scholarly journals Ekstrak Etanol Kopi Hijau Arabika (Coffea arabica L.) sebagai Antihiperglikemi pada Mencit (Mus musculus)

2020 ◽  
pp. 140-147
Author(s):  
Irawati Hamdani ◽  
Salfauqi Nurman
Keyword(s):  
Chlorogenic Acid ◽  
Blood Sugar ◽  
Mus Musculus ◽  
Coffea Arabica ◽  
Blood Sugar Level ◽  
Control Group ◽  
Green Coffee ◽  
Sugar Levels ◽  
Levene Test ◽  
Coffea Arabica L

Diabetes mellitus is an excessive level of blood sugar concentration disease. One of the compounds that can moderate the blood sugar level is chlorogenic acid that mostly found in green coffee. This study aims to determine the extract activity of Arabica (Coffea arabica L.) green coffee in decreasing the blood sugar level of mice (Mus musculus) that induced by alloxan monohydrate. The method is True Experimental Laboratories with the analysis of chlorogenic acid levels using a UV-Vis spectrophotometer. The research design is Post Test Control Group Design, using 24 mices that divided into six treatment groups. The groups consist of negative control (distilled water), Dose I (100 mg/kg bw), Dose II (200 mg/kg bw), Dose III (300 mg/kg bw), Dose IV (400 mg/kg bw), and positive control (metformin). Blood sugar levels of the mice is measured at the intervals of 1st day, 7th day, 21st day. The data is analyzed using the SPSS program with normality tests (Kolmogorov-Smirnov), homogeneity tests (Levene Test), and parametric statistical tests (One-Way ANOVA). The data results was normally distributed and homogeneous (P> 0.05) with several pairs of data in the treatment group were significantly different (P> 0.05). The extract of Arabica (Coffea arabica L.) green coffee contained 4.235% chlorogenic acid, could reduced the hyperglycemia mice blood sugar levels by the dose of 10.72% (Dose I); 19.85% (Dose II); 27.20% (Dose III); and 31.60% (Dose IV) with dose IV as the effective dose.

scholarly journals Mechanism of Pancreatic Islet Number Improvement on Hyperglycemic Wistar Rats (Rattus norvegicus) After Golden Sea Cucumber (Stichopus hermanii) Extract Administration

2020 ◽  
Vol 9 (3S) ◽  
pp. 320-324
Keyword(s):  
Blood Sugar ◽  
Pancreatic Islet ◽  
Blood Sugar Level ◽  
Sea Cucumber ◽  
Histopathological Examination ◽  
Ethanol Extract ◽  
Male Rats ◽  
Laboratory Research ◽  
Control Group ◽  
Sugar Levels

Diabetes mellitus constitutes a metabolic disorder indicated by a decrease in insulin secretion, insulin insensitivity, or a combination of both. Golden sea cucumber (Stichopus hermanii) is a natural resource of Indonesian waters with benefit for reducing blood sugar levels. This research aimed to determine the anti-hyperglycemic mechanism of golden sea cucumber.This study used a experimental laboratory research with Post-test Only Control Group. The sample of this study consisted of 25 male rats aged 60-70 days, divided into 5 groups: K(-), K(+), P1, P2, and P3 randomly. Rats from K(+), P1, P2, and P3 groups were injected with streptozotocin (STZ) with a dose of 50 mg/kg BW. Treatment was administered for 21 days. K(-) and K(+) groups were fed normally while P1, P2 and P3 groups were given golden sea cucumber 80% ethanol extract with a dose of 4,25 mg/kgBW/day, 8,50 mg/kgBW/day and 12,75 mg/kgBW/day respectively. On the 22nd day, fasting blood sugar level was measured and the number of pancreatic islet was counted with histopathological examination. The administration of golden sea cucumber (Stichopus hermanii) extract on rats with hyperglycemia does not reduce blood sugar level, but the extract administration increases the number of pancreatic islet. Golden sea cucumber (Stichopus hermanni) extract may improve the number of pancreatic islet and prevent the progressive damage of pancreatic islet.C

scholarly journals Test of Effectiveness of Thorny Palm Skin (Salacca Edulis) and Noni Extract (Morinda Citrifolia L) On Decreasing the Blood Sugar Rate of Male Mice (Mus Musculus)

2018 ◽  
Author(s):  
Ani Sulistyarsi ◽  
Sri Utami
Keyword(s):  
Blood Sugar ◽  
Mus Musculus ◽  
Blood Sugar Level ◽  
Hypothesis Test ◽  
Morinda Citrifolia ◽  
Control Treatment ◽  
Skin Extract ◽  
Sugar Solution ◽  
Direct Role ◽  
Sugar Levels

This research is meant to know the effectiveness of thorny palm skin (Salacca edualis) and noni(Morinda citrifolia L) extract on the decrease of mice’ blood sugar level (Mus musculus L.). The experimentalanimals used were male DDY strains of 2-3 months old with 27 samples. The mice were saturated with sugarsolution (Sukrosa) so as hyperglycemia occurred, then the mice were divided into 9 treatment groups and 3xreplicates namely; control treatment, thorny palm skin and noni extract treatment (F1) and treatment of 150,200, 250 mg / KgBB (F2) dose. Administration of sugar solution was given for 1 week. Giving sugar solutiondone orally, mice were given feed in the form of pellets and drinking water 2x a day. Blood sugar taken beforeand after administration of the extract using a glucometer (NESCO-Multiple Check). The data obtained werethen analyzed using varian analysis (Anava) and LSD test using SPSS 23. The result of the two-lane anavaanalysis showed that the significance level of 0,000 <0.05 which means the hypothesis test decision stated H0rejected means that there is the effect of giving thorny palm skin extract (Salacca edualis ) and the extract ofMorinda citrifolia L. to decrease blood sugar level. Thorny palm skin extract has a faster effect in loweringblood sugar levels of mice with a dose of 250 mg / kgBB treatment compared with noni fruit extract, as itcontains pterostilbene compounds, pterostilbene is an antidiabetic substance that plays a direct role indecreasing blood sugar levels.

scholarly journals Garlic: an alternative in reducing blood glucose on diabetic patients

2020 ◽  
Vol 7 (6) ◽  
pp. 2078
Author(s):  
Putri Dafriani ◽  
Roza Marlinda ◽  
Eliza Arman ◽  
Meldafia Idaman
Keyword(s):  
Blood Sugar ◽  
Group Intervention ◽  
Blood Sugar Level ◽  
Intervention Group ◽  
Antidiabetic Drugs ◽  
Control Group ◽  
Diabetic Patients ◽  
Post Test ◽  
Quasi Experimental ◽  
Sugar Levels

Background: Diabetes mellitus (DM), a metabolic disorder characterized by an increasing of blood sugar (hyperglycemia). Medication is one of the seven pillars of diabetes managementt. Garlic (Allium sativum), an alternative herb, also has an antidiabetic effect. The purpose of this study was to investigate the effect of garlic on the blood sugar level in type 2 diabetes mellitus.Methods: This study was a quasi-experimental design with two group post-test design. The participants were DM patients who only take medication without any supplemental herbs. The respondents were divided into two group; intervention group, given antidiabetic drugs and consume garlic 3 pieces of garlic/day for 2 weeks and control group only got antidiabetic drugs. Data were collected by performing blood sugar measurement using glucose-check on all respondents using capillary blood in the fingertips. Second measurement were taken after monitoring the consumption of garlic together with drugs for two weeks. Hypothesis testing used independent T-Test test.Results: The study result found that the average of blood sugar level after administering the treatment is 240 mg/dl in the intervention group, and 284 mg/dl in control group. It can be concluded that the administration of 3 pieces of garlic combining with antidiabetic drugs for 2 weeks has not been able to reduce blood sugar levels into normal limits.Conclusions: This combination found to lowering the blood sugar levels in a significant amount compare to only drugs. The length of the therapy could consider as a significant predictor.

scholarly journals Lowering blood sugar levels with kersen leaf stew (muntingia calabura l) and black onion (alium sativum) extract in mice (mus musculus)

2020 ◽  
Vol 9 (1) ◽  
pp. 15
Author(s):  
Eni Sumarliyah ◽  
Dede Nasrullah ◽  
Sukadiono . ◽  
Desta Pankyano
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Mus Musculus ◽  
Intervention Group ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Onion Extract ◽  
The Difference ◽  
Sugar Levels

Diabetes mellitus (DM) is a metabolic disease characterized by an increase in blood sugar levels. Blood sugar levels in patients with DM are mostly challenging to control, and this will threaten the occurrence of complications. Alternative therapies used are active flavonoids in reducing blood glucose. The purpose of this study was to analyze the decrease in blood sugar levels by administering cherry leaves stew and black onions to mice (mus musculus). The design of this study was the Quasy Experimental design (pretest-posttest with control group design). The sample in this study was 32 mice, 16 in the intervention group, and 16 comparison groups. There are independent variables (Kersen Leaf Stew and Black Onion Extract) and the dependent variable (Blood Glucose Level). The data were collected using an observation sheet, then analyzed using the independent sample T-test and Kolmogorov Smirnov test. The results of this study showed that the pre and post administration of cherry leaf decoction was 36.5 mg/dl, and the difference between pre and post administration of black onion extract was 24.3 mg/dl. While the analysis showed p = value 0.98, it showed no difference in the effectiveness of the two extracts in reducing blood sugar levels in mice. Obtained comparative test results from the two extracts were equally effective in lowering blood sugar in mice. Thus further research needs to be done with more samples.  

scholarly journals UJI AKTIVITAS ANTIDIABETES DARI EKSTRAK DAUN SESEWANUA (Clerodendron squamatum Vahl.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.)

PHARMACON ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 774
Author(s):  
Billy N. Nangoy ◽  
Edwin De Queljoe ◽  
Adithya Yudistira
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Pancreatic Beta Cells ◽  
Blood Sugar Level ◽  
Pancreatic Beta Cell ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Leaf Extracts ◽  
White Rats ◽  
Sugar Levels

ABSTRACTSesewanua leaves contain flavonoids which can be potentially as antidiabetic. Flavonoids reduce blood sugar levels by capturing free radicals that cause damage to pancreatic beta cells and inhibit pancreatic beta cell damage. The purpose of this study was to determine the effect of antidiabetic activity on the administration of Sesewanua (Clerodendron squamatum Vahl.) Leaf extracts in wistar white rats (Rattus norvegicus) induced by Aloxan. This type of research is a laboratory experiment using a completely randomized design. Test animals are grouped into 5 groups each consisting of 3 test animals. The negative control group (K-) was not treated, the positive control group (K +) was given metformin, groups 2, 3, and 4 were treated with different extract concentration of 200, 400, and 800 mg. Before the treatment was done the rats were examined the initial blood sugar level, then induced alloxan monohydrate 120 mg / kg BW intraperitonially (ip), and checked the blood sugar level on the 3rd day and continued with the administration of the leaf extracts of the animal every two days until the 14th day. The results showed that sesewanua leaf extracts with a concentration of 200, 400, and 800mg had a decreased activity in blood sugar levels from day 4 to day 14 with a decrease of 13.66 mg / dL in the concentration group 1, 43 mg / dL in the dose concentration 2, and 103 mg / dL in the concentration group 3. Keywords: Blood Glucose, Clerodendron squamatum Vahl., Flavonoids,  Rattus norvegicus ABSTRAKDaun sesewanua mengandung flavonoid yang dapat berpotensi sebagai antidiabetes. Flavonoid menurunkan kadar gula darah dengan cara menangkap radikal bebas penyebab kerusakan sel beta pankreas dan menghambat kerusakan sel beta pankreas. Tujuan penelitian ini adalah mengetahui efek aktivitas antidiabetes terhadap pemberian ekstrak Daun Sesewanua (Clerodendron squamatum Vahl.) pada Tikus Putih Galur Wistar (Rattus norvegicus) yang telah diinduksi Aloksan. Jenis penelitian ini adalah eksperimen laboratorium menggunakan rancangan acak lengkap. Hewan uji dikelompokan dalam 5 kelompok masing-masing terdiri dari 3 ekor hewan uji. Kelompok kontrol negatif (K-) tidak diberi perlakuan, kelompok kontrol positif (K+) diberikan metformin, Kelompok 2, 3, dan 4 diberi perlakuan dengan konsentras ekstrak yang berbeda-beda yaitu 200, 400, dan 800 mg. Sebelum perlakuan dilakukan tikus diperiksa kadar gula darah awal, kemudian diinduksi aloksan monohidrat 120 mg/kgBB secara intraperitonial (ip), dan diperiksa kadar gula darah pada hari ke-3 dan dilanjutkan dengan pemberian ekstrak daun sesewanua setiap dua hari sekali sampai hari ke-14. Hasil penelitian menunjukkan bahwa ekstrak daun sesewanua dengan konsentrasi 200, 400 , dan 800mg memiliki aktivitas penurunan kadar gula darah dari hari ke-4 sampai hari ke-14 dengan penurunan sebesar 13.66 mg/dL pada kelompok konsentrasi 1, 43 mg/dL pada kelompok konsentrasi 2, dan 103 mg/dL pada kelompok konsentrasi 3. Kata Kunci: Clerodendron squamatum Vahl., Flavonoid, Glukosa Darah, Rattus norvegicus

scholarly journals Pengaruh Spiritual Emotional Freedom Technique (Seft) Terhadap Penurunan Kadar Gula Darah Penderita Diabetes Mellitus Tipe 2 Di RSUD Kota Surakarta

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Ros Endah Happy Patriyani ◽  
Sunarsih Rahayu
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Life Style ◽  
Blood Sugar Level ◽  
Intervention Group ◽  
Control Group ◽  
Type 2 Dm ◽  
Sugar Levels ◽  
The Impact

Backgound: The incidence and severity levels of Diabetes Mellitus (DM) can be reduced through life style modification. The nurses’ ability in complementary modalities can help the patients to modify their life style by managing the stress levels; doing standard medical cares to help reducing and controlling blood sugar levels. One form of complementary modalities is SEFT. SEFT is one relaxation technique that can reduce anxiety and optimally reduce blood sugar level. Relaxation can affect hypothalamus to regulate and decrease the activity of the sympathetic nervous system. The purpose of this research is to find out the impact of SEFT to the decrease blood sugar levels on type 2 DM patients. Method: The method applied in the research was quasi-experimental pre-posttest with control group. The research population was 100 type 2 DM patients (50 respondents as intervention group and 50 respondents as control group). Samples were taken using purposive sampling method. The data was analyzed using t dependent test. Result: The result of the research shows that SEFT can reduce blood sugar levels of the type 2 DM patients with the value of p =0.000, and there was 220.060 points of blood sugar level reduction Conclusion: Nurses should teach type 2 DM patients to do SEFT; to monitor the blood sugar levels before and after SEFT.

scholarly journals The combined effect of magnetic and electric fields using on/off infrared light on the blood sugar level and the diameter of Langerhans islets of diabetic mice

2020 ◽  
Vol 13 (10) ◽  
pp. 2286-2293
Author(s):  
S. Suhariningsih ◽  
Suryani Dyah Astuti ◽  
Saikhu Akhmad Husen ◽  
Dwi Winarni ◽  
Dian Astri Rahmawati ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Electric Fields ◽  
Blood Sugar Level ◽  
Combined Treatment ◽  
Combined Effect ◽  
Infrared Light ◽  
Control Group ◽  
Diabetic Mice ◽  
Langerhans Islets ◽  
Sugar Levels

Background and Aim: At present, diabetes is treated with oral antidiabetic medicines, such as sulfonylureas and thiazolidine, as well as insulin injection. However, these methods have several shortcomings. Therefore, alternatives for treating diabetes mellitus (DM) are needed. This study aims to determine the combined effect of magnetic and electric fields on blood sugar levels and the diameter of Langerhans islets of diabetic mice. Materials and Methods: Induction of DM in mice was carried out by administering lard for 2 weeks and continued with an intraperitoneal injection of streptozotocin, dissolved in a 4.5 pH citrate buffer, and administered in a dose of 30 mg/kg bodyweight for 5 days. Treatments were used in combination with magnetic and electric fields using on/off infrared light. Blood samples were pipetted through the tip of mice's tails to establish the blood sugar level for each individual mouse. Histology preparation of the pancreas organ was affected using the histology standard as well as hematoxylin and eosin staining methods. Langerhans islet diameter data were analyzed using analysis of variance followed by Duncan's multiple range test. Data analysis was performed at α=0.05. Results: The results showed that the combined treatment of permanent magnetic and unidirectional electric fields (PS) caused changes in blood sugar levels that were not significantly different from the normal control group. The PS treatment improved the diameter of the Langerhans islets but not to a significant degree compared to other treatments. Conclusion: The use of PS treatment is effective for reducing the blood sugar levels of diabetic mice and improving the diameter of their Langerhans islets.

scholarly journals PENGARUH AIR REBUSAN DAUN HARENDONG BULU (Clidemia hirta) TERHADAP KADAR GULA DARAH MENCIT (Mus musculus)

2020 ◽  
Vol 3 (1) ◽  
pp. 7-12
Author(s):  
Okta Malia ◽  
Dian Samitra ◽  
Eka Lokaria
Keyword(s):  
Blood Sugar ◽  
Mus Musculus ◽  
Design Research ◽  
Control Group ◽  
Treatment Groups ◽  
Randomized Design ◽  
Completely Randomized Design ◽  
Sugar Levels ◽  
Boiled Water ◽  
One Way Anova

This study aims to determine the effect of the water boiled leaves of Clidemia hirta on blood sugar levels in Swiss Webster mice (Mus musculus). This research using a completely randomized design research design (CRD) with 5 treatment groups namely; Aquades control group (P0), 3 g sucrose treatment (P1), 3 g sucrose treatment + boiled bristle leaves boiled water at a dose of 0.13 ml/KgBB (P2), 3 g sucrose treatment + boiled bristle leaves boiled water at a dose of 0.26 ml/KgBB (P3), 3 g treatment of sucrose + boiled bristle leaves boiled water at a dose of 0.39 ml/KgBB (P4). Before administration of the extract, mice in the treatment groups P1, P2, P3 & P4 were induced using 3 g of sucrose for 5 days. Then after 5 days for groups P2, P3, and P4 followed by giving boiled water leaves for 7 days. The analysis result of One Way Anova Test shows that Fcount > Ftable (18.86 > 2.51). This shows the boiled water affects the blood sugar levels of male Swiss Webster mice. The concentration of extract at P4 (0.39 ml/KgBB) was more effective in reducing blood sugar levels.

PERBANDINGAN PENGARUH AIR KELAPA DAN MINUMAN ISOTONIK TERHADAP TINGKAT HIDRASI ATLET CABANG OLAHRAGA BOLA BASKET

2019 ◽  
Vol 1 (2) ◽  
pp. 15
Author(s):  
Siska Triana Budiman ◽  
Hamidie Ronald Daniel Ray
Keyword(s):  
Muscle Fatigue ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Coconut Water ◽  
Hydration Status ◽  
Control Group ◽  
Significant Difference ◽  
The Status ◽  
The Subject ◽  
Sugar Levels

The purpose of this research was to find out the comparison and the effect of coconut water and Isotonic drink on hydration status, to reduce anaerobic muscle fatigue and to anticipating blood sugar level increase of basketball athletes. This is quasy experimental research and use a pretest and posttest control group desain. The subject of this research are 18 basketball athletes from UPI's basketball student activity unit with ages 19-21 years old and divided randomly into 3 groups which is 2 treatment groups and control group. The subject given intervention coconut water, 250 ml of Isotonic drink and placebo, it given 30 minutes before the test. The hydration status on basketball athletes is seen from the color of urine and the muscle fatigue measured by using RAST (Running-based Anaerobic Sprint Test) by calculating the value of AF (Anaerobic Fatigue) and blood sugar levels is measured using Autocheck measuring instrument. The result of this research identified that mostly basketball athletes are get dehydration, There is a significant effect on the status of fatigue index according to the type of coconut Water and Isotonic Drink, and also there is a significant difference in the Blood Sugar level of basketball athletes according to the type of drink.

scholarly journals The Effectiveness of Acupressure and Smart Gymnastic on Fasting Blood Sugar Levels among Patients with Type II Diabetes Mellitus

2020 ◽  
Vol 3 (6) ◽  
pp. 687-694
Author(s):  
Dian Apri Nelyanti ◽  
Ta’adi Ta’adi ◽  
M. Choiroel Anwar
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Blood Sugar Level ◽  
Type Ii Diabetes Mellitus ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Type Ii ◽  
Significant Difference ◽  
Sugar Levels

Diabetes mellitus (DM) is a glucose metabolism disease characterized by an increase in blood sugar levels and impaired metabolism of fats, protein, and carbohydrates due to a lack of the hormone insulin, both absolutely and relatively. Alternative treatment of diabetes mellitus with complementary therapies, namely acupressure and smart gymnastic, can improve the fasting blood sugar level. This study aims to determine the effectiveness of acupressure and smart gymnastic on fasting blood sugar levels among patients with type II diabetes mellitus. True experimental study pretest and post-test with non-equivalent control group design were applied in this study. Repeated Measure, ANOVA test, showed a significant difference with the mean fasting blood sugar level p-value 0.000 (<0.05). The intervention group is better at lowering fasting blood sugar levels than control group 1 and control group 2 seen from the higher value difference. Conclusion of acupressure therapy with smart gymnastics three times a week for four weeks effectively reduces fasting blood sugar level in a patient with type II diabetes mellitus. This study can be used as a reference for further research, with a larger sample size, controlling the patient's diet, and a longer duration of intervention, so that the results obtained are more valid.

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