AGE BASED SPECULAR MICROSCOPIC EVALUATION OF FIRST 50 CORNEAL TISSUE OBTAINED THROUGH HCRP AT A NEWLY ESTABLISHED EYE BANK IN EASTERN INDIA

Background – Cornea transplantation has an important role in reducing the burden of corneal blindness but availability of corneal donor tissue is a significant limitation. The overall utilization of available cornea is further limited by the quality of donor corneal tissue.Specular microscopic evaluation of donor cornea is emerging as an indispensable tool of endothelial evaluation. Aim – Aim of this study to do an age based specular microscopic evaluation of first 50 corneal tissue obtained through hospital cornea retrieval program at a newly established eye bank in Eastern India Material and method – Total 50 corneo-scleral donor tissue were included in study after excluding the contraindication of cornea donation. Three tissues were could be not included in final assessment due to unavailability of specular microscopic image.47 tissues were divided in different age groups – <20 years (10 tissues),20-40 years (10 tissues),40-60 years (10 tissue) an >60 years (17 tissues). Specular microscopic evaluation was done with Konan eye bank keratoanlyser - CellChek® D® (Konan Medical, Irvine, CA). Endothelial cell density (ECD), corneal thickness (CT), coefficient of variance (CV) and percentage of hexagonal cells (6A) were evaluated and correlated with age. Result – The average age of donor was 47.02 years. The average CT, ECD, CV and 6A were 523.42 +/- 16.37 micron, 2222.87 +/- 514.62 cells/mm2, 35.27 +/- 4.04, 53.06 +/-8.30 % respectively.The difference in ECD was significantly high in age group <20 years than in comparison to those between 20-40 years (p value - 0.018),40-60 years (p value - 0.003) and more than 60 years (p value - 0.0001). There was a progressive decrease in ECD count with age but the change in ECD count between age group 20-40years and 40-60 years was not significant (p value - 0.12).ECD was significantly low in age group > 60 years in comparison to all other group i.e.<20 years (p value – 0.0001), 20-40 years (p value - 0.003) and 40-60 years (p value - 0.016). There was no significant difference in any other parameter (CT, CV, 6A) in any of the age group. Conclusion - Eye bank specular microscope is an important tool in proper evaluation of donor corneo-scleral button. The ECD is significantly high in tissue from younger age of donor with a progressive decrease in age.CCT,CV and 6A are found to have no correlation with age.

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A Comparative Study Between Preoperative Subconjunctival Bevacizumab Injection And Postoperative Topical Application In Prevention Of Recurrence After Excision Of Primary Pterygium In Egyptian Patients

QJM ◽

10.1093/qjmed/hcab109.004 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Basma Helal Mohamed ◽

Othman Ali Othman Ziko ◽

Hisham M Khairy Abd El Dayem ◽

Nancy Ezzelregal Khamis Ahmed

Keyword(s):

Corneal Thickness ◽

Anterior Segment ◽

P Value ◽

Eye Drops ◽

Subconjunctival Injection ◽

Fibrovascular Tissue ◽

Significant Difference ◽

Group 2 ◽

Group 1 ◽

Primary Pterygium

Abstract Purpose to compare between recurrence incidence after primary pterygium excision when using preoperative subconjunctival injection of Bevacizumab (Avastin) and using it as a postoperative eye drops. Methods thirty two eyes of thirty patients (two patients had bilateral pterygium) with primary pterygia were clinically examined, classified into 3 groups and operated by simple excision with bare sclera technique. Group 1 included 10 patients received Bevacizumab (Avastin) in the form of eye drops (10 mg/ml) 3 times daily for 6 days postoperative. Group 2 included 10 patients received preoperative Bevacizumab in the form of subconjunctival injection (1.25 mg/0.05ml) single dose 1 week preoperative. Group 3 included 10 patients (12 eyes) 2 patients with bilateral Pterygium didn’t receive any form of Bevacizumab. Postoperative follow up was done clinically and by serial photography at 1 week, 1 month, 3 months and 6 months searching for signs of recurrence and/or complications. Results The results showed different grades of recurrence in 18 eyes of 32.True recurrence was seen in 7 patients of 18 (1 patient in group 1, 2 in group 2 and 4 in group3).Recurrence grades in group 1and 2 who used the Bevacizumab (20%grade II, 50% grade III, and 30% grade IV). Recurrence could be predicted by 100% depending on fibrovascular tissue appearing in the surgical bed at 3 months postoperative (P value 0.038).Preoperative fleshy pterygium has high statistical significance in realation to recurrence(P value = 0.006).Patient’s sex, residence and occupation had no statistically significant value in the process of recurrence (P value > 0.05). Patients with recurrent Pterygia (in group 1&2) had statistically significant changes in the corneal K- readings at 3 months and 6 months.No significant difference in the limbal or central corneal thickness in the operated eye and the other eye (Pvalue > 0.05). Conclusion Bevacizumab (Avastin) is a well tolerated drug with multiple drug delivery methods.The eye drops give better results than the subconjunctival injection.Appearance of fibrovascular tissue in the surgical bed at 3 months predict the recurrence by 100%. Preoperative fleshy pterygia will mostly recur again whatever Bevacizumab form was used .The corneal thickness by anterior segment OCT has no role in prediction or detection of early pterygium recurrence.

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The pattern of central corneal thickness in patients attending a Tertiary Hospital in Dar-Es-Salaam

World Journal of Advanced Research and Reviews ◽

10.30574/wjarr.2021.9.2.0056 ◽

2021 ◽

Vol 9 (2) ◽

pp. 127-133

Author(s):

Annamary Stanislaus ◽

Ntsilane Susan Mosenene ◽

Celina Mhina ◽

John Stanslaus Kisimbi ◽

Frederick Robert Burgess ◽

...

Keyword(s):

Central Corneal Thickness ◽

Corneal Thickness ◽

Dar Es Salaam ◽

Applanation Tonometry ◽

P Value ◽

Muhimbili National Hospital ◽

National Hospital ◽

Cross Sectional ◽

Significant Difference ◽

The Mean

Background: Central Corneal Thickness (CCT) is an indicator of corneal health status as well as being an essential tool in assessment and management of corneal diseases. It is an important factor in the diagnosis and management of glaucoma as it affects the measurement of intraocular pressure. However, the pattern of central corneal thickness in our population is not known. Our study aimed to describe the CCT measurements and their variation with age and sex among patients attending the eye clinic at Muhimbili National Hospital (MNH), in Dar es Salaam, Tanzania. Methodology: A hospital-based descriptive, cross-sectional study used convenient sampling to recruit adult patients aged 18 years and above, presenting to the MNH between August 2016 and January 2017.Visual acuity assessment, Goldman applanation tonometry and CCT assessment using an ultrasound pachymeter were performed. Patients with previous intraocular surgery were excluded. Results: A total of 398 patients (208 males and 190 females) were recruited. The mean CCT was 526.64±38.30 µm; being 523.99±38.20 µm for males and 529.7±38.3 µm for females. 226 (56.85%) had CCT of less than 520 µm.There was no statistically significant difference in CCT between gender. The proportion of patients with thinner CCT increased with increasing age from 25.8% in those < 30 years to 75% in those aged 71years and above. The mean CCT decreased with increasing age with P-value<0.001. Conclusion: The average CCT in patients attending Muhimbili National Hospital is 526.64 µm (SD 38.30) which is generally thin, inversely proportion to age and similar that of other Africans and African-Americans. This finding has implications for the management of glaucoma in this population.

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KNOWLEDGE OF HEPATITIS PREVENTION AMONG REPRODUCTIVE AGE GROUP WOMEN FROM PAKISTAN DEMOGRAPHIC HEALTH SURVEY DATA 2012-13

Pakistan Journal of Public Health ◽

10.32413/pjph.v9i3.358 ◽

2020 ◽

Vol 9 (3) ◽

pp. 135-138

Author(s):

Faiz Rasul Awan ◽

Muhammad Safdar Baig ◽

Atiq ur Rehman Khan

Keyword(s):

International Development ◽

Survey Data ◽

Health Survey ◽

Demographic And Health Survey ◽

Reproductive Age ◽

P Value ◽

Cluster Sampling ◽

Age Group ◽

Significant Difference ◽

Reproductive Age Group

Background: Pakistan and Egypt bear more than 80% of the burden of disease as more than 12 million people are suffering from hepatitis B or C infection and there is addition of about 150000 new cases each year.Methods: We have used secondary data PDHS - Pakistan Demographic and Health Survey, DHS has become the gold standard of survey data in developing countries, a project by ORC Macro with financial support from the USAID for the International Development carried out as multistage, cluster sampling for its data collection on multiple questions, most pertinent from our study point view the maternal and child health related to knowledge attitude and practices of hepatitis and its prevention. Results:The final multivariate model six variables came out to be statistically significant with their adjusted odd's ration p-value and 95% confidence interval i.e., use of new disposable syringe every time for therapeutic injection purpose, the respondent being rich as wealth index, reading newspapers and magazines, watching television as source of information, area of residence being urban and with higher educational level came out to be most important variable which are making statistically significant difference for prevention of hepatitis among females of reproductive age group as our study population from Pakistan Demographic and Health Survey 2012-13. Conclusion: It is quite evident from the results of our study that use of new disposal syringes, being rich , being educated, having access to information resources like watching television, listening radio, reading newspaper & magazine and being as an urban dwellers are significant factor among women of reproductive age groups for prevention of hepatitis.

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Time to viral load suppression and its associated factors in cohort of patients taking antiretroviral treatment in East Shewa Zone, Oromiya, Ethiopia, 2018

10.21203/rs.2.11467/v1 ◽

2019 ◽

Author(s):

Jemal H Ali

Keyword(s):

Viral Load ◽

Marital Status ◽

Associated Factors ◽

Plasma Viral Load ◽

Baseline Viral Load ◽

Rank Test ◽

P Value ◽

People Living With Hiv ◽

Age Group ◽

Significant Difference

Abstract Background: Human immuno-deficiency virus is a virus that causes Acquired Immuno- Deficiency Syndrome. The key goal of ART is to achieve and maintain durable viral suppression. Thus, the most important use of the viral load is to monitor the effectiveness of therapy after initiation of ART. The main objective of the study was to determine the time for virological suppression and its associated factors among people living with HIV taking antiretroviral treatments in East shewa zone, Oromiya, Ethiopia. Methods: The study was conducted in East Shewa zone, Oromiya, Ethiopia from August 2017 to January 2018. Patients diagnosed with human immunodeficiency virus presenting to the study health centers between October 3, 2011 and March 1, 2013 were included in the study given the following criteria: age 18 years or greater, eligible to start ART. All patients with baseline viral load measurement were included in the study. Interaction between explanatory variables with the response variable was analyzed by using cross tab features of SPSS, IBM Inc. Significance group comparison was done by Kaplan Meier log rank test. Cox proportional hazard model was used to select significant factors to the variability between groups. Data was collected by using structured questionnaires and interview. A total of ETB 81,120.00 was utilized to carry out the study. Result: plasma viral load was suppressed below detection level in 72% of individuals taking different regimen of ART. The median HIV-1 plasma viral load in the cohort was log 5.3111 copies/ml. Survival curve difference were observed in category of marital status (p-value 0.023) and baseline CD4 values (p-value 0.023) whereas no significant difference were observed in Educational status (p-value 0.404), MUAC (p- value 0.407) BMI(p-value 0.335) and BTB(p-value 0.257). Estimated median time to PVL suppression was 181days (CI: 140.5-221.4) with the age group of 30-39years having minimum time to achieve suppression with 92 days (CI: 60.1-123.8) and the maximum time required to reach the level was age group between 50-59 years. Conclusion: Estimated time to achieve PVL after taking ART was found to be 181 days. Factors affecting time to suppression level was marital status and baseline CD4.

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Prevalence of Helicobacter Pylori Antibody among Outpatients of Federal Medical Center, Yenagoa, Niger Delta Region of Nigeria

International Journal Of Medical Science And Clinical Invention ◽

10.18535/ijmsci/v8i07.02 ◽

2021 ◽

Vol 8 (07) ◽

pp. 5521-5527

Author(s):

Dr Oluwayemisi Agnes Olorode ◽

Ofonime M. Ogba ◽

Williams E. Ebisin

Keyword(s):

Helicobacter Pylori ◽

Blood Test ◽

Medical Center ◽

P Value ◽

World Population ◽

Age Group ◽

Test Kit ◽

Significant Difference ◽

Chi Square Analysis ◽

Helicobacter Pylori Antibody

Helicobacter Pylori is the most common chronic bacterial infection (acquired early childhood) in humans affecting 50% of the world population and much attention has not been paid to this. This study was carried out between February and October 2019 to test for the presence of Helicobacter Pylori antibody among asymptomatic individuals attending Federal Medical Center, Yenagoa, Bayelsa State. A total of 200 {114(57%) males, 86(43%) females} blood samples were collected at ramdom into Ethylene diamine tetraacetic acid (EDTA) bottles and immediately transported to the laboratory for analysis using Helicobacter pylori Serology rapid blood test kit. Age was stratified to allow for comparison because the entire outcome was age dependent. Chi square analysis was conducted for the categorical variable. Findings showed that out of 200 samples examined, 88(44%) forty (40 (45%) males and 48(55%) females were positive to Helicobacter pylori infection while 112(56%) were negative. Females of age range 24 -33 had the highest prevalence of 24 (27%) while male of age group 14 to 23 had 21(24%); females of 34 to 44 was 16(18%); 54-63 had 4(05%) and the least was 44 to 53 years with prevalence of 3(03%). There was a significant difference across the age group and socio-demographic characteristic at p-value = 0.0001 < 0.05 and p-value =0.002068 < 0.05, p-value = 0.000916 <0.05 respectively. Observations showed the higher prevalence in females (53%) than their males (47%) counterparts; likewise the infected individuals host this organism ignorantly and busy treating out of line. Study with more than one diagnostic technique is recommended to determine the presence of Helicobacter pylori, as rapid blood test is limited due to the presence of antibody in the serum for long after eradication. In conclusion, routine medical examination on Helicobacter pylori is encouraged among individuals in respective of age and status.

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Clinico-biochemical profile of chronic kidney disease patients in elderly age group in a tertiary care centre

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20194997 ◽

2019 ◽

Vol 7 (11) ◽

pp. 4227

Author(s):

Atul V. Rajkondawar ◽

Amit Yele

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Elderly Patients ◽

Tertiary Care ◽

P Value ◽

Age Group ◽

Elderly Age ◽

Tertiary Care Centre ◽

Cross Sectional ◽

Significant Difference

Background: Chronic kidney disease (CKD) remains one of the major health problems in India. Renal function steadily deteriorates as age advances and advancing age has been indicted to have adverse implications in the disease progression to end stage renal disease (ESRD). With the present study, clinico-biochemical profiling of chronic kidney disease patients in geriatric age group as well as comparison with non-elderly patients was undertaken.Methods: In this cross-sectional observational study, 100 patients of CKD admitted in the tertiary care study centre were enrolled consecutively and assessed for symptoms, signs and biochemical parameters over two years. Study subjects were divided into two groups:- Group 1: Elderly patients- aged 60 years or more, and Group 2: Non-elderly patients- less than 60 years of age. Relevant comparisons were drawn statistically and tested for significance.Results: Pallor and pedal edema were observed to be the commonest clinical features across groups. Elderly group shows higher prevalence of severe anaemia (mean hemoglobin- 7.4 gm%). Higher prevalence of clinical and biochemical derangement was found in patients with relatively lower GFR. Elderly age group also had more prevalence of electrolyte abnormalities compared with non-elderly population, with statistically significant difference observed for hyponatremia (p value- 0.023), hypoproteinemia (p value- 0.0078) and blood urea level (p value- 0.0054).Conclusions: Understanding beforehand the biochemical abnormalities associated with old age in CKD patients helps in appropriate modifications in patient management.

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Comparison of Axial Ocular Measurements with Contact and Non-contact Biometry

Pakistan Journal of Ophthalmology ◽

10.36351/pjo.v36i1.922 ◽

2020 ◽

Vol 36 (1) ◽

Author(s):

Muhammad Arslan Ashraf ◽

Muhammad Suhail Sarwar ◽

Muhammad Awais Afzal ◽

Imran Khalid ◽

Sehrish Shahid

Keyword(s):

Corneal Thickness ◽

Anterior Chamber Depth ◽

Cross Sectional Study ◽

P Value ◽

Cross Sectional ◽

Kappa Test ◽

Parametric Data ◽

Significant Difference ◽

The Difference ◽

Graphical Presentation

Purpose: To compare between non-contact and contact biometry for measurements of central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and axial length (AL). Study Design: Descriptive Cross Sectional Study. Place and Duration of Study: Mayo Hospital, Lahore from June 2018 to December 2018. Material and Methods: Eighty-four subjects, (168 non-pathological eyes) visiting the eye outpatients department were recruited by non-probability convenience sampling. Patients with high refractive errors and suffering from any ocular pathology were excluded from the study. CCT, ACD, LT and AL were measured with non-contact Biometer (HAAG Streit) followed by Contact Biometer (Ultrasound) after taking consent from the patient. Data was entered and analyzed by using SPSS-21 and Medcalc software. Normality of quantitative data was checked with Shapiro Wilk test. Independent sample t test was used for parametric variable and Mann Whitney-U test was used for non-parametric data. For the agreement between two techniques Cohen’s Kappa test used and Bland-Altman plot was drawn for graphical presentation. P-value equal or less than 0.05 was taken as significant. Results: Mean age of 84 subject (female: 45.24% and male: 54.76%) was 53.05 ± 13.56 years. The AL was significantly longer for the non-contact measurement with the difference of 0.53 ± 0.32 mm (p < 0.001). Contact pachymetry was significantly higher with the difference of 8.67 ± 20.83 µm (p = 0.046). ACD was significantly deeper for non-contact measurements with the difference of 0.51 ± 0.32 mm (p < 0.001). Contact ultrasound A-scan measured LT significantly thicker with the difference of 0.59 ± 0.56 mm (p < 0.001). Conclusion: There is significant difference of axial ocular measurements (CCT, ACD, LT and AL) between contact (ultrasound A-scan) and non-contact (HAAG Streit) biometry (p < 0.05).

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The Comparison of Accelerated Corneal Crosslinking Treatment for Progressive Keratoconus in the Pediatric and Adult Age Groups: One-Year Results

10.21203/rs.3.rs-834768/v1 ◽

2021 ◽

Author(s):

Mustafa Berhuni ◽

Cem Ozturkmen

Keyword(s):

Visual Acuity ◽

Corneal Thickness ◽

Age Groups ◽

Age Group ◽

Preoperative Period ◽

Adult Group ◽

Adult Age ◽

Pediatric Age Group ◽

Significant Difference ◽

One Year

Abstract Purpose: To investigate the short-term results of accelerated crosslinking (A-CXL) treatment for progressive keratoconus in the pediatric and adult age groups. Materials and methods: The records of the 62 eyes of 40 patients who had undergone the A-CXL procedure (9 mV/cm2, 10 min) for progressive keratoconus between January 2015 and January 2019 were evaluated retrospectively. The patients were divided into 2 groups as the pediatric group (aged 17 years or less) and the adult group (aged 18 years or more) for statistical analysis. Pre- and post- 12th month A-CXL best-corrected visual acuity (BCVA), maximum keratometry (Kmax), sim K1, sim K2, corneal thickness at the thinnest point (thCT), and corneal astigmatism (CA) values of the patient groups were recorded. Results: The 29 eyes of 16 patients were included in the pediatric group and the 33 eyes of 24 patients were included in the adult group. The mean age was 13.50±3.05 years in the pediatric group and 23.58±4.37 years in the adult group. A significant improvement in BCVA and a significant decrease in thCT values were present in both groups 12 months after the surgery compared to the preoperative period. A decrease was present in the Kmax, sim K1, sim K2 and CA values in the pediatric group, but was not statistically significant. The decrease in Kmax, sim K1 and sim K2 values compared to the preoperative period was significant in the adult group, but the decrease in CA values was not significant. When the two groups were compared at the end of 12 months, only the sim K1 value was significantly lower in the adult group, and there was no significant difference between the other measurements. Conclusions: Better visual acuity improvement, a higher flattening rate, and less progression occur after 12 months with A-CXL treatment for progressive keratoconus in the adult age group compared to the pediatric age group.

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Socio Demographic Profile and Risperidone Response in New Versus Old Schizophrenia Patients

Journal of Nepalgunj Medical College ◽

10.3126/jngmc.v18i1.35208 ◽

2020 ◽

Vol 18 (1) ◽

pp. 82-85

Author(s):

Mohan Belbase ◽

Jyoti Adhikari

Keyword(s):

Negative Symptoms ◽

Total Duration ◽

P Value ◽

Base Line ◽

Age Group ◽

Old Patients ◽

Syndrome Scale ◽

Significant Difference ◽

The Mean ◽

Negative Syndrome

Introduction: Schizophrenia is a mental disorder characterized with disorganized thinking, perception, expression of reality with significant social and occupational dysfunction. Two groups of drugs are in recent use namely first generation (typicals) and second generation (atypical) antipsychotics. Risperidone is a broad spectrum antipsychotic and has a role as a first-line agent for first break, mild to moderately ill patients and for severely ill treatment–refractory patients. Aims: This article tries to compare the risperidone response in newly diagnosed schizophrenia patients versus old patients already on some antipsychotics other than risperidone. Methods: This is an experimental intervention study of patients attending to psychiatry OPD and indoor in Nepalgunj Medical College, Kohalpur. Total 40 patients (27 new and 13 old) were selected and sample was collected in one year from January 2018 till December 2018. Positive and negative syndrome scale questionnaire was used to record the positive and negative symptoms of schizophrenia on baseline (week 0). Patients were followed up on week 4 and week 8 and the same positive and negative syndrome scale questionnaire was applied to record the improvement. Risperidone was given in therapeutic dose (4-8mg) on the basis of symptoms and improvement. Results: The study subjects were divided into new N=27 (17 male and 10 female) and old N=13 (7 male and 6 female). Maximum number of schizophrenia cases were in age group 15-25 and 35-44 years comprising 30 % in each group. Mean total duration of illness in new group was 23.89 ± 29.51 months (median being 12.0 months) while in old group it was 123.69 ± 83.34 months (median being 96.0 months) with significant difference between two groups (p= <0.001).The mean risperidone dose in milligram on base line (week 0) was 4.15 ± 0.55 for old group while it was 4.04 ± 0.52 for new group. On week 4, the mean dose for old group was 5.08 ± 0.95 while for the new group it was 4.81 ± 1.08. On week 8, the dose for old group was 6.08 ± 1.32 while it was 5.15 ± 1.35 for new group. There was a significant difference in the drug dose on week 8 between old group and new group with p value of 0.047 (statistically significant). Conclusion: Our study suggests that schizophrenia is found in most productive age group. Risperidone is effective in both new and old schizophrenia patients however old patients need higher dose of risperidone than new patients.

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Gender- and age-related differences in misuse of face masks in COVID-19 prevention in central European cities

10.1101/2020.11.11.20224030 ◽

2020 ◽

Author(s):

Linda Eckl ◽

Stefan Hansch

Keyword(s):

Age Distribution ◽

Binomial Test ◽

P Value ◽

Age Group ◽

Middle Aged ◽

Chi Square ◽

Central European ◽

Gender And Age ◽

Significant Difference ◽

Chi Square Test

1ABSTRACTObjectiveCorrect use of face masks is required for their efficacy in preventing possible droplet infections with SARS-CoV-2. We tried to provide information about differences in the distribution of gender and age groups wearing face masks incorrectly.DesignPilot field studyMethodsVisual observation of mask use in public, not age- and gender-related places in central European large cities regarding incorrect mask-wearing (n=523); statistical analysis (nominal scale) in terms of gender and estimated age group using the total numbers, binomial test and chi-square test.ResultsThere is no significant difference (binomial test: p-value = 0.43) in mask misuse between the genders (female: 271 (51.8%), male: 252 (48.2%) and 0 non-binary individuals (0%)). There is a significant difference (chi-square test: p-value < 2.2e-16) in age group distribution (170 young 10-29 years (32.5%), 261 middle-aged 30-59 years (49.9%), 92 older adults ≥ 60 years (17.6%)). In total numbers, the highest counts were observed in middle-aged persons with 261 counts (49.9%).ConclusionOur study shows an uneven age-distribution of people wearing the face mask in public improperly.

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