scholarly journals A single session of aerobic exercise influences paraoxonase 1 activity and concentration (Una sola sesión de ejercicio aeróbico influye en la actividad y concentración de la paraoxonasa)

Retos ◽  
2015 ◽  
pp. 222-225
Author(s):  
J. Kyle Taylor ◽  
Michael R. Esco ◽  
Li Qian ◽  
Kathryn Dugan ◽  
Kathy Jones
Keyword(s):  
Aerobic Exercise ◽  
Thiobarbituric Acid ◽  
Normal Weight ◽  
Apolipoprotein A1 ◽  
Obese Group ◽  
Paraoxonase 1 ◽  
Exercise Session ◽  
Pon1 Activity ◽  
Apo B ◽  
Post Exercise

Our purpose was to examine changes in paraoxonase 1 (PON1) concentration and activity following a single aerobic exercise session. Sixteen men (32 ± 8 yrs.; BMI = 29.4 ± 6.8 kg/m2; % fat = 29 ± 13; VO2max = 38.3 ± 11.9 ml.min-1.kg-1; waist circumference = 93.7 ± 16.0 cm; HDL-C = 1.19 ± 0.21 and triglycerides = 1.22 ± 1.04 mmol’™l-1; direct LDL = 2.69 ± 0.73 mmol’™l-1) expended 400 kcals by treadmill walking at 65% of VO2max. Fasting blood samples were collected before (PRE), immediately post-exercise (IPE), 24 hours post-exercise, and 48 hours post-exercise. PON1 concentration, PON1 activity, lipids, apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B), and thiobarbituric acid reactive substances (TBARS) were analyzed for each time point. The men were divided into two groups based on their body mass index (BMI): Normal weight (NW) and Obese Group. At baseline, PON1 concentration and activity were significantly higher in the NW group as compared to the obese group. In addition, PON1 activity was significantly higher in the NW group as compared to the obese group for all time points. Furthermore, PON1 concentration and activity were significantly increased in the combined group immediately post-exercise and returned to baseline levels within 24 hours. PON1 activity was significantly increased in the Obese group IPE and this was observed with increases in HDLc, Apo A1, and TBARS.Key words. PON1 activity, Exercise, Lipids, Lipoproteins.Resumen. Nuestro objetivo fue examinar los cambios en la concentración y actividad de la paraoxonasa 1 (PON1) luego de una sola sesión de ejercicio aeróbico. Dieciséis hombres (32 ± 8 años; IMC = 29.4 ± 6.8 kg/m2; % grasa = 29 ± 13; VO2max = 38.3 ± 11.9 ml.min-1.kg-1; circunferencia de cintura = 93.7 ± 16.0 cm; HDL-C = 1.19 ± 0.21 y triglicéridos = 1.22 ± 1.04 mmol’™l-1; LDL directo = 2.69 ± 0.73 mmol’™l-1) hicieron ejercicio en una banda sin fin al 65% del VO2max hasta gastar 400 kcal. Se recolectaron muestras sanguíneas en ayuno antes (PRE), inmediatamente finalizado el ejercicio (IPE), 24 y 48 horas posteriores al ejercicio. Para cada una de esas muestras, se analizó la concentración y la actividad de PON1, y la concentración de lípidos, apolipoproteína A1 (Apo A1), apolipoproteína B (Apo B), y sustancias reactivas al ácido tiobarbitúrico (TBARS). Los participantes fueron asignados a dos grupos con base en un índice de masa corporal (IMC): grupo de peso normal (NW) y grupo de personas obesas. Los resultados de línea base indicaron que la concentración y actividad de PON1 fueron significativamente mayores en el grupo NW en comparación con el grupo de personas obesas. También se encontró que la actividad de PON1 fue significativamente mayor en el grupo NW en comparación con el grupo de personas obesas en las demás mediciones. Es más, la concentración y actividad de PON1 aumentó significativamente en ambos grupos combinados inmediatamente luego del ejercicio y regresó a sus niveles basales en 24 horas. La actividad de PON1 aumentó significativamente en el grupo de personas obesas IPE y esto se observó con aumentos en en HDLc, Apo A1 y TBARS.Palabras claves. actividad de PON1, ejercicio, lípidos, lipoproteínas.

scholarly journals Intestinal and Hepatic Uptake of Dietary Peroxidized Lipids and Their Decomposition Products, and Their Subsequent Effects on Apolipoprotein A1 and Paraoxonase1

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1258
Author(s):  
Xueting Jiang ◽  
Pragney Deme ◽  
Rajat Gupta ◽  
Dmitry Litvinov ◽  
Kathryn Burge ◽  
...  
Keyword(s):  
Cell Culture ◽  
Culture Media ◽  
Degradation Products ◽  
Apolipoprotein A1 ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Atherosclerotic Cardiovascular Disease ◽  
Metabolic Fate ◽  
Cell Culture Media ◽  
Decomposition Products

Both pro- and antiatherosclerotic effects have been ascribed to dietary peroxidized lipids. Confusion on the role of peroxidized lipids in atherosclerotic cardiovascular disease is punctuated by a lack of understanding regarding the metabolic fate and potential physiological effects of dietary peroxidized lipids and their decomposition products. This study sought to determine the metabolic fate and physiological ramifications of 13-hydroperoxyoctadecadienoic acid (13-HPODE) and 13-HODE (13-hydroxyoctadecadienoic acid) supplementation in intestinal and hepatic cell lines, as well as any effects resulting from 13-HPODE or 13-HODE degradation products. In the presence of Caco-2 cells, 13-HPODE was rapidly reduced to 13-HODE. Upon entering the cell, 13-HODE appears to undergo decomposition, followed by esterification. Moreover, 13-HPODE undergoes autodecomposition to produce aldehydes such as 9-oxononanoic acid (9-ONA). Results indicate that 9-ONA was oxidized to azelaic acid (AzA) rapidly in cell culture media, but AzA was poorly absorbed by intestinal cells and remained detectable in cell culture media for up to 18 h. An increased apolipoprotein A1 (ApoA1) secretion was observed in Caco-2 cells in the presence of 13-HPODE, 9-ONA, and AzA, whereas such induction was not observed in HepG2 cells. However, 13-HPODE treatments suppressed paraoxonase 1 (PON1) activity, suggesting the induction of ApoA1 secretion by 13-HPODE may not represent functional high-density lipoprotein (HDL) capable of reducing oxidative stress. Alternatively, AzA induced both ApoA1 secretion and PON1 activity while suppressing ApoB secretion in differentiated Caco-2 cells but not in HepG2. These results suggest oxidation of 9-ONA to AzA might be an important phenomenon, resulting in the accumulation of potentially beneficial dietary peroxidized lipid-derived aldehydes.

scholarly journals Acute Citrulline-Malate Oral Supplementation does not Improve Post-Aerobic-Exercise Autonomic Response in Normotensive and Hypertensive Subjects: a Pilot Randomized Controlled Study

2020 ◽  
Vol 22 (4) ◽  
pp. 242-249
Author(s):  
Juliano Casonatto ◽  
Adeluci Moraes ◽  
Kamila Grandolfi
Keyword(s):  
Aerobic Exercise ◽  
Autonomic Response ◽  
Exercise Session ◽  
Controlled Study ◽  
Post Exercise ◽  
Oral Supplementation ◽  
Z Scores ◽  
Normotensive Subjects ◽  
Citrulline Malate ◽  
E 32

AbstractThe present study was designed to investigate whether citrulline malate (CM) supplementation might influence post-aerobic-exercise autonomic response in normotensive and hypertensive subjects. Forty individuals (20 normotensives and 20 hypertensives) were randomly assigned to one of the four experimental groups (normotensive-placebo [NP], normotensive-CM [NC], hypertensive-placebo [HP], and hypertensive-CM [HC]). The participants ingested CM (6 g) or placebo dissolved in water (100 ml) 120 min before the exercise session. The exercise session was conducted on a treadmill and consisted of 40 min of running/walking at 60-70% HRreserve. The heart rate variability (HRV) was recorded continuously for 60 min post-exercise. In normotensive subjects at “post-30”, LF increased and HF decreased after the CM supplementation (16% [P=0.041] and -32% [P=0.037], respectively). No significant differences were found in “pre”, “post-30” and “post-60” considering the pooled (NP, NC, HP, and HC) z-scores for time and frequency HRV domains. These results suggest that a single dose of CM supplementation does not promote significant effects on post-exercise autonomic modulation in normotensive and hypertensive subjects. Keywords: Autonomic Nervous System. Citrulline Malate. Hypertension. Exercise. ResumoO presente estudo foi desenvolvido para investigar se a suplementação de citrulina malato (CM) pode influenciar a resposta autonômica após exercício aeróbico em indivíduos normotensos e hipertensos. Quarenta indivíduos (20 normotensos e 20 hipertensos) foram aleatoriamente designados para um dos quatro grupos experimentais (normotenso-placebo [NP], normotenso-CM [NC], hipertenso-placebo [HP] e hipertenso-placebo [HP] e hipertenso-CM [HC]). Os participantes ingeriram CM (6 g) ou placebo dissolvido em água (100 ml) 120 minutos antes da sessão de exercícios. A sessão de exercícios foi realizada em esteira e consistiu em 40 minutos de corrida/caminhada a 60-70% da FCres. A variabilidade da frequência cardíaca (VFC) foi registrada continuamente por 60 minutos após o exercício. Nos normotensos “pós-30”, houve aumento para LF e redução para HF após a suplementação de CM (16% [P=0,041] e -32% [P=0,037], respectivamente). Não foram encontradas diferenças significativas nos momentos "pré", "pós-30" e "pós-60", considerando os escores-z combinados (NP, NC, HP e HC), tanto para os indicadores de domínio do tempo, quando para os de domínio da frequência. Estes resultados sugerem que uma dose única de suplementação de CM não promove efeitos significativos na modulação autonômica após exercício em indivíduos normotensos e hipertensos. Palavras-chave: Sistema Nervoso Autônomo. Citrulina Malato. Hipertensão, Exercício.

scholarly journals Sitagliptin-Dependent Differences in the Intensity of Oxidative Stress in Rat Livers Subjected to Ischemia and Reperfusion

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Małgorzata Trocha ◽  
Małgorzata Krzystek-Korpacka ◽  
Anna Merwid-Ląd ◽  
Beata Nowak ◽  
Małgorzata Pieśniewska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Ischemia Reperfusion ◽  
Antioxidant Properties ◽  
Thiobarbituric Acid ◽  
Treated Group ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Tbars Level ◽  
Rat Livers

Purpose. Ischemia/reperfusion (IR) is the main cause of liver damage after transplantation. We evaluated the effect of sitagliptin (STG) on oxidative stress parameters in the rat liver under IR. Methods. Rats were treated with STG (5 mg/kg) (S and SIR) or saline solution (C and CIR). Livers from CIR and SIR were subjected to ischemia (60 min) and reperfusion (24 h). During reperfusion, aminotransferases (ALT and AST) were determined in blood samples. Thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), paraoxonase-1 (PON1), glutathione peroxidase (GPx), and the mRNA expression of SOD1 were determined in liver homogenates after reperfusion. Different regions of livers were also histologically evaluated. Results. The PON1 activity was higher, and the TBARS level was lower in SIR than in CIR. There was an inverse relationship between TBARS and PON1 levels in the whole cohort. The GPx activity was lower in ischemic than in nonischemic groups regardless of the STG treatment. In SIR, the SOD1 activity was higher compared to that in CIR. In S, the expression of SOD1 mRNA was the highest of all examined groups and positively correlated with the SOD1 activity in the whole animal cohort. During IR aminotransferases, the activity in the drug-treated group was lower in all examined points of time. In drug-treated groups, the percentage of steatosis was higher than that in nontreated groups regardless of IR. Conclusions. The protective effect of STG on the rat liver, especially its antioxidant properties, was revealed under IR conditions.

scholarly journals Cytokines, Adipokines, and Bone Markers at Rest and in Response to Plyometric Exercise in Obese vs Normal Weight Adolescent Females

2020 ◽  
Vol 11 ◽  
Author(s):  
Nigel Kurgan ◽  
Katherine McKee ◽  
Melissa Calleja ◽  
Andrea R. Josse ◽  
Panagiota Klentrou
Keyword(s):  
Inflammatory Cytokines ◽  
Bone Markers ◽  
Adolescent Females ◽  
Normal Weight ◽  
Obese Group ◽  
Low Grade ◽  
Obese Adolescent ◽  
Post Exercise ◽  
Plyometric Exercise ◽  
Tnf Α

BackgroundIn adults, excess adiposity has been associated with low-grade, chronic inflammation and compromised bone health, but less is known about these linkages in children. The purpose of this study was to compare the circulating levels of inflammatory cytokines, adipokines, osteokines, and bone markers at rest and in response to plyometric exercise between obese and normal weight adolescent females.MethodsTen normal weight (BMI = 21.3 ± 2) and 10 obese (BMI = 32.9 ± 4), postmenarcheal females, aged 13–17 years, performed one bout of plyometric exercise (5 circuits; 120 jumps). Blood samples were taken at rest, 5 min, 1 h, and 24 h post-exercise. Tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), insulin, leptin, osteocalcin, carboxy-terminal telopeptide (CTX), sclerostin, and parathyroid hormone (PTH) were measured in serum.ResultsCytokines were not different between groups at rest or over time with IL-6 increasing (+31%; p = 0.04) 5 min post-exercise and TNF-α decreasing (-9%; p = 0.001) 1 h post-exercise. Insulin and leptin were higher in the obese compared to the normal weight females. In both groups, insulin significantly increased 5 min post-exercise but remained elevated 1 h post-exercise only in the obese group. Leptin did not change in response to exercise. Osteocalcin was lower in the obese group across time and increased (+12%; p = 0.02) 24 h post-exercise in both groups. CTX was similar between groups at rest and decreased (-24%; p < 0.001) 1 h post-exercise. Sclerostin was similar between groups at rest, but there was a significant interaction reflecting a significant increase (+29%; p = 0.04) 5 min post-exercise in the obese group and a non-significant decrease (-13%; p = 0.08) in normal weight controls. PTH increased 5 min post-exercise, dropped 1 h post-exercise to lower than pre-exercise, and returned to baseline 24 h post-exercise in both groups.ConclusionObese adolescent females from our study had no evidence of resting inflammation or differences in bone resorption but show blunted bone formation when compared to normal weight controls. The direction and temporal changes in inflammatory cytokines, adipokines, and bone turnover markers to exercise were similar in both groups, reflecting an overall bone anabolic response for most biomarkers, except sclerostin, which increased only in the obese females immediately post-exercise, suggesting a different systemic regulation of sclerostin depending on adiposity.

scholarly journals Differences in Nervous Autonomic Control in Response to a Single Session of Exercise in Bodybuilders Using Anabolic Androgenic Steroids

2021 ◽  
Vol 80 (1) ◽  
pp. 93-101
Author(s):  
Jefferson Fernando Coelho Rodrigues Júnior ◽  
Alexandre Sérgio Silva ◽  
Glêbia Alexa Cardoso ◽  
Valmir Oliveira Silvino ◽  
Acácio Salvador Veras-Silva ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Repeated Measures ◽  
Recovery Period ◽  
Autonomic Nerve ◽  
Exercise Session ◽  
Anabolic Androgenic Steroids ◽  
Control Group ◽  
Frequency Spectra ◽  
Post Exercise ◽  
Androgenic Steroids

Abstract Considering the role of autonomic nerve activity in blood pressure control, this study aimed to investigate the cardiac autonomic nerve responses after an aerobic exercise session in Anabolic Androgenic Steroids (AAS) users. Twenty men (AAS, n = 9; control group, n = 11) performed an aerobic exercise session (60 min, 70 to 80% of HRmax). Heart rate variability (HRV) was assessed before and during a 60-min post-exercise recovery period. RMSSD (root mean square successive difference of the RR intervals) and the LF/HF ratio (low frequency/high frequency spectra) were also evaluated. The Student's t-test for independent samples was used to compare differences between initial group characteristics. Repeated measures ANOVA was used to compare pre- and post-exercise HRV recovery (p < 0.05). AAS had a lower SDNN (standard deviation of the intervals) (40.8 ± 16.8 vs. 71.6 ± 24.7 ms; p = 0.04, d = 1.4) and a higher LF/HF (3.4 ± 2.1 vs. 1.8 ± 0.9%; p = 0.03, d = 0.9) before exercise. AAS and controls had similar RMSSD (14.0 ± 15.8 vs. 18.9 ± 12.1 ms; p = 0.20) and a LF/HF (2.8 ± 1.6 vs. 2.4 ± 1.2 ms; p = 0.41) immediately post-exercise. The between-groups comparison revealed a higher HF/LF at 30 min (4.3 ± 1.4 vs. 2.5 ± 1.3%; p = 0.008, d = 1.3) and 60 min (5.0 ± 2.2 vs. 2.3 ± 0.8%; p = 0.001, d = 1.6) for the AAS group in the recovery time. This study demonstrated impaired parasympathetic activity at rest and immediately after the exercise session as an adverse effect of AAS usage, but similar behavior regarding the restoration of sympathetic activity.

Plasma glycerol during the acute post-exercise recovery period: influence of exercise intensity

2013 ◽  
Vol 9 (2) ◽  
pp. 103-108
Author(s):  
R.J. Bloomer ◽  
T.M. Farney
Keyword(s):  
Aerobic Exercise ◽  
High Intensity ◽  
Recovery Period ◽  
Area Under The Curve ◽  
Fat Oxidation ◽  
High Intensity Exercise ◽  
Exercise Session ◽  
Exercise Recovery ◽  
Post Exercise ◽  
Post Exercise Recovery

Intensity of exercise can influence substrate utilization, with increasing intensity resulting in lower rates of fat oxidation and the reliance on carbohydrate as the preferred fuel. Fat oxidation (or more specifically, mobilization) can be assessed via the measurement of circulating glycerol, with most prior research focusing on aerobic exercise and measurements obtained during the actual exercise bout. The present study determined the degree of fat oxidation/mobilization by measuring plasma glyctierol concentrations during the one hour post-exercise recovery period following three difference exercise bouts. On four different days, exercise trained men (n=12; 23.7±1.1 years) either rested quietly or performed aerobic cycle exercise (60 min at 70% heart rate reserve), 60 s cycle sprints at 100% max wattage obtained during graded exercise testing (GXT) - a total of five, or 15 s cycle sprints at 200% max wattage obtained during GXT - a total of 10. Blood was collected before and at 1, 30 and 60 min post-exercise. Haematocrit and haemoglobin were measured to correct for changes in plasma volume. Glycerol was analysed in plasma and the area under the curve was calculated. Glycerol increased across time (P<0.0001) from pre-exercise (8.4±0.3 μg/dl) to 1 min (13.1±0.7 μg/dl), 30 min (11.3±0.6 μg/dl) and 60 min (9.1±0.5 μg/dl) post-exercise, with 1 min and 30 min post-exercise greater than pre-exercise and 60 min post-exercise (P<0.05). Area under the curve was greater (P=0.0004) for aerobic exercise (24.7±2.0 μg/dl/h), 60 second sprints (23.4±1.9 μg/dl/h) and 15 sec sprints (24.4±1.5 μg/dl/h), as compared to rest (15.3±0.8 μg/dl/h), with no differences noted between exercise bouts (P≯0.05). All exercise bouts increase circulating glycerol, with no differences noted between bouts. Although previous data indicate that low intensity aerobic exercise results in greater fat oxidation than high intensity exercise (when assessed during the actual exercise session), our findings suggest that high intensity exercise may result in similar fat oxidation/mobilization as compared to aerobic exercise during the acute post-exercise period.

Effect of a Single Session of Acute Aerobic Exercise on the Activities of High Density Lipoprotein Enzymes

2018 ◽  
Vol 55 (1) ◽  
pp. 18
Author(s):  
Priyanka S. Bannikoppa ◽  
Sheila Uthappa ◽  
Tinku Thomas ◽  
Anura V. Kurpad ◽  
Indu Mani
Keyword(s):  
High Density Lipoprotein ◽  
Aerobic Exercise ◽  
Acute Exercise ◽  
Density Lipoprotein ◽  
High Density ◽  
Paraoxonase 1 ◽  
Matched Pair ◽  
Post Exercise ◽  
Time Points ◽  
Single Bout

High Density Lipoprotein (HDL) is considered to be an anti-atherogenic molecule and its beneficial function is driven by a number of enzymes such as LCAT (Lecithin Cholesterol Acyl Transferase), PON1 (Paraoxonase 1), PAF-AH (Platelet-Activating Factor Acetyl Hydrolase) and CETP (Cholesteryl Ester Transfer Protein). Low HDL-C level is the most prevalent dyslipidemia seen in India and exercise is one reliable way to improve its levels. While acute exercise is known to increase HDL-C levels, not much is known about its effects on HDL functions. This study was aimed at assessing the effect of a single bout of acute aerobic exercise on key HDL functions. Ten healthy adult male volunteers (20-35 years) were made to exercise at 65-80% VO2 max to expend 200 Kcal using a modified Bruce protocol. Plasma samples were collected at different time points (before exercise, 15 min, 1 hour, 2 hours, 4 hours, 24 hours, 48 hours post-exercise) for analysis of HDL anti-inflammatory function and its related enzyme activities. Friedman ANOVA followed by post-hoc Wilcoxon matched pair test, showed that PON1 activity increased immediately but reached significance 48 hours post-exercise (Z = -2.666, p = 0.008). CETP and LCAT activities were decreased significantly at the 4th hour post-exercise and continued to be low even up to 48 hours (Z = -2.666, p = 0.008), whereas HDL-C levels, MPO activity and HDL-II did not vary significantly at different time points. Enhanced activity of the antioxidant enzyme PON1, in combination with decreased activities of pro-atherogenic enzymes CETP and LCAT suggest that even a single bout of acute exercise could be effective in eliciting athero-protective changes in HDL function independent of HDL-C levels.

scholarly journals A Single Dose of Beetroot Juice Does Not Change Blood Pressure Response Mediated by Acute Aerobic Exercise in Hypertensive Postmenopausal Women

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1327 ◽  
Author(s):  
Ana Luiza Amaral ◽  
Igor M. Mariano ◽  
Victor Hugo V. Carrijo ◽  
Tállita Cristina F. de Souza ◽  
Jaqueline P. Batista ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Postmenopausal Women ◽  
Blood Pressure Response ◽  
Aerobic Exercise Training ◽  
Exercise Session ◽  
Beetroot Juice ◽  
Post Exercise ◽  
Before And After

Objective: To verify if acute intake of beetroot juice potentiates post-exercise hypotension (PEH) in hypertensive postmenopausal women. Methods: Thirteen hypertensive postmenopausal women (58.1 ± 4.62 years and 27.4 ± 4.25 kg/m²) were recruited to participate in three experimental sessions, taking three different beverages: Beetroot juice (BJ), placebo nitrate-depleted BJ (PLA), and orange flavored non-caloric drink (OFD). The participants performed moderate aerobic exercise training on a treadmill, at 65–70% of heart rate reserve (HRR), for 40 min. After an overnight fast, the protocol started at 07h when the first resting blood pressure (BP) was measured. The beverage was ingested at 07h30 and BP was monitored until the exercise training started, at 09h30. After the end of the exercise session, BP was measured every 15 min over a 90-min period. Saliva samples were collected at rest, immediately before and after exercise, and 90 min after exercise for nitrite (NO2−) analysis. Results: There was an increase in salivary NO2− with BJ intake when compared to OFD and PLA. A slight increase in salivary NO2− was observed with PLA when compared to OFD (p < 0.05), however, PLA resulted in lower salivary NO2− when compared to BJ (p < 0.001). There were no changes in salivary NO2− with the OFD. Systolic and diastolic BP decreased (p < 0.001) on all post exercise time points after all interventions, with no difference between the three beverages. Conclusion: Acute BJ intake does not change PEH responses in hypertensive postmenopausal women, even though there is an increase in salivary NO2−.

scholarly journals Serum Cystatin C Is a Determinant of Paraoxonase Activity in Hemodialyzed and Renal Transplanted Patients

2009 ◽  
Vol 26 (3) ◽  
pp. 141-148 ◽  
Author(s):  
Éva Varga ◽  
Ildikó Seres ◽  
Mariann Harangi ◽  
Ferenc Sztanek ◽  
László Asztalos ◽  
...  
Keyword(s):  
Renal Failure ◽  
Cystatin C ◽  
Sandwich Elisa ◽  
Thiobarbituric Acid ◽  
Protective Role ◽  
Paraoxonase 1 ◽  
Ldl Oxidation ◽  
Pon1 Activity ◽  
Serum Cystatin C ◽  
The Relationship

Background: Human paraoxonase-1 (PON1) inhibits LDL-oxidation and atherogenesis, and possesses lactonase activity. Decreased PON1 activity was found in hemodialyzed and renal transplanted patients. Cystatin C plays a protective role in atherosclerosis, and is a new, sensitive marker of renal function. The relationship between these two markers in renal failure has not been investigated.Aims: The goal of this study was to clarify the relationship between PON1 activity, cystatin C and homocysteine in chronic renal failure. We also determined the levels of oxidatively modified LDL (oxLDL) and thiobarbituric acid reactive substances (TBARS) to characterize lipid peroxidation.Patients and methods: 74 hemodialized (HD), 171 renal transplanted patients (TRX), and 110 healthy controls (C) were involved in the study. PON1 activity and TBARS levels were measured spectrophotometrically. OxLDL level was determined with sandwich ELISA.Results: There was a negative correlation between PON1 activity and cystatin C level. Homocysteine level correlated negatively with PON1 activity, and positively with cystatin C level. OxLDL and TBARS levels were significantly higher in the HD and TRX groups compared to C.Conclusions: Cystatin C may be a good predictive factor not only for homocysteine levels but for the antioxidant status in patients with renal failure and renal transplantation.

scholarly journals EFFECT OF A THERMOGENIC SUPPLEMENTATION ON POST AEROBIC EXERCISE HEMODYNAMIC RESPONSES IN HEALTHY YOUNG MEN

2020 ◽  
Vol 20 (38) ◽  
pp. 155-162
Author(s):  
Vilton Emanoel Lopes de Moura E Silva ◽  
Valmir Oliveira Silvino ◽  
Jefferson Fernando Coelho Rodrigues Júnior ◽  
Alyson Felipe da Costa Sena ◽  
Carlos Eduardo Neves Amorim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Aerobic Exercise ◽  
Statistical Significance ◽  
Group Versus ◽  
Test Group ◽  
Exercise Session ◽  
Control Group ◽  
Exercise Recovery ◽  
Post Exercise ◽  
Post Exercise Recovery

Introduction: The use of food supplements with esthetic or performance-enhancing goals has been largely investigated. Thermogenics are supplements that increase energy expenditure through thermogenesis and are widely consumed by individuals seeking to improve body composition and exercise performance. Objective: To evaluate the effects of a commercially available thermogenic supplement on post-exercise blood pressure responses. Materials and Methods: Twenty-seven healthy thermogenic supplements users participated in the study. Nine were assigned in the control group (21.67 ± 1.87 years), nine in the thermogenic group (24.00 ± 4.18), and nine in the placebo group (23.67 ± 3.04). The volunteers performed a treadmill aerobic exercise session for 60 minutes at 65 to 85% max heart rate. The hemodynamic variables were measured at rest and during 60 minutes in the post-exercise recovery. The normality of the data was evaluated using the Shapiro-Wilk test. Baseline momentum and post-exercise recovery were analyzed using the two-way ANOVA test (group versus time factors), with Bonferroni post-hoc test. The level of statistical significance was set at p <0.05. Results: The thermogenic supplement did not significantly compromise post-exercise hypotension when compared to the other groups. However, thermogenic supplementation increased the blood pressure in >5 mmHg, which reportedly plays an important role in cardiovascular diseases. Conclusion: The use of the thermogenic Lipo 6 Black Ultra Concentre Nutrex ® did not alter PEH in healthy youngsters. However, since an increase in the blood pressure was observed, this supplementation must be administered with caution.

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