Durability of different types of Mouthwashes on the Salivary Buffering system in Orthodontic Patients.

The fast elevation of the salivary pH in orthodontic patients has acritical role to safe the teeth and encourage the orthodontic treatment after acidic challenger. As their baseline salivary pH is dropped during fixed orthodontic treatments.Aims: this study was aimed to evaluate the durability of three types of mouthwashes on the salivary buffering capacity in orthodontic patients at 0, 5, 10, 15 mints after acidic challenger using direct pH meter.Material and method: 80 orthodontic patients; age range (13-21years) were distributed into four groups; 20/ each, the salivary pH were recorded using compact pH meter (LAQUAtwin, HORIBA's, Kyoto, Japan) before and after administration of carbonated beverage (100 mm coca cola) and directly after gargling with 100 ml of the tested mouthwashes (herbal, green tea and chlorohexidine mouthwash) beside tap water as placebo control. The pH was documented again at 0, 5, 10 and 15 mins after each mouthwash gargling. One way ANOVA analysis and Duncan multiple were used for salivary pH analysis, p≤0.05.Results: non-significant differences were found at 0, 5, 10, 15 mints in comparison with baseline pH after herbal mouthwash gargling, the same result was shown with chlorohexidine mouth wash but with less defined border. Salivary pH after green tea gargling showed clear oscillatory results after the same tested periods.Conclusions: Herbal mouthwash is the best type to improve salivary pH for longer duration after acidic challenger. While Chlorohexidine mouthwash shows beneficial effects in elevation salivary pH with less duration. Green tea mouthwash fail to control salivary pH for long duration.

Download Full-text

Expression of Longevity Genes Induced by a Low-Dose Fluvastatin and Valsartan Combination with the Potential to Prevent/Treat “Aging-Related Disorders”

International Journal of Molecular Sciences ◽

10.3390/ijms20081844 ◽

2019 ◽

Vol 20 (8) ◽

pp. 1844 ◽

Cited By ~ 2

Author(s):

Miodrag Janić ◽

Mojca Lunder ◽

Srdjan Novaković ◽

Petra Škerl ◽

Mišo Šabovič

Keyword(s):

Low Dose ◽

Telomerase Activity ◽

Treatment Discontinuation ◽

Placebo Control ◽

Middle Aged ◽

Beneficial Effects ◽

Genes Expression ◽

Longevity Genes ◽

Before And After ◽

Stored Blood

The incidence of aging-related disorders may be decreased through strategies influencing the expression of longevity genes. Although numerous approaches have been suggested, no effective, safe, and easily applicable approach is yet available. Efficacy of low-dose fluvastatin and valsartan, separately or in combination, on the expression of the longevity genes in middle-aged males, was assessed. Stored blood samples from 130 apparently healthy middle-aged males treated with fluvastatin (10 mg daily), valsartan (20 mg daily), fluvastatin-valsartan combination (10 and 20 mg, respectively), and placebo (control) were analyzed. They were taken before and after 30 days of treatment and, additionally, five months after treatment discontinuation. The expression of the following longevity genes was assessed: SIRT1, PRKAA, KLOTHO, NFE2L2, mTOR, and NF-κB. Treatment with fluvastatin and valsartan in combination significantly increased the expression of SIRT1 (1.8-fold; p < 0.0001), PRKAA (1.5-fold; p = 0.262) and KLOTHO (1.7-fold; p < 0.0001), but not NFE2L2, mTOR and NF-κB. Both fluvastatin and valsartan alone significantly, but to a lesser extent, increased the expression of SIRT1, and did not influence the expression of other genes. Five months after treatment discontinuation, genes expression decreased to the basal levels. In addition, analysis with previously obtained results revealed significant correlation between SIRT1 and both increased telomerase activity and improved arterial wall characteristics. We showed that low-dose fluvastatin and valsartan, separately and in combination, substantially increase expression of SIRT1, PRKAA, and KLOTHO genes, which may be attributed to their so far unreported pleiotropic beneficial effects. This approach could be used for prevention of ageing (and longevity genes)–related disorders.

Download Full-text

Effects of green tea and chamomile tea on plaque pH, salivary pH, Streptococcus mutans count

Indian Journal of Pharmaceutical and Biological Research ◽

10.30750/ijpbr.5.4.1 ◽

2017 ◽

Vol 5 (04) ◽

pp. 01-03

Author(s):

M.A. Adil Ahmed ◽

B. Pavani ◽

Tasneem L. Tanzila ◽

Gabby Dharshana S. Thanga ◽

B. Thejaswini ◽

...

Keyword(s):

Streptococcus Mutans ◽

Green Tea ◽

Test Results ◽

Beneficial Effects ◽

Regular Consumption ◽

Plaque Ph ◽

Significant Difference ◽

Before And After ◽

Interesting Alternative

Aim: Green tea is healthy beverage and is a part of our day to day life. Similarly, chamomile tea is known for its aspirin like properties. Beneficial effects of these tea includes protection against dental caries, periodontal disease and tooth loss and found that can a decrease in streptococcus mutans count as well as increase in pH. Hence the present study was to compare the pH of saliva and plaque, before and after the intake of green tea and to evaluate the role of green tea and chamomile tea on growth of s.mutans in culture using saliva. Material and Methods: Salivary samples were collected from 30 healthy individuals aged 20-30 years with certain criteria. The pH of saliva was determined by collecting samples before, immediately after and 15 min, 30 min after drinking tea using pH meter. Similarly the microbial colonies were also counted. The Data obtained were analyzed using Wilcoxon’s, Friedman's and Mann Whitney test. Results: There was statistically no significant difference between salivary streptococcus mutans count before and after (p 0.001) intake of green tea and chamomile tea. Conclusion: The result of the present study has proved that consumption of green tea and chamomile tea inhibit salivary Streptococcus mutans count and cause reduction of pH in saliva. So, it is advisable to encourage the regular consumption of this widely available, tasty and inexpensive beverage as an interesting alternative to other drinks.

Download Full-text

Study the Relationship Between Estrogen Hormone and Calcium in Normal Females Before and After Menopause in Baghdad / Iraq

Al-Kitab Journal for Pure Sciences ◽

10.32441/kjps.v2i1.152 ◽

2018 ◽

Vol 2 (1) ◽

Author(s):

Sameerah Mustafa ◽

Asal Tawfeeq ◽

Hadeel Hasan

Keyword(s):

Oral Contraceptive ◽

Healthy Controls ◽

Serum Samples ◽

Oral Contraceptive Pills ◽

Contraceptive Pills ◽

Menopausal Women ◽

Before And After ◽

Group A ◽

Group B ◽

Age Range

This study involved the collection of (90) samples of women serum which included (30) serum samples collected from women before menopause (reproductive women) in the age range of (22-43) years and were considered as (group A- control). While, (group B) included (30) serum samples collected from women using oral contraceptive pills between the ages of (22-43) years old. Whereas, another (30) serum samples were collected from women after menopause between the ages of (43-54) years and were considered as (group C). All of the collected serum samples were subjected to a number of serological and chemical tests for the measurement of (E2, HDL, LDL and Ca). Then, the obtained data were statistical analyzed and results showed a significant decrease (p˂ 0.05) in (E2 ,Ca and HDL) levels in menopausal women compared to that of the normal healthy controls. While, there were non-significant decrease (p> 0.05) in (E2, Ca and HDL) levels in women taking oral contraceptive when compared to the normal healthy controls. On the other hand, a significant increase (p˂ 0.05) was recorded in LDL level in menopausal women compared to that of the normal healthy controls whereas, no-significant increase (p˃ 0.05) in the LDL level in women taking oral contraceptives when compared to the control women.

Download Full-text

Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists

Cells ◽

10.3390/cells10010185 ◽

2021 ◽

Vol 10 (1) ◽

pp. 185

Author(s):

Clara Depommier ◽

Rosa Maria Vitale ◽

Fabio Arturo Iannotti ◽

Cristoforo Silvestri ◽

Nicolas Flamand ◽

...

Keyword(s):

Metabolic Syndrome ◽

Univariate Analysis ◽

Metabolic Effects ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Akkermansia Muciniphila ◽

Beneficial Effects ◽

Daily Ingestion ◽

Before And After ◽

Palmitoyl Glycerol

Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in the context of obesity and associated metabolic disorders. Although a first proof-of-concept of its beneficial effects has been established in the context of metabolic syndrome in humans, mechanisms are not yet fully understood. This study aimed at deciphering whether the bacterium exerts its beneficial properties through the modulation of the endocannabinoidome (eCBome). Circulating levels of 25 endogenous endocannabinoid-related lipids were quantified by liquid chromatography with tandem mass spectrometry (LC-MS/MS) in the plasma of overweight or obese individuals before and after a 3 months intervention consisting of the daily ingestion of either alive or pasteurized A. muciniphila. Results from multivariate analyses suggested that the beneficial effects of A. muciniphila were not linked to an overall modification of the eCBome. However, subsequent univariate analysis showed that the decrease in 1-Palmitoyl-glycerol (1-PG) and 2-Palmitoyl-glycerol (2-PG), two eCBome lipids, observed in the placebo group was significantly counteracted by the alive bacterium, and to a lower extent by the pasteurized form. We also discovered that 1- and 2-PG are endogenous activators of peroxisome proliferator-activated receptor alpha (PPARα). We hypothesize that PPARα activation by mono-palmitoyl-glycerols may underlie part of the beneficial metabolic effects induced by A. muciniphila in human metabolic syndrome.

Download Full-text

Reduction in mobility and COVID-19 transmission

Nature Communications ◽

10.1038/s41467-021-21358-2 ◽

2021 ◽

Vol 12 (1) ◽

Cited By ~ 7

Author(s):

Pierre Nouvellet ◽

Sangeeta Bhatia ◽

Anne Cori ◽

Kylie E. C. Ainslie ◽

Marc Baguelin ◽

...

Keyword(s):

Predictive Ability ◽

Control Measures ◽

Social Distancing ◽

Beneficial Effects ◽

Mobility Data ◽

Strict Control ◽

Before And After ◽

Proxy Measure ◽

Lower Transmission ◽

The Relationship

AbstractIn response to the COVID-19 pandemic, countries have sought to control SARS-CoV-2 transmission by restricting population movement through social distancing interventions, thus reducing the number of contacts. Mobility data represent an important proxy measure of social distancing, and here, we characterise the relationship between transmission and mobility for 52 countries around the world. Transmission significantly decreased with the initial reduction in mobility in 73% of the countries analysed, but we found evidence of decoupling of transmission and mobility following the relaxation of strict control measures for 80% of countries. For the majority of countries, mobility explained a substantial proportion of the variation in transmissibility (median adjusted R-squared: 48%, interquartile range - IQR - across countries [27–77%]). Where a change in the relationship occurred, predictive ability decreased after the relaxation; from a median adjusted R-squared of 74% (IQR across countries [49–91%]) pre-relaxation, to a median adjusted R-squared of 30% (IQR across countries [12–48%]) post-relaxation. In countries with a clear relationship between mobility and transmission both before and after strict control measures were relaxed, mobility was associated with lower transmission rates after control measures were relaxed indicating that the beneficial effects of ongoing social distancing behaviours were substantial.

Download Full-text

Brain Training and Sulforaphane Intake Interventions Separately Improve Cognitive Performance in Healthy Older Adults, Whereas a Combination of These Interventions Does Not Have More Beneficial Effects: Evidence from a Randomized Controlled Trial

Nutrients ◽

10.3390/nu13020352 ◽

2021 ◽

Vol 13 (2) ◽

pp. 352

Author(s):

Rui Nouchi ◽

Qingqiang Hu ◽

Toshiki Saito ◽

Natasha Yuriko dos Santos Kawata ◽

Haruka Nouchi ◽

...

Keyword(s):

Older Adults ◽

Active Control ◽

Processing Speed ◽

Cognitive Functions ◽

Controlled Trial ◽

Memory Performance ◽

Brain Training ◽

Beneficial Effects ◽

Before And After ◽

Double Blinded

Background: Earlier studies have demonstrated that a single-domain intervention, such as a brain-training (BT) game alone and a sulforaphane (SFN) intake, positively affects cognition. This study examined whether a combined BT and SFN intake intervention has beneficial effects on cognitive function in older adults. Methods: In a 12-week double-blinded randomized control trial, 144 older adults were randomly assigned to one of four groups: BT with SFN (BT-S), BT with placebo (BT-P), active control game (AT) with SFN (AT-S), and active control game with placebo (AT-P). We used Brain Age in BT and Tetris in AT. Participants were asked to play BT or AT for 15 min a day for 12 weeks while taking a supplement (SFN or placebo). We measured several cognitive functions before and after the intervention period. Results: The BT (BT-S and BT-P) groups showed more improvement in processing speed than the active control groups (AT-S and AT-P). The SFN intake (BT-S and AT-S) groups recorded significant improvements in processing speed and working memory performance unlike the placebo intake groups (BT-P and AT-P). However, we did not find any evidence of the combined intervention’s beneficial effects on cognition. Discussion: We discussed a mechanism to improve cognitive functions in the BT and SFN alone interventions.

Download Full-text

Hemodynamic Responses in Lower Limb Lymphedema Patients Undergoing Physical Therapy

Biology ◽

10.3390/biology10070642 ◽

2021 ◽

Vol 10 (7) ◽

pp. 642

Author(s):

Bianca Brix ◽

Olivier White ◽

Christian Ure ◽

Gert Apich ◽

Paul Simon ◽

...

Keyword(s):

Physical Therapy ◽

Lymphatic System ◽

Orthostatic Intolerance ◽

Hemodynamic Responses ◽

Stand Test ◽

Beneficial Effects ◽

Sit To Stand ◽

Complete Decongestive Therapy ◽

Before And After ◽

Baseline Values

Background: Lymphedema arises due to a malfunction of the lymphatic system, leading to extensive tissue swelling. Complete decongestive therapy (CDT), which is a physical therapy lasting for 3 weeks and includes manual lymphatic drainages (MLD), leads to fluid mobilization and increases in plasma volume. Here, we investigated hemodynamic responses induced by these fluid shifts due to CDT and MLD. Methods: Hemodynamic parameters were assessed continuously during a sit-to-stand test (5 min baseline, 5 min of standing, and 5 min of recovery). This intervention was repeated on days 1, 2, 7, 14, and 21 of CDT, before and after MLD. Volume regulatory hormones were assessed in plasma samples. Results: A total number of 13 patients took part in this investigation. Resting diastolic blood pressure significantly decreased over three weeks of CDT (p = 0.048). No changes in baseline values were shown due to MLD. However, MLD led to a significant decrease in heart rate during orthostatic loading over all epochs on therapy day 14, as well as day 21. Volume regulatory hormones did not show changes over lymphedema therapy. Conclusion: We did not observe any signs of orthostatic hypotension at rest, as well as during to CDT, indicating that lymphedema patients do not display an elevated risk of orthostatic intolerance. Although baseline hemodynamics were not affected, MLD has shown to have potential beneficial effects on hemodynamic responses to a sit-to-stand test in patients undergoing lymphedema therapy.

Download Full-text

Tea Polyphenols in Promotion of Human Health

Nutrients ◽

10.3390/nu11010039 ◽

2018 ◽

Vol 11 (1) ◽

pp. 39 ◽

Cited By ~ 88

Author(s):

Naghma Khan ◽

Hasan Mukhtar

Keyword(s):

Green Tea ◽

Animal Studies ◽

Neurological Diseases ◽

Black Tea ◽

Polyphenolic Compounds ◽

Tea Polyphenols ◽

Beneficial Effects ◽

Gallocatechin Gallate ◽

Prevention Of Cancer ◽

Pharmacologically Active

Tea is the most widely used beverage worldwide. Japanese and Chinese people have been drinking tea for centuries and in Asia, it is the most consumed beverage besides water. It is a rich source of pharmacologically active molecules which have been implicated to provide diverse health benefits. The three major forms of tea are green, black and oolong tea based on the degree of fermentation. The composition of tea differs with the species, season, leaves, climate, and horticultural practices. Polyphenols are the major active compounds present in teas. The catechins are the major polyphenolic compounds in green tea, which include epigallocatechin-3-gallate (EGCG), epigallocatechin, epicatechin-3-gallate and epicatechin, gallocatechins and gallocatechin gallate. EGCG is the predominant and most studied catechin in green tea. There are numerous evidences from cell culture and animal studies that tea polyphenols have beneficial effects against several pathological diseases including cancer, diabetes and cardiovascular diseases. The polyphenolic compounds present in black tea include theaflavins and thearubigins. In this review article, we will summarize recent studies documenting the role of tea polyphenols in the prevention of cancer, diabetes, cardiovascular and neurological diseases.

Download Full-text

Computed Tomography and Bronchoscopy in Endobronchial Tuberculosis

Canadian Respiratory Journal ◽

10.1155/2003/496296 ◽

2003 ◽

Vol 10 (8) ◽

pp. 445-448 ◽

Cited By ~ 11

Author(s):

Halil Yanardag ◽

Cüneyt Tetikkurt ◽

Seza Tetikkurt ◽

Sabriye Demirci ◽

Tuncer Karayel

Keyword(s):

Computed Tomography ◽

Retrospective Study ◽

Therapeutic Response ◽

Histopathological Examination ◽

Computed Tomographic ◽

Before And After ◽

Endobronchial Tuberculosis ◽

Age Range

BACKGROUND: The therapeutic response to endobronchial tuberculosis is usually evaluated by bronchoscopy. Currently, there are no published studies investigating the use of computed tomography for the evaluation of therapeutic response in endobronchial tuberculosis.OBJECTIVE: A retrospective study was performed to evaluate the bronchoscopic and computed tomographic features of endobronchial tuberculosis before and after treatment. The aim of this study was to investigate the usefulness of computed tomography for the assessment of treatment.METHODS: The clinical, pathological and bronchoscopic features of endobronchial tuberculosis were evaluated in 55 patients. The age range of the patients was 21 to 52 years. Computed tomography and bronchoscopy were performed before and after treatment.RESULTS: Diagnosis of tuberculosis was confirmed by culture and histopathological examination. Bronchoscopic examination revealed 89 endobronchial lesions of various types in 55 patients. The exudative type was the most common. Follow-up bronchoscopy revealed that exudative-, ulcerative- and granular-type lesions healed completely. Computed tomography performed after treatment correlated well with the follow-up bronchoscopic findings.CONCLUSION: The results suggest that follow-up computed tomography is useful for the evaluation of therapeutic response and complications associated with endobronchial tuberculosis, and may replace bronchoscopy.

Download Full-text

Cyclosporine increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00543.2007 ◽

2008 ◽

Vol 294 (3) ◽

pp. R811-R818 ◽

Cited By ~ 31

Author(s):

Chao-Hung Wang ◽

Wen-Jin Cherng ◽

Ning-I Yang ◽

Chia-Ming Hsu ◽

Chi-Hsiao Yeh ◽

...

Keyword(s):

Critical Role ◽

Serum Levels ◽

Blood Levels ◽

Short Term ◽

Endothelial Progenitor ◽

Beneficial Effects ◽

Dpp Iv ◽

Before And After ◽

Cell Mobilization

Cyclosporin A (CsA) improves the success rate of transplantation. The CD26/dipeptidylpeptidase IV (DPP IV) system plays a critical role in mobilizing endothelial progenitor cells (EPCs) from bone marrow. This study investigated whether CsA manipulates CD26/DPP IV activity and increases EPC mobilization. C57BL/6 mice were divided into control and CsA-treated groups. Before and after hindlimb ischemia was induced, circulating EPC number and serum levels of different cytokines were measured. Compared with the controls, CsA treatment significantly increased the blood levels of stroma-derived factor-1α and stem cell factor after ischemic stress ( P < 0.001). The CsA group displayed a significant increase in the number of circulating EPCs (sca-1+KDR+ and c-kit+CD31+ EPCs, both P < 0.05). In vivo, CsA caused a significant increase in the numbers of EPCs incorporated into the Matrigel and ischemic limbs ( P < 0.05). In the peripheral blood, CsA significantly decreased CD26+ cell numbers and attenuated the plasma CD26/DPP IV activity ( P < 0.001). Furthermore, short-term CsA treatment significantly improved the perfusion of ischemic limbs and decreased the spontaneous digital amputation rate. In summary, CsA manipulates the mobilization of EPCs into the circulation via the CD26/DPP IV system. Short-term CsA treatment has beneficial effects on angiogenesis of ischemic tissues.

Download Full-text