scholarly journals The Medical Benefits of Vitamin K2 on Calcium-Related Disorders

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 691
Author(s):  
Zeyad Khalil ◽  
Benyamin Alam ◽  
Amir Reza Akbari ◽  
Harbans Sharma
Keyword(s):  
Cerebral Palsy ◽  
Public Libraries ◽  
Positive Impact ◽  
Gastrointestinal Disease ◽  
Vitamin K2 ◽  
Beneficial Effects ◽  
Broken Bones ◽  
Confounding Variables ◽  
Medical Benefits ◽  
Parathyroid Disease

Background: Due to the potentially crucial role of vitamin K2 in calcium metabolism, a deficit can disrupt many mechanisms, resulting in an array of different issues, such as broken bones, stiff arteries and poor fertility. Although there has been existing research, the potential of vitamin K2 as a treatment for conditions including cerebral palsy, parathyroid disease, heart disease and gastrointestinal disease is unknown. This review discusses the biochemistry of vitamin K and the metabolism of calcium, followed by an analysis of the current literature available on vitamin K2 and its prospects. Methods: Using public libraries including PubMed and Wiley, we searched for existing research on the metabolism and use of vitamin K2 that has been conducted in the preceding two decades. Results: Data indicated that vitamin K2 had a positive impact on osteoporosis, cardiovascular disease, parathyroid disorders, cerebral palsy and sperm motility. Conclusion: Due to the existence of confounding variables and limitations in the quality and volume of research conducted, further investigation must be done to see whether the beneficial effects seen are reproducible and must assess the viability of vitamin K2 as treatment in isolation for these conditions.

scholarly journals Effects of Dynamic Elastomeric Fabric Orthoses on Children with Cerebral Palsy

2009 ◽  
Vol 33 (4) ◽  
pp. 339-347 ◽  
Author(s):  
Martin John Matthews ◽  
Martin Watson ◽  
Barbara Richardson
Keyword(s):  
Cerebral Palsy ◽  
Single Case ◽  
Phase 1 ◽  
Functional Mobility ◽  
Gait Velocity ◽  
Controlled Study ◽  
Patient Specific ◽  
Spastic Diplegia ◽  
Cost Index ◽  
Beneficial Effects

This phase 1 exploratory study aimed to establish proof of concept of the effects of dynamic elastomeric fabric orthoses (DEFOs) on the gait of children with spastic diplegic cerebral palsy. Replicated single case experiments employing an ABA methodology were carried out on eight subjects (median age 5.5 years, range 3–13 years; 4 girls/boys) utilizing quantitative/qualitative data collection. Outcome measures were: Ten metre walking test (10MWT); physiological cost index (PCI); visual analogue scale (VAS) scoring of perceived gait changes; functional mobility changes using Patient Specific Functional Scale (PSFS); subject/carer perceptions recorded in daily diaries. Results identified following analysis of quantitative data indicated a treatment effect from the orthoses which could be corroborated by participant subjective impressions and comments. Statistically significant ( p < 0.05) intervention-related improvements in gait velocity and gait consistency were identified respectively in 5/8 and 4/8 subjects. Power calculations support the feasibility of a larger controlled study to further investigate this orthotic intervention. This study indicates that DEFO leggings can confer beneficial effects on the gait of some children with spastic diplegia resulting from CP. These findings have implications for orthotic intervention with this subject group.

Wpływ substancji zawartych w pieczarkach na organizm człowieka

2018 ◽  
Vol 21 (2) ◽  
Author(s):  
Jacek Majewski ◽  
Michał Orylski ◽  
Maciej Majewski ◽  
Julia Rasała
Keyword(s):  
Agaricus Bisporus ◽  
Positive Impact ◽  
Human Immune System ◽  
Button Mushroom ◽  
Beneficial Effects ◽  
White Button Mushroom ◽  
Lower Body Weight ◽  
Estrogen Synthesis ◽  
Lower Blood ◽  
Iga Production

Agaricus bisporus (white button mushroom) contains significant amounts of dietary fibers, microelements and other important compounds. While it is often underrated, numerous studies prove its positive impact on health. Several compounds found in Agaricus bisporus provide beneficial effects on diabetic and cardiovascular diseases and may lower blood glucose, cholesterol and LDL. Those mushrooms are also a potential breast cancer chemopreventive agent since they were proven to suppress aromatase and estrogen synthesis. Therefore, it may be useful in estrogen-dependent breast tumors. What is more, white button mushroom contains low amount of fat and is low calorie. It can be effectively used in diets to lower body weight. Also, compounds found in white button mushroom have impact on human immune system. They lead to increase of IgA production and stimulates lymphocytes by increasing levels of interleukin. Therefore, white button mushroom is not only valuable thanks to its taste but also because of its impact on human health. Properly prepared it can be an important ingredient of everyday meals.

Pro-/Anti-Inflammatory Bioactive Proteins and Peptides

2020 ◽  
pp. 106-141
Author(s):  
Fatma Esra Güneş
Keyword(s):  
Bioactive Peptides ◽  
Positive Impact ◽  
Antioxidant Properties ◽  
Specific Protein ◽  
Food Proteins ◽  
Protein Fragments ◽  
Beneficial Effects ◽  
Potential Benefits ◽  
Anti Inflammatory ◽  
New Generation

Bioactive peptides (BP) are specific protein fragments that can affect biological processes or substrates that have a positive impact on functions and conditions on body health. Plant and animal sources that contain physiologically active food proteins, native or processed, are rich sources of bioactive peptides. Bioactive peptides derived from food proteins have been demostrated to have variety of beneficial effects, such as anti-inflammatory and antioxidant properties. BP are accepted the new generation of biologically active regulators; they can prevent oxidation and microbial degradation in foods and furthermore improve quality of life by treating various diseases and disorders. The present review highlights the recent findings on the roles of various food-derived bioactive peptides in inflammation and oxidative stress and discuss the potential benefits and limitations of using these compounds against the burden of chronic diseases.

scholarly journals Probiotics: Versatile Bioactive Components in Promoting Human Health

Medicina ◽  
2020 ◽  
Vol 56 (9) ◽  
pp. 433 ◽  
Author(s):  
Javad Sharifi-Rad ◽  
Célia F. Rodrigues ◽  
Zorica Stojanović-Radić ◽  
Marina Dimitrijević ◽  
Ana Aleksić ◽  
...  
Keyword(s):  
Human Health ◽  
Positive Impact ◽  
Intestinal Flora ◽  
Pharmaceutical Products ◽  
Beneficial Effects ◽  
Food And Nutrition ◽  
Post Market ◽  
Health Care Applications ◽  
Probiotic Strains ◽  
And Control

The positive impact of probiotic strains on human health has become more evident than ever before. Often delivered through food, dietary products, supplements, and drugs, different legislations for safety and efficacy issues have been prepared. Furthermore, regulatory agencies have addressed various approaches toward these products, whether they authorize claims mentioning a disease’s diagnosis, prevention, or treatment. Due to the diversity of bacteria and yeast strains, strict approaches have been designed to assess for side effects and post-market surveillance. One of the most essential delivery systems of probiotics is within food, due to the great beneficial health effects of this system compared to pharmaceutical products and also due to the increasing importance of food and nutrition. Modern lifestyle or various diseases lead to an imbalance of the intestinal flora. Nonetheless, as the amount of probiotic use needs accurate calculations, different factors should also be taken into consideration. One of the novelties of this review is the presentation of the beneficial effects of the administration of probiotics as a potential adjuvant therapy in COVID-19. Thus, this paper provides an integrative overview of different aspects of probiotics, from human health care applications to safety, quality, and control.

scholarly journals Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue

2020 ◽  
Vol 9 (1) ◽  
pp. 213
Author(s):  
Bárbara María Varela-Rodríguez ◽  
Paula Juiz-Valiña ◽  
Luis Varela ◽  
Elena Outeiriño-Blanco ◽  
Susana Belén Bravo ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Molecular Mechanisms ◽  
De Novo ◽  
Positive Impact ◽  
De Novo Lipogenesis ◽  
Beneficial Effects ◽  
Proteomic Approach ◽  
Subcutaneous Adipose

Bariatric surgery (BS) is the most effective treatment for obesity and has a positive impact on cardiometabolic risk and in the remission of type 2 diabetes. Following BS, the majority of fat mass is lost from the subcutaneous adipose tissue depot (SAT). However, the changes in this depot and functions and as well as its relative contribution to the beneficial effects of this surgery are still controversial. With the aim of studying altered proteins and molecular pathways in abdominal SAT (aSAT) after body weight normalization induced by BS, we carried out a proteomic approach sequential window acquisition of all theoretical mass spectra (SWATH-MS) analysis. These results were complemented by Western blot, electron microscopy and RT-qPCR. With all of the working tools mentioned, we confirmed that after BS, up-regulated proteins were associated with metabolism, the citric acid cycle and respiratory electron transport, triglyceride catabolism and metabolism, formation of ATP, pyruvate metabolism, glycolysis/gluconeogenesis and thermogenesis among others. In contrast, proteins with decreased values are part of the biological pathways related to the immune system. We also confirmed that obesity caused a significant decrease in mitochondrial density and coverage, which was corrected by BS. Together, these findings reveal specific molecular mechanisms, genes and proteins that improve adipose tissue function after BS characterized by lower inflammation, increased glucose uptake, higher insulin sensitivity, higher de novo lipogenesis, increased mitochondrial function and decreased adipocyte size.

Full-Dimensionality of Relating in Romantic Relationships

2012 ◽  
Vol 3 ◽  
pp. 67-80 ◽  
Author(s):  
Anca M. Miron ◽  
Frances H. Rauscher ◽  
Alexandra Reyes ◽  
David Gavel ◽  
Kourtney K. Lechner
Keyword(s):  
Romantic Relationships ◽  
Positive Affect ◽  
Romantic Relationship ◽  
Positive Impact ◽  
Long Distance ◽  
Beneficial Effects ◽  
Long Distance Relationships ◽  
The Relationship ◽  
High Orientation ◽  
Practical Implications

We propose that an orientation toward relating to one's romantic partner via multiple sensory channels has beneficial effects for the relationship, especially for long-distance relationships. We used Wicklund's (2004) conceptualisation of full-dimensionality of relating and Brehm's (1999) emotional intensity theory to test the effects of a sensory multidimensional orientation and difficulty of maintaining the romantic relationship on feelings of love and commitment. In Study 1, we tested 55 participants involved in a long-distance romantic relationship and found that a multidimensional orientation fended off the detrimental effects of difficulty of maintaining the relationship: when partners experienced high difficulty, those with a high orientation experienced more positive affect, love, and commitment than those with a low orientation. In Study 2, data from 31 long-distance and 23 geographically-close participants indicated that a high multidimensionality orientation had a greater positive impact in long-distance relationships than in geographically-close relationships. In Study 3, 40 long-distance participants were asked to write about two times when it was either difficult but possible or nearly impossible to maintain their current relationship. Positive affect for the partner, love, and desire to be with the partner in the future were highest for the participants in the possible condition who preferred relating to the partner on multiple sensory channels. Altogether, these studies underline the importance of multidimensional orientation in romantic relationships, especially when intimates perceive maintaining the relationship as being difficult but manageable. Theoretical and practical implications of this new concept of sensory multidimensionality orientation are discussed.

scholarly journals Metabolic Effects of Bariatric Surgery

2018 ◽  
Vol 64 (1) ◽  
pp. 72-81 ◽  
Author(s):  
Piriyah Sinclair ◽  
Neil Docherty ◽  
Carel W le Roux
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Metabolic Surgery ◽  
Positive Impact ◽  
Metabolic Effects ◽  
Beneficial Effects ◽  
Treatment Of Obesity ◽  
The Impact ◽  
The Brain

Abstract BACKGROUND Obesity can be defined as a chronic subcortical brain disease, as there is an important neurophysiological component to its etiology based on changes in the functioning of those areas of the brain controlling food intake and reward. Extensive metabolic changes accompany bariatric surgery-based treatment of obesity. Consequently, the term “metabolic” surgery is being increasingly adopted in relation to the beneficial effects these procedures have on chronic diseases like type 2 diabetes. CONTENT In the present review, we focus on the key biochemical and physiological changes induced by metabolic surgery and highlight the beneficial effects accrued systemically with the use of an organ-based approach. Understanding the impact on and interactions between the gut, brain, adipose tissue, liver, muscle, pancreas, and kidney is key to understanding the sum of the metabolic effects of these operations. SUMMARY Further mechanistic studies are essential to assess the true potential of metabolic surgery to treat metabolic comorbidities of obesity beyond type 2 diabetes. Approaches that may mitigate the metabolic side effects of surgery also require attention. Understanding the positive impact of metabolic surgery on metabolic health may result in a wider acceptance of this intervention as treatment for metabolic, comorbid conditions.

scholarly journals Quercetin Improves the Endocrine Function of Rat Testicular Tissue Under in Vitro Conditions

2021 ◽  
Vol 70 (1-2) ◽  
pp. 1-5
Author(s):  
Filip Benko ◽  
Patrik Hrnčiar ◽  
Norbert Lukáč ◽  
Róbert Kirchner ◽  
Eva Tvrdá
Keyword(s):  
Positive Impact ◽  
Endocrine System ◽  
Testicular Tissue ◽  
Endocrine Function ◽  
Enzyme Linked Immunosorbent Assay ◽  
Beneficial Effects ◽  
Wide Range ◽  
Male Hormones ◽  
The Impact

Summary Compounds of natural origin are often used for their beneficial effects on the male endocrine system and the synthesis of steroid biomolecules in testicular tissue. One of such compounds is quercetin (QUE), which belongs to the flavonoid family and is found in a wide range of vegetables, fruits and plant products. The purpose of this study is to evaluate the impact of QUE on the endocrine function of rat testicular fragments under in vitro conditions. Testicular fragments from adult Wistar rats (n=9), cultured in the D-MEM medium with different concentrations of QUE (namely 1, 10 and 100 µmol/L) for 24 h at 37°C (5% CO2), were used in the experiment conducted. Following culture, the medium was separated and the levels of cholesterol (CHOL) and male hormones were measured. CHOL values were quantified spectrophotometrically, whereas the concentrations of androstenedione (ANDRO), dehydropeiandrosterone (DHEA) and testosterone (TEST) were quantified using the enzyme-linked immunosorbent assay (ELISA) commercial kit. The results obtained indicate that 10 µmol/L QUE significantly increased (P<0.001; P<0.05) the concentrations of all the steroid biomolecules considered (CHOL, ANDRO, DHEA and TEST) when compared to the control samples. Accordingly, our findings confirm the positive impact of QUE on the endocrine function and steroidogenesis of rat testicular tissue under in vitro conditions.

scholarly journals A Recent Insight Regarding the Phytochemistry and Bioactivity of Origanum vulgare L. Essential Oil

2020 ◽  
Vol 21 (24) ◽  
pp. 9653
Author(s):  
Adelina Lombrea ◽  
Diana Antal ◽  
Florina Ardelean ◽  
Stefana Avram ◽  
Ioana Zinuca Pavel ◽  
...  
Keyword(s):  
Essential Oil ◽  
Positive Impact ◽  
Biological Activities ◽  
Skin Disorders ◽  
Origanum Vulgare ◽  
Beneficial Effects ◽  
Therapeutic Benefits ◽  
Dermatological Disorders ◽  
Phytochemical Profile ◽  
Geographical Characteristics

Origanum vulgare L. is a widely used aromatic plant, especially due to its content in essential oil, mainly rich in carvacrol and thymol. The ethnopharmacological uses of Origanum vulgare L. essential oil (OEO) comprise digestive, respiratory, or dermatological disorders. The review focuses on the increasing number of recent studies investigating several biological activities of OEO. The bioactivities are in tight relation to the phytochemical profile of the essential oil, and also depend on taxonomic, climatic, and geographical characteristics of the plant material. The antibacterial, antifungal, antiparasitic, antioxidant, anti-inflammatory, antitumor, skin disorders beneficial effects, next to antihyperglycemic and anti-Alzheimer activities were reported and confirmed in multiple studies. Moreover, recent studies indicate a positive impact on skin disorders of OEO formulated as nanocarrier systems in order to improve its bioavailability and, thus, enhancing its therapeutic benefits. The review brings an up to date regarding the phytochemistry and bioactivity of Origanum vulgare L. essential oil, underlining also the most successful pharmaceutical formulation used for skin disorders.

Social and psychological aspects of readiness of parents for the involvement of children with cerebral palsy in adaptive physical education classes

2021 ◽  
Vol 2 (2) ◽  
pp. 65-72
Author(s):  
Tatiana V. Sviridova ◽  
Anna A. Kuzivanova ◽  
Yuliia G. Semenova ◽  
Arsenii A. Modestov
Keyword(s):  
Cerebral Palsy ◽  
Positive Impact ◽  
People With Disabilities ◽  
Physical Culture ◽  
National Medical ◽  
Adaptive Physical Education ◽  
The Family ◽  
Children With Cerebral Palsy ◽  
Medical Indications ◽  
Positive Results

Introduction. Participation in the sports movement is an effective tool for the full-fledged socialization of people with disabilities. In this regard, one of the socially significant tasks of the state is to ensure the availability of conditions for practicing various sports and adaptive physical culture (APhC) for people with disabilities. Materials and methods. To study the socio-psychological readiness of the family to include a disabled child in APhC classes, a survey was conducted on 67 parents of children with cerebral palsy (CP). CP patients were observed at the National Medical Research Center of Children’s Health of the Ministry of Health of Russia in 2019-2020. The criteria for the inclusion of participants in the group of subjects were the informed consent of the parents, the presence of medical indications, and the absence of contraindications for the child to engage in APhC training. Results. There is presented objective data indicating a positive attitude of respondents to APhC as one of the most effective tools for the development of movements in children. The factors that determine the socio-psychological readiness of parents for this type of rehabilitation are awareness of the child’s health, emotional stability and focus on achieving positive results in the child’s socialization, sufficient adherence to treatment. Socio-psychological factors reducing the likelihood of including children in APhC classes include a pessimistic assessment of the child’s health and social prospects, insufficient awareness of the positive impact of APhC classes on the physical development of a CP child, an incomplete awareness of the institutions in which this type of assistance can be obtained, the place of residence, the low physical activity of parents. Conclusion. The study of the socio-psychological profiles of parents with different motivations for the participation of a CP child in APhC classes proves the need for a differentiated approach to the management of psychological and pedagogical work with parents.

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