Study of essential and toxic elements content in medicinal herbs harvested in Ukraine

Author(s):  
Pawel Konieczynski ◽  
Roman Lysiuk ◽  
Marlena Kopistecka ◽  
Marek Wesolowski

Purpose: Medicinal plants can origin both from their cultivation, and from collection in natural locations, therefore investigation of their chemical composition is indispensable for assuring the appropriate quality. Thus, the aim of the studies was evaluation of medicinal plants collected in natural locations in Ukraine in the light of their elemental contents, taking into consideration both essential elements - P, Cu, Zn, Fe, and toxic – Cr, Pb, Cd and Ni. Methods: The microwave-assisted digestion was applied for preparation of the samples prior to analysis of plant samples to quantitative determination of investigated elements by the flame technique of atomic absorption spectroscopy. Results: The results of studies show that there is a large differentiation of medicinal herbs originating from Ukraine from the point of view of their elemental contents. In many cases, e.g. birch leaves, the impact of botanical plant species on the level of elements was crucial. Hence, the loadings of principal components confirmed that the highest influence on the differentiation of studied plant samples had the concentrations of Cr, Zn, Cd and Fe. The impact of a place of growth on the level of selected elements such as Cd and Fe in St John’s wort was noticed, too. The analysis of toxic metals concentration in all studied plant samples has also shown that Pb and Cd level didn’t exceed the norms established by the European Union Commission in 2006. Conclusion: It is recommended to monitor heavy metals concentrations in medicinal herbs originating from Ukraine available in the European pharmaceutical market.

Author(s):  
V.B. Belov

The article examines the results of the last Bundestag elections. They marked the end of the Angela Merkel era and reflected the continuation of difficult party-political and socio-economic processes in the informal leader of the European Union. The main attention of the research focuses on the peculiarities of the election campaign of the leading parties and of the search for ways of further development of Germany in the face of urgent economic and political challenges. These challenges include the impact of the coronavirus crisis, the impact of the energy and digital transition to a climate-neutral economy, and the complex international situation. Based on original sources, the author analyzes the causes of the SPD victory and the CDU/CSU bloc defeat, the results of the negotiations of the Social Democrats with the Greens and Liberals, the content of the coalition agreement from the point of view of the prospects for the development of domestic and foreign policy and the economy of Russia's main partner in the west of the Eurasian continent. The conclusion is made about the absence of breakthrough ideas, the consistent continuation of the course started by the previous government for a carbon-free economy and the strengthening of the role of Germany in Europe and the world. For this course, conflicts and problems in achieving the set goals will be immanent due to the compromising nature of the coalition agreements.


2015 ◽  
Vol 60 (11) ◽  
pp. 1-15
Author(s):  
Olga Leszczyńska-Luberek

The author presents the importance of the new European System of National and Regional Accounts (ESA 2010) for statistics of the general government sector. She pays particular attention to the development of data for the excessive deficit procedure. The article explains the methodological changes made to the studies in this field parallel to the ESA 2010. It discusses, among others, issues related to defining the deficit and debt of the general government, as well as the determination of a new way registering transfer of liabilities of pension schemes. It also presents the impact of new methodological guidelines for the relationship of deficit and debt to GDP in the Member States of the European Union.


2019 ◽  
Vol 102 (3) ◽  
pp. 801-809
Author(s):  
Ana Carolina Kogawa ◽  
Ana Elisa Della Torre Pires ◽  
Hérida Regina Nunes Salgado

Abstract Background: Atorvastatin, a lipid-regulating drug, was the best-selling drug in the world in the early 2000s. Thus, monitoring of this drug is important because it is accessible to a large portion of the population. In addition, its quality control is fundamental to provide quality medicines. Method of analysis can be the first step in the rational use of pharmaceuticals. Objective/Methods: In this context, a critical review of analytical methods present in the literature and official compendia for the pharmaceutical quality control of atorvastatin was made. Results: Among the analytical methods most used in the evaluation of atorvastatin, HPLC is highlighted, followed by HPLC coupled to MS, and spectrophotometry in UV. Tablets are the most studied pharmaceutical samples, and plasma is the most studied biological matrix. In the literature, studies with atorvastatin-based pharmaceutical products are more common than biological materials. Acetonitrile is the organic solvent most commonly used in the methods surveyed to evaluate atorvastatin. Conclusions: Currently, awareness of the impact that the analytical choice has on the health of the operator and the environment is growing. Therefore, the suitability of existing methods for the determination of atorvastatin can be made to adhere to the current analytical chemistry. In this way, the analytical, environmental, and human consciousness will remain united. Highlights: Although the literature shows interesting methods from an economic and environmental point of view, such as UV, Vis miniaturized, and TLC, they can still be improved to meet the requirements of the current sustainable analytical chemistry.


2016 ◽  
Vol 686 ◽  
pp. 33-38 ◽  
Author(s):  
Tadeusz Otko ◽  
Wojciech Zębala

Semi-manufactured parts dedicated for precise machining often have internal stresses which have remained after previous cutting and plastic processing. These stresses reside in a fixed state of balance over the entire volume of the workpiece. Removal of the machining allowance is associated with a change in the state of balance and deformation of the workpiece, which affect its dimensional and shape accuracy. The study, involving non-stress removal of precisely defined volume of the machining allowance and determination of the impact of this treatment on the deformation of the workpiece surface is presented. It is important from the point of view of dimensional tolerance of the axially symmetrical workpiece, finally processed by turning.


2021 ◽  
Vol 2 (02) ◽  
pp. 94-103
Author(s):  
Maria Bibi ◽  
Samiullah Khan ◽  
Attiq-Ur-Rehman Kakar ◽  
Naqeebullah Khan ◽  
Abdul Hakeem Tareen ◽  
...  

Background: Medicinal plants have been used to treat various diseases for several years throughout the world. Xylanthemum macropodum is a medicinal plant with a vast application as a home remedy in Balochistan. Objective: The current study was conducted to determine the levels of essential and non-essential elements in Xylanthemum macropodum collected from Quetta (Balochistan, Pakistan). Methods: Analysis was conducted for eleven elements by using atomic absorption spectrophotometer and flame photometer. Results: The essential and non-essential elements that were detected in Xylanthemum macropodum are K, Na, Ca, Fe, Cu, Co, Ni, Mn, Cr, Cd and Pb, respectively. The result of the concentration of determined elements are in the order of K> Na> Ca> Fe> Cu> Co> Ni> Mn> Cd> Cr> Pb in Xylanthemum macropodum 3000> 1600> 790.25> 92.36> 85.31> 49.24> 40.94> 20.94> 6.655> 1.61> 1.18 µg/g respectively. Conclusions: Mn, Na and Pb were found within the permissible limit given by World Health Organization, while Ca, Cu, Fe, Ni, Cd and Cr were beyond the permissible limits. However, there is no permissible limit for K and Co.


2021 ◽  
Vol 1203 (2) ◽  
pp. 022080
Author(s):  
Martin Marek ◽  
Jana Korytárová

Abstract This article aims at presenting the economic impacts of implementing the basic principles of construction demolition waste management in terms of saving construction costs. Emphasis is placed on fulfilling the 3R principle, i.e. reducing waste, reusing it, and recycling resources and products. Construction and demolition waste represents the largest mass waste flow in the EU, e.g. in 2018, it represented 36% of the total waste production in the whole EU- 27. The European Union is gradually introducing measures to reduce the production of construction waste compared to the Czech Republic, where the share of construction demolition waste on the total production was up to 42% in 2018. This value exceeds the EU-27 average. The article analyses available statistical data from the national CZSO and the European statistical office EUROSTAT on the waste production classified according to EWC-STAT, which is a classification of waste according to Directive No. 2150/2002. Items monitoring the waste produced by the construction industry are listed on the 41st to 43rd place of the EWC-STAT list of all monitored waste. The data obtained allows comparing three branches of construction production, the 41st Building construction, 42nd Civil engineering, and 43rd Specialized construction activities. Another possibility to obtain data is to use a division according to the waste producer economic activity (CZ NACE). The data obtained in this way is compared with the performance indicators of the national economy. By comparing the size of the construction demolition waste production with the performance of the national economy (especially the GDP indicator), the degree of their interdependence was determined. The aim of the analysis is to assess the relation between the country’s economic performance and the production of construction and demolition waste. The next step was to perform an analysis from the point of view of the 3R principle in order to examine the impact of measures to reduce the construction demolition waste production in connection with the already initiated processes of its possible recycling or reuse.


2010 ◽  
Vol 10 (1) ◽  
pp. 1850188 ◽  
Author(s):  
Joseph Pelzman ◽  
Amir Shoham

The United States and the European Union have generated dozens of bilateral Regional Trading Agreements (RTA) across the globe. All of these trading arrangements have detailed agreements on rules of origin (ROOs). Those rules are required in order to ensure that the perceived benefits of the Free Trade Agreements (FTA) are not subverted or deflected. These rules have their greatest impact on a firm's cost structure when applied to the trade of intermediate goods. Determination of the origin of final goods becomes more complicated where imported intermediates are used and the WTO 'substantial transformation' rules are implemented. There is relatively little literature on the impact of these rules of origin on trade. (Cadot et al., 2006; Duttagupta and Panagariya, 2002; and Falvey and Reed, 1998, 2002). The existing literature hypothesizes that these rules can easily be used to restrict or suppress trade between countries, or to divert trade away from more efficient suppliers to less efficient ones. The empirical evidence to support the trade distortions is based on the number and complexity of the rules of origin. In order to determine the degree to which the post-RTA trade flows are indeed affected by ROO requires a micro-based review of increased transaction costs, rather than the number of rules. The intent of this paper is to suggest a formal methodology, which relies on the literature about tariff-equivalents, to evaluate rules of origin requirements. The suggested approach, applied at the 5-digit HS level will provide a more robust evaluation of ROOs. The suggested methodology could also be used to investigate the oft-asserted hypothesis that with time and reduced tariff barriers, the costs associated with ROOs will diminish.


1977 ◽  
Vol 99 (2) ◽  
pp. 375-379 ◽  
Author(s):  
C. L. S. Wu ◽  
S. W. E. Earles

A method is described for analyzing the kinematic and dynamic response of a linkage mechanism in which one bearing has a known clearance. Assuming the clearance to be represented by a massless link, the analysis predicts the occurrence of contact-loss. Part of an extensive experimental investigation is presented in which the impact accelerations resulting from contact-loss are measured. A good correlation is shown to exist between the predicted and measured times of contact-loss. Although the analysis may predict no contact-loss, it does not readily indicate, from a design point of view, how this condition could be produced.


BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fahd Elkhalloufi ◽  
Saber Boutayeb ◽  
Fouzia Mamouch ◽  
Latifa Rakibi ◽  
Sanae Elazzouzi ◽  
...  

Abstract Background In 2020, Morocco recorded more than 59,370 new cases of cancer and more than 35,265 cases of death (International Agency for Research on Cancer, Annual report Morocco, 2020). Cancer is always accompanied by socially constructed, differentiated, and contingent interpretations and practices according to the socio-cultural and religious characteristics of each region. The study aims at describing the evolution of the socio-cultural and religious aspects of Moroccan cancer patients followed at the National Institute of Oncology (NIO) of Rabat between 2010 and 2020. Methods We have prospectively studied all cancer cases diagnosed at the National Oncology Institute (NIO), Rabat in 2019. We have collected 1102 cases. The data collected was compared with the results of the study carried out in 2010 (1600 cases). Statistical analysis has been assessed by SPSS 20 software and the correlations between socio-cultural characteristics were examined using a chi-square test. Results From a socio-economic point of view, almost all patients claim that cancer is a costly disease as well as a disease that leads to a drop in income and the inevitable impoverishment of Moroccan patients. The illiteracy rate is still high; rising from 38% in 2010 to 42.80% in 2020. On the psychological level, damage to body image (alopecia, mastectomy, hysterectomy,) can lead to stigmatizing and harms the marital relationship. The number of patients experiencing divorce and marital separation that seems to occur following cancer pathology remains high, despite a decrease of nearly 50% between 2010 and 2020. Concerning the spiritual aspect, in the Arab-Amazigh-Muslim culture, the impact of the occurrence of cancer is very particular, and the repercussions are assessed differently depending on the degree of conviction. For practicing believers, cancer is considered a divine test and an opportunity to improve. In the Qur’an, God tests the best of his disciples to reward them The rate of practicing believers has evolved from 49% in 2010 to 85.50% in 2020.But for non-practicing believers, cancer is regarded as a divine punishment coming from outside. New behaviors reported by this research concern the use of “roquia”. This spiritual cure is considered as an anti-cancer remedy. It uses Allah’s words from the holy “qur’an”, his faires names and his attributes. 42% of patients use “roquia”. Concerning phytotherapy, there was an increase in the percentage of participants using medicinal plants and even the most harmful plants (Arestiloch, Euphorbia) from 26% in 2010 to 51.50% in 2020. Conclusion The precarious social level of cancer patients, the lack of social and medical coverage, illiteracy, and lack of knowledge of religion, as well as dissatisfaction with conventional medicine, may lead patients to the use of traditional medicine (medicinal plants, visit of “marabouts”, “roquia”). This can have a negative impact on the quality of access to oncology care.


2006 ◽  
Vol 30 (1) ◽  
pp. 15-18
Author(s):  
Vladas Stauskas

When discussing the priorities and leverage in urban development, we usually use such concepts as „economic potential“, „financial investment“, „a great quantity of constructions1“, etc. However, the final result should in fact strive for human happiness, health, love for your city, wish to live there. The urban structure of a city always contains a system of open green spaces. These areas are important not only from ecological and aesthetical point of view, but also for social communication as well as raising the economic value of plots. The paper, giving an example of contemporary development of the resort of Palanga, deals with tendencies and problems resulting from the privatization process and great mistakes in locating urbanized plots in the areas of the Lithuanian seaside. The areas, which in the Master Plan are foreseen for new parks, forests and hydroparks, started to be used for construction of private buildings. Generally, in Lithuania not only resort areas, but also any open spaces and even outer wood areas suffer from a bad tendency to treat them exceptionally as potential plots for building construction. In the case of Palanga we meet with the danger of continuous urbanization of the seaside, what consequently means decrease of the quality of the resort as well as fall in land prices in future. Progressive examples from foreign countries and the European Union directives are given, where the quantity of green areas in a city is considered as one of the most important criteria of its modernity and quality. The paper is based on a continuous experience of the author and on the recent work at Institute of Architecture and Contraction on the impact of land privatization on land prices and urban development. Reasonable balance between private and public interests is nesessary, and we still lack it.


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