scholarly journals A Review on Polymeric Wound Dress for the Treatment of Burns and Diabetic Wounds

2021 ◽  
Vol 6 (2) ◽  
pp. 44-50
Author(s):  
Ashkan Farazin ◽  
Zahra Torkpour ◽  
Shakiba Dehghani ◽  
Ramin Mohammadi ◽  
Mina D. Fahmy ◽  
...  

Today, various commercial dressings have been developed and introduced to the market. The diversity makes it difficult for the nurse to choose the right type. Although the most important reason to use a wound dress is to protect the wound from infection and prevent infection, but in fact, the main purpose of using these materials is to speed up the wound healing process. Traumatic injuries result in an epithelial wound that disrupts the continuity of the skin surface. These differences reveal as abrasions, punctures, and injuries. Wounds are divided into two types; the skin is either cut or ruptured, including deep wounds and bruises, or surface wounds. Expedited wound healing has been considered since the archaic era of human civilization, with the earliest reported case from the Ancient Egyptians. Wound lesions in mummified humans were observed to be cover with animal skin, with signs of (primary/secondary) wound healing present. A "new wound dressing" is an advanced wound dress used in wound management as biocompatible and biodegradable biomaterials that heal wounds and burns. In the past, it was believed that dry wounds had expedited healing and wet wounds have been found to promote using re-epithelization and result in reduced scar formation. Wounds can be treated using various types of natural polymers and materials. Also, techniques like electrospinning and freeze-drying techniques can be used for the fabrication of standard wound dress. These wounds are associated with bandages, inflammation, bleeding, pain, and pus. In this work, we consider various types of wounds and techniques to treat the wound. Susceptibility to these areas, due to special symptoms for each of them. Products like hydrogels, hydrocolloids, films, sponges, and nano-fiber polymeric materials are used to promote healing. In this review, we examine the ideal products for the treatment of wounds in diabetic patients.

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 961
Author(s):  
Sibusiso Alven ◽  
Vuyolwethu Khwaza ◽  
Opeoluwa O. Oyedeji ◽  
Blessing A. Aderibigbe

The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.


Materials ◽  
2019 ◽  
Vol 12 (16) ◽  
pp. 2540 ◽  
Author(s):  
Federica Paladini ◽  
Mauro Pollini

Recent data have reported that the burden of infections related to antibiotic-resistant bacteria in the European Union and European Economic Area (EEA) can be estimated as the cumulative burden of tuberculosis, influenza, and human immunodeficiency virus (HIV). In wound management, the control of infections represents a crucial issue and a multi-billion dollar industry worldwide. For diabetic wounds ulcers, in particular, infections are related to the majority of amputations in diabetic patients, which today represent an increasing number of the elderly. The greatest barrier to healing is represented by the biofilm, an organized consortium of bacteria encapsulated in a self-produced extracellular polymeric substance with high resistance to conventional antimicrobial therapies. There is an urgent need for novel anti-biofilm strategies and novel antimicrobial agents and, in this scenario, silver nanotechnology has received tremendous attention in recent years in therapeutically enhanced healthcare. Due to its intrinsic therapeutic properties and the broad-spectrum antimicrobial efficacy, silver nanoparticles have opened new horizons towards novel approaches in the control of infections in wound healing. This review aims at providing the reader with an overview of the most recent progress in silver nanotechnology, with a special focus on the role of silver in the wound healing process.


2021 ◽  
Vol 9 (08) ◽  
pp. 1142-1159
Author(s):  
Ansumita Borsaikia ◽  
◽  
Saikat Sen ◽  
Pal Gogoi ◽  
Biplab Kumar Dev ◽  
...  

In most recent couple of a few years, there has been a unprecedented advancement in understanding the biochemical and cell occasions of typical injury recuperating or wound healing. Healing is survival mechanism and represents a trial to take care of normal complex body part and performance.Wound healing could be a process by which tissue regeneration occurs. Healing of wounds, either accidental or surgical interventions, involves complex activities of blood cells, tissues, soluble mediators, cytokines and several other growth factors. This increased cellular activity of damaged tissue enhances metabolic demands and active drug therapy. The main objective of treating a wound is to either shorten the time required for healing process or to reduce the undue effects. Plants because of presence of assorted valuable active phytoconstituents have immense potential for management and treatment of wounds over the years. All the Traditional systems of medicine, Ayurveda, Siddha and Unani describe applications of medication of plant, mineral and animal origin to treat and heal wounds. Herbal drugs induce healing and regeneration of lost tissue by number of mechanisms. Due to their traditional applicability, affordability and safety plants gained a reputed position within the world of wound management and repair.The present review is a trial to focus on various Indian ethno-medicinal plants which are to be scientifically proved for the treatment of wounds. Beside this review also emphasis on normal wound healing process, pharmacological activities and role of plants in wound management and parameters accustomed assess wound healing.


2020 ◽  
Vol 11 (SPL4) ◽  
pp. 937-948
Author(s):  
Tanaji D Nandgude ◽  
Syed Nateque Naser

A wound is damage to the typical anatomic structure. Wound healing is an immediate therapeutic response to injury. It is a creation of the combined response of some cell types towards injury. Wound healing takes place by a sequence of molecular events which cooperate to fix tissue integrity and cell work. In typical healthy individual under ordinary conditions, these physiological events take place smoothly. Though sometimes, these molecular events are arrested, this brings about in struggle to heal. There is an assortment of approaches for the way toward managing and controlling both acute injuries (acute wounds) and ceaseless non-mending wounds (chronic non-healing wounds). The principal objective of these two cases is to achieve better-wound healing. Ideal formulations of wound healing should not only enhance the healing process but also reduce pain, infection and loss of electrolytes, proteins and liquids from the injury. A broad scope of items typically introduced with target various parts of the wound healing process depends on numerous types of wounds and novel polymers utilised for the conveyance of medications to both acute and ceaseless injuries. These include alginate, hydrocolloids, hydrofibers, polyurethane, and hydrogels. This article gives particular importance to different novel approaches in the management of wound healing. This review draws out the data and hopes to provide understanding into traditional, current and imminent techniques and methods for wound management.


Author(s):  
Mokhamad Tirono ◽  
Farid Samsu Hananto ◽  
Ahmad Abtokhi

Background: Treatment of wounds in diabetes often gets less than perfect healing. One of the reasons for the difficulty in treating wounds in diabetes is the growth of aerobic and anaerobic bacteria. This study aims to determine the pulse voltage and treatment time that can optimally inactivate bacteria, and their effect on wound healing in mice suffering from diabetes. Methods: The study used electrical stimulation with a direct voltage of 10 volts given a pulse voltage of 50-80 volts, a width of 50 µs, and the number of pulses of 65 per second. The research samples were Staphylococcus aureus (S. aureus) and Pseudo-monas aeruginosa (P. aeruginosa) bacteria that grew on beef and mice (Mus musculus) with diabetes. The treatment for S. aureus and P. aeruginosa bacteria was carried out using a pulse voltage of 50-80 volts for 5-15 min/day and repeated for 3 days. Meanwhile, treatment of mice wounds was carried out with a pulse voltage of 80 volts for 15 min/day and repeated for 7 days. Results: The results showed that treatment with a pulse voltage of 50-80 volts and a treatment time of 5-15 min significantly reduced the number of S. aureus and P. aeruginosa bacteria in beef (p£0.05). Treatment with a pulse voltage of 80 volts for 15 min made beef free from bacteria. Meanwhile, treatment with a pulse voltage of 80 volts for 15 min per day for seven days resulted in the wound state of three mice in the maturation phase and two mice in the proliferation phase on day 8 with an average wound area of 0.108 cm 2. Conclusion: The treatment with a pulse voltage of 80 volts for 15 min made the beef sterile, the mice wounds healed quickly, and the mice not stressed. The higher the blood glucose level, the slower the wound healing process.  


2018 ◽  
Vol 315 (1) ◽  
pp. H71-H79 ◽  
Author(s):  
Alan J. Mouton ◽  
Osvaldo J. Rivera ◽  
Merry L. Lindsey

After myocardial infarction, remodeling of the left ventricle involves a wound-healing orchestra involving a variety of cell types. In order for wound healing to be optimal, appropriate communication must occur; these cells all need to come in at the right time, be activated at the right time in the right amount, and know when to exit at the right time. When this occurs, a new homeostasis is obtained within the infarct, such that infarct scar size and quality are sufficient to maintain left ventricular size and shape. The ideal scenario does not always occur in reality. Often, miscommunication can occur between infarct and remote spaces, across the temporal wound-healing spectrum, and across organs. When miscommunication occurs, adverse remodeling can progress to heart failure. This review discusses current knowledge gaps and recent development of the roles of inflammation and the extracellular matrix in myocardial infarction remodeling. In particular, the macrophage is one cell type that provides direct and indirect regulation of both the inflammatory and scar-forming responses. We summarize current research efforts focused on identifying biomarker indicators that reflect the status of each component of the wound-healing process to better predict outcomes.


Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4368
Author(s):  
Zintle Mbese ◽  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe

Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine is a developing biomedical field with the potential to decrease the need for an organ transplant. Wound management is challenging, particularly for chronic injuries, despite the availability of various types of wound dressing scaffolds in the market. Some of the wound dressings that are in clinical practice have various drawbacks such as poor antibacterial and antioxidant efficacy, poor mechanical properties, inability to absorb excess wound exudates, require frequent change of dressing and fails to offer a suitable moist environment to accelerate the wound healing process. Collagen is a biopolymer and a major constituent of the extracellular matrix (ECM), making it an interesting polymer for the development of wound dressings. Collagen-based nanofibers have demonstrated interesting properties that are advantageous both in the arena of skin regeneration and wound dressings, such as low antigenicity, good biocompatibility, hemostatic properties, capability to promote cellular proliferation and adhesion, and non-toxicity. Hence, this review will discuss the outcomes of collagen-based nanofibers reported from the series of preclinical trials of skin regeneration and wound healing.


2021 ◽  
Vol 40 ◽  
pp. 01002
Author(s):  
Dina Shokatayeva ◽  
Irina Savitskaya ◽  
Aida Kistaubayeva

The biological activity of postbiotic from Bacillus subtilis exometabolites was determined due to protein content - 0.541±13.4 mg/ml, the level of proteases - 7.8±0.3 U/ml and the presence of antimicrobial substances. A biocomposite material was developed by co-aggregation of bacterial cellulose, chitosan and Bacillus exometabolites. Modified BC gel film possesses high antagonistic activity against causative agents of wound infections: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis. The use of the obtained material in treatment of wounds on laboratory animals reduces healing time by an average of 20%. The developed bioactive wound dressings is intended for local application in order to optimize the wound healing process.


Author(s):  
. Rohmayanti ◽  
Estrin Handayani

Diabetes mellitus is a group of metabolic disease which facilitates diabetic wound foot. To prevent long diabetic wound complication and worse condition it is needed wound care for diabetic patient. Modern bandage has been used for recent wound care technique. The principles of modern wound care product are maintaining and watching over the humid environment of the wound to facilitate the wound healing process, maintaining liquid tissue deprivation and cell decease. This research was aimed to find out how modern wound bandage is applied to the diabetic patient and to find out the influence in healing wound phase. This research is qualitative research using phenomenology approach, 4 wound diabetic patients who were hospitalized for 2 weeks using modern wound care method in Magelang regency were participated. The participants were elected using purposive sampling method. Observation and interview were used to obtain data, data was analyzed using explanation building method. The results of this research have 4 topics which are wound examination, type of modern bandage, the way of wound care, and the influence toward the wound. Bates-Jensen Wound was used for the wound examination, the type of bandage used were hydrogel and wound ointment, TIME management approach was used in wound care, and the wound care influences the decreasing of wound size, wound proliferation and granulation. Modern bandage application of diabetic wound influences the decreasing of wound size, wound proliferation and granulation. Paramedic is suggested to use modern wound care method in diabetic wound management.


2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110425
Author(s):  
Jiaqi Zeng ◽  
Zhen Li ◽  
Feiyan Lin ◽  
Shaohong Fu ◽  
Jingyi Li ◽  
...  

Skin aging is an inevitable physiological process and periorbital wrinkling is an active sign of the process. Laser therapy is an effective method for improving periorbital wrinkles and wound care after laser therapy can accelerate the wound healing process. This case report describes a typical case of a 47-year-old male that presented with a 10-year history of gradually-worsening bilateral periorbital wrinkles. These were treated using a 2940 nm erbium (Er):YAG lattice laser combined with recombinant bovine basic fibroblast growth factor (bFGF) gel and hydrogel (HG) treatment on the left side of his face compared with laser therapy and bFGF gel on the right side of his face. HG combined with bFGF gel treatment after 2940 nm Er:YAG lattice laser therapy improved postoperative swelling and pigmentation compared with bFGF gel alone; and it promoted periorbital wrinkle improvement and wound healing. In conclusion, HG combined with GFs after laser therapy could be an alternative therapy for periorbital wrinkles.


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