Doping Agency ◽  
Last Stage

Magnesium is a cofactor of different enzymatic reactions involved in anabolic and catabolic processes that affect muscular performance during exercise. In addition, it has been suggested that magnesium could participate in maintaining muscle integrity during demanding effort. The main purpose of this study was to analyze the effects of magnesium supplementation in preventing muscle damage in professional cyclists taking part in a 21-day cycling stage race. Eighteen male professional cyclists (n = 18) from two teams were recruited to participate in the research. They were divided into 2 groups: the control group (n = 9) and the magnesium-supplemented group (n = 9). The supplementation consisted of an intake of 400 mg/day of magnesium during the 3 weeks of competition. Blood samples were collected according to World Anti-Doping Agency rules at three specific moments during competition: immediately before the race; mid competition; and before the last stage. Levels of serum and erythrocyte magnesium, lactate dehydrogenase, creatinine kinase, aspartate transaminase, alanine transaminase, myoglobin, aldolase, total proteins, cortisol and creatinine were determined. Serum and erythrocyte magnesium levels decreased during the race. Circulating tissue markers increased at the end of the race in both groups. However, myoglobin increase was mitigated in the supplemented group compared with the controls. We conclude that magnesium supplementation seems to exert a protective effect on muscle damage.

scholarly journals Liver morphology and morphometry and plasma biochemical parameters of Wistar rats that received leaf infusion of Rudgea viburnoides Benth. (Rubiaceae)

2009 ◽  
Vol 52 (2) ◽  
pp. 407-412 ◽  
Author(s):  
Juliana Castro Monteiro ◽  
Sérgio Luis Pinto da Matta ◽  
Fabrícia de Souza Predes ◽  
Tânia Toledo de Oliveira
Keyword(s):  
Plasma Levels ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Alanine Transaminase ◽  
Histopathological Analysis ◽  
Aspartate Transaminase ◽  
Total Proteins ◽  
Daily Dose ◽  
Liver Morphology ◽  
Morphology And Morphometry

Rudgea viburnoides leaves are widely used in popular Brazilian medicine as a diuretic, antirheumatic, hypotensive and blood depurative tea. The present study was carried out to investigate the effects of this infusion on the liver and on the plasma biochemical parameters of Wistar rats. Two groups received the R. viburnoides leaf infusion at a daily dose of 10 or 20g dry-leaves/L water, during 40 days. The histopathological analysis did not show degenerated areas or infiltration of leucocytes. Hepatic morphometry showed accumulation of fat in the hepatocytes of the treated groups. There was no significant change in the plasma levels of urea, creatinin, uric acid, direct bilirubin, cholesterol, total proteins, albumin, gamma glutamyl tranferase (gamma-GT), alanine transaminase (ALT), aspartate transaminase (AST), chlorine, phosphate and calcium. A significant reduction in the plasma levels of triacylglycerol (TAG) occurred in the group that received the higher dose.

scholarly journals Changes in the Concentrations of Some Plasma Proteins During Acute Inflammation in Dogs

2017 ◽  
Vol 1 (1) ◽  
pp. 85-89
Author(s):  
Dimirtinka Zapryanova ◽  
Teodora Mircheva ◽  
Tsanko Hristov ◽  
Lazarin Lazarov ◽  
Aleksander Atanasov ◽  
...  
Keyword(s):  
Body Weight ◽  
Plasma Proteins ◽  
Acute Inflammation ◽  
Control Group ◽  
Post Inoculation ◽  
Lumbar Region ◽  
Total Proteins ◽  
Blood Samples ◽  
Inflammatory Conditions ◽  
Experimental Group

Abstract The purpose of the present study was to analyse the changes in concentrations of total proteins, albumin, globulins and albumin/globulin ratio in dogs with experimentally induced acute inflammation. The study was performed on 9 mongrel dogs (experimental group) and 6 mongrel dogs (control group) at the age of 2 years and body weight 12-15 kg. The acute inflammation was reproduced by inoculation of 2 ml turpentine oil in the lumbar region subcutaneously and in same quantity saline in control dogs. Blood samples were collected into heparinized tubes before inoculation (hour 0) then at hours 6, 24, 48, 72 and on days 7, 14, 21. The statistical analysis of the data was performed using one way analysis of variance (ANOVA). The level of albumin statistically decreased in the experimental dogs from at 72nd h to day 14 while the concentration of globulins increased from the 72nd h to day 21. On days 7 and 14 the albumin/globulin ratio slightly decreased. During the whole post inoculation period the values of total protein have not changed. The dates of the present study confirm that albumin, albumin/globulin ratio and globulins are sensitive factors in inflammatory conditions in dogs.

scholarly journals Study the relationship between the liver functions and interleukin- 10 in female thalassaemia patients in Kirkuk city

2019 ◽  
Vol 24 (2) ◽  
pp. 1
Author(s):  
Afnan Y. Bakr ◽  
, Mousa M. Marbut ◽  
Ahmed H.AL-Ani
Keyword(s):  
Interleukin 10 ◽  
Alanine Transaminase ◽  
Total Serum ◽  
Control Group ◽  
Aspartate Transaminase ◽  
Blood Disease ◽  
Liver Functions ◽  
History Of ◽  
Alkaline Phosphate ◽  
The Relationship

This study was conducted in thalassaemia center at Azadi Teaching Hospital in Kirkuk city from the  beginning of August 2017 to the end of April 2018. One hundred female subjects were participated in the study (70)  thalassaemic patients and Thirty (30) persons as control group how they were non thalasaemic. with no family history of hereditary blood disease attendants to different clinics of Azadi hospital, who were assessed by a clinician. All subjects were aged between 8- 15 years. Age  and body mass index (BMI), were measured for all subjects in this study and used for the measurement of serum interleukin10, serum feritine, serum (GOT), Serum (GPT), serum (ALP) and total serum bilirubine. The results of current study showed that serum alkaline phosphate (ALP), Serum Alanine transaminase (ALT), serum Aspartate transaminase (GOT), Total serum bilirubine are Highly significance increase (p<0.01) in thalassaemic patients when compared to control group. In Conclusion, serum interleukin-10(IL-10) has high significant increases level in thalassaemic patients compared to control group.   http://dx.doi.org/10.25130/tjps.24.2019.021  

scholarly journals The electrophoretic pattern of serum proteins in dogs with babesiosis

2019 ◽  
Vol 88 (4) ◽  
pp. 425-432 ◽  
Author(s):  
Csilla Tóthová ◽  
Branislav Lukáč ◽  
Marián Kadaši ◽  
Darina Baranová ◽  
Tatiana Weissová ◽  
...  
Keyword(s):  
Serum Proteins ◽  
Clinical Signs ◽  
Electrophoretic Pattern ◽  
Control Group ◽  
Babesia Canis ◽  
Total Proteins ◽  
Blood Samples ◽  
Γ Globulins ◽  
Healthy Dogs ◽  
G Ratio

This study was aimed at the evaluation of the electrophoretic pattern of serum proteins in dogs naturally infected with Babesia canis. Blood samples were collected from 37 dogs infected with B. canis and showing clinical signs consistent with the disease. The sick animals were classified as dogs with physiologic and decreased red blood cell (RBC) values. Twenty-five healthy dogs formed the control group. The concentrations of total proteins and protein fractions were measured in blood serum. The values of total proteins, albumin and albumin/globulin (A/G) ratio in dogs with babesiosis were significantly lower than in healthy ones (P < 0.001). In the globulin fractions, significantly higher relative concentrations of α1-, β1- and β2-globulins (P < 0.01), and non-significantly higher values of α2- and γ-globulins were found in dogs with babesiosis with a double α2-zone in six out of 37 animals. Marked differences were observed also between the two groups of sick animals, with significantly lower values of albumin and A/G ratio (P < 0.05), and significantly higher values of α1- and β1-globulins in dogs with decreased RBC (P < 0.05 and P < 0.01, respectively). Presented results indicate marked alterations in the electrophoretic pattern of serum proteins in dogs with babesiosis suggesting its usefulness for the evaluation of pathophysiological changes caused by the disease and for diagnostic of disease severity.

scholarly journals Growth and Blood Parameters of Weaned Crossbred Beef Calves Fed Forage Kale (Brassica oleraceaspp.acephala)

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Y. Chorfi ◽  
Y. Couture ◽  
G. F. Tremblay ◽  
R. Berthiaume ◽  
D. Cinq-Mars
Keyword(s):  
Nutritive Value ◽  
Liver Enzymes ◽  
Blood Parameters ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Total Proteins ◽  
Pasture Management ◽  
Blood Samples ◽  
Beef Calves ◽  
Glutamyl Transferase

Forty lightweight calves (206.4±3.2 kg) were randomly distributed to four treatments: (Control) low nutritive value pasture and hay plus 1 kg d−1of rolled barley; (Pasture) management intensive pasture; (Haylage) timothy haylage; and (Kale) 50% timothy haylage −50% kale pasture. Blood samples were analysed for thyroid hormones, liver enzymes, glucose, cholesterol, total proteins (TP), albumin, globulins, and urea-N. At the end of the trial, the Pasture group was the heaviest with323.6±4.2 kg BW and 1.54 kg ADG. Final BW and ADG were similar for the Kale and Haylage groups. Blood T3was higher for Kale than for the other groups. The T3/T4ratio was greater for Control at the end of the experiment. There were no treatment differences for T4, aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), glutamate dehydrogenase (GLDH), cholesterol, and glucose. Blood urea-N was lower for Kale and higher for Pasture; however albumin concentrations were greater for Pasture and similar for other treatments. Except for the Control group, calves had a lower concentration of circulating globulins at the end than at the beginning of the experiment. This study showed that Kale could be fed to backgrounding calves without detrimental effects on performance.

Failure of Magnesium Supplementation to Influence Marathon Running Performance or Recovery in Magnesium-Replete Subjects

1992 ◽  
Vol 2 (2) ◽  
pp. 154-164 ◽  
Author(s):  
Sonja Terblanche ◽  
Timothy D. Noakes ◽  
Steven C. Dennis ◽  
De Wet Marais ◽  
Michael Eckert
Keyword(s):  
Muscle Damage ◽  
Muscle Function ◽  
Serum Magnesium ◽  
Magnesium Content ◽  
Control Group ◽  
Marathon Running ◽  
Magnesium Supplementation ◽  
Double Blind ◽  
Running Performance ◽  
Rate Of Recovery

This study examined the effect of magnesium supplementation on muscle magnesium content, on running performance during a 42-kni marathon footrace, and on muscle damage and the rate of recovery of muscle function following the race. Twenty athletes were divided equally into two matched groups and were studied for 4 weeks before and 6 weeks after a marathon in a double-blind trial; the experimental group received magnesium supplement (365 mg per day) and the control group, placebo. Magnesium supplementation did not increase either muscle or serum magnesium concentrations and had no measurable effect on 42-km marathon running performance. Extra magnesium ingestion also had no influence on the extent of muscle damage or the rate of recovery of muscle function. The latter was significantly reduced immediately after the marathon but returned to normal within 1 week. Thus, magnesium supplementation in magnesium-replete subjects did not enhance performance or increase resistance to muscle damage during the race, or the rate of recovery of muscle function following the race.

293 Effect of Supplementing Rumen-protected Methionine on Blood Parameters and Ruminal Metabolites in Lactating Holstein Dairy Cows

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 160-160
Author(s):  
Jialin Wei ◽  
Zhijun Cao ◽  
Yuanxiao Li
Keyword(s):  
Dairy Cows ◽  
Crude Protein ◽  
Volatile Fatty Acids ◽  
Blood Parameters ◽  
Alanine Transaminase ◽  
Nitrogen Utilization ◽  
Control Group ◽  
Aspartate Transaminase ◽  
Dietary Crude Protein ◽  
Holstein Dairy Cows

Abstract The aim of the present study was to evaluate the effects of reducing dietary crude protein (CP) levels and supplementing rumen-protected methionine (RPM) on blood parameters and ruminal metabolites in lactating Holstein dairy cows. A total of 30 lactating Holstein dairy cows (60 ± 7 d in milk; mean ± SD) were randomly assigned to 1 of 2 treatments: diet containing 17.3% CP without RPM (control group; CON); diet containing 16.4% CP with supplementing 15.0 g/d of RPM (treatment group; RPM). All repeated, continuous data were subjected to PROC MIXED procedure of SAS (SAS version 9.2, SAS Institute Inc., Cary, NC.). The results related to blood showed that cows in RPM group exhibited lower concentration of blood urea nitrogen than that in CON group (P &lt; 0.001). Moreover, there were no differences among treatments on concentrations of aspartate transaminase, alanine transaminase, alkaline phosphatase, globulin and albumin (P &gt; 0.05). In ruminal metabolites, microbial CP (MCP) of dairy cows in RPM group was higher compared with CON group (P = 0.006). The concentrations of butyrate, valerate and isovalerate of RPM group were higher than that of CON group at 2h after feeding (P &lt; 0.05). In conclusion, lower dietary CP with RPM supplementation could improve nitrogen utilization of dairy cows and synthesis of MCP in rumen, as well as change volatile fatty acids production at 2h after feeding.

scholarly journals Effect of Methanolic Extract of Corn Silk on Cisplatin-Induced Nephrotoxicity in Rats

2018 ◽  
Vol 7 ◽  
pp. e1258
Author(s):  
Nader Tanideh ◽  
Fariba Zarifi ◽  
Shima Rafiee ◽  
Maryam Khastkhodaei ◽  
Omid Koohi Hosseinabadi ◽  
...  
Keyword(s):  
Biochemical Markers ◽  
Methanolic Extract ◽  
Serum Levels ◽  
Hepatic Function ◽  
Alanine Transaminase ◽  
Control Group ◽  
Distilled Water ◽  
Aspartate Transaminase ◽  
Corn Silk ◽  
Pre Treatment

Background: Cisplatin is a cytotoxic agent in cancer therapy. Nephrotoxicity is considered as a side effect of cisplatin usage. Using rate models, we studied the possible protective impact of corn-silk (CS) extract against cisplatin-induced nephrotoxicity.Materials and Methods: Thirty-five experimental rats were divided into five groups (n=7 per each group) as follow: C1: Control received distilled water only; C2: received one dose of cisplatin, and CS: received 300 mg/kg/day of CS. Both CS1 and CS2 received 200 and 300 mg/kg/day of the CS extract orally, individually, for eight consecutive days. CS1 and CS2 received a single dose of cisplatin on the first day only. The specific biochemical markers and histopathological alterations were evaluated.Result: According to our results, cisplatin administration could have induced severe degeneration in all parts of the nephron tubules and liver. Pre-treatment with CS exhibited a significant decrease in the malondialdehyde (MDA) levels as compared to the values obtained after treatment with cisplatin alone (P<0.01). Moreover, the CS extract with 200 mg dose showed significant (P<0.01) protection against the cisplatin-induced elevation of blood urea nitrogen. Further, the serum levels of alanine transaminase and aspartate transaminase were higher in the cisplatin-treated groups, when compared to the control group (P<0.05). Furthermore, the hepatic function was also improved in cisplatin-treated animals, which were pre-treated with CS.Conclusion: CS has the potential to attenuate nephrotoxicity and lipid peroxidation induced by cisplatin in rats.[GMJ.2018;7:e1258]

scholarly journals Effect of Immersion in Cold Water on Creatine Kinase and Myoglobin Levels in Soccer Players

2020 ◽  
Vol 22 (2) ◽  
pp. 151-155
Author(s):  
Fernanda Bortolo Pesenti-Tofalini ◽  
Eduardo Rossi Spartalis ◽  
Alessandra Miyuki Okino ◽  
Danielle Venturini ◽  
Ariobaldo Frisseli ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Room Temperature ◽  
Cold Water ◽  
Intervention Group ◽  
Athletic Injuries ◽  
Soccer Players ◽  
Control Group ◽  
Blood Samples ◽  
And Control

The objective of this study was to analyze the effect of body immersion in cold water on creatine kinase and myoglobin levels in soccer athletes. For this, 10 soccer players aged between 16 and 18 years old, submitted to 5 blood samples, were analyzed: fasting, post-match, after 24, 48 and 72 hours. At the end of the match they were randomized into intervention group (GI) and control (CG). GI immersion in cold water, water plate at the level of the iliac crests, 10 ° C, for 10 minutes and the GC immersed in water at room temperature at the same height and for the same period of time. The levels of creatine kinase did not change in the analyzed groups and moments. Myoglobin levels increased significantly after the match and returned to baseline after 24 and 72 hours, with a peak in 48 hours. There was no difference between the intervention groups at all the evaluated moments. It was concluded that immersion in cold water did not alter the creatine kinase and myoglobin levels in relation to the control group in soccer athletes, indicating that for this population immersion in cold water was not able to reduce muscle damage after exercise. Keywords: Athletic Injuries. Myalgia. Fatigue. Cryotherapy. Resumo O objetivo deste estudo foi analisar o efeito da imersão corporal em água fria nos níveis de creatinoquinase e mioglobina em atletas de futebol. Para isto, foram analisados 10 atletas de futebol com idade entre 16 e 18 anos, submetidos à 5 coletas sanguíneas: em jejum, após jogo, após 24, 48 e 72 horas. Ao término do jogo foram aleatorizados em grupo intervenção (GI) e controle (GC). O GI realizou imersão em água fria, lâmina da água à altura das cristas ilíacas, 10ºC, por 10 minutos e o GC realizou imersão em água à temperatura ambiente à mesma altura e durante o mesmo período de tempo. Os níveis de creatinoquinase não apresentaram alteração nos grupos e momentos analisados. Já os níveis de mioglobina aumentaram significativamente após o jogo e retornaram aos valores basais após 24 e 72 horas, com pico em 48 horas. Não houve diferença entre os grupos de intervenção em todos os momentos avaliados. Conclui-se então que a imersão em água fria não alterou os níveis de creatinoquinase e mioglobina em relação ao grupo controle em atletas de futebol, indicando que para esta população a imersão em água fria não foi capaz de reduzir o dano muscular após exercício. Palavras-chave: Traumatismos em Atletas. Mialgia. Fadiga. Crioterapia.

scholarly journals Fetal death in the women with cholestasis pregnancy

2020 ◽  
pp. 274-278
Author(s):  
M. A. Kachkovskiy ◽  
O. V. Kosheleva
Keyword(s):  
Pregnant Women ◽  
Fetal Death ◽  
Gestational Hypertension ◽  
Risk Group ◽  
Main Group ◽  
Alanine Transaminase ◽  
Control Group ◽  
Aspartate Transaminase ◽  
Obstetric Ultrasound ◽  
Fetal Hypoxia

Background. The development of fetal death among pregnant women with cholestasis pregnancy (CP) is possible.Aim. The purposeи is to determine the interconnection between clinico-anamnestic and laboratory indicators of pregnant women with CP and fetal death.Patients and methods. 211 pregnant women were examined. The main group – 144 (68%) women with CP, controlgroup – 67 (32%) patients without symptoms of this disease. There are 2 subgroups depending on the presence or absence of fetal death among pregnant women with CP. A complex of standard clinical and diagnostic studies was performed, including obstetric ultrasound and cardiotocography. Results. In the group of patients with CP, postpartum hemorrhages (p<0.05), intrauterine fetal hypoxia (p<0.001) were significantly more frequent, fetal death was noted only in the main group (2.1%). In both subgroups miscarriages were more common in the history (p = 0.019). Most women with CHP had diseases of the hepatobiliary system, gestational hypertension and kidney disease (p<0.05). In the subgroup with fetal death arterial hypertension existed significantly more frequent before pregnancy (p<0.05). The itchy skin was extremely permanent among patients with CP and fetal death. The subgroup with fetal death significantly differed from the control group for hyperfermentemia both during pregnancy (alanine transaminase (ALT) – p<0.001, aspartate transaminase (AST) – p = 0.001, alkaline phosphatase (APH) – p = 0.001), and after delivery (ALT –p = 0.002, AST – p = 0.033, APH – p = 0.006).Conclusions. Women with CP, with a miscarriage in anamnesis or hypertension are in a risk group of fetal death. A more frequent study of the fetal condition is needed among patients with persistent itching at CP.

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