scholarly journals Karakteristik dan Evaluasi Granul Ekstrak Daun Kersen (Muntingia calabura L.) dengan Metode Granulasi Basah

2021 ◽  
Vol 1 ◽  
pp. 1737-1746
Author(s):  
Muti Syabania ◽  
Dwi Bagus Pambudi ◽  
W Wirasti ◽  
St Rahmatullah
Keyword(s):  
Flow Rate ◽  
Leaf Extract ◽  
Natural Antioxidants ◽  
The Body ◽  
Theory And Practice ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Evaluation Test ◽  
Rate Test ◽  
Muntingia Calabura

AbstractKersen (Muntingia calabura L.) is a medicinal plant that has the effect of being a source of natural antioxidants that can counteract free radicals in the body. The purpose of this study was to determine the characteristics of Kersen leaf extract granules (Muntingia calabura L.) which can meet the physical requirements of good granules. The method of making granules is by using the wet granulation method. The evaluation of the granules carried out includes tests of moisture content, flow rate, angle of repose, and compressibility. Data analysis was carried out qualitatively by referring to the literature on the Theory and Practice of Industrial Pharmacy Editions II and III as well as Pharmaceutical Technology Textbooks. The granule characteristics of all formulas meet the requirements of a good granule evaluation test. The characteristics of the granules that are close to perfect are in formula II with 20% Avicel pH 101 and 10% Amprotab. The results of the evaluation of the granules obtained were 1.00% water content test, 19.08 gr/second flow rate test, 26.92˚ angle of repose test, 9.80% compressibility test.Keywords: Kersen Leaf Extract, Granules, Characteristics. AbstrakKersen (Muntingia calabura L.) adalah tanaman obat yang mempunyai efek sebagai sumber antioksidan alami yang dapat menangkal radikal bebas dalam tubuh. Tujuan dari penelitian ini yaitu untuk mengetahui karakteristik granul ekstrak daun Kersen (Muntingia calabura L.) yang dapat memenuhi persyaratan fisik granul yang baik. Metode pembuatan granul yaitu dengan menggunakan metode granulasi basah. Evalusi granul yang dilakukan yaitu meliputi uji kadar air, laju aliran, sudut diam, dan kompresibilitas. Analisis data dilakukan secara kualitatif dengan mengacu pada literatur buku Teori dan Praktek Farmasi Industri Edisi II dan III serta buku Pelajaran Teknologi Farmasi. Karakteristik granul semua formula memenuhi syarat dalam uji evaluasi granul yang baik. Karakteristik granul yang mendekati sempurna yaitu pada formula II dengan kadar avicel ph 101 20% dan amprotab 10%. Hasil evaluasi granul yang didapat yaitu uji kadar air 1,00%, uji laju alir 19,08 gr/detik, uji sudut diam 26,92˚, uji kompresibilitas 9,80%. Kata kunci: Ekstrak Daun Kersen, Granul, Karakteristik.

scholarly journals Evaluasi Granul Ekstrak Daun Nangka (Artocarpus heterophyllus L.) dengan Menggunakan Metode Granulasi Basah

2021 ◽  
Vol 1 ◽  
pp. 1182-1193
Author(s):  
Intan Amalina Istiqomah ◽  
Dwi Bagus Pambudi ◽  
St. Rahmatullah ◽  
S Slamet
Keyword(s):  
Physical Properties ◽  
Water Content ◽  
Flow Rate ◽  
Leaf Extract ◽  
Extraction Process ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Artocarpus Heterophyllus ◽  
Pharmacological Studies ◽  
Rate Test

AbstractJackfruit leaf (Artocarpus heterophyllus L.) is a potential plant that has passed pharmacological studies showing its anti-inflammatory, antibacterial, antiviral, anticancer, antihypertensive, and diuretic activities. The purpose of this study was to determine whether the granules of jackfruit leaf extract (Artocarpus heterophyllus L.) met the physical requirements of good granules. The first step in this research is to carry out the simplicia extraction process of jackfruit leaves using the maceration method using 96% ethanol as solvent. And in the manufacture of granules using the wet granulation method. In the study, the results of the evaluation of the granules of the angle of repose of formula I and formula IV were 24,220, formula II and formula III were 26,380. The average Granule Flow Rate Test for formula I is 3.4 seconds, formula II averages 2.91 seconds, formula III averages 2.59, and formula IV averages 2.75 seconds and falls into the cohesive range. The water content test in formulas I, II, III, and IV was 1%. And in the compressibility test of formula I the results are 11%, formula II is 7.85%, formula III is 8.99%, and formula IV is 3.92%. From these data, it can be concluded that the granules in formulas I, II, III, and IV have good physical properties because in the physical properties test all formulas meet the requirements.Keywords: Jackfruit leaves; granule evaluation; granules; wet granulation. AbstrakDaun Nangka (Artocarpus heterophyllus L.) adalah tanaman potensial yang telah melewati studi farmakologi yang menunjukkan adanya aktivitas antiinflamasi, antibakteri, antivirus, antikanker, antihipertensi, dan diuretik. Tujuan dari penelitian ini adalah mengetahui apakah granul ekstrak daun nangka (Artocarpus heterophyllus L.) memenuhi persyaratan fisik granul yang baik. Langkah pertama pada penelitian ini adalah dengan melakukan proses ekstraksi simplisia daun nangka menggunakan metode maserasi dengan menggunakan pelarut etanol 96%. Dan pada pembuatan granul dengan menggunakan metode granulasi basah. Pada penelitian didapatkan hasil evaluasi granul sudut diam formula I dan formula IV hasilnya 24,220, formula II dan formula III hasilnya 26,380. Uji Laju Alir Granul formula I rata-ratanya 3,4 detik, formula II rata-ratanya 2,91 detik, formula III rata-ratanya 2,59, dan formula IV rata-ratanya 2,75 detik dan masuk kedalam rentang kohesif. Uji Kadar air pada formula I, II, III, dan IV hasilnya adalah 1%. Dan pada uji kompresibilitas formula I hasilnya 11%, formula II 7,85%, formula III 8,99%, dan formula IV 3,92%. Dari data tersebut dapat disimpulkan bahwa granul pada formula I, II, III, dan IV memiliki sifat fisik yang baik karena pada uji sifat fisik granul semua formula memenuhi syarat. Kata kunci : Daun nangka; evaluasi granul; granul; granulasi basah.

scholarly journals POTENSI ANTIOKSIDAN ALAMI PADA EKSTRAK DAUN JAMBLANG (Syzigium cumini (L.) Skeels)

2017 ◽  
Vol 18 (02) ◽  
pp. 107-112
Author(s):  
Ayu Nirmala Sari
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Leaf Extract ◽  
Natural Antioxidants ◽  
The Body ◽  
Antioxidant Potential ◽  
Negative Effects ◽  
Antioxidant Content ◽  
Dpph Method ◽  
In Cells

Various diseases can be triggered by the condition of oxidative stress in the body. Oxidative stress is a condition that occurs in cells when free radicals are present in excess amounts. To reduce the negative effects and negative effects of these free radicals, the body needs antioxidants. The aim of this research is to know the antioxidant potential of black plum leaf extract (Syzigium cumini (L.) Skeel) using DPPH method. Based on the results of antioxidant potential testing in black plum leaf extract known that it has antioxidant content that is classified as very active with an IC 50 value of 8.85. The results of this study indicate that the leaves of black plum (Syzigium cumini (L.) Skeel have the potential to be developed as a source of natural antioxidants for humans.

scholarly journals Sand Granules Ekstrak Etanol Daun Kirinyuh (Eupatorium inulifolium Kunth.) sebagai Larvasida Alami Pemberantas Demam Berdarah Dengue

2020 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Puji Hartati ◽  
Yance Anas ◽  
Ririn Lispita Wulandari
Keyword(s):  
Aedes Aegypti ◽  
Flow Rate ◽  
Larval Mortality ◽  
Ethanol Extract ◽  
Physical Characteristics ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Larvicidal Effect

ABSTRAK             Penelitian sebelumnya telah mengungkap efek larvasida ekstrak etanol daun kirinyuh (Eupatorium inulifolium Kunth.) terhadap larva nyamuk Aedes aegypti. Ekstrak ini selanjutnya dapat dikembangkan dalam bentuk sediaan sand granules sehingga mudah digunakan sebagai larvasida alami. Penelitian ini bertujuan untuk mendapatkan formula sand granules ekstrak etanol daun Eupatorium inulifolium Kunth (EEDE) yang memenuhi standar karakteristik fisik granul dan menguji efek larvasidanya pada larva nyamuk Aedes aegypti. Sand granules EEDE dibuat dengan metode  granulasi basah dengan variasi konsentrasi kollidon (1%-5%), explotab (1%-3%) dan sacharum lactis (78,44%-84,44%). Karakteristik fisik berbagai formula Sand granules EEDE yang diuji adalah kecepatan alir dan sudut diam. Uji efek larvasida dilakukan pada 25 ekor larva instar III nyamuk Aedes aegypti selama 24 jam dengan replikasi sebanyak 5 kali. Hasil penelitian menunjukkan bahwa semua formula Sand granules EEDE (F1-F5) memenuhi standar karakteristik fisik dengan kecepatan alir (16,69-19,35) g/detik dan sudut diam granul 32,94°-35,76°. F1-F5 juga memiliki efek larvasida terhadap larva nyamuk Aedes aegypti dengan persentase kematian larva dalam 24 jam sebesar (33,0-39,2) %. Akan tetapi, efek larvasida tersebut lebih kecil dibandingkan dengan EEDE 670 ppm (49,6%) dan Temefos® 0,01 ppm (100,0%). Hasil penelitian ini juga menyimpulkan bahwa proses pembuatan sand granules akan menyebabkan penurunan efek larvasida EEDE. Kata Kunci: Daun kirinyuh, efek larvasida, karakteristik fisik, sand granules  ABSTRACT Previous studies reported Eupatorium inulifolium Kunth. leaves ethanol extract (ELEE) have a larvicidal effect on Aedes aegypti larvae. This extract can be developed into sand granules formulation, making it easy to use as a natural larvicidal. This study means to obtain the ELEE sand granules formula that meets the granule's physical characteristics standard, and asses it's a larvicidal effect on Aedes aegypti larvae. Sand granules of ELEE produced with the wet granulation method. The differences between formulas are variations of Kollidon (1%-5%), Explotab (1%-3%), and Saccharum Lactis (78.44%-84.44%) concentration. The physical characteristics of the various KLEE sand granules formulas observed are flow rate and angle of repose. The assay of the ELEE larvicidal effect was carried out on twenty-five Aedes aegypti Instar III larvae for 24 hours with five replications. The results showed that all ELEE sand granules formulas (F1-F5) met the physical characteristics standard, with a flow rate (16.69-19.35) g/sec and an angle of repose 32.94 °-35.76°. F-F5 also had larvicidal effects on Aedes aegypti larvae, with larval mortality within 24 hours (33.0-39.2) %. However, their larvicidal effect is slight compared to ELEE 670 ppm (49.6%) and Temefos® 0.01 ppm (100.0%). This study also concludes that the process of sand granules preparation will diminish the larvicidal effects of ELEE. Keywords: Kirinyuh leaves, larvacidal effect, physical characteristics, sand granules

scholarly journals EFFECTIVENESS OF CHERRY LEAF EXTRACT (Muntingia calabura) WITH DIFFERENT LEVELS AS TREATMENT OF SEEDS OF SANGKURIANG CATFISH (Clarias gariepinus) INFECTED BY Trichodina sp

2018 ◽  
Vol 1 (1) ◽  
pp. 41
Author(s):  
Moh. Nurhuda ◽  
Marry Ann Kholista ◽  
Yuliani Ismi ◽  
Nurfitri Maulidiya ◽  
Hariyadi Hariyadi ◽  
...  
Keyword(s):  
Human Body ◽  
Leaf Extract ◽  
Clinical Symptoms ◽  
Clarias Gariepinus ◽  
Outer Part ◽  
Quality Measurement ◽  
The Body ◽  
Triterpenoid Saponin ◽  
Randomized Design ◽  
Muntingia Calabura

Sangkuriang catfish (Clarias gariepinus) is a leading commodity of Indonesian freshwater fishery. Production continues to increase in 2016 reached 22%. cultivators experience constraints on seeding and enlargement due to ectoparasites Trichodina sp. this parasite attacks the outer part of the body marked by the spots on the body. Prevention and treatment of many usses of chemicals that can adversely affect the human body and environtment, so it takes another alternative to replace these chemicals that can adversely affect the human body and environment, so it takes another alternative to replace these chemicals. Cherry Leaf contain compounds Flavonoid, Tannin, Triterpenoid, Saponin and Polifenol as antioxidants, Cherry Leaf useful as an antibacterial. The method used in this research is the experimental method and using Completely Randomized Design (RAL). Concentrations of cherry leaf extract (Muntingia calabura) given include 1%, 2%, 3%, 4% and 5% there were 5 treatments and 4 replications. The data obtained were analyzed by ANAVA method (variance analysis) followed by LSD test. The results showed that the use of cherry leaf extract (Muntingia calabura) in treating Trichodina sp parasite has a very real effect with the best value on the presentation of Leukocrit is 2% concentration that produces Leukocrit percentage of 2.68% and percentage of Hematocrit 2% with Hematocrit yield of 11.83%. The clinical symptoms are white spots in all body, pale color, decreased appetite of the mucus that comes out, often rubbing the body to the wall. The result of water quality measurement shows temperature: 24 - 27,2oC, DO: 4,1 - 6,9 and pH: 6 - 8.KEY WORDS: Muntingia calabura, Trichodiniasis, Sangkuriang Catfish, Leukocrit, Hematocrit.

scholarly journals UJI PENANGKAPAN RADIKAL 2,2-difenil-1-pikrilhidrazil (DPPH) OLEH EKSTRAK ETANOL BUNGA KECOMBRANG (Nicolaia speciosa (Bl.) Horan) DAN BUAH TALOK (M. calabura L. )

2019 ◽  
Vol 12 (1) ◽  
pp. 41-53
Author(s):  
Tatang Irianti ◽  
Hari Purnomo ◽  
Kuswandi Kuswandi ◽  
Sindu Nuranto ◽  
Damiana Nitya Kanistri ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Ethyl Acetate ◽  
Carbonyl Group ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Natural Antioxidants ◽  
The Body ◽  
Scavenging Activity ◽  
Muntingia Calabura

ABSTRACT The process of excessive free radicals  in our body plays a major part in the development of chronic and degenerative illness such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases. The recently study reported that free radical and oxidants play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. Therefore, natural antioxidants can be explored to prevent degenerative diseases and in the present paper we have investigated antioxidant activity of extracts from Nicolaia speciose (Bl.) Horan flower and Muntingia calabura L.  fruit for its free radical scavenging activity using 2,2-diphenyl, 1-picryl hydrazil (DPPH) radical scavenging activity. The results revealed that both ethyl acetate fractions of N.  speciaose and M. calabura have the highest antioxidant activitiy with IC50 29.81 and 14.48 µg/ml respectively.   The antioxidant activity of both ethanolic extracts were more potent than hexan and water fractions with IC50 39.27 and 137.20 µg/ml respectively. The investigation of IC50 values indicated that the antioxidant activity show moderate to very active. Active compounds were identified using thin layer chromatography with FeCl3, AlCl3, 2,4-DNPH and anisaldehide-H2SO4 spray reagents. Chromatogram of ethylacetate fraction showed that spots on the hRf 12 and 56 were thought to contain phenolic compounds with a carbonyl group, while the hRf 37 was suspected flavone compounds with 3-OH group and the hRf 50 was alleged the ortho-dihydroxy flavone or ortho hydroxy and free carbonyl. Chromatogram of ethyl acetate of talok fruits fraction showed that spots on the hRf 19.31 and 44 were suspected flavone compounds with ortho-hydroxy-carbonyl group and or ortho-hydroxy. ABSTRAK Radikal bebas berlebih dalam tubuh dapat memicu tumbuhnya sel kanker, penyumbatan pembuluh jantung, kerusakan oksidatif otak dan penuaan dini. Hal ini menyebabkan penelitian tentang potensi antioksidan terus mengalami peningkatan, terutama antioksidan alami dari tanaman. Bunga kecombrang (Nicolaia speciosa (BI.) Horan) dan buah talok (Muntingia Calabura L.) dilaporkan aktif sebagai antioksidan dan mengandung senyawa aktif dengan tingkat kepolaran yang berbeda. Oleh karena itu, penelitian ini bertujuan untuk menguji aktivitas dengan penangkapan radikal bebas fraksi-fraksi ekstrak bunga kecombrang dan buah talok serta karakterisasi golongan senyawa aktifnya. Hasil fraksinasi ekstrak diuji dengan larutan DPPH 0,4 mM dan diukur dengan spektrofotometer UV-Vis pada panjang gelombang 517 nm. Hasil absorbansi sampel dan kontrol diolah untuk mendapatkan persen penangkapan radikal DPPH dan aktivitas antioksidan dievaluasi melalui nilai IC50. Senyawa aktif diidentifikasi menggunakan kromatografi lapis tipis dengan penampak bercak FeCl3, AlCl3, 2,4-DNPH dan anisaldehid-H2SO4.  Fraksi-fraksi ekstrak bunga kecombrang dan buah talok menunjukkan tingkat kekuatan antioksidan antara sedang sampai sangat aktif. Fraksi etil asetat bunga kecombrang serta buah talok memiliki aktivitas penangkapan radikal bebas tertinggi dengan IC50 sebesar 29,81 µg/ml dan 14,48 µg/ml. Pada fraksi etil asetat ini, buah talok mempunyai potensi aktivitas antioksidan dua kali lipatnya dari bunga kecombrang.  Fraksi air, ekstrak etanol serta fraksi heksan bunga kecombrang memiliki IC50 sebesar 39,27 µg/ml, 44,08 µg/ml, dan 135,36 µg/ml. Sedangkan ekstrak etanol, fraksi air serta fraksi heksan buah talok memiliki IC50 sebesar 137,20 µg/ml, 282,47 µg/ml, dan 2611,70 µg/ml. Hasil KLT fraksi etil asetat buah kecombrang menunjukkan bahwa bercak pada hRf 12 dan 56 mengandung senyawa fenolik dengan gugus karbonil, sedangkan hRf 37 diduga senyawa flavon dengan gugus 3-OH dan pada hRf 50 merupakan flavon dengan o-dihidroksi dan atau o-hidroksi karbonil bebas. Kemudian hasil KLT fraksi etil asetat buah talok menunjukkan bahwa bercak dengan nilai hRf  19, 31, dan 44 merupakan flavon dengan gugus o-hidroksi karbonil dan atau gugus o-dihidroksi. Bercak pada hRf 31 juga mengindikasikan adanya senyawa terpenoid.    

scholarly journals Optimasi Campuran Manitol-Sukrosa Untuk Tablet Hisap Ekstrak Daun Dewa (Gynura Procumbens (Lour) Merr)) Secara Granulasi Basah Dengan Metode Simplex Lattice Design

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Youstiana Dwi Rusita
Keyword(s):  
Physical Properties ◽  
Flow Rate ◽  
Leaf Extract ◽  
T Test ◽  
Wet Granulation ◽  
Response Characteristics ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula

Abstract: Dewa Leaves, Lozenges, Simplex Lattice Design. Dewa is an Indonesian traditional medicinal plants are efficacious among others to the tonsils. Dewa leaf extract can be prepared as lozenges because it is more practical and effective than the traditional way in the form of infusion. This study aimed to get the optimum formula mannitol - sucrose using the simplex lattice design that has more value than triall error. Dewa leaf aqueous extract obtained by maceration leaf powder dewa with 70% ethanol and then evaporated to obtain a thick extract is dried with aerosil. This study is based on the method simplex lattice design with two components, namely FI (100% mannitol), F II (100% sucrose), F III (50% mannitol: 50% sucrose). The method used in the manufacture of leaf extract lozenges Dewa was wet granulation using the binder PVP. The granules tested flow rate, compactibility and granules ditablet to test the taste responses. Of the value of the response characteristics of the granules obtained the largest total selected as the optimum formula. Furthermore ditablet and tested physical properties which include uniformity of weight, hardness and friability of tablets. Data of physical properties of the granules suction of the optimum formula theoretically and statistically tested using the t test (T-test). The results showed that the optimum formula derived from a mixture of mannitol 70% - sucrosa 30%. From the results of the t test (T-test) and compactibility flow rate did not different significantly betwen theoretical experiment. To test the taste responses acceptable 98% of respondents. Dewa leaf extract lozenges optimum formula produced meets the physical properties of the tablet.

Karakteristik Granul Ekstrak Rebung Apus (Gigantochloa apus) Dengan Metode Granulasi Basah

2021 ◽  
Vol 1 ◽  
pp. 856-864
Author(s):  
Tetania Putri P ◽  
St. Rahmatullah ◽  
Dwi Bagus Pambudi ◽  
S Slamet
Keyword(s):  
American Academy ◽  
Research Method ◽  
Digestive System ◽  
The Body ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
American Academy Of Pediatrics ◽  
Bamboo Shoots ◽  
Bowel Movements ◽  
Optimal Formula

AbstractApus shoots (Gigantochloa apus) is a plant that can be used as an appetite enhancer, because it contains curcumin compounds in it. According to the American Academy of Pediatrics, dietary fiber has a very important function in the body, which can make children full and facilitate the digestive system. Children's diet with sufficient fiber, can prevent constipation (difficult bowel movements). The purpose of this study was to determine the characteristics of the granules of apus shoots (Gigantochloa apus) extract that met the physical requirements of good granules. The research method for making granules of apus shoots (Gigantochloa apus) extract was wet granulation. The data obtained from this study is that the 1st granule formula is the optimal formula among the three formulas tested because the flow is faster, namely 23.47 gr/second so that the angle of repose is getting smaller, namely 30.02⁰ and the compressibility of 7% obtained is small so that the granules are smaller got good.Key words : Bamboo shoots Extract, Granules, Wet Granulation. AbstrakTanaman rebung apus (Gigantochloa apus) merupakan tanaman yang dapat digunakan sebagai penambah nafsu makan, karena mengandung senyawa kurkumin didalamnya. Menurut American Academy Ofpediatrics, Serat pangan memiliki fungsi yang sangat penting dalam tubuh yaitu dapat membuat anak kenyang dan memperlancar sistem pencernaan. Pola makan anak dengan serat yang cukup, bisa mencegah sembelit (susah buang air besar). Tujuan dari penelitian ini adalah untuk mengetahui karakteristik granul ekstrak rebung apus (Gigantochloa apus) yang memenuhi persyaratan fisik granul yang baik. Metode penelitian pada pembuatan granul ekstrak rebung apus (Gigantochloa apus) adalah granulasi basah. Data yang diperoleh dari penelitian ini adalah formula granul ke 1 merupakan formula yang optimal diantara tiga formula yang diuji karena sifat aliran lebih cepat yaitu 23,47 gr/detik sehingga sudut diam semakin kecil yaitu 30,02⁰ dan kompresibilitas 7% yang didapatkan kecil sehingga granul yang didapat baik.Kata kunci : Ekstrak Rebung apus, Granul, Granulasi Basah.

Preparation and evaluation of valnemulin hydrochloride taste-masking granules

2021 ◽  
Vol 18 ◽  
Author(s):  
Yongjie Liang ◽  
Danlei Hu ◽  
Yuanyuan Yan ◽  
Dongmei Chen ◽  
Shuyu Xie
Keyword(s):  
Sustained Release ◽  
Residence Time ◽  
Solid Dispersion ◽  
Corn Starch ◽  
The Body ◽  
Self Control ◽  
Angle Of Repose ◽  
Taste Masking ◽  
Wet Granulation ◽  
Valnemulin Hydrochloride

Background: The bitter taste and strong irritation of valnemulin hydrochloride limit its wide clinical application in pigs by oral. Method: In order to improve its palatability and residence time in the body, the valnemulin hydrochloride taste-masking granules with sustained-release were prepared by combining solid dispersion based on fatty acid with wet granulation. The formulation was screened by orthogonal test with content, yield, grain size and angle of repose as evaluation indexes. Result: The results showed that the optimal granules were composed of corn starch, sucrose, citric acid, valnemulin hydrochloride and myristic acid at a ratio of 40: 20: 20: 11: 19. The daily feed intake of pigs in the optimum taste-masking granule groups was similar to that of its self-control, and significantly higher than that in the valnemulin hydrochloride active ingredient group, suggesting that the optimum granules have satisfactory palatability. The prepared granules improved the oral bioavailability of valnemulin hydrochloride by 3.04 folds and extended its mean residence time (MRT) by 2.33 folds. Conclusion: The granules developed in this study could obviously improve the palatability and sustained release of valnemulin hydrochloride. The producing method of granules by combining solid dispersion powder with wet granulation can provide ideas for other drugs with poor palatability and a short half-life.

EFFECT OF BODY MASS INDEX ON PEAK EXPIRATORY FLOW RATE

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
K. Subramanyam ◽  
Dr. P. Subhash Babu
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Normal Weight ◽  
The Body ◽  
Health Care Centre ◽  
Expiratory Flow ◽  
Group B

Obesity has become one of the major health issues in India. WHO defines obesity as “A condition with excessive fat accumulation in the body to the extent that the health and wellbeing are adversely affected”. Obesity results from a complex interaction of genetic, behavioral, environmental and socioeconomic factors causing an imbalance in energy production and expenditure. Peak expiratory flow rate is the maximum rate of airflow that can be generated during forced expiratory manoeuvre starting from total lung capacity. The simplicity of the method is its main advantage. It is measured by using a standard Wright Peak Flow Meter or mini Wright Meter. The aim of the study is to see the effect of body mass index on Peak Expiratory Flow Rate values in young adults. The place of a study was done tertiary health care centre, in India for the period of 6 months. Study was performed on 80 subjects age group 20 -30 years, categorised as normal weight BMI =18.5 -24.99 kg/m2 and overweight BMI =25-29.99 kg/m2. There were 40 normal weight BMI (Group A) and 40 over weight BMI (Group B). BMI affects PEFR. Increase in BMI decreases PEFR. Early identification of risk individuals prior to the onset of disease is imperative in our developing country. Keywords: BMI, PEFR.

STUDY ON DEVELOPMENT OF PASTA PRODUCT WITH INCORPORATION OF OCIMUM SANCTUM (BASIL) TO ENHANCE THE SENSORY AND NUTRITIONAL QUALITY

2018 ◽  
Vol 24 (2) ◽  
Author(s):  
PIYUSH MISHRA ◽  
DEVENDRA KUMAR BHATT
Keyword(s):  
Ambient Temperature ◽  
Shelf Life ◽  
Nutritional Quality ◽  
Leaf Extract ◽  
Storage Stability ◽  
Natural Antioxidants ◽  
Sensory Properties ◽  
Ocimum Sanctum ◽  
Leaf Powder

Pasta was prepared by incorporation of Ocimum sanctum (Basil) for better textural and sensory properties. The pasta was incorporated with the leaf extract of Ocimum sanctum at different concentrations of control, 5, 10, and 15.The natural antioxidants present in the O. sanctum leaf powder that was incorporated in the fruit leather showed extended shelf-life over three months when compared with control, without any added preservative at ambient temperature. Also the nutritional stability of the product was studied under two flexible packages of polypropylene and polyester out of that the products packed in polypropylene showed better storage stability .

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