scholarly journals Chemical Factors which Prompt Oral Pathological Phenomena In Some Nutrition Diseases

2019 ◽  
Vol 70 (5) ◽  
pp. 1884-1887
Author(s):  
Raoul Vasile Lupusoru ◽  
Gabriel Topor ◽  
Ingrith Crenguta Miron ◽  
Mihaela Grigore ◽  
irina Esanu
Keyword(s):  
Morphological Changes ◽  
Medical Knowledge ◽  
Point Of View ◽  
The Body ◽  
Diabetic Coma ◽  
Human Organism ◽  
Functional Changes ◽  
General Pathology ◽  
Chemical Factors ◽  
Object Of Study

In so-called general pathology, the centre of gravity must fall precisely on the experimental pathology, on the analysis of experimental pathological processes. To understand the life of a diseased organism, it is necessary to know the morphological changes at different stages of development of the pathological processes. Morphopathology deals with the study of morphological changes in a diseased organism. Both disciplines, namely both pathophysiology, as well as morphopathology, complement each other and together constitute a vast field of medical knowledge, namely the so-called pathology (pathos = suffering, disease, and logos = science). Physiopathology uses the data of the morphological changes found as a result of the pathological processes and it is closely related to the pathological anatomy, which deals with the same problems, but from another point of view: both have the same object of study, namely, the diseased human organism. Any pathological action provokes from the very beginning a defence of the body, directed against the injurious agent or the lesion. Pathological phenomena are recognized not only by studying the functional changes of the body and its various parts; taking into account the unity between function and form, it is necessary to study the morphological changes. From the research carried the following resulted: from the total of 165 cases, 102 cases (61.81%) presented diabetes, 34 cases (20.62%) obesity, 29 cases (17.57%) gout. In the treatment of oral mucosal lesions, strong antiseptics will be avoided since these are necrotizing (multiple cases of diabetic angiopathy are known), attention should also be paid to performing fixed or mobile prosthetic works that do not have to traumatize the periodontium and the mucosa of the prosthetic field in order to avoid the possibility of over-infection. Avoid bleeding manoeuvres in case of a diabetic patient with high blood sugar, taking into account the risk of diabetic coma.

The Questions of Medical Informatics

1996 ◽  
Vol 35 (01) ◽  
pp. 8-11
Author(s):  
I. Dimitrov
Keyword(s):  
Information System ◽  
Medical Informatics ◽  
Information Technologies ◽  
Point Of View ◽  
Human Organism ◽  
Mathematical Apparatus ◽  
Medical Problems ◽  
Medical Computing ◽  
Object Of Study

AbstractEach science is identified with the questions it raises with respect to its object of study. This paper discusses the formulation of the basic questions of medical informatics. From a historical point of view, it first dealt with the problems of medical computing. Thereby, three classical questions arose: How can existing computers and information technologies assist in medical activities? Which components of the mathematical apparatus of informatics can be used for solving medical problems, and how and what activities of a physician are subject to algoritmization? The present time raises a new circle of questions centered around the basic one: How is the information system of the human organism structured and how does it function? This question and others form the basis of a new trend in medical informatics.

scholarly journals Submicroscopic Investigation of Components of the Hematoencephalic Barrier in Newborns with Perinatal Hypoxic Damage

2021 ◽  
Vol 6 (1) ◽  
pp. 25-31
Author(s):  
O. V. Kihtenko ◽  
◽  
H. I. Hubina-Vakulik ◽  
O. M. Pliten ◽  
S. M. Potapov
Keyword(s):  
Neonatal Period ◽  
Morphological Changes ◽  
Clinical Manifestations ◽  
Basement Membranes ◽  
The Body ◽  
Intrauterine Development ◽  
Functional Changes ◽  
Body Tissues ◽  
Study Results ◽  
Intrauterine Hypoxia

The biggest losses from the entire period of childhood fall on the neonatal period of development of ontogenesis. Clinical manifestations of diseases and morphofunctional disorders that occur during intrauterine development or during childbirth play an important role in the formation of the child's health and are recorded during the neonatal period of development. The more accurate is the diagnosis of pathology in this age range, the more correct and effective will be the measures of treatment and rehabilitation. This will reduce to a minimum social loss and limit the formation of chronic pathology and deviations in the physical, mental and intellectual development of children. The hematoencephalic barrier is the most important dynamic structure that it is responsible for brain homeostasis and takes an active participation in the body tissues resistance to the harmful effects of perinatal hypoxic stress alongside with other structural and functional formations of the central nervous system. The purpose of the work was to identify characteristic morphological and functional changes in the components of the hematoencephalic barrier of newborns who underwent to perinatal hypoxia at the subcellular level using submicroscopic examination. Results and discussion. The study results present a fragment of a large work which deals with pathomorphological and compensatory changes in the components of the hematoencephalic barrier in deceased newborns. The latter were carried in conditions of chronic intrauterine hypoxia and undergoing acute ante-, intranatal hypoxia were studied using ordinary histology, morphometry, immunohistochemical reactions. Submicroscopic examination allowed deepening the level of surveillance. The morphological changes in newborns who were carried under conditions of chronic intrauterine hypoxia, they underwent acute intrauterine hypoxia and died in the acute period of hypoxic-ischemic encephalopathy. These newborns can be divided into two groups. The first group: pathological changes which were the result of acute asphyxia – edema, death and desquamation of endothelial cells as well as damage of gliacytes and their further death both as a result of cytotoxic edema (edema and lysis) and due to shrinkage of the nucleus with subsequent karyorrhexis. The presence of apoptotic changes in pericytes was registered. The second group of pathomorphological changes had signs which were formed under the «chronic» influence of the damaging factor (in this study it was chronic intrauterine hypoxia): general decrease of the microcirculatory bed in the volume; significant decrease in the number of capillaries with a «sleeve» of astrocytes processes; damage of the basement membranes of the capillaries (uneven thickness, blurring, bilayering)

scholarly journals Skin Aging & Modern Age Anti-aging Strategies

2019 ◽  
pp. 15-60
Author(s):  
Abdul Kader Mohiuddin
Keyword(s):  
Structural Changes ◽  
Skin Aging ◽  
Layered Composite ◽  
Point Of View ◽  
The Body ◽  
Hormonal Changes ◽  
Adjacent Layer ◽  
Functional Changes ◽  
Extracellular Matrix Components ◽  
Physiological And Biochemical

As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, “photoaging” is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue.

Morphological Changes in the Rat Granulosa Cell Surface During Differentiation Induced by Estradiol and Gonadotropins

1977 ◽  
Vol 35 ◽  
pp. 484-485
Author(s):  
P. Bagavandoss ◽  
JoAnne S. Richards ◽  
A. Rees Midgley
Keyword(s):  
Cell Surface ◽  
Granulosa Cell ◽  
Morphological Changes ◽  
Follicular Development ◽  
Female Rats ◽  
Functional Changes ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

During follicular development in the mammalian ovary, several functional changes occur in the granulosa cells in response to steroid hormones and gonadotropins (1,2). In particular, marked changes in the content of membrane-associated receptors for the gonadotropins have been observed (1).We report here scanning electron microscope observations of morphological changes that occur on the granulosa cell surface in response to the administration of estradiol, human follicle stimulating hormone (hFSH), and human chorionic gonadotropin (hCG).Immature female rats that were hypophysectcmized on day 24 of age were treated in the following manner. Group 1: control groups were injected once a day with 0.1 ml phosphate buffered saline (PBS) for 3 days; group 2: estradiol (1.5 mg/0.2 ml propylene glycol) once a day for 3 days; group 3: estradiol for 3 days followed by 2 days of hFSH (1 μg/0.1 ml) twice daily, group 4: same as in group 3; group 5: same as in group 3 with a final injection of hCG (5 IU/0.1 ml) on the fifth day.

Dynamical Peculiarities of Concatenational Changes in Functional Cardiovascular Parameters

2018 ◽  
Vol 3 (82) ◽  
Author(s):  
Eurelija Venskaitytė ◽  
Jonas Poderys ◽  
Tadas Česnaitis
Keyword(s):  
Time Series ◽  
Time Series Analysis ◽  
Functional State ◽  
The Body ◽  
Functional Changes ◽  
High Intensity Training ◽  
Series Analysis ◽  
Greco Roman ◽  
St Segment ◽  
Standard Lead

Research  background  and  hypothesis.  Traditional  time  series  analysis  techniques,  which  are  also  used  for the analysis of cardiovascular signals, do not reveal the relationship between the  changes in the indices recorded associated with the multiscale and chaotic structure of the tested object, which allows establishing short-and long-term structural and functional changes.Research aim was to reveal the dynamical peculiarities of interactions of cardiovascular system indices while evaluating the functional state of track-and-field athletes and Greco-Roman wrestlers.Research methods. Twenty two subjects participated in the study, their average age of 23.5 ± 1.7 years. During the study standard 12 lead electrocardiograms (ECG) were recorded. The following ECG parameters were used in the study: duration of RR interval taken from the II standard lead, duration of QRS complex, duration of JT interval and amplitude of ST segment taken from the V standard lead.Research  results.  Significant  differences  were  found  between  inter-parametric  connections  of  ST  segment amplitude and JT interval duration at the pre and post-training testing. Observed changes at different hierarchical levels of the body systems revealed inadequate cardiac metabolic processes, leading to changes in the metabolic rate of the myocardium and reflected in the dynamics of all investigated interactions.Discussion and conclusions. It has been found that peculiarities of the interactions of ECG indices interactions show the exposure of the  functional changes in the body at the onset of the workload. The alterations of the functional state of the body and the signs of fatigue, after athletes performed two high intensity training sessions per day, can be assessed using the approach of the evaluation of interactions between functional variables. Therefore the evaluation of the interactions of physiological signals by using time series analysis methods is suitable for the observation of these processes and the functional state of the body.Keywords: electrocardiogram, time series, functional state.

Clinical, morphological and biochemical signs of polymycotoxicosis in highly productive cows

2020 ◽  
pp. 14-17
Author(s):  
Irina A. Shkuratova ◽  
◽  
Lyudmila I. Drozdova ◽  
Aleksander I. Belousov ◽  
Keyword(s):  
Metabolic Disorders ◽  
Hepatorenal Syndrome ◽  
Morphological Changes ◽  
Clinical Manifestations ◽  
The Body ◽  
Feed Mixture ◽  
Milk Productivity ◽  
Structural Disorders ◽  
Increased Sensitivity ◽  
Penicillium Spp

Mycotoxicological monitoring of forages shows that the problem of mycotoxicosis has been relevant for several decades. Minimal doses of mycotoxins in feed lead to a decrease in milk productivity, increased sensitivity to infectious and non-infectious diseases. When several mycotoxins enter the body simultaneously, a synergistic effect develops, causing a significant increase in toxicity. Feed contaminated with several types of fungi and their toxins is dangerous for dairy cattle. It was found that the feed mixture contained the types of associations of Aspergillus spp. fungi + Fusarium; Aspergillus spp. + Penicillium spp. + Mucor spp; Fusarium + Penicillium; Mucor spp. + Fusarium + Ustilaginales. Pathogenetic features of metabolic and morphological changes in highly productive cows with polymycotoxicosis were studied. Feeding food contaminated with various metabolites of mold fungi leads to the development of signs of chronic toxemia in animals. Clinical manifestations are the development of diarrhea and dehydration, with a decrease in milk productivity. Metabolic disorders feature the development of an inflammatory process, metabolic acidosis, hyperfermentonemia, with an increase in the amount of creatinine and urea in the blood serum. Metabolic signs indicate the development of hepatorenal syndrome due to structural disorders of the liver and kidneys. Histological signs of polymicotoxicosis are intracapillary and hemorrhagic glomerulonephritis, hepatocyte micronecrosis, and proliferation of connective tissue stroma cells, which leads to the development of atrophic cirrhosis in the interstitial and circular phases.

Comparative assessment of morphological mechanisms of maintaining structural liver homeostasis in the dynamics of exposure to coal-rock dust and sodium fluoride on the body

2020 ◽  
pp. 189-194
Author(s):  
M. S. Bugaeva ◽  
O. I. Bondarev ◽  
N. N. Mikhailova ◽  
L. G. Gorokhova
Keyword(s):  
Sodium Fluoride ◽  
Morphological Changes ◽  
The Body ◽  
System Level ◽  
Production Factor ◽  
Coal Rock ◽  
The Impact ◽  
Structural Homeostasis ◽  
Rock Dust

Introduction. The impact on the body of such factors of the production environment as coal-rock dust and fluorine compounds leads to certain shift s in strict indicators of homeostasis at the system level. Maintaining the relative constancy of the internal environment of the body is provided by the functional consistency of all organs and systems, the leading of which is the liver. Organ repair plays a crucial role in restoring the structure of genetic material and maintaining normal cell viability. When this mechanism is damaged, the compensatory capabilities of the organ are disrupted, homeostasis is disrupted at the cellular and organizational levels, and the development of the main pathological processes is noted.The aim of the study is to compare the morphological mechanisms of maintaining structural homeostasis of the liver in the dynamics of the impact on the body of coal-rock dust and sodium fluoride.Materials and methods. Experimental studies were conducted on adult white male laboratory rats. Features of morphological mechanisms for maintaining structural homeostasis of the liver in the dynamics of exposure to coal-rock dust and sodium fluoride were studied on experimental models of pneumoconiosis and fluoride intoxication. For histological examination in experimental animals, liver sampling was performed after 1, 3, 6, 9, 12 weeks of the experiment.Results. The specificity of morphological changes in the liver depending on the harmful production factor was revealed. It is shown that chronic exposure to coal-rock dust and sodium fluoride is characterized by the development of similar morphological changes in the liver and its vessels from the predominance of the initial compensatory-adaptive to pronounced violations of the stromal and parenchymal components. Long-term inhalation of coal-rock dust at 1–3 weeks of seeding triggers adaptive mechanisms in the liver in the form of increased functional activity of cells, formation of double-core hepatocytes, activation of immunocompetent cells and endotheliocytes, ensuring the preservation of the parenchyma and the general morphostructure of the organ until the 12th week of the experiment. Exposure to sodium fluoride leads to early disruption of liver compensatory mechanisms and the development of dystrophic changes in the parenchyma with the formation of necrosis foci as early as the 6th week of the experiment.Conclusions. The study of mechanisms for compensating the liver structure in conditions of long-term exposure to coal-rock dust and sodium fluoride, as well as processes that indicate their failure, and the timing of their occurrence, is of theoretical and practical importance for developing recommendations for the timely prevention and correction of pathological conditions developing in employees of the aluminum and coal industry.The authors declare no conflict of interests.

FUNCTIONAL STATUS AND ADAPTIVE POTENTIAL IN FOREIGN STUDENTS WITH DIFFERENT TYPES OF VEGETATIVE REGULATION DURING TUITION

2020 ◽  
pp. 118-126
Author(s):  
A.M. Satarkulova
Keyword(s):  
Heart Rate ◽  
Foreign Students ◽  
Autonomic Regulation ◽  
The Body ◽  
Functional Changes ◽  
Different Types ◽  
Type 3 ◽  
Adaptive Abilities

The assessment and dynamic control over students’ status is a very important task. It allows timely detection of prenosological status prior to pathology and health maintenance in students. The objective of the paper is to assess the adaptive abilities of the body, to analyze changes in heart rate variability indicators in students with various types of autonomic regulation, to identify prenosological status and precursory pathological symptoms. Materials and Methods. The study enrolled 302 students from India, aged 21.54±1.43. Programming complex «Psychophysiologist» was used to register the main HRV parameters within 5 minutes. Health status was evaluated according to the index of functional changes and the scale of functional states. Results. N.I. Shlyk (2009) distinguished two groups of students with different types of autonomic regulation: type 1 (53 %) with moderate and type 2 (5 %) with marked characteristics of central regulation profile, type 3 (35 %) with moderate and type 4 (7 %) with marked characteristics of autonomous regulation profile. Main parameters of HRV and adaptation potential were defined for each student.All the parameters characterized functional and health status. Conclusions. It was shown that 82 % of trial subjects (type 1), 53 % (type 2), 94 % (type 3) and 95 % (type 4) demonstrated satisfactory adaptation and their physiological processes were at an optimal level. 18 % of students (type 1) demonstrated reduced adaptive abilities of the body. Moreover, they were under moderate stress. 47 % of subjects (type 2) were also under a significant stress, which was proven by excessively high SI, low SDNN and TP, and an increased index of functional changes. 5 % of students (type 4) revealed dysfunctional characteristics in the heart rhythm, peculiar to pathology. Keywords: foreign students, heart rate variability, types of autonomic regulation, adaptation potential, functional status. Оценка состояния студентов и динамический контроль за ним является важной задачей, поскольку позволяет своевременно выявлять у студентов донозологические состояния, предшествующие патологии, и способствовать сохранению здоровья. Цель. Оценка адаптивных возможностей организма, анализ изменений показателей вариабельности сердечного ритма у студентов с различными типами вегетативной регуляции, выявление донозологических состояний и ранних признаков патологии. Материалы и методы. В исследовании участвовало 302 студента в возрасте 21,54+1,43 года из Индии. Регистрировались основные параметры ВСР в течение 5 мин с использованием программно-аппаратного комплекса «Психофизиолог». Состояние и уровень здоровья оценивались по индексу функциональных изменений и шкале функциональных состояний. Результаты. По способу, предложенному Н.И. Шлык, выделены группы студентов с различными типами вегетативной регуляции: I (53 %) и II типы (5 %) – с умеренным и выраженным преобладанием центрального контура регуляции соответственно, III (35 %) и IV типы (7 %) – с умеренным и выраженным преобладанием автономного контура регуляции соответственно. У каждого из студентов определены основные параметры ВСР и адаптационного потенциала, характеризующие функциональное состояние и уровень здоровья. Выводы. Показано, что для 82 % обследуемых с I типом, 53 % со II типом, 94 % c III типом и 95 % с IV типом регуляции характерно состояние удовлетворительной адаптации, физиологические процессы сохраняются на оптимальном уровне. В группе студентов I типа у 18 % студентов адаптивные возможности организма снижены, выявлено состояние умеренного напряжения. У 47 % обследуемых II типа также зафиксировано состояние резко выраженного напряжения, индикатором которого является чрезмерно высокое значение SI, низкие величины SDNN и ТP, повышенное значение индекса функциональных изменений. В группе студентов с IV типом у 5 % учащихсяв регуляции ритма сердца выявлены дисфункциональные признаки, характерные для патологии. Ключевые слова: иностранные студенты, вариабельность сердечного ритма, типы вегетативной регуляции, адаптационный потенциал, функциональное состояние.

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