scholarly journals Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview

Toxics ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 14
Author(s):  
Mathilda Alsen ◽  
Catherine Sinclair ◽  
Peter Cooke ◽  
Kimia Ziadkhanpour ◽  
Eric Genden ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Flame Retardants ◽  
Endocrine Disrupting Chemicals ◽  
National Institutes Of Health ◽  
Future Research ◽  
National Library ◽  
Comprehensive Overview ◽  
Carcinogenic Effect ◽  
Increased Risk ◽  
Endocrine Disrupting

Endocrine disruptive chemicals (EDC) are known to alter thyroid function and have been associated with increased risk of certain cancers. The present study aims to provide a comprehensive overview of available studies on the association between EDC exposure and thyroid cancer. Relevant studies were identified via a literature search in the National Library of Medicine and National Institutes of Health PubMed as well as a review of reference lists of all retrieved articles and of previously published relevant reviews. Overall, the current literature suggests that exposure to certain congeners of flame retardants, polychlorinated biphenyls (PCBs), and phthalates as well as certain pesticides may potentially be associated with an increased risk of thyroid cancer. However, future research is urgently needed to evaluate the different EDCs and their potential carcinogenic effect on the thyroid gland in humans as most EDCs have been studied sporadically and results are not consistent.

scholarly journals Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

2021 ◽  
Vol 22 (2) ◽  
pp. 933
Author(s):  
Maria E. Street ◽  
Karine Audouze ◽  
Juliette Legler ◽  
Hideko Sone ◽  
Paola Palanza
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Current Understanding ◽  
Future Research ◽  
Developmental Origins ◽  
Research Needs ◽  
Important Class ◽  
Testing Strategies ◽  
Endocrine Disrupting ◽  
Health And Disease

Endocrine disrupting chemicals (EDCs) are exogenous chemicals which can disrupt any action of the endocrine system, and are an important class of substances which play a role in the Developmental Origins of Health and Disease (DOHaD) [...]

scholarly journals Removal of endocrine disrupting chemicals and microbial indicators by a decentralised membrane bioreactor for water reuse

2012 ◽  
Vol 2 (2) ◽  
pp. 67-73 ◽  
Author(s):  
T. Trinh ◽  
B. van den Akker ◽  
H. M. Coleman ◽  
R. M. Stuetz ◽  
P. Le-Clech ◽  
...  
Keyword(s):  
Water Reuse ◽  
Membrane Bioreactor ◽  
Endocrine Disrupting Chemicals ◽  
Membrane Bioreactors ◽  
Log10 Reduction ◽  
High Quality ◽  
Comprehensive Overview ◽  
Microbial Indicators ◽  
Endocrine Disrupting ◽  
Small Footprint

Submerged membrane bioreactors (MBRs) have attracted a significant amount of interest for decentralised treatment systems due to their small footprint and ability to produce high quality effluent, which is favourable for water reuse applications. This study provides a comprehensive overview of the capacity of a full-scale decentralised MBR to eliminate 17 endocrine disrupting chemicals (EDCs) and five indigenous microbial indicators. The results show that the MBR consistently achieved high removal of EDCs (>86.5%). Only 2 of the 17 EDCs were detected in the MBR permeate, namely two-phenylphenol and 4-tert-octylphenol. Measured log10 reduction values of vegetative bacterial indicators were in the range of 5–5.3 log10 units, and for clostridia, they were marginally lower at 4.6 log10 units. Removal of bacteriophage was in excess of 4.9 log10 units. This research shows that MBRs are a promising technology for decentralised water reuse applications.

scholarly journals Assessing exposure of young children to common endocrine-disrupting chemicals in the home environment: a review and commentary of the questionnaire-based approach

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Karin English ◽  
Bridget Healy ◽  
Paul Jagals ◽  
Peter D. Sly
Keyword(s):  
Young Children ◽  
Exposure Assessment ◽  
Home Environment ◽  
Flame Retardants ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting Chemical ◽  
Direct Exposure ◽  
Endocrine Disrupting ◽  
Improved Methods ◽  
Infants And Young Children

AbstractAlthough infants and young children are particularly vulnerable to endocrine disrupting chemical (EDC) exposure, there is an absence of comprehensive exposure data for this age group. As young children spend the majority of their time indoors, improved methods of exposure assessment are needed to characterise the health risks from exposures in the home environment. Biologic assessment, which has been considered the gold standard for exposure assessment in recent years, is difficult to conduct in young children. Questionnaires are an alternative and indirect method of predicting exposure, which may overcome some of the limitations of direct exposure assessment.The feasibility of using a questionnaire-based approach to predict exposure of young children to EDCs in the home has yet to be comprehensively reviewed. Moreover, there is no one questionnaire that has been validated for predicting the exposure of infants to common EDCs in the home.The aim of this review is to discuss the use and validation of the questionnaire-based approach to predict exposure of children to chemicals from three common classes of EDCs in the home, namely, plasticisers, flame retardants, and insecticides. We discuss the strengths and weaknesses of the questionnaire-based approach as well as the important pathways of exposure in the home environment, by which to guide the design and validation of future exposure questionnaires.The findings from our review indicate that the questionnaire-based approach is a valuable tool in the prediction of exposure to persistent organic pollutants, as well as to toxicants that have consistent patterns of exposure. With improvements to the design and validation process, the questionnaire-based approach may also prove to be a reliable instrument in predicting exposure to EDCs with short-half lives, including bisphenol A, phthalates, and pyrethroid and organophosphate insecticides.

scholarly journals Resumen de Conferencias

2018 ◽  
Vol 5 (2) ◽  
pp. 5-33
Author(s):  
Asociación Colombiana de Endocrinología Diabetes y Metabolismo
Keyword(s):  
Type 2 Diabetes ◽  
Thyroid Cancer ◽  
Endocrine Disrupting Chemicals ◽  
Duration Of Treatment ◽  
Endocrine Disrupting ◽  
Síndrome Metabólico ◽  
Non Coding Rnas

Listado Conferencia Hipotiroidismo congénito: ¿qué se afecta además de la tiroides? . Raúl Calzada León Conferencia La etapa fetal extrauterina. Raúl Calzada León Conferencia Mecanismos del síndrome de resistencia a hormonas tiroideas (RTH). Guillermo Juvenal Conferencia Diagnóstico y tratamiento del hipopituitarismo. Karina Danilowicz Conferencia Deficiencia combinada de hormonas hipofisiarias. Karina Danilowicz Conferencia Melatonina, GH y trastornos metabólicos. Hugo Fideleff Conferencia Etapa de transición: una visión crítica. Hugo Fideleff Conferencia Tiroides y fertilidad. Marcos Abalovich Conferencia Síndromes hereditarios de tumores hipofisarios. Moisés Mercado Conferencia Impacto metabólico en la fertilidad del varón. Roald Gómez Pérez Conferencia Tratamiento del exoftalmos. Alicia Gauna Conferencia Terapias orientadas a la lesión metastásica en carcinoma diferenciado de tiroides. Inés Califano Conferencia Cirugía bariátrica y metabólica. César Ernesto Guevara Pérez Conferencia Endocrine disrupting chemicals, estrogen and epigenetics. Jon Entine Conferencia Insuficiencia renal y osteoporosis. Salomón Jasqui Conferencia Rebote adiposo temprano y riesgo cardiometabólico futuro: edad de inicio vs. persistencia de la obesidad. Raquel Burrows Conferencia Hasta dónde debemos tener en cuenta consideraciones de economía de la salud en nuestra práctica clínica. Juan José Gagliardino Conferencia ¿Estamos listos para implementar programas de prevención primaria en Latinoamérica? Pablo Aschner Conferencia Ginecomastia. Pablo Knoblovits (Argentina) Conferencia La disfunción eréctil en el síndrome metabólico. Pablo Knoblovits Conferencia Hiperaldosteronismo primario. Alejandro Román González, Carlos Alfonso Builes-Barrera Conferencia Obesidad, efectos ambientales y compuestos químicos. Fernando Lizcano Conferencia Microcarcinoma papilar de tiroides y vigilancia activa. Hernán Tala Conferencia The old and new times in treatment for osteoporosis? What medication for whom, sequence and duration of treatment?.  Michael McClung Conferencia Diabetes, osteoporosis and obesity: are they related?  Michael McClung, MD Conferencia Deregulation of non-coding Rnas in thyroid cancer. Alfredo Fusco, Pierlorenzo Pallante, Romina Sepe, Simona Pellecchia, Marco De Martino, Francesco Esposito, Alfredo Fusco Conferencia The new understanding of type 2 diabetes - simplicity revealed. Roy Taylor. Professor of Medicine and Metabolism, Newcastle University, UK

scholarly journals Paternal Occupational Exposure to Endocrine-Disrupting Chemicals as a Risk Factor for Leukaemia in Children: A Case-Control Study from the North of England

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Mark S. Pearce ◽  
Lucy R. Baxter ◽  
Louise Parker
Keyword(s):  
Occupational Exposure ◽  
Case Control Study ◽  
Endocrine Disrupting Chemicals ◽  
Control Group ◽  
Live Births ◽  
The North ◽  
Increased Risk ◽  
Endocrine Disrupting ◽  
Control Study ◽  
Polychlorinated Organic Compounds

Occupations with exposures to a variety of chemicals, including those thought to be potential endocrine disruptors, have been associated with an increased risk of leukaemia in offspring. We investigated whether an association exists between paternal occupations at birth involving such exposures and risk of leukaemia in offspring. Cases (n=958) were matched, on sex and year of birth, to controls from two independent sources, one other cancers, one cancer-free live births. Paternal occupations at birth were classified, using an occupational exposure matrix, as having “very unlikely,” “possible,” or “likely” exposure to six groups of potential endocrine-disrupting chemicals. There was a significantly increased risk of acute nonlymphocytic leukaemia (ANLL) for polychlorinated organic compounds (OR 1.95, 95% CI 1.08–3.54) only in comparison with cancer-free controls, and for phthalates (OR 1.61, 95% CI 1.00–2.61) only with registry controls. A number of other, including inverse, associations were seen, but limited to one control group only. No associations were seen with likely paternal exposure to heavy metals. The associations identified in this study require further investigation, with better exposure and potential confounding (for example maternal variables) information, to evaluate the likelihood of true associations to assess whether they are real or due to chance.

Effects of endocrine disruptors in aquatic mammals

2003 ◽  
Vol 75 (11-12) ◽  
pp. 2235-2247 ◽  
Author(s):  
M. C. Fossi ◽  
Letizia Marsili
Keyword(s):  
Endocrine Disruptors ◽  
Food Chain ◽  
State Of The Art ◽  
Endocrine Disrupting Chemicals ◽  
Future Research ◽  
Toxicological Effects ◽  
Aquatic Food Chain ◽  
Endocrine Disrupting ◽  
Aquatic Food ◽  
Aquatic Mammals

In the last few decades, various studies have shown that aquatic mammals are sensitive to the toxicological effects of certain xenobiotic compounds, including the large class of endocrine-disrupting chemicals (EDCs). Since some EDCs, particularly organochlorines, tend to bioaccumulate and biomagnify in the aquatic food chain, various aquatic mammals, particularly those high in the food chain, such as pinnipeds, odontocete cetaceans, and polar bears, are potentially "at risk". The main aim of this chapter is to define the state of the art on effects of endocrine disruptors in aquatic mammals, both freshwater and marine. Another aim is to formulate recommendations for future research in this field and finally to define what can be done internationally for hazard/risk assessment and communication of the findings.

scholarly journals Environmental Obesogens and Human Health

2021 ◽  
Author(s):  
Archisman Mahapatra ◽  
Priya Gupta ◽  
Anjali Suman ◽  
Rahul Kumar Singh
Keyword(s):  
Human Health ◽  
Endocrine Disruption ◽  
Adult Population ◽  
Endocrine Disrupting Chemicals ◽  
Model Systems ◽  
Health Concern ◽  
Increased Risk ◽  
Endocrine Disrupting ◽  
The World ◽  
Underlying Mechanisms

Obesity is an alarming public health concern that contributes to a substantially increased risk of multiple chronic disorders, including diabetes. As per WHO data, in 2016, almost 39% adult population of the world is overweight, 13% of them were obese. There is prominent evidence on the involvement of environmental endocrine-disrupting chemicals, termed obesogens, in the prevalence of this growing worldwide pandemic, obesity. The exaggerated effect of obesogens on endocrine disruption, lipid metabolism and homeostasis, adipocyte functioning, impaired thermogenesis, inflammation, epigenetics, and overall human health will be covered in this chapter. This chapter will discuss the environmental obesogen hypothesis, the epidemiological and experimental evidence of obesogens, its chemical characteristics, and possible mechanism of actions. It will also focus on some recent indications of obesogens and their correlation in COVID-19 disease pathogenesis. This chapter will try to conclude with strategies for identifying the underlying mechanisms of obesogens within model systems and the human body, including future directions.

scholarly journals The Impact of Endocrine-Disrupting Chemicals on Female Fertility

2020 ◽  
Vol 71 (6) ◽  
pp. 286-294
Author(s):  
Aida Petca ◽  
Nicoleta Maru ◽  
Mihai Cristian Dumitrascu ◽  
Madalina Sighencea ◽  
Florica Sandru ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Polycystic Ovary ◽  
Endocrine Disrupting Chemicals ◽  
Antral Follicle ◽  
Lower Probability ◽  
Vitro Fertilization ◽  
Increased Risk ◽  
Endocrine Disrupting ◽  
The Impact

Nowadays, infertility is a prevalent problem among couples. Exposure to endocrine-disrupting chemicals (EDCs) may influence the female reproductive outcomes through multiple mechanisms, being one of the important causes of infertility. These compounds may interfere with some fertility and fecundity markers, leading to increased time to pregnancy, increased risk of spontaneous abortion, shorter menstrual cycles, early age at menopause, anovulation or delayed ovulation, smaller preovulatory follicles, increased serum FSH, decreased synthesis of estradiol and progesterone, low plasma levels of anti-Mullerian hormone and decreased antral follicle count. Endocrine-disrupting chemicals may also impair in vitro fertilization outcomes, being responsible for: a lower probability of implantation, reduced fertilization rates, diminished probability of clinical pregnancy, and near term pregnancies after in vitro fertilization. Another mechanism of altering the female reproductive function is through the disorders induced by EDCs, such as polycystic ovary syndrome, uterine fibroids, and endometriosis. Those conditions may finally lead to infertility.

scholarly journals To Cull or Not To Cull? Considerations for Studies of Endocrine-Disrupting Chemicals

Endocrinology ◽  
2016 ◽  
Vol 157 (7) ◽  
pp. 2586-2594 ◽  
Author(s):  
Alexander Suvorov ◽  
Laura N. Vandenberg
Keyword(s):  
Laboratory Animal ◽  
Animal Studies ◽  
Metabolic Diseases ◽  
Endocrine Disrupting Chemicals ◽  
Animal Experiments ◽  
Postnatal Growth ◽  
Increased Risk ◽  
Wide Range ◽  
Endocrine Disrupting ◽  
Health Related

The power of animal models is derived from the ability to control experimental variables so that observed effects may be unequivocally attributed to the factor that was changed. One variable that is difficult to control in animal experiments is the number and composition of offspring in a litter. To account for this variability, artificial equalization of the number of offspring in a litter (culling) is often used. The rationale for culling, however, has always been controversial. The Developmental Origins of Health and Disease concept provides a new context to evaluate the pros and cons of culling in laboratory animal studies, especially in the context of endocrine-disrupting chemicals. Emerging evidence indicates that culling, especially of large litters, can drastically change the feeding status of a pup, which can result in compensatory growth with long-term consequences for the animal, including increased risk of cardio-metabolic diseases. Similarly, culling of litters to intentionally bias sex ratios can alter the animal's behavior and physiology, with effects observed on a wide range of outcomes. Thus, in an attempt to control for variability in developmental rates, culling introduces an uncontrolled or confounding variable, which itself may affect a broad spectrum of health-related consequences. Variabilities in culling protocols could be responsible for differences in responses to endocrine-disrupting chemicals reported across studies. Because litter sex composition and size are vectors that can influence both prenatal and postnatal growth, they are essential considerations for the interpretation of results from laboratory animal studies.

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