scholarly journals Concept of the influence of SARS -COV-2 viruses on cell malignancy

2021 ◽  
Vol 11 (4) ◽  
pp. 37-40
Author(s):  
Ivan Reva ◽  
Tatsuo Yamamoto ◽  
Galina Reva ◽  
Dmitriy Zvyagintsev ◽  
Viktor Usov ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Effective Treatment ◽  
Cancer Development ◽  
Intercellular Interactions ◽  
Cytopathic Effects ◽  
Cambial Cells ◽  
Available Information ◽  
Cell Malignancy ◽  
In Cells

To date, in the context of the COVID 19 pandemic, there are rumors and speculations about the consequences of the infection, as well as a concern on growing cancer risk due to vaccines and vaccination. In this study we reviewed the concepts of the viral action on cancer development and analyzed the data on the possibility of the malignant effect of the SARS-CoV-2 virus on cells. Analysis of the literature data showed that SARS-CoV-2 damages cells, like other viruses, but does not lead to their mutations. There are no changes in DNA, there is only misregulation of repression and expression of the genome, a perversion of signaling intercellular interactions that disrupt the mechanisms of differentiation and specialization of cells. The need of viruses to multiply in cambial cells of tissues contributes to the induction of their proliferation and the lack of specialization. Thus, the available information on the cytopathic effects caused by viruses in cells infected with COVID-19 does not yet provide information on the malignant effect of SARS-CoV-2. Our study is aimed at collecting and analyzing data that are necessary for planning effective treatment of patients with COVID 19 and predicting outcomes in the long term after the disease.

Placental Therapy as Panacea: An Insight to Its Therapeutic Potential

2020 ◽  
Vol 06 ◽  
Author(s):  
Sayed Md Mumtaz ◽  
Madhu Gupta ◽  
Ramesh K. Goyal
Keyword(s):  
Tissue Regeneration ◽  
Therapeutic Potential ◽  
Biologically Active ◽  
Bioactive Components ◽  
Biochemical Mechanisms ◽  
Clinically Significant ◽  
Available Information ◽  
Clinical Potential ◽  
Placental Extract

Abstract:: The placenta that maintains and regulates the growth of fetus, consists of various biological treasures nutrients such as cytomedines, vitamins, trace elements, amino acids, peptides, growth factors and other biologically active constituents. Their therapeutic usefulness can well define in the terms of biochemical mechanisms of various components present in it. Biomedical waste derived extract is also a panacea for treatment of various diseases. Placental therapy has been reported specifically to have potent action on recovery of diseases and tissue regeneration. Placental bioactive components and their multi targeting identity prompted us to compile the précised information on placental extract products. However, some findings are needed to be explored by scientific community to prove their clinical potential with clinically significant statistical conclusions. In the light of available information and the usefulness of the placental extract, it is necessary for the development of various formulations for various unmet meet for the treatment as well as access their adverse effects as well as contradictions and precisely evaluated in the short and in the long-term periods.

Long‐term risk of cancer development among anti‐Th/To antibody‐positive systemic sclerosis patients: comment on the article by Mecoli et al.

2021 ◽  
Author(s):  
Yuta Yamashita ◽  
Yasuhiko Yamano ◽  
Yoshinao Muro ◽  
Haruka Koizumi ◽  
Takuya Takeichi ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Cancer Development ◽  
Risk Of Cancer

scholarly journals Is Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus?

2021 ◽  
Vol 22 (12) ◽  
pp. 6444
Author(s):  
Anna Gabryanczyk ◽  
Sylwia Klimczak ◽  
Izabela Szymczak-Pajor ◽  
Agnieszka Śliwińska
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Deficiency ◽  
Cancer Development ◽  
Increased Risk

There is mounting evidence that type 2 diabetes mellitus (T2DM) is related with increased risk for the development of cancer. Apart from shared common risk factors typical for both diseases, diabetes driven factors including hyperinsulinemia, insulin resistance, hyperglycemia and low grade chronic inflammation are of great importance. Recently, vitamin D deficiency was reported to be associated with the pathogenesis of numerous diseases, including T2DM and cancer. However, little is known whether vitamin D deficiency may be responsible for elevated cancer risk development in T2DM patients. Therefore, the aim of the current review is to identify the molecular mechanisms by which vitamin D deficiency may contribute to cancer development in T2DM patients. Vitamin D via alleviation of insulin resistance, hyperglycemia, oxidative stress and inflammation reduces diabetes driven cancer risk factors. Moreover, vitamin D strengthens the DNA repair process, and regulates apoptosis and autophagy of cancer cells as well as signaling pathways involved in tumorigenesis i.e., tumor growth factor β (TGFβ), insulin-like growth factor (IGF) and Wnt-β-Cathenin. It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation. Although, numerous studies revealed that adequate vitamin D concentration prevents or delays T2DM and cancer development, little is known how the vitamin affects cancer risk among T2DM patients. There is a pressing need for randomized clinical trials to clarify whether vitamin D deficiency may be a factor responsible for increased risk of cancer in T2DM patients, and whether the use of the vitamin by patients with diabetes and cancer may improve cancer prognosis and metabolic control of diabetes.

scholarly journals Endo-sponge Assisted Early Surgical Closure of Ileal Pouch-anal Anastomotic Leakage Preserves Long-term Function: A Cohort Study

2019 ◽  
Vol 13 (12) ◽  
pp. 1537-1545
Author(s):  
Karin A Wasmann ◽  
Maud A Reijntjes ◽  
Merel E Stellingwerf ◽  
Cyriel Y Ponsioen ◽  
Christianne J Buskens ◽  
...  
Keyword(s):  
Cohort Study ◽  
Effective Treatment ◽  
Anastomotic Leakage ◽  
Ileal Pouch ◽  
Pelvic Sepsis ◽  
Surgical Closure ◽  
Pouch Failure ◽  
Pouch Function ◽  
And Control

Abstract Background and Aims Endo-sponge [Braun Medical] assisted early surgical closure [ESC] is an effective treatment to control pelvic sepsis after ileal pouch-anal anastomosis [IPAA] leakage, and became standard treatment in our centre from 2010 onwards. The aim of this cohort study was to assess the long-term pouch function of ulcerative colitis [UC] patients treated with ESC or conventional management [CM] for anastomotic leakage after IPAA. Methods Consecutive patients who underwent an IPAA for UC between 2002 and 2017 were included. Patients treated with ESC [2010–2017] or CM [2002–2009] for anastomotic leakage were compared with control patients without anastomotic leakage of the corresponding time period. Main endpoints were long-term pouch function on a 3-point scale and pouch failure, as measured with the validated pouch dysfunction score questionnaire. Results Some 280 of 334 patients [84%] returned the pouch dysfunction questionnaire, of whom 18 were treated with ESC and 22 with CM for anastomotic leakage. Control cohorts included 133 [2010–2017] and 107 patients [2002–2009]. Between ESC-treated patients and control patients, pouch function [p = 0.647] and pouch failure rates [0/18 versus 5/133, p >0.99] were similar. CM resulted in worse pouch function [p = 0.016] and a higher pouch failure rate [5/22 versus 5/107, p = 0.013] compared with control patients. Conclusions ESC, in contrast to CM, for IPAA leakage in UC patients is associated with preservation of pouch function and preclusion of pouch failure, probably due to early and effective treatment of pelvic sepsis.

scholarly journals Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Krzysztof Michalak ◽  
Aleksandra Sobolewska-Włodarczyk ◽  
Marcin Włodarczyk ◽  
Justyna Sobolewska ◽  
Piotr Woźniak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Enzyme Activity ◽  
Antibiotic Therapy ◽  
Effective Treatment ◽  
Social Problem ◽  
Fenton Reaction ◽  
Current Paper ◽  
Bivalent Cations

Long-term fluoroquinolone-associated disability (FQAD) after fluoroquinolone (FQ) antibiotic therapy appears in recent years as a significant medical and social problem, because patients suffer for many years after prescribed antimicrobial FQ treatment from tiredness, concentration problems, neuropathies, tendinopathies, and other symptoms. The knowledge about the molecular activity of FQs in the cells remains unclear in many details. The effective treatment of this chronic state remains difficult and not effective. The current paper reviews the pathobiochemical properties of FQs, hints the directions for further research, and reviews the research concerning the proposed treatment of patients. Based on the analysis of literature, the main directions of possible effective treatment of FQAD are proposed: (a) reduction of the oxidative stress, (b) restoring reduced mitochondrion potential ΔΨm, (c) supplementation of uni- and bivalent cations that are chelated by FQs and probably ineffectively transported to the cell (caution must be paid to Fe and Cu because they may generate Fenton reaction), (d) stimulating the mitochondrial proliferation, (e) removing FQs permanently accumulated in the cells (if this phenomenon takes place), and (f) regulating the disturbed gene expression and enzyme activity.

Mo2003 Long-Term Prospective Observational Study of Cancer Risk Among Pantoprazole Users

2015 ◽  
Vol 148 (4) ◽  
pp. S-765
Author(s):  
Douglas A. Corley ◽  
Francesca Kolitsopoulos ◽  
Jennifer L. Schneider
Keyword(s):  
Cancer Risk ◽  
Observational Study ◽  
Prospective Observational Study

DIAGNOSTIC MARKERS OF ANTIPHOSPHOLIPID SYNDROME

2021 ◽  
Vol 2 (1) ◽  
pp. 5-10
Author(s):  
Galyamova K.I.
Keyword(s):  
Autoimmune Disease ◽  
Antiphospholipid Syndrome ◽  
Pregnancy Complications ◽  
Main Part ◽  
Diagnostic Markers ◽  
Systemic Autoimmune Disease ◽  
Term Study ◽  
Long Term Study ◽  
In Cells

Antiphospholipid syndrome is a systemic autoimmune disease, the main part of pathogenesis of which is induc-tion of an inflammatory and procoagulant state in cells, thrombosis of venous and/or arterial vessels and, as a consequence, pregnancy complications. [4] Despite the long-term study of this pathology, the mechanism of its development is still not fully understood, what makes it more difficult to diagnose, prevent and treat this disease and to assess the risks of its complications.

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