scholarly journals Analysis of Mortality Factors in COVID-19 Patients; Systematic Review

2021 ◽  
Vol 2 (3) ◽  
pp. 1032-1042
Author(s):  
Yunita Liana ◽  
Pariyana ◽  
Mariana
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Laboratory Test ◽  
Neurological Disease ◽  
Test Results ◽  
C Reactive Protein ◽  
Mortality Factors ◽  
Reactive Protein ◽  
Laboratory Test Results ◽  
The Relationship

Abstract.   Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The increase in the number of COVID-19 cases is progressing quickly and has been spread between countries. As of October 14, 2020, there are 213 countries/regions around the world that have reported Covid-19 with a total of 38,002,699 confirmed cases of which 1,083,234 died. The purpose of this study was to determine the relationship between mortality factors and mortality in COVID-19 patients to predict the patient's prognosis. This research method is a systematic review through a literature review on mortality factors in COVID-19 patients Literature searches were accessed through internet searches using the Pubmed database based on the preferred reporting items for systemic review and meta-analysis (PRISMA). A systematic search was carried out on 18 October - 20 October 2020 with the keywords “COVID-19” AND “Death” OR “Decease” AND “Factor Associated”. There were 8 literature selected that met the inclusion and exclusion criteria. Based on the findings of the eight journals, mortality is old age, male, has a clinical condition of hypertension, obesity, diabetes, cardiovascular disease, lung disease, neurological disease, lymphophenia laboratory test results, hyperlactate dehydrogenase, increased procalcitonin, increased neutrophils, increased C-reactive protein, and increased D-dimer. All literature reported that a p value <0.05 was obtained from the analysis of the relationship between mortality factors and cases of death in COVID-19 patients. There is a significant relationship between mortality factors and the death of COVID-19 patients, where the mortality factors are elderly, male, have a clinical condition of hypertension, obesity, diabetes, cardiovascular disease, lung disease, neurological disease, lymphophenia laboratory test results, hyperlactate dehydrogenase, increase in procalcitonin, increase in neutrophils, increase in C-reactive protein, and increase in D-dimers in which the prognosis of patients who have mortality factors tends to be worse. Keywords: Mortality, Coronavirus, COVID-19

Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index

2010 ◽  
Vol 69 (11) ◽  
pp. 1976-1982 ◽  
Author(s):  
Hanneke J M Kerkhof ◽  
Sita M A Bierma-Zeinstra ◽  
Martha C Castano-Betancourt ◽  
Moniek P de Maat ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Genetic Variation ◽  
Body Mass ◽  
Analysis Of Covariance ◽  
C Reactive Protein ◽  
Knee Oa ◽  
Reactive Protein ◽  
Serum Crp ◽  
The Relationship

ObjectiveTo study the relationship between serum C reactive protein (CRP) levels, genetic variation in the CRP gene and the prevalence, incidence and progression of radiographic osteoarthritis (ROA) in the Rotterdam Study-I (RS-I). A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed.MethodsThe association between CRP levels and genetic variation in the CRP gene and ROA was examined in 861 patients with hand OA, 718 with knee OA, 349 with hip OA and 2806 controls in the RS-I using one-way analysis of covariance and logistic regression, respectively. PubMed was searched for articles published between January 1992 and August 2009 assessing the relationship between CRP levels and OA.ResultsIn RS-I the prevalence of knee OA, but not hip OA or hand OA, was associated with 14% higher serum CRP levels compared with controls (p=0.001). This association disappeared after adjustment for age and especially body mass index (BMI) (p=0.33). Genetic variation of the CRP gene was not consistently associated with the prevalence, incidence or progression of OA within RS-I. The systematic review included 18 studies (including RS-I) on serum CRP levels and the prevalence, incidence or progression of OA. Consistently higher crude CRP levels were found in cases of prevalent knee OA compared with controls. No association was observed between serum CRP levels and the prevalence of knee OA following adjustment for BMI (n=3 studies, meta-analysis p value=0.61).ConclusionThere is no evidence of association between serum CRP levels or genetic variation in the CRP gene with the prevalence, incidence or progression of OA independent of BMI.

scholarly journals Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis

2018 ◽  
Vol 73 ◽  
pp. 85-114 ◽  
Author(s):  
Sarah R. Horn ◽  
Madison M. Long ◽  
Benjamin W. Nelson ◽  
Nicholas B. Allen ◽  
Philip A. Fisher ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

Hypothyroidism and cardiovascular system

2016 ◽  
Vol 94 (7) ◽  
pp. 497-503 ◽  
Author(s):  
A. F. Verbovoy ◽  
Lyudmila A. Sharonova ◽  
O. V. Kosareva ◽  
N. I. Verbovaya ◽  
Yu. A. Dolgikh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Thyroid Dysfunction ◽  
Myocardial Remodeling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed. The article describes characteristics of myocardial remodeling, its dysfunction and their correlation with risk factors of cardiovascular diseases in patients with hypothyroidism.

scholarly journals The Interaction of C - Reactive Protein, Bisphenol A, & Cardiovascular Disease: A Demographical Analysis

2016 ◽  
Vol 9 (3) ◽  
pp. 63 ◽  
Author(s):  
Hassan Naji
Keyword(s):  
Cardiovascular Disease ◽  
Bisphenol A ◽  
Quantitative Research ◽  
The Body ◽  
Spearman Correlation ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Impact ◽  
The Relationship

<p><strong>OBJECTIVE: </strong>The main objective of the study was to investigate the role of C-reactive protein on the relationship between Bisphenol A &amp; Cardiovascular Disease, where the C-reactive protein has been taken as a moderating variable.</p><p><strong>METHODS: </strong>Quantitative research design has been incorporated for evaluating the role of C-reactive protein. Similarly, non-parametric Spearman correlation test has been conducted to assess the relationship between BPA and CVD. The data was taken out from the National Health and Nutrition Examination Survey (NHANES), which was collected in the year 2009-2010.</p><p><strong>RESULTS: </strong>The impact of urinary Bisphenol A on serum C-reactive protein was found statistically significant according to the Spearman correlation coefficient, <em>r</em>s<em>= </em>.06, <em>p </em>= .015. The scatter plots found that there is no relationship between the two variables; this observation held true after filtering the outliers from the plot.</p><p><strong>CONCLUSION:</strong> The results might have positive change by contributing to the body of knowledge on bisphenol A and by rising scientific examination of substances used by the people in the daily life. Further research to identify other possible causes of CVD and elevation of CRP is recommended.</p>

Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease

2000 ◽  
Vol 98 (5) ◽  
pp. 531-535 ◽  
Author(s):  
Stephen J. CLELAND ◽  
Naveed SATTAR ◽  
John R. PETRIE ◽  
Nita G. FOROUHI ◽  
Henry L. ELLIOTT ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
Cell Activation ◽  
Density Lipoprotein ◽  
Low Grade ◽  
C Reactive Protein ◽  
Endothelial Cell Activation ◽  
Reactive Protein ◽  
The Relationship

Low-grade chronic inflammation, characterized by elevated plasma concentrations of C-reactive protein (CRP), is associated with an increased risk of atherosclerotic cardiovascular disease. Endothelial cell activation is an early event in atherogenesis, and previous studies have reported correlations between indirect markers of endothelial cell activation and CRP concentration. Therefore, in the present study, we measured CRP concentration (and leptin concentration as an index of fat mass) in nine healthy subjects (mean age 53±8.1 years; body mass index 27±3.2 kg/m2; mean arterial blood pressure 101±9.0 mmHg) undergoing measurement of basal endothelial nitric oxide (NO) synthesis using intra-brachial infusions of NG-monomethyl-l-arginine (l-NMMA; a substrate inhibitor of endothelial NO synthase) and noradrenaline (a non-specific control vasoconstrictor). In univariate analysis, CRP concentration was correlated with (i) the percentage decrease in forearm blood flow (FBF) during l-NMMA infusion (r = 0.85, P = 0.004); and (ii) the serum leptin concentration (r = 0.65, P = 0.05). In multivariate analysis, the relationship between CRP concentration and the FBF response to l-NMMA remained significant when age and leptin (t = 2.65, P = 0.045), age and BMI (t = 3.69, P = 0.014), or age and low-density-lipoprotein-cholesterol plus high-density-lipoprotein-cholesterol (t = 3.37, P = 0.044), were included in regression models. In contrast, the response of FBF to noradrenaline was not significantly related to CRP concentration. These data demonstrate for the first time a relationship between low-grade chronic inflammation and basal endothelial NO synthesis (measured using an invasive method), and support the notion that endothelial dysfunction is a critical intermediate phenotype in the relationship between inflammation and cardiovascular disease.

scholarly journals The view of a general practitioner on immediate access for patients to their laboratory test results

2018 ◽  
Vol 57 (3) ◽  
pp. 375-382
Author(s):  
Syed Ghulam Sarwar Shah ◽  
Amir Hannan ◽  
Bruce Elliott ◽  
Ingrid Brindle ◽  
Richard Fitton
Keyword(s):  
General Practice ◽  
General Practitioner ◽  
Laboratory Test ◽  
Text Messages ◽  
Test Results ◽  
Traditional Practice ◽  
Online Tools ◽  
Laboratory Test Results ◽  
The Relationship

Abstract This position paper presents the role of laboratory test results in traditional general practice and provides a recommendation for responsible sharing of results with patients for improved safety, efficiency and outcomes. This paper looks at the relationship between the laboratory, the general practitioner consultation, the patient, safety and general practice capacity. We suggest changes in the traditional practice of communicating laboratory test results whereby normal or abnormal results are made available to patients as soon as they become available. We also endorse the opinion that using online tools such as email or text messages could enhance the provision of rapid access to laboratory test results for patients.

scholarly journals Increased Serum Levels of Cadmium are Associated with an Elevated Risk of Cardiovascular Disease in Adults

2021 ◽  
Author(s):  
Siyu Ma ◽  
Jie Zhang ◽  
Cheng Xu ◽  
Min Da ◽  
Yang Xu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
White Blood Cells ◽  
Serum Levels ◽  
Blood Levels ◽  
C Reactive Protein ◽  
Epidemiological Evidence ◽  
Reactive Protein ◽  
Health And Nutrition ◽  
The Relationship ◽  
Inflammation Parameters

Abstract Previous studies have determined the effects of exposure to some heavy metals on cardiovascular disease (CVD); however, the association between exposure to cadmium and CVD in adults remains unclear. The relationship between serum levels of cadmium and the risk of CVD was studied by analysing available data from 38,223 participants who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2016. After adjusting for all covariates, we found that higher serum cadmium concentrations were positively related to both the overall risk of CVD (odds ratio (OR): 1.45; 95% confidence interval (CI): 1.22, 1.72; p for trend <0.001) and the risks of its subtypes, including congestive heart failure, coronary heart disease, heart attack and stroke. Elevated levels of cadmium were associated with increased levels of lipids and inflammation parameters, including blood triglycerides, total cholesterol, white blood cells (WBCs) and C-reactive protein (CRP). Our study provided epidemiological evidence that cadmium may increase the risk of CVD by elevating blood lipids and inflammation. CapsuleHigh blood levels of Cd are associated with increased risks of overall CVD and four of the CVD subtypes

scholarly journals Is there a relationship between dental and/or periodontal pathology and values of C-reactive protein, Homocysteine and Lipoprotein (a) in patients with cardiovascular disease? A case control study

2020 ◽  
Vol 3 (05) ◽  
Author(s):  
Beatriz Gonzalez Navarro ◽  
Enric Jané Salas ◽  
Jose Lopez Lopez ◽  
Xavier Pintó Sala
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Case Control Study ◽  
Case Control ◽  
C Reactive Protein ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Reactive Protein ◽  
The Relationship ◽  
Control Study

Background Dental pathology [dental caries (DC) and apical periodontitis (AP)] and/or periodontal pathology (PD) could influence the onset of cardiovascular disease (CVD). The relationship between conventional CVD risk factors and dento-periodontal pathology has been well demonstrated; however, there is less evidence of the relationship between these pathologies and emerging or unconventional CVD risk factors, including C-reactive protein (CRP), Homocysteine ​​(Hcy) and Lipoprotein a (Lp (a). Methods This case-control study included 99 patients with CVD and 50 healthy controls. All participants underwent a detailed medical history, an intraoral examination, an orthopantomography and a blood test. All the analyses were performed on the data set, using all available information with intention to treat criteria. Results A greater number of patients in the study group presented PD (p <0.001) and AP (p <0.001) compared to the control group. However, we did not find significant differences in the prevalence of caries between both groups (p <0.287). Moreover, none of oral variables was significantly related to concentrations of CRP, Hcy or Lp(a). Conclusions Patients with CVD present more PD and a greater number of AP, suggesting an association between dento-periodontal pathology and cardiovascular pathology. The concentrations of CRP, homocysteine and Lp(a) are not related to the degree of dento-periodontal pathology, so we believe that more studies are necessary to assess this possible association.

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