scholarly journals Faktor Risiko yang Berhubungan dengan Kejadian Kelainan Bawaan pada Neonatus

e-CliniC ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Febriano Matthew ◽  
Rocky Wilar ◽  
Adrian Umboh
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Literature Review ◽  
Maternal Age ◽  
Congenital Abnormalities ◽  
Common Factor ◽  
Congenital Disorders ◽  
Factors Associated ◽  
Organ Systems ◽  
History Of

Abstract Congenital abnormalities are one of the main causes of infant mortality worldwide. Their symptoms vary from mild to severe. This study was aimed to determine the risk factors associated with the incidence of congenital abnormalities. This was a literature review study. The results obtained 10 articles that discussed about the risk factors of congenital abnormalities. The incidence of congenital abnormalities was more common in males. The most common factor was the maternal age of 20+ years Especially in Indonesia, there was no significant data about the risk factors related to the incidence of congenital abnormalities, however, two journals from Indonesia showed an increased incidence of congenital abnormalities in women infected during pregnancy. In addition, there were other risk factors found only in one to two journals, such as exposure to cigarettes, consumption of drugs or narcotics, and family history of previous congenital disorders. The review also covered several congenital disorders classified in organ systems dominated by the cardiovascular system. In conclusion, the risk factors associated with congenital abnormalities are maternal age, multiparity, history of abortion, congenital abnormalities in previous pregnancies, gestational diabetes, exposure to cigarette smoke, consumption of alcohol, consumption of drugs, not taking folic acid, family history of congenital abnormalities, consanguinity, and low socioeconomic statusKeywords: risk factor, birth defect, congenital anomalies, neonates                                                                         Abstrak Kelainan kongenital merupakan salah satu penyebab utama kematian bayi di dunia dengan gejala bervariasi dari ringan hingga berat. Penelitian ini bertujuan untuk mengetahui faktor risiko yang berhubungan dengan kejadian kelainan kongenital. Jenis penelitian ialah literature review. Hasil penelitian mendapatkan 10 artikel mengenai faktor risiko kejadian kelainan kongenital. Kejadian kelainan kongenital lebih sering terjadi pada jenis kelamin laki-laki. Faktor risiko yang paling sering ialah usia ibu saat hamil mulai 20 tahun hingga lebih. Khusus di Indonesia belum ada data bermakna yang menunjukkan faktor risiko yang berhubungan dengan kejadian kelainan kongenital, namun dua artikel dari Indonesia menunjukkan peningkatan kejadian kelainan kongenital pada ibu yang terinfeksi saat hamil. Faktor risiko lainnya yang hanya didapatkan pada satu hingga dua jurnal saja seperti, paparan rokok, konsumsi obat maupun narkoba, serta riwayat keluarga yang pernah mengalami kejadian kelainan bawaan sebelumnya. Hasil kajian juga mendapatkan beberapa diagnosis penyakit kelaianan kongenital yang di golongkan dalam sistem organ, didominasi oleh sistem kardiovaskular. Simpulan penelitian ini ialah faktor risiko yang berhubungan dengan kelainan kongenital ialah usia ibu, multiparitas, riwayat abortus, kelainan ba kongenital waan pada kehamilan sebelumnya, diabetes gestasional, paparan asap rokok, konsumsi alkohol, konsumsi obat-obatan, tidak mengonsumsi asam folat, riwayat keluarga mengalami kelainan kongenital, adanya hubungan darah antara ayah dan ibu, dan status sosioekonomi rendahKata kunci: faktor resiko, kelainan kongenital, neonatus

scholarly journals Study of Risk Factors Associated with Suicide Attempt in Patients with Bipolar Disorder Type I

2020 ◽  
Vol 11 (02) ◽  
pp. 291-298
Author(s):  
Karthick Subramanian ◽  
Vikas Menon ◽  
Siddharth Sarkar ◽  
Vigneshvar Chandrasekaran ◽  
Nivedhitha Selvakumar
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Logistic Regression ◽  
Family History ◽  
Suicide Attempt ◽  
Coping Strategies ◽  
Binary Logistic Regression ◽  
Type I ◽  
Factors Associated ◽  
History Of

Abstract Background Suicide is the leading contributor to mortality in bipolar disorder (BD). A history of suicidal attempt is a robust predictive marker for future suicide attempts. Personality profiles and coping strategies are the areas of contemporary research in bipolar suicides apart from clinical and demographic risk factors. However, similar research in developing countries is rarer. Objectives The present study aimed to identify the risk factors associated with suicidal attempts in BD type I (BD-I). Materials and Methods Patients with BD-I currently in clinical remission (N = 102) were recruited. Sociodemographic details and the clinical data were collected using a semistructured pro forma. The psychiatric diagnoses were confirmed using the Mini-International Neuropsychiatric Interview 5.0. The National Institute of Mental Health–Life Chart Methodology Clinician Retrospective Chart was used to chart the illness course. Presumptive Stressful Life Events Scale, Coping Strategies Inventory Short Form, Buss–Perry aggression questionnaire, Past Feelings and Acts of Violence, and Barratt Impulsivity scale were used to assess the patient’s stress scores, coping skills, aggression, violence, and impulsivity, respectively. Statistical Analysis Descriptive statistics were used for demographic details and characteristics of the illness course. Binary logistic regression analyses were performed to identify the predictors for lifetime suicide attempt in BD-I. Results A total of 102 patients (males = 49 and females = 53) with BD-I were included. Thirty-seven subjects (36.3%) had a history of suicide attempt. The illness course in suicide attempters more frequently had an index episode of depression, was encumbered with frequent mood episodes, especially in depression, and had a higher propensity for psychiatric comorbidities. On binary logistic regression analysis, the odds ratios (ORs) for predicting a suicide attempt were highest for positive family history of suicide (OR: 13.65, 95% confidence interval [CI]: 1.28–145.38, p = 0.030), followed by the presence of an index depressive episode (OR: 6.88, 95% CI: 1.70–27.91, p = 0.007), and lower scores on problem-focused disengagement (OR: 0.72, 95% CI: 0.56–0.92, p = 0.009). Conclusion BD-I patients with lifetime suicide attempt differ from non-attempters on various course-related and temperamental factors. However, an index episode depression, family history of suicide, and lower problem-focused engagement can predict lifetime suicide attempt in patients with BD-I.

scholarly journals 346. Factors Associated with Hypertension in Young Adults with Perinatally-Acquired HIV Infection: a Case–Control Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S184-S184
Author(s):  
Patrick O’Neil ◽  
Patrick Ryscavage ◽  
Kristen A Stafford
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Family History ◽  
Case Control Study ◽  
Case Control ◽  
Systemic Hypertension ◽  
Early Management ◽  
Factors Associated ◽  
History Of ◽  
Control Study

Abstract Background The incidence of systemic hypertension (HTN) among perinatally-HIV-infected (PHIV) patients appears to increase as they enter adulthood. Among non-perinatally HIV-infected adults both traditional and HIV-associated risk factors have been found to contribute to HTN. Whether these same factors contribute to HTN in PHIV is unknown. The purpose of this study was to determine the socio-demographic, clinical, virologic, and immunologic factors associated with HTN among a cohort of PHIV adolescents and young adults, aged ≥18 years. Methods We conducted a case–control study among a population of 160 PHIV adults with and without HTN who were receiving care at the University of Maryland and aged 18–35 years as of December 31, 2017. Covariates assessed included traditional risk factors such as age, family history of HTN, and smoking, as well as HIV- and antiretroviral-associated covariates. Results We identified 49 HTN cases (30.6%) and 111 (69.4%) controls. There were no significant differences in the odds of most traditional (age, gender, race, family history of HTN, tobacco, alcohol, and/or other drug use) or HIV-associated (CD4 nadir <100 cells/mm3, individual ART exposure, ART interruption) risk factors among PHIV adults with HTN compared with those with no diagnosis of HTN. Cases had lower odds of a history of treatment with lopinavir/ritonavir (LPV/r). Cases had 3.7 (95% CI 1.11, 12.56) times the odds of a prior diagnosis of chronic kidney disease (CKD) compared with controls after controlling for CD4 nadir and ARV treatment history. Conclusion The results of this study suggest that most traditional and HIV-related risk factors do not appear to increase the odds of having HTN in this PHIV cohort. However, HTN among PHIV may be driven in part by CKD, and a focus on the prevention and early management of CKD in this group may be necessary to prevent the development of HTN. Additionally, there may be as yet unidentified risk factors for HTN among PHIV which require further exploration. Given the large and growing population of PHIV entering adulthood worldwide, it is imperative to explore risk factors for and effects of HTN in large, diverse PHIV populations. Disclosures All authors: No reported disclosures.

scholarly journals A family history of type 2 diabetes increases risk factors associated with overfeeding

Diabetologia ◽  
2010 ◽  
Vol 53 (8) ◽  
pp. 1700-1708 ◽  
Author(s):  
D. Samocha-Bonet ◽  
L. V. Campbell ◽  
A. Viardot ◽  
J. Freund ◽  
C. S. Tam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Family History ◽  
Factors Associated ◽  
History Of

scholarly journals Risk Factors for Early Recurrence of Gallstones in Patients Undergoing Laparoscopy Combined With Choledochoscopic Lithotomy: A Single-Center Prospective Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Bo Wang ◽  
Anhua Huang ◽  
Min Jiang ◽  
Haidong Li ◽  
Wenqing Bao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Prospective Study ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Gallbladder Wall ◽  
Postoperative Recurrence ◽  
Factors Associated ◽  
History Of

Objective: For patients with gallstones, laparoscopy combined with choledochoscopic lithotomy is a therapeutic surgical option for preservation rather than the removal of the gallbladder. However, postoperative recurrence of gallstones is a key concern for both patients and surgeons. This prospective study was performed to investigate the risk factors for early postoperative recurrence of gallstones.Methods: The clinical data of 466 patients were collected. Each patient was followed up for up to 2 years. The first follow-up visit occurred 4 months after the operation, and a follow-up visit was carried out every 6 months thereafter. The main goal of each visit was to confirm the presence or absence of gallbladder stones. The factors associated with gallstone recurrence were analyzed by univariate analysis and Cox regression.Results: In total, 466 eligible patients were included in the study, and 438 patients (180 men and 258 women) completed the 2-year postoperative follow-up. The follow-up rate was 94.0%. Recurrence of gallstones was detected in 5.71% (25/438) of the patients. Univariate analysis revealed five risk factors for the recurrence of gallstones. Multivariate Cox regression analysis showed that multiple gallstones, a gallbladder wall thickness of ≥4 mm, and a family history of gallbladder stones were the three predictive factors for postoperative recurrence of gallstones (P &lt; 0.05).Conclusion: The overall 2-year recurrence rate of gallstones after the operation was 5.71%. Multiple gallstones, a gallbladder wall thickness of ≥4 mm, and a family history of gallstones were the three risk factors associated with early postoperative recurrence of gallstones.

scholarly journals Parental risk factors associated with congenital heart disease in a Thai population: multivariable analysis

2021 ◽  
Vol 15 (6) ◽  
pp. 267-276 ◽  
Author(s):  
Chayamon Suwansumrit ◽  
Worawan Jittham
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Cigarette Smoke ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Multivariable Analysis ◽  
Significant Risk ◽  
Maternal Exposure ◽  
Factors Associated ◽  
History Of

Abstract Background Congenital heart diseases (CHDs) are the most common types of birth defects and contribute to a large proportion of infant morbidities and mortalities worldwide. These defects may require multiple surgical interventions impacting the infant's quality of life. Objectives To identify risk factors associated with CHD in a population of Thai children. Methods We conducted a case–control study of patients attending the Pediatric Clinic, Naresuan University Hospital, Thailand. We included data from pediatric patients diagnosed with CHDs as cases, and patients without cardiovascular abnormalities as controls. Risk data were collected from July 2019 to April 2020 using face-to-face interviews. Multiple logistic regression was used to analyze parental factors associated with CHDs. Results We included 249 cases classified into 2 groups according to severity and 304 patients as controls. For those less-severely affected (155 patients, 62.2%), ventricular septal defect (27.7%) was the most prevalent, whereas for those with severe CHDs, tetralogy of Fallot was the most prevalent (14.0%). There was no difference in sex distribution or maternal obstetric history between the groups. In multivariable analysis, a family history of CHDs (adjusted odds ratio [AOR] 4.67, 95% confidence interval (CI) 1.61–13.57, P = 0.005) and maternal exposure to second-hand cigarette smoke (AOR 1.58, 95% CI 1.03–2.42, P = 0.002) were identified as significant risk factors for CHDs. Conclusion A family history of CHDs and maternal exposure to second-hand cigarette smoke are associated with having offspring with CHDs in the population studied. These findings help us to encourage affected parents to obtain a fetal echocardiogram.

scholarly journals Profile of Hypospadias Cases in Central Java, Indonesia

2015 ◽  
Vol 1 (1) ◽  
pp. 16
Author(s):  
Ziske Maritska ◽  
Ardy Santosa ◽  
Mahayu Dewi Ariani ◽  
Achmad Zulfa Juniarto ◽  
Sultana MH Faradz
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Environmental Factors ◽  
Observational Study ◽  
Maternal Age ◽  
Genetic Factors ◽  
Multifactorial Disease ◽  
Central Java ◽  
Birth Characteristics ◽  
History Of

Background: Hypospadia is believed to be a multifactorial disease.  The risk factors that may induce the formation of hypospadias are environmental factors, endocrine disruptors, and genetic factors. The aim of this study was to describe the profile of hypospadias patients who visited the Center for Biomedical Research (CEBIOR), Faculty of Medicine, Diponegoro University, Semarang, Indonesia.Methods: This study is an observational study, using patients’ medical record in CEBIOR from 2010 to 2012. The hypospadias cases were classified into syndromic, isolated and severe hypospadias based on their phenotype. The history of pregnancy, birth characteristics, and family history of the patients were described.Results: There were 120 cases of hypospadias, consisted of 48.33% severe hypospadias, 41.67% mild isolated hypospadias and 10% syndromic hypospadias. There were 38.33% hypospadias cases whose mothers were being exposed to repellant usage and 39.17% cases whose fathers were smoking. Forty (33.33%) probands’ mothers were aged above 35 years old when they gave birth to their affected son.Conclusion: Majority of hypospadias cases were severe and mild isolated. Environtmental factors including maternal age more than 35 years old, use of repellant, and smoking fathers were found in this study.  

scholarly journals Risk factors associated with spontaneous abortion in Dr. Soetomo General Hospital Surabaya: a case-control study

2021 ◽  
Vol 7 (1) ◽  
pp. 65-80
Author(s):  
Safira Zakira ◽  
Gatut Hardianto
Keyword(s):  
Risk Factors ◽  
General Hospital ◽  
Spontaneous Abortion ◽  
Maternal Death ◽  
Maternal Age ◽  
Case Control ◽  
Bivariate Analysis ◽  
Factors Associated ◽  
History Of ◽  
Maternal Disease

The Maternal Mortality Ratio (MMR) in Indonesia is still fairly high. One of the top three causes of maternal death is bleeding. Spontaneous abortion is an early pregnancy problem leading to the occurrence of bleeding and direct maternal death. The causes of spontaneous abortion vary and can be caused by multiple factors. Early identification of risk factors is necessary to reduce mortality and morbidity due to spontaneous abortion and its complications. This study's objective was to identify the risk factors of spontaneous abortion in Dr. Soetomo General Hospital. This study was an observational analytic with a case-control approach. The population was all pregnant women hospitalized at the Obstetrics and Gynaecology Department in Dr. Soetomo General Hospital from January 2017 to December 2018. The samples were 120 in total, included  40 cases and 80 controls taken by consecutive sampling. The data were analyzed using univariate and bivariate analysis with the Chi-square test. The results based on the bivariate analysis showed history of previous abortion (p <0.001), chronic maternal disease (p <0.001), hemoglobin levels (p = 0.020), maternal age (p= 0.026), gravidity (p= 0.036), and  infection (p= 0.037) had significant correlation with spontaneous abortion. In conclusion, risk factors associated with spontaneous abortion in Dr. Soetomo General Hospital were history of previous abortion, chronic maternal disease, anemia, advanced maternal age, multigravidity, and infection. Positive pregnancy outcomes are expected to play a role in reducing MMR in Indonesia. Therefore, high-risk pregnant women are suggested to carry out regular Antenatal care recommendations with intensive supervision.

scholarly journals Risk Factors Associated with Gestational Diabetes among Pregnant Women in Owerri Municipal Council, Southeastern Nigeria

2013 ◽  
Vol 5 (1) ◽  
pp. 39-46 ◽  
Author(s):  
JC Nwaokoro ◽  
CO Emerole ◽  
SNO Ibe ◽  
AN Amadi ◽  
INS Dozie
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Significant Relationship ◽  
Previous History ◽  
Southeastern Nigeria ◽  
Family History Of Diabetes ◽  
Factors Associated ◽  
History Of

Background Gestational diabetes is emerging as a serious public health problem in Nigeria where the largest number of people with diabetes in Africa occurs. Current studies in Nigeria give an overall prevalence of gestational diabetes as 13.4% among pregnant women with unidentified risk factors. Aims and Objectives This study aimed at investigating the risk factors associated with gestational diabetes. Materials and Methods A cross-section analytical study design was adopted for this research and comprising a total of 100 pregnant women receiving ante-natal health care service at the Federal Medical Center, Owerri. A structured questionnaire including a set of detailed pre-determined questions was administered on the subjects. Data collected were analyzed statistically, using chi-square and T test. Results The results obtained suggest that there is a significant relationship (p<0.05) between previous macrosomic baby, parity, previous history of caesarean section, family history of diabetes and occurrence of gestational diabetes, respectively. However, there is no significant relationship (p>0.05) between history of miscarriages and stillbirth, socioeconomic status and occurrence of gestational diabetes. A family history of diabetes is independently and significantly associated with the development of gestational diabetes itself even after adjusting for other risk factors. Conclusion This study will be a working tool to guide obstetricians and midwives in counseling and advising women of their risk of developing GDM. DOI: http://dx.doi.org/10.3126/ajms.v5i1.8302 Asian Journal of Medical Science Vol.5(1) 2014 pp.39-46  

Factors associated with recurrent transient global amnesia: systematic review and pathophysiological insights

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ioannis Liampas ◽  
Maria Raptopoulou ◽  
Stefanos Mpourlios ◽  
Vasileios Siokas ◽  
Zisis Tsouris ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Family History ◽  
Positive Family History ◽  
Transient Global Amnesia ◽  
Personal History ◽  
Factors Associated ◽  
Family Medical History ◽  
History Of ◽  
Global Amnesia

Abstract The examination of the risk factors that affect the recurrence of transient global amnesia (TGA) may shed light on the pathophysiological substrate of the disease. A systematic review was performed to identify the factors associated with the recurrence of TGA. MEDLINE, EMBASE, CENTRAL and PsycINFO were meticulously searched. Observational controlled studies involving patients with single (s-TGA) and recurrent TGA (r-TGA) according to Hodges and Warlow’s criteria were retrieved. Differences in the demographic characteristics, personal and family medical history, previous exposure to precipitating events and laboratory findings were examined. Retrieved evidence was assessed in the context of the individual article validity, based on the numerical power and methodological quality of each study. Nine cohort studies with retrospective, prospective or mixed design were retrieved. In total, 1989 patients with TGA were included, 269 of whom suffered from r-TGA (13.5%). R-TGA presented an earlier age of onset. Evidence was suggestive of a relationship between recurrence and a family or personal history of migraine, as well as a personal history of depression. There was weaker evidence that associated recurrence with a positive family history of dementia, a personal history of head injury and hippocampal lesions in diffusion-weighted MRI. On the other hand, no connection was found between recurrence and electroencephalographic abnormalities, impaired jugular venous drainage, cardiovascular risk factors, atrial fibrillation, previous cerebrovascular events, exposure to precipitating events, a positive family history of TGA and hypothyroidism. Important pathophysiological insights that arised from these findings were discussed.

scholarly journals Socio-demographic risk factors associated with febrile seizures at Puducherry: a retrospective study

2020 ◽  
Vol 7 (5) ◽  
pp. 1130
Author(s):  
Gobinaath . ◽  
Arun Daniel J.
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Age At Onset ◽  
Febrile Seizures ◽  
Factors Associated ◽  
Younger Age ◽  
History Of ◽  
Demographic Risk ◽  
Tract Infections ◽  
Demographic Risk Factors

Background: Febrile seizures occur commonly in the under 5 age group and is associated with few risk factors causing its recurrence like very high fever, family history of seizures, low sodium levels and younger age of onset which are subject to seasonal and wide geographical variations. This study aimed at detecting the major risk factors associated with recurrent febrile seizures in an Indian population.Methods: A retrospective hospital-based study was conducted among a total of 300 cases aged 6 months to 5 years attending to the paediatric OPD with history of fever followed by febrile seizures. Information regarding socio-demographic and clinical variables associated with febrile seizure was collected and analyzed.Results: The mean age of the study participants was 25.6±2.2 months and majority (60%) were males. Family history of seizures was present in 25.3% (n=76) of the children with febrile seizures. Respiratory infections (73.3%) and gastroenteritis (17%) were the major infective reasons associated with the occurrence of febrile seizures followed by pneumonia (6.3%) and urinary tract infections (5%). Recurrence of FS was significantly higher among the children with family history of FS (p=0.009), age at onset lesser (p<0.001) and simple FS seizures.Conclusions: Younger age at onset and positive family history of seizures were important socio-demographic risk factors associated with recurrent febrile seizures.

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