Sulfur isotopic compositions of the lithospheric mantle sulfides from the Udachnaya pipe (Yakutia)

2020 ◽  
Author(s):  
Olga Ilyina ◽  
Alexey Agashev ◽  
Bertrand Moine
Keyword(s):  
Lithospheric Mantle ◽  
Sulfur Isotopes ◽  
Basic Research ◽  
Kimberlite Pipe ◽  
West African ◽  
Udachnaya Pipe ◽  
Depleted Mantle ◽  
Isotope Ratio Mass Spectrometer ◽  
Isotope Study

<p>Sulfide inclusions in Neoproterozoic West African diamonds have revealed mass-independently fractionated sulfur isotopes in them [Smit et.al., 2019]. This feature is a sign of Archean surface changes traced in the mantle. Here we present an S isotope study of the unique fresh mantle deep-seated peridotites, eclogites and pyroxenites with rare or without any secondary alterations from the Udachnaya-East pipe. This research will give better understanding the role of subduction in the formation of the lithospheric mantle under the Siberian craton. Sulfur isotopes (<sup>34</sup>S/<sup>32</sup>S which is denoted as δ<sup>34</sup>S) were measured in the sulfides from eclogites, peridotites and pyroxenites using an Isoprime isotope ratio mass spectrometer (IRMS) with classic configuration with 4 collectors. The sulfides from eclogites are pyrrotite, pentlandites and chalcopyrites. They have δ<sup>34</sup>S values from +0,67 to +3,08 per mil (‰). Sulfides in peridotites are pyrrotite-pentlandite-chalcopyrites assemblages and they have δ<sup>34</sup>S values from +0,22 to +3,55 ‰. These δ<sup>34</sup>S values from eclogites and peridotites are broadly overlap with the field for depleted mantle and chondrites (-1,9 to +0,35‰) [Labidi et.al., 2013; 2014]. Sulfides from pyroxenites are pyrrotite and they have δ<sup>34</sup>S values from -3,62 to +1,49 ‰. These δ<sup>34</sup>S values have a wider range than the estimates for depleted mantle. The δ<sup>34</sup>S values in our samples are close to those in the depleted mantle, but still have deviation from it and do not fractionated. Our data did not detect mass-independently fractionated sulfur isotopes in the mantle samples from the Udachnaya pipe. Thus subduction of the earth’s crust did not play role in the values of sulfur isotopes of the lithospheric mantle sampled by Udachnaya kimberlite pipe. The source of sulfur in these rocks probably was the astenospheric mantle.</p><p>References</p><ol><li>Smit et. al., 2019</li> <li>Labidi et. al., 2013; 2014</li> </ol><p>This study was supported by the Russian Foundation for Basic Research № 18-05-70064</p>

From Trinidad and Tobago to the World: Determining the role of Calypso in a new Era

2020 ◽  
Vol 5 ◽  
pp. 7-11
Author(s):  
Malek Abdel-Shehid
Keyword(s):  
Trinidad And Tobago ◽  
Regional Integration ◽  
West African ◽  
Major Influence ◽  
New Era ◽  
Transatlantic Slave Trade ◽  
Cultural Sovereignty ◽  
Caribbean Culture ◽  
Musical Cultures

Calypso is a popular Caribbean musical genre that originated in the island nation of Trinidad and Tobago. The genre was developed primarily by enslaved West Africans brought to the region via the transatlantic slave trade during the seventeenth and eighteenth centuries. Although West-African Kaiso music was a major influence, the genre has also been shaped by other African genres, and by Indian, British, French, and Spanish musical cultures. Emerging in the early twentieth century, Calypso became a tool of resistance by Afro-Caribbean working-class Trinbagonians. Calypso flourished in Trinidad due to a combination of factors—namely, the migration of Afro-Caribbean people from across the region in search of upward social mobility. These people sought to expose the injustices perpetrated by a foreign European and a domestic elite against labourers in industries such as petroleum extraction. The genre is heavily anti-colonial, anti-imperial, and anti-elitist, and it advocated for regional integration. Although this did not occur immediately, Calypsonians sought to establish unity across the region regardless of race, nationality, and class through their songwriting and performing. Today, Calypso remains a unifying force and an important part of Caribbean culture. Considering Calypso's history and purpose, as well as its ever-changing creators and audiences, this essay will demonstrate that the goal of regional integration is not possible without cultural sovereignty.

Cubilin, the Intrinsic Factor-Vitamin B12 Receptor in Development and Disease

2020 ◽  
Vol 27 (19) ◽  
pp. 3123-3150 ◽  
Author(s):  
Renata Kozyraki ◽  
Olivier Cases
Keyword(s):  
Vitamin B12 ◽  
Cancer Progression ◽  
Intrinsic Factor ◽  
Basic Research ◽  
Toxic Substances ◽  
Human Pathology ◽  
Peripheral Membrane Protein ◽  
Epidermal Growth ◽  
Fgf8 Signaling

Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic substances including albumin, vitamin D-binding protein or cadmium. Cubilin is a peripheral membrane protein consisting of 8 Epidermal Growth Factor (EGF)-like repeats and 27 CUB (defined as Complement C1r/C1s, Uegf, BMP1) domains. This structurally unique protein interacts with at least two molecular partners, Amnionless (AMN) and Lrp2/Megalin. AMN is involved in appropriate plasma membrane transport of Cubilin whereas Lrp2 is essential for efficient internalization of Cubilin and its ligands. Observations gleaned from animal models with Cubn deficiency or human diseases demonstrate the importance of this protein. In this review addressed to basic research and medical scientists, we summarize currently available data on Cubilin and its implication in renal and intestinal biology. We also discuss the role of Cubilin as a modulator of Fgf8 signaling during embryonic development and propose that the Cubilin-Fgf8 interaction may be relevant in human pathology, including in cancer progression, heart or neural tube defects. We finally provide experimental elements suggesting that some aspects of Cubilin physiology might be relevant in drug design.

scholarly journals Twitter in Marketing Practice of the Religious Media. An Empirical Study on Catholic Weeklies in Poland

Religions ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 421
Author(s):  
Iwona Leonowicz-Bukała ◽  
Andrzej Adamski ◽  
Anna Jupowicz-Ginalska
Keyword(s):  
Communication Channel ◽  
Basic Research ◽  
Marketing Practice ◽  
Religious Media ◽  
The Social ◽  
Social Media Platforms ◽  
Twitter Account ◽  
Research Questions ◽  
Marketing Tool

This article presents the partial conclusion of the research project devoted to marketing activity of Polish Catholic opinion-forming weeklies on the social media platforms. The main aim of this article is to present the results of the study on the use of Twitter as a marketing tool by Polish nationwide Catholic opinion-forming weeklies. The basic research questions concerned the extent of utilizing the platform by the magazines’ editors to create and distribute the content of their media product, maintain and develop brand communication and self-promotion. The case studies and the content analysis of the accounts of the three magazines—Gość Niedzielny, Tygodnik Katolicki Niedziela and Przewodnik Katolicki—show that there are three different ways in how the editors of the magazines understand the role of the Twitter account of the title they represent—as an ‘active communicator’, ‘active communicator and community supporter’ or ‘community supporter’. The conclusions show that the studied media fairly efficiently use the visual and distributional potential of the platform as well as some of its features, at the same time missing the chance to build a brand-loyal community. They also limit the role of Twitter to that of a supplement for the main communication channel, which is the printed weekly and its website.

scholarly journals The microbiome’s relationship with congenital heart disease: more than a gut feeling

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Dan Feng ◽  
Jason T. Christensen ◽  
Anji T. Yetman ◽  
Merry L. Lindsey ◽  
Amar B. Singh ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Patient Population ◽  
Congenital Heart ◽  
Basic Research ◽  
Intestinal Epithelial ◽  
Barrier Dysfunction ◽  
Intestinal Dysbiosis ◽  
Epithelial Barrier Dysfunction

AbstractPatients with congenital heart disease (CHD) are at risk for developing intestinal dysbiosis and intestinal epithelial barrier dysfunction due to abnormal gut perfusion or hypoxemia in the context of low cardiac output or cyanosis. Intestinal dysbiosis may contribute to systemic inflammation thereby worsening clinical outcomes in this patient population. Despite significant advances in the management and survival of patients with CHD, morbidity remains significant and questions have arisen as to the role of the microbiome in the inflammatory process. Intestinal dysbiosis and barrier dysfunction experienced in this patient population are increasingly implicated in critical illness. This review highlights possible CHD-microbiome interactions, illustrates underlying signaling mechanisms, and discusses future directions and therapeutic translation of the basic research.

scholarly journals DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk

2021 ◽  
Vol 18 (14) ◽  
pp. 7486
Author(s):  
Mirosław Śnit ◽  
Maciej Misiołek ◽  
Wojciech Ścierski ◽  
Anna Koniewska ◽  
Grażyna Stryjewska-Makuch ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Laryngeal Cancer ◽  
Basic Research ◽  
Control Groups ◽  
Allele Distribution ◽  
Study Results ◽  
Risk Patients ◽  
And Control ◽  
The Relationship

AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer. RESULTS: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups. CONCLUSIONS: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer.

scholarly journals Role of Insulin in Health and Disease: An Update

2021 ◽  
Vol 22 (12) ◽  
pp. 6403
Author(s):  
Md Saidur Rahman ◽  
Khandkar Shaharina Hossain ◽  
Sharnali Das ◽  
Sushmita Kundu ◽  
Elikanah Olusayo Adegoke ◽  
...  
Keyword(s):  
Insulin Signaling ◽  
Basic Research ◽  
Future Research ◽  
Protective Effects ◽  
Glucose Levels ◽  
Physiological Processes ◽  
Blood Glucose Levels ◽  
Wide Range ◽  
Health And Disease

Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose levels; insulin acts via an anabolic pathway, while glucagon performs catabolic functions. Insulin regulates glucose levels in the bloodstream and induces glucose storage in the liver, muscles, and adipose tissue, resulting in overall weight gain. The modulation of a wide range of physiological processes by insulin makes its synthesis and levels critical in the onset and progression of several chronic diseases. Although clinical and basic research has made significant progress in understanding the role of insulin in several pathophysiological processes, many aspects of these functions have yet to be elucidated. This review provides an update on insulin secretion and regulation, and its physiological roles and functions in different organs and cells, and implications to overall health. We cast light on recent advances in insulin-signaling targeted therapies, the protective effects of insulin signaling activators against disease, and recommendations and directions for future research.

New approaches to crustal evolution studies and the origin of granitic rocks: what can the Lu-Hf and Re-Os isotope systems tell us?

1996 ◽  
Vol 87 (1-2) ◽  
pp. 339-352 ◽  
Author(s):  
Clark M. Johnson ◽  
Steven B. Shirey ◽  
Karin M. Barovich
Keyword(s):  
Continental Crust ◽  
Isotope Ratios ◽  
Granitic Rocks ◽  
Nd Isotope ◽  
Volcanic Arcs ◽  
Depleted Mantle ◽  
Os Isotopes ◽  
Isotope System ◽  
Os Isotope

ABSTRACT:The Lu-Hf and Re-Os isotope systems have been applied sparsely to elucidate the origin of granites, intracrustal processes and the evolution of the continental crust. The presence or absence of garnet as a residual phase during partial melting will strongly influence Lu/Hf partitioning, making the Lu–Hf isotope system exceptionally sensitive to evaluating the role of garnet during intracrustal differentiation processes. Mid-Proterozoic (1·1–1·5Ga ) ‘anorogenic’ granites from the western U.S.A. appear to have anomalously high εHf values, relative to their εNd values, compared with Precambrian orogenic granites from several continents. The Hf-Nd isotope variations for Precambrian orogenic granites are well explained by melting processes that are ultimately tied to garnet-bearing sources in the mantle or crust. Residual, garnet-bearing lower and middle crust will evolve to anomalously high εHf values over time and may be the most likely source for later ‘anorogenic’ magmas. When crustal and mantle rocks are viewed together in terms of Hf and Nd isotope compositions, a remarkable mass balance is apparent for at least the outer silicate earth where Precambrian orogenic continental crust is the balance to the high-εHf depleted mantle, and enriched lithospheric mantle is the balance to the low-εHf depleted mantle.Although the continental crust has been envisioned to have exceptionally high Re/Os ratios and very radiogenic Os isotope compositions, new data obtained on magnetite mineral separates suggest that some parts of the Precambrian continental crust are relatively Os-rich and non-radiogenic. It remains unclear how continental crust may obtain non-radiogenic Os isotope ratios, and these results have important implications for Re-Os isotope evolution models. In contrast, Phanerozoic batholiths and volcanic arcs that are built on young mafic lower crust may have exceptionally radiogenic Os isotope ratios. These results highlight the unique ability of Os isotopes to identify young mafic crustal components in orogenic magmas that are essentially undetectable using other isotope systems such as O, Sr, Nd and Pb.

The role of backyard farms in two West African urban landscapes

2018 ◽  
Vol 170 ◽  
pp. 34-47 ◽  
Author(s):  
Imogen Bellwood-Howard ◽  
Martina Shakya ◽  
Gabin Korbeogo ◽  
Johannes Schlesinger
Keyword(s):  
West African ◽  
Urban Landscapes

scholarly journals Promoting research to improve maternal, neonatal, infant and adolescent health in West Africa: the role of the West African Health Organisation

2017 ◽  
Vol 15 (S1) ◽  
Author(s):  
Issiaka Sombie ◽  
Aissa Bouwayé ◽  
Yves Mongbo ◽  
Namoudou Keita ◽  
Virgil Lokossou ◽  
...  
Keyword(s):  
West Africa ◽  
Adolescent Health ◽  
West African ◽  
The West ◽  
African Health

scholarly journals Notes from the Editors

2014 ◽  
Vol 108 (2) ◽  
pp. iii-ix
Keyword(s):  
Basic Research ◽  
Decision Makers ◽  
The Other ◽  
Good Effect ◽  
Scholarly Journals ◽  
Other Hand ◽  
Relevant Work

We introduce this issue with a thought. There has been much made of the need for our discipline to be “policy relevant,” and much ridicule has been directed at the Review recently that comments how little the Review offers that is relevant for decision makers. But what does it mean to be policy relevant? Generally, scholarly journals publish the best in basic research, which hopefully can be used by those in positions of authority to good effect. This often means that there are no catchy titles, nor opinion-editorial pieces that are so often portrayed as the model of policy relevant work. In our view, the role of the Review is to expand knowledge on important scholarly questions, not only to publish work that is currently popular or somehow ordained as useful by pundits. There is certainly a place for such work, but not in the pages of the Review. On the other hand, we as the editors of the Review understand the need to make the Review accessible to as broad an audience as possible, and we have made great efforts to do just that.

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