scholarly journals Evaluasi Granul Ekstrak Daun Nangka (Artocarpus heterophyllus L.) dengan Menggunakan Metode Granulasi Basah

2021 ◽  
Vol 1 ◽  
pp. 1182-1193
Author(s):  
Intan Amalina Istiqomah ◽  
Dwi Bagus Pambudi ◽  
St. Rahmatullah ◽  
S Slamet
Keyword(s):  
Physical Properties ◽  
Water Content ◽  
Flow Rate ◽  
Leaf Extract ◽  
Extraction Process ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Artocarpus Heterophyllus ◽  
Pharmacological Studies ◽  
Rate Test

AbstractJackfruit leaf (Artocarpus heterophyllus L.) is a potential plant that has passed pharmacological studies showing its anti-inflammatory, antibacterial, antiviral, anticancer, antihypertensive, and diuretic activities. The purpose of this study was to determine whether the granules of jackfruit leaf extract (Artocarpus heterophyllus L.) met the physical requirements of good granules. The first step in this research is to carry out the simplicia extraction process of jackfruit leaves using the maceration method using 96% ethanol as solvent. And in the manufacture of granules using the wet granulation method. In the study, the results of the evaluation of the granules of the angle of repose of formula I and formula IV were 24,220, formula II and formula III were 26,380. The average Granule Flow Rate Test for formula I is 3.4 seconds, formula II averages 2.91 seconds, formula III averages 2.59, and formula IV averages 2.75 seconds and falls into the cohesive range. The water content test in formulas I, II, III, and IV was 1%. And in the compressibility test of formula I the results are 11%, formula II is 7.85%, formula III is 8.99%, and formula IV is 3.92%. From these data, it can be concluded that the granules in formulas I, II, III, and IV have good physical properties because in the physical properties test all formulas meet the requirements.Keywords: Jackfruit leaves; granule evaluation; granules; wet granulation. AbstrakDaun Nangka (Artocarpus heterophyllus L.) adalah tanaman potensial yang telah melewati studi farmakologi yang menunjukkan adanya aktivitas antiinflamasi, antibakteri, antivirus, antikanker, antihipertensi, dan diuretik. Tujuan dari penelitian ini adalah mengetahui apakah granul ekstrak daun nangka (Artocarpus heterophyllus L.) memenuhi persyaratan fisik granul yang baik. Langkah pertama pada penelitian ini adalah dengan melakukan proses ekstraksi simplisia daun nangka menggunakan metode maserasi dengan menggunakan pelarut etanol 96%. Dan pada pembuatan granul dengan menggunakan metode granulasi basah. Pada penelitian didapatkan hasil evaluasi granul sudut diam formula I dan formula IV hasilnya 24,220, formula II dan formula III hasilnya 26,380. Uji Laju Alir Granul formula I rata-ratanya 3,4 detik, formula II rata-ratanya 2,91 detik, formula III rata-ratanya 2,59, dan formula IV rata-ratanya 2,75 detik dan masuk kedalam rentang kohesif. Uji Kadar air pada formula I, II, III, dan IV hasilnya adalah 1%. Dan pada uji kompresibilitas formula I hasilnya 11%, formula II 7,85%, formula III 8,99%, dan formula IV 3,92%. Dari data tersebut dapat disimpulkan bahwa granul pada formula I, II, III, dan IV memiliki sifat fisik yang baik karena pada uji sifat fisik granul semua formula memenuhi syarat. Kata kunci : Daun nangka; evaluasi granul; granul; granulasi basah.

scholarly journals Karakteristik dan Evaluasi Granul Ekstrak Daun Kersen (Muntingia calabura L.) dengan Metode Granulasi Basah

2021 ◽  
Vol 1 ◽  
pp. 1737-1746
Author(s):  
Muti Syabania ◽  
Dwi Bagus Pambudi ◽  
W Wirasti ◽  
St Rahmatullah
Keyword(s):  
Flow Rate ◽  
Leaf Extract ◽  
Natural Antioxidants ◽  
The Body ◽  
Theory And Practice ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Evaluation Test ◽  
Rate Test ◽  
Muntingia Calabura

AbstractKersen (Muntingia calabura L.) is a medicinal plant that has the effect of being a source of natural antioxidants that can counteract free radicals in the body. The purpose of this study was to determine the characteristics of Kersen leaf extract granules (Muntingia calabura L.) which can meet the physical requirements of good granules. The method of making granules is by using the wet granulation method. The evaluation of the granules carried out includes tests of moisture content, flow rate, angle of repose, and compressibility. Data analysis was carried out qualitatively by referring to the literature on the Theory and Practice of Industrial Pharmacy Editions II and III as well as Pharmaceutical Technology Textbooks. The granule characteristics of all formulas meet the requirements of a good granule evaluation test. The characteristics of the granules that are close to perfect are in formula II with 20% Avicel pH 101 and 10% Amprotab. The results of the evaluation of the granules obtained were 1.00% water content test, 19.08 gr/second flow rate test, 26.92˚ angle of repose test, 9.80% compressibility test.Keywords: Kersen Leaf Extract, Granules, Characteristics. AbstrakKersen (Muntingia calabura L.) adalah tanaman obat yang mempunyai efek sebagai sumber antioksidan alami yang dapat menangkal radikal bebas dalam tubuh. Tujuan dari penelitian ini yaitu untuk mengetahui karakteristik granul ekstrak daun Kersen (Muntingia calabura L.) yang dapat memenuhi persyaratan fisik granul yang baik. Metode pembuatan granul yaitu dengan menggunakan metode granulasi basah. Evalusi granul yang dilakukan yaitu meliputi uji kadar air, laju aliran, sudut diam, dan kompresibilitas. Analisis data dilakukan secara kualitatif dengan mengacu pada literatur buku Teori dan Praktek Farmasi Industri Edisi II dan III serta buku Pelajaran Teknologi Farmasi. Karakteristik granul semua formula memenuhi syarat dalam uji evaluasi granul yang baik. Karakteristik granul yang mendekati sempurna yaitu pada formula II dengan kadar avicel ph 101 20% dan amprotab 10%. Hasil evaluasi granul yang didapat yaitu uji kadar air 1,00%, uji laju alir 19,08 gr/detik, uji sudut diam 26,92˚, uji kompresibilitas 9,80%. Kata kunci: Ekstrak Daun Kersen, Granul, Karakteristik.

scholarly journals Optimasi Campuran Manitol-Sukrosa Untuk Tablet Hisap Ekstrak Daun Dewa (Gynura Procumbens (Lour) Merr)) Secara Granulasi Basah Dengan Metode Simplex Lattice Design

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Youstiana Dwi Rusita
Keyword(s):  
Physical Properties ◽  
Flow Rate ◽  
Leaf Extract ◽  
T Test ◽  
Wet Granulation ◽  
Response Characteristics ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula

Abstract: Dewa Leaves, Lozenges, Simplex Lattice Design. Dewa is an Indonesian traditional medicinal plants are efficacious among others to the tonsils. Dewa leaf extract can be prepared as lozenges because it is more practical and effective than the traditional way in the form of infusion. This study aimed to get the optimum formula mannitol - sucrose using the simplex lattice design that has more value than triall error. Dewa leaf aqueous extract obtained by maceration leaf powder dewa with 70% ethanol and then evaporated to obtain a thick extract is dried with aerosil. This study is based on the method simplex lattice design with two components, namely FI (100% mannitol), F II (100% sucrose), F III (50% mannitol: 50% sucrose). The method used in the manufacture of leaf extract lozenges Dewa was wet granulation using the binder PVP. The granules tested flow rate, compactibility and granules ditablet to test the taste responses. Of the value of the response characteristics of the granules obtained the largest total selected as the optimum formula. Furthermore ditablet and tested physical properties which include uniformity of weight, hardness and friability of tablets. Data of physical properties of the granules suction of the optimum formula theoretically and statistically tested using the t test (T-test). The results showed that the optimum formula derived from a mixture of mannitol 70% - sucrosa 30%. From the results of the t test (T-test) and compactibility flow rate did not different significantly betwen theoretical experiment. To test the taste responses acceptable 98% of respondents. Dewa leaf extract lozenges optimum formula produced meets the physical properties of the tablet.

scholarly journals Extraction and Evaluation of Lepidium Sativum and Flax Seeds Mucilage as a Pharmaceutical Granulation Binder

2021 ◽  
Author(s):  
Nagla Algali Layas
Keyword(s):  
Physical Properties ◽  
Angle Of Repose ◽  
Lepidium Sativum ◽  
Wet Granulation ◽  
Binding Agent ◽  
Flax Seeds ◽  
Good Flow

The powders holdtogether by a binder to form granule. Some excipients of natural origins arecurrently available as an alternative over the synthetic ones in pharmaceuticalformulation. The aim of this study was to isolate the mucilage from differentplant seeds and compare them to evaluate the binding effects. In present studyan effort was made to investigate the efficacy of mucilage obtained from Lepidiumsativum and flax seeds as granules excipient. The mucilage   was extracted from selected seeds byconventional method by precipitation of soaked and blended seeds in acetone.The dried mucilages were subjected to several phytochemical and physicochemicalproperties. Granules were formulated by wet granulation method by usingextracted mucilage as a binding agent and comparison was made against thegranules prepared with standard binder as PVP. The granules evaluated byvarious physical properties such as (bulk and tapped densities, Hausner’sratio, Carr’s index, angle of repose and friability). The results showed thatthe granules prepared from extracted mucilage as a binder had good flow andmechanical properties, all evaluated parameters were within the permissiblelimits. Thus, mucilage could be used as an alternative binding agent in pharmaceuticalgranules.

scholarly journals Formulasi Masker Ekstrak Daun Pepaya (Carica Papaya L.) Sebagai Anti Jerawat

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Intan Pratiwi ◽  
Youstiana Dwi Rusita
Keyword(s):  
Water Content ◽  
Flow Rate ◽  
Leaf Extract ◽  
Skin Irritation ◽  
Skin Layer ◽  
Skin Cells ◽  
Organoleptic Test ◽  
Test Parameters ◽  
Irritation Test ◽  
Method Of Production

Abstract Background: Mask is one of the effective facial skin cleanser. Mask has merit as deep cleansing,it’s cleaning the dirt on the skin layer deeper, binds skin cells that have died, refine pores of the skin, clean the remnants of excess fat on the surface of the skin’s face, reduce skin irritation, smoothing layer outer skin and nourish the skin, so it looks bright. This study uses papaya leaf extract has a content of the enzyme papain, alkaloids, pseudokapain, glikosid, karposid and saponins. Alkaloid contained in papaya leaves is a kind karpain which has anti bacterial activity. The advantages of the mask is the method of production can be prepared in a simple way. Masks in this study is made in the form of powder to make it easier to use and storage. Method: This study have purpose to determine the results of mask powder formulation of papaya leaf extract as an anti acne that meet the test parameters include physical, organoleptic test, water content test, pH test, and flow rate of irritation test. Result: This research is experimental observation. The results of organoleptic test mask bone-white powder, scented roses and soft textured, the results of water content of 7.5%, a flow rate of over 9 seconds, pH of 6.35. Conclusion: The results of irritation test to the 20  olunteers did not show any reaction of irritation.

Diastase Activity Retention and Physical Properties of Honey/Arabic Gum Mixtures After Spray Drying and Storage

2017 ◽  
Vol 13 (6) ◽  
Author(s):  
Katarzyna Samborska ◽  
Aleksandra Wasilewska ◽  
Ewa Gondek ◽  
Ewa Jakubczyk ◽  
Anna Kamińska-Dwórznicka
Keyword(s):  
Heat Treatment ◽  
Particle Size ◽  
Physical Properties ◽  
Water Content ◽  
Spray Drying ◽  
Angle Of Repose ◽  
Limit Values ◽  
Arabic Gum ◽  
Particle Size Increase ◽  
Size And Morphology

Abstract The effect of heat treatment (75 °C) and spray drying with the addition of Arabic gum (inlet/outlet air temperature 180/75 °C), on the diastase activity of multifloral honey (MH) and rape honey (RH) was investigated. The physical properties of the powders (particle size and morphology, water content and activity, bulk loose and tapped density, angle of repose, hygroscopicity) directly after drying and after 12 weeks of storage were studied. During heat treatment, diastase activity decreased gradually, to decline below limit values after 180 min. Diastase activity in the powders was lower than in fresh honeys, but it was concluded that temperature was not the only factor affecting this decrease. Powders were characterized by low water content and medium flowability, which was improved after storage due to particle size increase. Diastase activity in powders was stable during storage.

scholarly journals Sand Granules Ekstrak Etanol Daun Kirinyuh (Eupatorium inulifolium Kunth.) sebagai Larvasida Alami Pemberantas Demam Berdarah Dengue

2020 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Puji Hartati ◽  
Yance Anas ◽  
Ririn Lispita Wulandari
Keyword(s):  
Aedes Aegypti ◽  
Flow Rate ◽  
Larval Mortality ◽  
Ethanol Extract ◽  
Physical Characteristics ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Larvicidal Effect

ABSTRAK             Penelitian sebelumnya telah mengungkap efek larvasida ekstrak etanol daun kirinyuh (Eupatorium inulifolium Kunth.) terhadap larva nyamuk Aedes aegypti. Ekstrak ini selanjutnya dapat dikembangkan dalam bentuk sediaan sand granules sehingga mudah digunakan sebagai larvasida alami. Penelitian ini bertujuan untuk mendapatkan formula sand granules ekstrak etanol daun Eupatorium inulifolium Kunth (EEDE) yang memenuhi standar karakteristik fisik granul dan menguji efek larvasidanya pada larva nyamuk Aedes aegypti. Sand granules EEDE dibuat dengan metode  granulasi basah dengan variasi konsentrasi kollidon (1%-5%), explotab (1%-3%) dan sacharum lactis (78,44%-84,44%). Karakteristik fisik berbagai formula Sand granules EEDE yang diuji adalah kecepatan alir dan sudut diam. Uji efek larvasida dilakukan pada 25 ekor larva instar III nyamuk Aedes aegypti selama 24 jam dengan replikasi sebanyak 5 kali. Hasil penelitian menunjukkan bahwa semua formula Sand granules EEDE (F1-F5) memenuhi standar karakteristik fisik dengan kecepatan alir (16,69-19,35) g/detik dan sudut diam granul 32,94°-35,76°. F1-F5 juga memiliki efek larvasida terhadap larva nyamuk Aedes aegypti dengan persentase kematian larva dalam 24 jam sebesar (33,0-39,2) %. Akan tetapi, efek larvasida tersebut lebih kecil dibandingkan dengan EEDE 670 ppm (49,6%) dan Temefos® 0,01 ppm (100,0%). Hasil penelitian ini juga menyimpulkan bahwa proses pembuatan sand granules akan menyebabkan penurunan efek larvasida EEDE. Kata Kunci: Daun kirinyuh, efek larvasida, karakteristik fisik, sand granules  ABSTRACT Previous studies reported Eupatorium inulifolium Kunth. leaves ethanol extract (ELEE) have a larvicidal effect on Aedes aegypti larvae. This extract can be developed into sand granules formulation, making it easy to use as a natural larvicidal. This study means to obtain the ELEE sand granules formula that meets the granule's physical characteristics standard, and asses it's a larvicidal effect on Aedes aegypti larvae. Sand granules of ELEE produced with the wet granulation method. The differences between formulas are variations of Kollidon (1%-5%), Explotab (1%-3%), and Saccharum Lactis (78.44%-84.44%) concentration. The physical characteristics of the various KLEE sand granules formulas observed are flow rate and angle of repose. The assay of the ELEE larvicidal effect was carried out on twenty-five Aedes aegypti Instar III larvae for 24 hours with five replications. The results showed that all ELEE sand granules formulas (F1-F5) met the physical characteristics standard, with a flow rate (16.69-19.35) g/sec and an angle of repose 32.94 °-35.76°. F-F5 also had larvicidal effects on Aedes aegypti larvae, with larval mortality within 24 hours (33.0-39.2) %. However, their larvicidal effect is slight compared to ELEE 670 ppm (49.6%) and Temefos® 0.01 ppm (100.0%). This study also concludes that the process of sand granules preparation will diminish the larvicidal effects of ELEE. Keywords: Kirinyuh leaves, larvacidal effect, physical characteristics, sand granules

Roles of the Main Physical Properties of the Wet Granulation Product of Hawthorn leaf Extract Mixtures in High Shear Granulation

2016 ◽  
Vol 41 (4) ◽  
pp. e13047 ◽  
Author(s):  
Zhe Li ◽  
Juan Luo ◽  
Qieying Jiang ◽  
Guowei Zhao ◽  
Zhenggen Liao ◽  
...  
Keyword(s):  
Physical Properties ◽  
Leaf Extract ◽  
Wet Granulation ◽  
High Shear

FORMULASI GRANUL EFFERVESCENT EKSTRAK ETANOL 90% BUAH LABU AIR (Lagenaria siceraria) SEBAGAI ANTIOKSIDAN DENGAN VARIASI GAS GENERATING AGENT

2020 ◽  
Vol 5 (2) ◽  
pp. 220-229
Author(s):  
Dyera Forestryana ◽  
◽  
Yunitha Hestiarini ◽  
Aristha Novyra Putri
Keyword(s):  
Citric Acid ◽  
Moisture Content ◽  
Sodium Bicarbonate ◽  
Physical Properties ◽  
Tartaric Acid ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Lagenaria Siceraria ◽  
Flow Properties ◽  
Compressibility Index

Water pumpkin (Lagenaria siceraria) is a vegetable that contains secondary metabolites that are beneficial to health. Its use as a vegetable is less attractive to the people so that to increase its utilization, dosage forms are made that can attract public interest, one of which is effervescent granules. Effervescent granules are the most popular dosage form because they can serve in fresh drinks. This study aims to determine the effect of variations in the concentration of acids (citric acid-tartaric acid) and base (sodium bicarbonate) on the physical properties of the formula. The water pumpkin effervescent granules made with various ratios of citric acid, tartaric acid, and sodium bicarbonate consisting of FI (2: 1: 2.5); F II (1: 2: 2,5); F III (2: 1: 3,52); F IV (1: 2: 3,44). The granule made by the wet granulation method. The physical properties of the formula included organoleptic, moisture content, flow properties, compressibility index, pH, solubility time, and acceptability test. Based on the results of the evaluation of physical properties, the granule formula of the water pumpkin effervescent meets the standard requirements with a moisture content of 1.26% -2.26%, flow properties from 6.33 to 7.0 seconds, angle of repose 31.14˚-33.69 ˚, compressibility index 13.61% -17.08%, pH 6.1-7.1 and dissolving time 191-223.33 seconds. Variations of citric acid-tartaric acid and sodium bicarbonate affect the physical properties and taste of the effervescent granules. Based on the acceptability test showed that the panelists liked the water pumpkin effervescent granules in FII.

scholarly journals SABUN EKSTRAK MANGKOKAN (Nothopanax ScutellaiumMerr) SEBAGAI ANTIBAKTERI TERHADAP Staphylococcus aureus

2017 ◽  
Vol 10 (01) ◽  
Author(s):  
Galuh Ratmana Hanum ◽  
Syahrul Ardiansyah
Keyword(s):  
Staphylococcus Aureus ◽  
Physical Properties ◽  
Factorial Design ◽  
Water Content ◽  
Significant Influence ◽  
Leaf Extract ◽  
Ph Value ◽  
The Difference ◽  
One Way Anova

The soap of mangkokan (Nothopanax Scuteliaium Merr) leaf extract is a soap made from extracts of leaves mangkokan (Nothopanax Scuteliaium Merr) with different concentration of mangkokan leaf extract, among others, 70%, 80% and 90%. The Purpose of this research to determine the effect of concentration of mangkokan soap on the physical properties and microbiology. Physical properties include pH and water content while Microbiology includes the inhibitation of the bacterium Staphylococcus aureus. Analysis in this reasearch using one way anova factorial design 1 x 3. The results obtained in this reasearch is the difference in concentration of mangkokan (Nothopanax Scuteliaium Merr) leaf extract significantly affect the pH value of the soap and the difference in concentration of mangkokan (Nothopanax Scuteliaium Merr) leaf extract there is no significant influence on the water content and the inhibition of bacterial.   Keywords : Soap, Leaves Mangkokan, Staphylococcus aureus.

STUDY ON PHYSICAL AND SENSORICAL CHARACTERISTICS OF FLESH RESTRUCTURED WITH SAGO CATFISH JERKY

2014 ◽  
Vol 4 (2) ◽  
pp. 55-64
Author(s):  
Amir Jayani ◽  
Zulman Efendi ◽  
Devi Silsia
Keyword(s):  
Physical Properties ◽  
Water Content ◽  
Analysis Of Variance ◽  
Test Data ◽  
Organoleptic Test ◽  
Significant Difference

This study aims to gain influence the thickness and concentration variations affect the characteristics of sago binder physical properties of catfish jerky. As well as getting influence the thickness and concentration variations affect the level of binder sago joy panelists in terms of organoleptic test. Data were analyzed by analysis of variance using the Analysis Of Variance (ANOVA). If there is a significant difference followed by a further test of DMRT 5% level (physical properties). While the hedonic test performed using Kruskal Wallis analysis. Results uniformity analysis (ANOVA) showed catfish fillet thickness and concentration of sago affect the physical properties of the water content and the level of violence. Where catfish jerky using sago binder 5% and 10% significantly different. The use of sago binder 5% and 10% led to an increase in water content. Besides the addition of the binder resulted in increasing levels of violence catfish jerky. Based on the statistics found that the influence of the thickness and concentration of the binder sago aroma, flavor and color of the sixth jerky catfish were not significantly different. But the texture was significantly different.

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