scholarly journals UJI AKTIVITAS ANTIDIABETES DARI EKSTRAK DAUN SESEWANUA (Clerodendron squamatum Vahl.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.)

PHARMACON ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 774
Author(s):  
Billy N. Nangoy ◽  
Edwin De Queljoe ◽  
Adithya Yudistira
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Pancreatic Beta Cells ◽  
Blood Sugar Level ◽  
Pancreatic Beta Cell ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Leaf Extracts ◽  
White Rats ◽  
Sugar Levels

ABSTRACTSesewanua leaves contain flavonoids which can be potentially as antidiabetic. Flavonoids reduce blood sugar levels by capturing free radicals that cause damage to pancreatic beta cells and inhibit pancreatic beta cell damage. The purpose of this study was to determine the effect of antidiabetic activity on the administration of Sesewanua (Clerodendron squamatum Vahl.) Leaf extracts in wistar white rats (Rattus norvegicus) induced by Aloxan. This type of research is a laboratory experiment using a completely randomized design. Test animals are grouped into 5 groups each consisting of 3 test animals. The negative control group (K-) was not treated, the positive control group (K +) was given metformin, groups 2, 3, and 4 were treated with different extract concentration of 200, 400, and 800 mg. Before the treatment was done the rats were examined the initial blood sugar level, then induced alloxan monohydrate 120 mg / kg BW intraperitonially (ip), and checked the blood sugar level on the 3rd day and continued with the administration of the leaf extracts of the animal every two days until the 14th day. The results showed that sesewanua leaf extracts with a concentration of 200, 400, and 800mg had a decreased activity in blood sugar levels from day 4 to day 14 with a decrease of 13.66 mg / dL in the concentration group 1, 43 mg / dL in the dose concentration 2, and 103 mg / dL in the concentration group 3. Keywords: Blood Glucose, Clerodendron squamatum Vahl., Flavonoids,  Rattus norvegicus ABSTRAKDaun sesewanua mengandung flavonoid yang dapat berpotensi sebagai antidiabetes. Flavonoid menurunkan kadar gula darah dengan cara menangkap radikal bebas penyebab kerusakan sel beta pankreas dan menghambat kerusakan sel beta pankreas. Tujuan penelitian ini adalah mengetahui efek aktivitas antidiabetes terhadap pemberian ekstrak Daun Sesewanua (Clerodendron squamatum Vahl.) pada Tikus Putih Galur Wistar (Rattus norvegicus) yang telah diinduksi Aloksan. Jenis penelitian ini adalah eksperimen laboratorium menggunakan rancangan acak lengkap. Hewan uji dikelompokan dalam 5 kelompok masing-masing terdiri dari 3 ekor hewan uji. Kelompok kontrol negatif (K-) tidak diberi perlakuan, kelompok kontrol positif (K+) diberikan metformin, Kelompok 2, 3, dan 4 diberi perlakuan dengan konsentras ekstrak yang berbeda-beda yaitu 200, 400, dan 800 mg. Sebelum perlakuan dilakukan tikus diperiksa kadar gula darah awal, kemudian diinduksi aloksan monohidrat 120 mg/kgBB secara intraperitonial (ip), dan diperiksa kadar gula darah pada hari ke-3 dan dilanjutkan dengan pemberian ekstrak daun sesewanua setiap dua hari sekali sampai hari ke-14. Hasil penelitian menunjukkan bahwa ekstrak daun sesewanua dengan konsentrasi 200, 400 , dan 800mg memiliki aktivitas penurunan kadar gula darah dari hari ke-4 sampai hari ke-14 dengan penurunan sebesar 13.66 mg/dL pada kelompok konsentrasi 1, 43 mg/dL pada kelompok konsentrasi 2, dan 103 mg/dL pada kelompok konsentrasi 3. Kata Kunci: Clerodendron squamatum Vahl., Flavonoid, Glukosa Darah, Rattus norvegicus

scholarly journals THE EFFECTIVENESS OF CORIANDER (Coriandrum sativum L.) EXTRACTS ON REDUCING THE BLOOD SUGAR LEVELS OF ALLOXAN INDUCED WISTAR MALE RATS (Rattus norvegicus L.)

2020 ◽  
Vol 6 (1) ◽  
pp. 36-44
Author(s):  
Kalvin Dersing
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Water Extract ◽  
Coriandrum Sativum ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Wistar Strain ◽  
Sugar Levels

AbstractBackground : Diabetes mellitus is the most common metabolic syndrome in the whole world with an incidence of 1-8%. This disease arises when insufficient insulin is produced or insulin cannot function properly.The ability of coriander juice water extract is expected to reduce blood glucose levels because the action is similar to insulin and can stimulate insulin release. Purpose : Knowing effectiveness coriander extract (Coriandrum sativum L.)to decline blood sugar levels in male white rats (Rattus norvegicus L.) wistar strain induced by alloxan. Method : This is a pure experimental study (true-experiment) using a pre and post test design with control group design using subjects namely white rats (Rattus norvegicus L.) male Wistar strain aged 10-12 weeks with a weight of 150-200 grams. By looking at changes in blood sugar levels during administration of alloxan and administration of coriander extract. Results : There were significant changes in some groups induced alloxan (p <0.05), but the effect of coriander extract was not very significant (p> 0.05). Conclusion : Coriander extract can control blood sugar levels to be stable or normal, but it takes longer and more research.  Keywords : coriander extract, blood sugar levels, alloxan

scholarly journals UJI EFEKTIVITAS EKSTRAK BUAH PINANG YAKI (Areca vestiaria) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) YANG DI INDUKSI ALOKSAN

PHARMACON ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 416
Author(s):  
Raynaldo M. Ludong ◽  
Edwin De Queljoe ◽  
Herny E. I. Simbala
Keyword(s):  
Treatment Group ◽  
Beta Cell ◽  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Pancreatic Beta Cell ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Sample Treatment ◽  
Treatment Groups ◽  
Sugar Levels

ABSTRACTThe result of phytochemical analysis showed that Pinang Yaki extracts contains tannins, flavonoids and triterpenoid. One of the compounds thought to have antidiabetic activity is flavonoids. Flavonoids are generally thought to regenerate pancreatic beta cell damage due to aloxan induction and can reduce blood glucose levels by stimulating pancreatic beta cell to produce insulin. This study aims to determine the effectiveness of areca nut extract to reduce blood sugar levels of male white wistar rats which are induced by aloxan. This Type of research is laboratory experiments using Complete Random Design (CRD). Twelve rats were divided into 4 treatment groups with each group consisting of 3 rats. The first group was the negative control group (K-) only given aquades, the second Group was positive control (K+) given metformin, group three was the sample treatment group (PS1) with an extract dose of 400 mg, and the sample treatment group (PS2) with an extract dose of 800 mg. Previously rats were examined the fasting blood sugar, then induced aloxan monohydrate dose of 150 mg/kgBW intraperitoneally, and blood sugar levels were examined once in every two days for 7 days. On the 8th  day extract was given and blood sugar levels were examined every two days until the 14th day. The result showed that extract of Pinang Yaki fruit at a dosage of 400 mg  and 800 mg had activities to reduce blood    sugar levels on the 8th to 14th day with a decrease of 38 mg/dL for the PS1 treatment groups and 29 mg/dL for the PS2 sample treatment group. Keywords  : Areca vestiaria, Rattus Norvegicus, Blood Sugar Levels, Flavonoids ABSTRAKHasil analisis Fitokimia menunjukkan bahwa ekstrak buah Pinang yaki (Areca vestiaria) mengandung senyawa tanin, flavonoid dan triterpenoid. Salah satu senyawa yang diduga memiliki aktivitas sebagai antidiabetes adalah flavonoid. Flavonoid secara umum diduga dapat meregenerasi kerusakan sel beta pankreas akibat induksi aloksan dan dapat menurunkan kadar glukosa darah dengan merangsang sel beta pankreas untuk memproduksi insulin. Penelitian ini bertujuan mengetahui efektivitas ekstrak buah Pinang Yaki terhadap Penurunan kadar gula darah tikus putih jantan galur wistar yang dinduksi aloksan. Jenis penelitian ini ialah eksperimen laboratorium. Menggunakan Rancangan Acak Lengkap (RAL). Dua belas ekor tikus di bagi kedalam 4 kelompok perlakuan dengan masing-masing kelompok terdiri dari 3 ekor tikus. Kelompok Pertama merupakan kelompok Kontrol negative (K-) dengan hanya di berikan aquades, kelompok kedua merupakan kontrol positif (K+) yang diberikan metformin, Kelompok tiga merupakan kelompok Perlakuan sampel (PS1) dengan dosis ekstrak 400 mg, dan kelompok perlakuan sampel (PS2) dengan dosis ekstrak 800 mg. Sebelumnya tikus dilakukan pemeriksan gula darah puasa, selanjutnya diinduksi aloksan monohidrat dosis 150 mg/kgBB secara intraperitoneal, dan dilakukan pemeriksaan kadar gula darah dua hari sekali selama 7 hari. Pada hari ke-8 dilakukan pemberian ekstrak dan dilakukan pemeriksaan kadar gula darah setiap dua hari sekali sampai hari ke-14. Hasil penelitian menunjukkan bahwa ekstrak buah pinang yaki dosis 400 mg dan 800 mg memiliki aktivitas menurunkan kadar gula darah pada hari ke-8 sampai hari ke-14 dengan penurunan sebesar 38 mg/dL untuk kelompok perlakuan sampel PS1 dan 29 mg/dL untuk kelompok perlakuan sampel PS2. Kata kunci  : Areca vestiaria, Rattus norvegicus, Kadar Gula Darah, Flavonoid

UJI AKTIVITAS PENURUNAN KADAR GULA DARAH EKSTRAK ETANOL DAUN PINANG YAKI (Areca vestiaria) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) YANG DIINDUKSI ALOKSAN

PHARMACON ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 449
Author(s):  
Rifo Mongi ◽  
Herny E. I. Simbala ◽  
Edwin De Queljoe
Keyword(s):  
Treatment Group ◽  
Blood Sugar ◽  
Group Treatment ◽  
Rattus Norvegicus ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Research Subjects ◽  
Treatment Groups ◽  
Sugar Levels

ABSTRACTThe results of phytochemical analysis showed that Areca vestiaria leaves contain terpenoids, steroids and tannins. One compound that is thought to have antidiabetic activity is tannin. This study aims to determine the decrease of blood sugar levels caused by ethanol extract of pinang yaki leaves (Areca vestiaria) in male white wistar (Rattus norvegicus) strain induced by aloxan. This type of research is laboratory experiments using a Completely Randomized Design (CRD). The research subjects were twelve mice divided into 4 treatment groups with each group consisting of 3 mice. The first group was the negative control group (K-) not given treatment, the second group was positive control (K+) given metformin, the third group was the treatment group sample I (PSl) with an extract dose of 400 mg / kgBW, and the fourth group was the group treatment of sample 2 (PS2) with an extract dose of 800 mg / kgBW. Before being treated in mice, fasting blood sugar was examined, and then aloxan monohydrate 150 mg / kgBW induced intraperitonially (ip), and blood sugar levels were examined once every two days until the  day. After that, it was continued with the administration of ethanol extacts of pinang yaki leaves every two days until the  day. The results showed that extracts of pinang yaki leaves at a dose of 400 mg / kgBW and 800 mg / kgBW decreased the blood sugar levels from day 8 to day 14 with a decreasing value of 61.33 mg / mL for treatment groups 1 and 3l mg / mL for treatment group 2.Keywords       : Areca vestiaria, Rattus norvegicus, Tannin, Blood glucose. ABSTRAK Hasil analisis Fitokimia menunjukan bahwa ekstrak daun pinang yaki (Areca vestiaria) mengandung senyawa terpenoid, steroid dan tannin. Salah satu senyawa yang diduga memiliki aktivitas sebagai antidiabetes adalah tannin. Penelitian ini bertujuan untuk mengetahui aktivitas penurunan kadar gula darah yang disebabkan oleh ekstrak etanol daun pinang yaki (Areca vestiaria) pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi aloksan. Jenis penelitian ini ialah eksperimen laboratorium menggunakan Rancangan Acak Lengkap (RAL). Subyek penelitian dua belas ekor tikus dibagi ke dalam 4 kelompok perlakuan dengan masing-masing kelompok terdiri dari 3 ekor tikus. Kelompok pertama merupakan kelompok kontrol negatif (K-) tidak diberi perlakuan, kelompok kedua merupakan kontrol positif (K+) yang diberikan metformin, kelompok ketiga merupakan kelompok perlakuan sampel 1 (PS1) dengan dosis ekstrak 400 mg/kgBB, dan kelompok keempat yang merupakan kelompok perlakuan sampel 2 (PS2) dengan dosis ekstrak 800 mg/kgBB. Sebelum diberi perlakuan pada tikus dilakukan pemeriksaan gula darah puasa, dan selanjutnya tikus diinduksi aloksan monohidrat 150 mg/kgBB secara intraperitonial (ip), dan dilakukan pemeriksaan kadar gula darah dua hari sekali sampai hari ke-7. Setelah itu dilanjutkan dengan pemberian ekstrak etanol daun pinang yaki setiap dua hari sekali hingga hari ke-14. Hasil penelitian menunjukan bahwa ekstrak daun pinang yaki dengan dosis 400 mg/kgBB dan 800 mg/kgBB memiliki aktivitas penurunan kadar gula darah dari hari ke-8 sampai hari ke -14 dengan penurunan sebesar 61,33 mg/mL untuk kelompok perlakuan 1 dan 31 mg/ml untuk kelompok perlakuan 2. Kata kunci      : Areca vestiaria, Rattus norvegicus, Tannin, Glukosa darah.

scholarly journals Mechanism of Pancreatic Islet Number Improvement on Hyperglycemic Wistar Rats (Rattus norvegicus) After Golden Sea Cucumber (Stichopus hermanii) Extract Administration

2020 ◽  
Vol 9 (3S) ◽  
pp. 320-324
Keyword(s):  
Blood Sugar ◽  
Pancreatic Islet ◽  
Blood Sugar Level ◽  
Sea Cucumber ◽  
Histopathological Examination ◽  
Ethanol Extract ◽  
Male Rats ◽  
Laboratory Research ◽  
Control Group ◽  
Sugar Levels

Diabetes mellitus constitutes a metabolic disorder indicated by a decrease in insulin secretion, insulin insensitivity, or a combination of both. Golden sea cucumber (Stichopus hermanii) is a natural resource of Indonesian waters with benefit for reducing blood sugar levels. This research aimed to determine the anti-hyperglycemic mechanism of golden sea cucumber.This study used a experimental laboratory research with Post-test Only Control Group. The sample of this study consisted of 25 male rats aged 60-70 days, divided into 5 groups: K(-), K(+), P1, P2, and P3 randomly. Rats from K(+), P1, P2, and P3 groups were injected with streptozotocin (STZ) with a dose of 50 mg/kg BW. Treatment was administered for 21 days. K(-) and K(+) groups were fed normally while P1, P2 and P3 groups were given golden sea cucumber 80% ethanol extract with a dose of 4,25 mg/kgBW/day, 8,50 mg/kgBW/day and 12,75 mg/kgBW/day respectively. On the 22nd day, fasting blood sugar level was measured and the number of pancreatic islet was counted with histopathological examination. The administration of golden sea cucumber (Stichopus hermanii) extract on rats with hyperglycemia does not reduce blood sugar level, but the extract administration increases the number of pancreatic islet. Golden sea cucumber (Stichopus hermanni) extract may improve the number of pancreatic islet and prevent the progressive damage of pancreatic islet.C

scholarly journals Garlic: an alternative in reducing blood glucose on diabetic patients

2020 ◽  
Vol 7 (6) ◽  
pp. 2078
Author(s):  
Putri Dafriani ◽  
Roza Marlinda ◽  
Eliza Arman ◽  
Meldafia Idaman
Keyword(s):  
Blood Sugar ◽  
Group Intervention ◽  
Blood Sugar Level ◽  
Intervention Group ◽  
Antidiabetic Drugs ◽  
Control Group ◽  
Diabetic Patients ◽  
Post Test ◽  
Quasi Experimental ◽  
Sugar Levels

Background: Diabetes mellitus (DM), a metabolic disorder characterized by an increasing of blood sugar (hyperglycemia). Medication is one of the seven pillars of diabetes managementt. Garlic (Allium sativum), an alternative herb, also has an antidiabetic effect. The purpose of this study was to investigate the effect of garlic on the blood sugar level in type 2 diabetes mellitus.Methods: This study was a quasi-experimental design with two group post-test design. The participants were DM patients who only take medication without any supplemental herbs. The respondents were divided into two group; intervention group, given antidiabetic drugs and consume garlic 3 pieces of garlic/day for 2 weeks and control group only got antidiabetic drugs. Data were collected by performing blood sugar measurement using glucose-check on all respondents using capillary blood in the fingertips. Second measurement were taken after monitoring the consumption of garlic together with drugs for two weeks. Hypothesis testing used independent T-Test test.Results: The study result found that the average of blood sugar level after administering the treatment is 240 mg/dl in the intervention group, and 284 mg/dl in control group. It can be concluded that the administration of 3 pieces of garlic combining with antidiabetic drugs for 2 weeks has not been able to reduce blood sugar levels into normal limits.Conclusions: This combination found to lowering the blood sugar levels in a significant amount compare to only drugs. The length of the therapy could consider as a significant predictor.

scholarly journals Antidiabetes Serbuk Umbi Tanaman Yakon (Smallanthus sonchifolius) pada Kadar Gula Darah Tikus Putih (Rattus norvegicus)

2021 ◽  
Vol 7 (1) ◽  
pp. 56-62
Author(s):  
Thatit Nurmawati ◽  
Yeni Kartika Sari ◽  
Fina Ayu Ningtyas
Keyword(s):  
Treatment Group ◽  
Blood Sugar ◽  
T Test ◽  
Control Group ◽  
Control Group Design ◽  
Glucose Levels ◽  
Smallanthus Sonchifolius ◽  
White Rats ◽  
Comparison Results ◽  
Sugar Levels

The routine and long-term use of oral antidiabetic drugs in DM patients can make the public's perception worried about the side effects of the drug. In the Yakon (SS) plant tuber there is Fructooligosacaraide (FOS) which can reduce blood sugar levels. The research objective was to determine the effect of Yakon plant tubers on blood sugar levels in white rats with type 2 diabetes mellitus model. This type of research was experimental with a pre-post test design with control-group design. Independent variable, administration of Yakon plant tuber powder, dependent variable, blood glucose levels. The sample was divided into 2 groups (dose 1, dose 2) and a control group, each of 6 rats. The mice were given a high carbohydrate diet for 9 weeks. Treatment dose 1 (100 mg / kgBB) for 3 days. Measurement of blood sugar levels using Gluco-Dr. Data analysis used Paired Sample T-test, Independent Sample T-test, and One Way Anova. The results showed that the rats in the treatment group dose 1 experienced a decrease in the average blood sugar level of 122.83 mg / dl (p 0.002) (p 0.009). This shows that there is an effect of using Yakon plant tuber powder on blood sugar levels. The results of this study were the control group and the treatment group dose 1 (Sig. (2-tailed) = 0.000, α = 0.05). Meanwhile, the comparison results showed that there was a difference between the control group and the treatment group at dose 1, Based on the above research, Yakon tubers can be used to reduce blood sugar levels.

scholarly journals Therapeutic Effect of Red Spinach (Amaranthus tricolor L.) Extract on Pancreatic MDA Levels Rats (Rattus norvegicus) Exposed to MLD-STZ

2021 ◽  
Vol 7 (3) ◽  
pp. 129-133
Author(s):  
Kartika Rahma ◽  
Ois Nurcahyanti
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Amaranthus Tricolor ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels ◽  
Spinach Extract ◽  
Sugar Levels

Background: Several studies have reported that an increase in blood glucose in patients with diabetes mellitus (DM) can cause complications to death that occur due to oxidative stress conditions due to excessive ROS production. Red spinach extract was found to be rich in antioxidant compounds. However, there has been no further research on the ability of red spinach to lower blood glucose levels and prevent oxidative stress, which can be seen from the levels of malondialdehyde (MDA; a marker of oxidative stress) in the DM body.Objective: This study aims to determine whether there is a change in blood glucose levels and MDA levels in DM animal models between the groups that were given red spinach extract and not.Methods: This study used white rats (Rattus norvegicus) which were divided into 5 groups: K(-) group in which the rats were not induced by diabetogenic agent and were not treated; K(+) group, the rats were made DM induced by multiple low dose streptozotocin (MLD-STZ); and T1, T2, and T3 groups were exposed to MLD-STZ and treated with red spinach extract (Amaranthus tricolor L.) at a dose of 200 mg/kgBW, 300 mg/kgBW and 400 mg/kgBW, respectively. Blood sugar levels were checked before and after treatment with extract using glucometer digital. Meanwhile, MDA levels were measured by TBA test using protein isolates from the pancreas of each rat.Results: The results showed that the average MDA levels in the K-, K+, T1, T2, and T3 groups were 1.759±0.08, 2.280±0.15, 2.303±0.11, 1.927±0.06, and 1.801±0.04. While the average blood sugar levels in the K-, K+, T1, T2, and T3 groups were 114.4±8.82, 464±72.78, 421.2±37.60, 140.6±20.19, and 176±13.06.Conclusion: It can be concluded that the administration of red spinach extract therapy in DM model rats was able to reduce both glucose levels and MDA levels. By lowering the levels of MDA compounds, it is also believed to be able to prevent oxidative stress in cells which causes tissue damage.

scholarly journals Ekstrak Etanol Kopi Hijau Arabika (Coffea arabica L.) sebagai Antihiperglikemi pada Mencit (Mus musculus)

2020 ◽  
pp. 140-147
Author(s):  
Irawati Hamdani ◽  
Salfauqi Nurman
Keyword(s):  
Chlorogenic Acid ◽  
Blood Sugar ◽  
Mus Musculus ◽  
Coffea Arabica ◽  
Blood Sugar Level ◽  
Control Group ◽  
Green Coffee ◽  
Sugar Levels ◽  
Levene Test ◽  
Coffea Arabica L

Diabetes mellitus is an excessive level of blood sugar concentration disease. One of the compounds that can moderate the blood sugar level is chlorogenic acid that mostly found in green coffee. This study aims to determine the extract activity of Arabica (Coffea arabica L.) green coffee in decreasing the blood sugar level of mice (Mus musculus) that induced by alloxan monohydrate. The method is True Experimental Laboratories with the analysis of chlorogenic acid levels using a UV-Vis spectrophotometer. The research design is Post Test Control Group Design, using 24 mices that divided into six treatment groups. The groups consist of negative control (distilled water), Dose I (100 mg/kg bw), Dose II (200 mg/kg bw), Dose III (300 mg/kg bw), Dose IV (400 mg/kg bw), and positive control (metformin). Blood sugar levels of the mice is measured at the intervals of 1st day, 7th day, 21st day. The data is analyzed using the SPSS program with normality tests (Kolmogorov-Smirnov), homogeneity tests (Levene Test), and parametric statistical tests (One-Way ANOVA). The data results was normally distributed and homogeneous (P> 0.05) with several pairs of data in the treatment group were significantly different (P> 0.05). The extract of Arabica (Coffea arabica L.) green coffee contained 4.235% chlorogenic acid, could reduced the hyperglycemia mice blood sugar levels by the dose of 10.72% (Dose I); 19.85% (Dose II); 27.20% (Dose III); and 31.60% (Dose IV) with dose IV as the effective dose.

scholarly journals PENGARUH PEMBERIAN EKSTRAK UMBI BAWANG MERAH (Allium cepa L) TERHADAP KADAR GULA DARAH TIKUS WISTAR (Rattus norvegicus) YANG DIINDUKSI DENGAN ALOKSAN

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Bryan Y. Kairupan ◽  
Mona P. Wowor ◽  
Christi Mambo
Keyword(s):  
Blood Sugar ◽  
Allium Cepa ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Control Group ◽  
Glucose Levels ◽  
Onion Bulbs ◽  
Blood Glucose Levels ◽  
Allium Cepa L ◽  
Sugar Levels

Abstract: People sure that onion bulbs ( Allium cepa L ) has a lot of advantage for health one of which is to lower blood sugar levels. The objective of this research were study the effectiveness of administration of onion bulbs extract on blood glucose levels of Wistar rats (Rattus norvegicus) induced by alloxan. The subject of research using laboratory animals such as male Wistar rats that were 18 samples were divided into 6 groups, the negative control group, and 5 groups of Wistar rats with alloxan-induced hyperglycemic dose of 130 mg / kg body weight of rats. In the group with hyperglycemic rats given onion bulbs extract at a dose of 9 mg, 18 mg, and 36 mg / 200 g body weight of rats, the positive control group was given novomix flexpen, and 1 group were only given alloxan. Data obtained from the results of blood sugar tests in all groups Wistar rats on the first day, second day, third in minutes 0, 6, 12, 18, and 24 hours. The results showed extract of onion bulbs (Allium cepa L) had an effect on blood glucose levels drop Wistar rats that had induced alloxan.Keywords: Allium cepa L, onion bulbs, blood sugar levels, alloxanAbstrak: Umbi bawang merah (Allium cepa L) diyakini masyarakat memiliki banyak manfaat bagi kesehatan salah satunya yaitu menurunkan kadar gula darah. Penelitian ini bertujuan untuk menguji pengaruh pemberian ekstrak umbi bawang merah terhadap kadar gula darah tikus wistar (Rattus norvegicus) yang diinduksi aloksan. Subjek penelitian menggunakan hewan uji berupa tikus wistar jantan yang berjumlah 18 ekor yang dibagi dalam 6 kelompok, kelompok kontrol negatif, dan 5 kelompok tikus wistar hiperglikemik yang diinduksi aloksan dengan dosis 130 mg/kg berat badan tikus. Kelompok tikus hiperglikemik diberi ekstrak umbi bawang merah dengan dosis 9 mg, 18 mg, dan 36 mg/ 200 g BB tikus, kelompok kontrol positif diberikan novomix flexpen, dan 1 kelompok yang hanya diberikan aloksan. Data diperoleh dari hasil pemeriksaan gula darah pada semua kelompok tikus wistar pada hari pertama, hari kedua, ketiga pada menit ke- 0, jam ke- 6, 12, 18, dan 24. Hasil penelitian menunjukkan pemberian ekstrak umbi bawang merah (Allium cepa L) mempunyai efek terhadap penurunan kadar gula darah tikus Wistar yang telah diinduksi aloksan.Kata kunci: Allium cepa L, Umbi Bawang Merah, Kadar Gula Darah, Aloksan

scholarly journals Effect of Iles-Iles (Amorphophallus oncophyllus) Synbiotic Effervescent Tablet to Decrease in Blood Sugar Levels in Hyperglycemic White Rat (Rattus norvegicus)

2020 ◽  
Vol 2 ◽  
pp. 00004
Author(s):  
Ngatirah Ngatirah ◽  
Meidi Syaflan ◽  
Satria A. N
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Normal Dose ◽  
White Rats ◽  
Randomized Design ◽  
Treatment Dose ◽  
Completely Randomized Design ◽  
Sugar Levels ◽  
And Control ◽  
Effervescent Tablet

This study aims to determine the effect of giving Iles-iles synbiotic effervescent tablets to decrease blood sugar levels of hyperglycemic white rats and find out the lowest dose of effervescent tablets in decreasing blood sugar levels. This study used the Completely Randomized Design (CRD) with single factor (dose of Iles-iles synbiotic effervescent tablet) with 4 levels (dose 0.045 gram/day (½ normal dose), dose 0.09 gram/day (normal dose), dose 0.18 gram/day (2X normal dose) and Control (without treatment dose). The analysis carried out was blood sugar levels and rat body weight. The administration of Iles-iles synbiotic effervescent tablets can reduce blood sugar levels in white mice but does not affect changes in the weight of white mice. The biggest decrease in blood sugar levels in white rats for synbiotic month was obtained from the administration of a dose of 0.18 grams/day (normal 2X dose) which was as much as 49.16% The administration of effervescent tablets in the fourth week with a normal dose of 0.09 grams/200 grams of weight has been able to reduce blood sugar levels in white rats to normal levels.&nbsp;

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