scholarly journals СУЧАСНІ МОЖЛИВОСТІ ЗАСТОСУВАННЯ ДЕТОКСИКАЦІЙНИХ ЛАЗЕРНИХ ПРОГРАМ ПРИ КУПІРУВАННІ ЗАПІЙНИХ ФОРМ АЛКОГОЛІЗАЦІЇ

2021 ◽  
Vol 1 (1) ◽  
pp. 1-14
Author(s):  
Юрій Чуєв
Keyword(s):  
Alcohol Dependence ◽  
Rating Scales ◽  
High Efficiency ◽  
Clinical Feature ◽  
Therapeutic Effects ◽  
Rehabilitation Programs ◽  
Positive Therapeutic Effect ◽  
Pre Treatment ◽  
Psychopathological Disorders ◽  
New Generation

In recent years, there has been a significant complication of the clinical picture of somatoneurological and mental status of patients with intoxicated forms of alcohol dependence. The aim of the study was to clinically evaluate the effectiveness of the innovative complex in the complex and the development of a therapeutic algorithm for its use in drug practice. The object of our scientific and practical interests in recent years has been modeling, testing and implementation of a new generation of non-drug and pharmacological methods of treatment of acute and urgent drug pathology, and its consequences, creating a set of innovative laser treatment and rehabilitation programs. The therapeutic efficacy of the laser infusion therapeutic complex was evaluated using pre-treatment rating scales, first, third and fifth days of treatment. In the course of therapy a clinical and laboratory study, general blood and urine tests, biochemical blood test were performed. Based on the data, we can conclude about the high efficiency of laser infusion detoxification as a means of alleviating the drunken form of alcohol dependence. The rate of reduction of somatoneurological and psychopathological disorders was significantly higher in the case of using an innovative treatment module based on laser technology than in the process of therapy with traditional drugs. Clinical interpretation of the obtained results in the main group allowed recording the tendency to a more pronounced positive dynamics, which manifested in a smoother disappearance of post-intoxication symptoms. In our opinion, the main clinical feature of the laser complex is the differences in the intensity of the positive therapeutic effect, indicating the presence of pronounced detoxifying properties. Thus, the therapeutic effects of the proposed laser detoxification program are extremely necessary to alleviate the drunken form of alcohol dependence in drug practice. The obtained results expand the current possibilities of etiopathogenetic therapy and allow recommending the inclusion of the developed method in complex therapeutic and rehabilitation programs for the treatment of drug addicts.

scholarly journals Diagnosis and therapy of functional tremor a systematic review illustrated by a case report

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Michael Bartl ◽  
Rebekka Kewitsch ◽  
Mark Hallett ◽  
Martin Tegenthoff ◽  
Walter Paulus
Keyword(s):  
Magnetic Stimulation ◽  
Rating Scales ◽  
Psychiatric Symptoms ◽  
Psychological Treatment ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Clinical Feature ◽  
Diagnostic Feature ◽  
Therapeutic Effects ◽  
Relaxation Techniques ◽  
Diagnosis And Therapy

Abstract Background Diagnosis of functional movement disorders and specifically functional tremor (FT) (representing 50% of them) remains demanding. Additionally, due to heterogeneity of the disorders, structured concepts and guidelines for diagnosis and therapy are difficult to establish. Ascertaining the state of knowledge to derive instructions for operating procedures is the aim of this review. Main text Based on a standardized systematic literature research using the term “psychogenic tremor” in the MEDLINE database dating back ten years, 76 studies were evaluated. Conventional features of FT are variability of frequency and amplitude. Further, response to distraction by motor and cognitive tasks is a key diagnostic feature in differentiation between organic and functional origin. A variety of electrophysiological tests have been evaluated including surface electromyography and accelerometry to establish laboratory-supported criteria for diagnosing tremor. Also, finger tapping tests have been used to identify FT, showing positive potential as supplementary evidence. Imaging studies in general are mostly underpowered and imaging cannot be used on an individual basis. Therapeutic studies in FT often have a diagnostic component. Cognitive behavioral therapy should be the preferred psychological treatment independent of additional psychiatric symptoms. Other psychotherapeutic methods show lack of evidence concerning FT. Relaxation techniques and physiotherapy are an important additional feature, especially in children and adolescents. In regard to drug therapy, randomized and blinded trials are not available. A significant decrease in rating scales could be detected after active, not sham repetitive transcranial magnetic stimulation with a long-lasting effect. Also root magnetic stimulation seems to be effective. The clinical feature of tremor entrainment in FT can be used in combination with biofeedback as so-called tremor retrainment, using self-modulation of frequency and severity, to bring the movements under volitional control. Conclusion Diagnosis and treatment of FT is challenging and should include a combination of intensive clinical examination and targeted addition of standardized testing, especially electrophysiological methods. Often therapeutic effects have a diagnostic component. A multimodal strategy, considering psychological factors as a potential origin as well as maintaining effects seems to be most effective.

The Effect of Dietary Glutathione and Coenzyme Q10 on the Prevention and Treatment of Inflammatory Bowel Disease in Mice

2004 ◽  
Vol 74 (1) ◽  
pp. 74-85 ◽  
Author(s):  
Liu ◽  
Russell ◽  
Smith ◽  
Bronson ◽  
Milbury ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Dextran Sulfate ◽  
Coenzyme Q ◽  
Histological Evaluation ◽  
Therapeutic Effects ◽  
Prevention Study ◽  
Prevention And Treatment ◽  
Inflammatory Bowel ◽  
Pre Treatment

Because reactive oxygen species have been implicated as mediators of inflammatory bowel disease (IBD), we evaluated the potential preventive and therapeutic effects of two dietary antioxidants, glutathione (GSH) and coenzyme Q10 (CoQ10) on dextran sulfate sodium (DSS)-induced colitis in mice. Fifty female 8-wk old Swiss-Webster mice were randomly assigned to 4 groups for a pre-treatment 'prevention' study: (1) GSH (1% of diet); (2) CoQ10 (200 mg/kg/d); (3) DSS only (3% of drinking water); (4) control (no treatment). The mice in groups 1 and 2 were fed with GSH or CoQ10 for 21 wks, and the mice in groups 1, 2 and 3 were provided DSS from wk 7 for 4 cycles (1 cycle = 1 wk DSS followed by 2-wk water). Another 50 mice were randomly assigned to 4 groups for a 21-wk 'treatment' study where the mice in groups 1, 2, and 3 were administered DSS for 6 cycles (18 wks) to induce colitis. GSH and CoQ10 were added from wk 7 until the completion of the protocol. Loose stools and hemocult positivity were modestly but significantly reduced with GSH or CoQ10 at several periods during the intervention in both the prevention and treatment studies. In contrast, histological evaluation revealed increases in colonic dysplasia and ulceration with GSH or CoQ10. Thus, in this mouse model, GSH and CoQ10 appear to have a beneficial effect on acute signs of IBD, but may have an adverse impact on the chronic pathophysiology of the disease. Further studies using additional animal models are required to determine whether GSH or CoQ10 provide a favorable or unfavorable benefit:risk ratio in the prevention or treatment of IBD.

scholarly journals Recent Advancements in Polythiophene-Based Materials and Their Biomedical, Geno Sensor and DNA Detection

2021 ◽  
Vol 22 (13) ◽  
pp. 6850
Author(s):  
Seyyed Mojtaba Mousavi ◽  
Seyyed Alireza Hashemi ◽  
Sonia Bahrani ◽  
Khadije Yousefi ◽  
Gity Behbudi ◽  
...  
Keyword(s):  
Biomedical Engineering ◽  
High Efficiency ◽  
Polymeric Materials ◽  
The Novel ◽  
Electrode Coating ◽  
Effective Response ◽  
Hiv Drugs ◽  
New Generation ◽  
New Compounds ◽  
Anti Hiv

In this review, the unique properties of intrinsically conducting polymer (ICP) in biomedical engineering fields are summarized. Polythiophene and its valuable derivatives are known as potent materials that can broadly be applied in biosensors, DNA, and gene delivery applications. Moreover, this material plays a basic role in curing and promoting anti-HIV drugs. Some of the thiophene’s derivatives were chosen for different experiments and investigations to study their behavior and effects while binding with different materials and establishing new compounds. Many methods were considered for electrode coating and the conversion of thiophene to different monomers to improve their functions and to use them for a new generation of novel medical usages. It is believed that polythiophenes and their derivatives can be used in the future as a substitute for many old-fashioned ways of creating chemical biosensors polymeric materials and also drugs with lower side effects yet having a more effective response. It can be noted that syncing biochemistry with biomedical engineering will lead to a new generation of science, especially one that involves high-efficiency polymers. Therefore, since polythiophene can be customized with many derivatives, some of the novel combinations are covered in this review.

scholarly journals The Bacterial Enzyme Cas13 Interferes with Neurite Outgrowth from Cultured Cortical Neurons

Toxins ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 262
Author(s):  
Qin-Wei Wu ◽  
Josef P. Kapfhammer
Keyword(s):  
Rna Editing ◽  
Cortical Neurons ◽  
High Efficiency ◽  
Primary Cultures ◽  
Cultured Neurons ◽  
Therapeutic Tool ◽  
Bacterial Enzyme ◽  
Rna Targeting ◽  
Cultured Cortical Neurons ◽  
New Generation

The CRISPR-Cas13 system based on a bacterial enzyme has been explored as a powerful new method for RNA manipulation. Due to the high efficiency and specificity of RNA editing/interference achieved by this system, it is currently being developed as a new therapeutic tool for the treatment of neurological and other diseases. However, the safety of this new generation of RNA therapies is still unclear. In this study, we constructed a vector expressing CRISPR-Cas13 under a constitutive neuron-specific promoter. CRISPR-Cas13 from Leptotrichia wadei was expressed in primary cultures of mouse cortical neurons. We found that the presence of CRISPR-Cas13 impedes the development of cultured neurons. These results show a neurotoxic action of Cas13 and call for more studies to test for and possibly mitigate the toxic effects of Cas13 enzymes in order to improve CRISPR-Cas13-based tools for RNA targeting.

scholarly journals Alleviation of Oxidative Stress in Dental Pulp Cells Following 4-Hexylresorcinol Administration in a Rat Model

2021 ◽  
Vol 11 (8) ◽  
pp. 3637
Author(s):  
Jun-Ho Chang ◽  
Dae-Won Kim ◽  
Seong-Gon Kim ◽  
Tae-Woo Kim
Keyword(s):  
Oxidative Stress ◽  
Dental Pulp ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Mandibular Incisor ◽  
Tnf Α ◽  
Total Antioxidant ◽  
Pulp Cells ◽  
Pre Treatment

Damaged dental pulp undergoes oxidative stress and 4-hexylresorcinol (4HR) is a well-known antioxidant. In this study, we aimed to evaluate the therapeutic effects of a 4HR ointment on damaged dental pulp. Pulp cells from rat mandibular incisor were cultured and treated with 4HR or resveratrol (1–100 μM). These treatments (10–100 μM) exerted a protective effect during subsequent hydrogen peroxide treatments. The total antioxidant capacity and glutathione peroxidase activity were significantly increased following 4HR or resveratrol treatment (p < 0.05), while the expression levels of TNF-α and IL1β were decreased following the exposure to 4HR pre-treatment in an in vitro model. Additionally, the application of 4HR ointment in an exposed dental pulp model significantly reduced the expression of TNF-α and IL1β (p < 0.05). Conclusively, 4HR exerted protective effects against oxidative stress in dental pulp tissues through downregulating TNF-α and IL1β.

Industrial Sewing Machine Design and Development of Digital Design and Simulation Platform

2013 ◽  
Vol 365-366 ◽  
pp. 917-920
Author(s):  
De Fa Zhang ◽  
Yi Cong Gao
Keyword(s):  
Energy Saving ◽  
High Performance ◽  
High Efficiency ◽  
Machine Intelligence ◽  
Digital Design ◽  
Machine Design ◽  
Design And Development ◽  
Sewing Machine ◽  
Great Leap Forward ◽  
New Generation

In recent years, industrial sewing machine intelligence can be increased. Compared with the traditional equipment, the new generation of domestic equipment in the "high efficiency, energy saving, special" has realized great-leap-forward development. In the performance, will towards high precision, high efficiency, high performance, intelligent direction; in function, to the miniaturization, multi-function direction; in the program, to the systematic, integrated direction. The design and development of industrial sewing machine digitization design packaging platform are discussed.

scholarly journals Efficiency Evaluation of the Ejector Cooling Cycle using a New Generation of HFO/HCFO Refrigerant as a R134a Replacement

Energies ◽  
2018 ◽  
Vol 11 (8) ◽  
pp. 2136 ◽  
Author(s):  
Bartosz Gil ◽  
Jacek Kasperski
Keyword(s):  
High Efficiency ◽  
Coefficient Of Performance ◽  
Condensation Temperature ◽  
Evaporation And Condensation ◽  
Wide Range ◽  
Theoretical Investigations ◽  
Maximum Coefficient ◽  
C 30 ◽  
New Generation ◽  
And Control

Theoretical investigations of the ejector refrigeration system using hydrofluoroolefins (HFOs) and hydrochlorofluoroolefin (HCFO) refrigerants are presented and discussed. A comparative study for eight olefins and R134a as the reference fluid was made on the basis of a one-dimensional model. To facilitate and extend the possibility of comparing our results, three different levels of evaporation and condensation temperature were adopted. The generator temperature for each refrigerant was changed in the range from 60 °C to the critical temperature for a given substance. The performed analysis shown that hydrofluoroolefins obtain a high efficiency of the ejector system at low primary vapor temperatures. For the three analyzed sets of evaporation and condensation temperatures (te and tc equal to 0 °C/25 °C, 6 °C/30 °C, and 9 °C/40 °C) the maximum Coefficient of Performance (COP) was 0.35, 0.365, and 0.22, respectively. The best performance was received for HFO-1243zf and HFO-1234ze(E). However, they do not allow operation in a wide range of generator temperatures, and, therefore, it is necessary to correctly select and control the operating parameters of the ejector.

scholarly journals MEs in Nano-Medicine

2012 ◽  
Vol 134 (06) ◽  
pp. 36-41
Author(s):  
Guy M. Genin ◽  
Ram V. Devireddy
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Osteogenesis Imperfecta ◽  
High Efficiency ◽  
Medical Diagnostics ◽  
Imperial College ◽  
Current Generation ◽  
The Core ◽  
Nano Medicine ◽  
New Generation

This article reviews the use of mechanical engineering techniques in the field of nano-engineered medicines. Nano-engineered solutions now exist for a range of medical diagnostics, therapeutics, and imaging, and are at the core of many of the current generation of regenerative medicine and tissue engineering strategies. Nanoparticles can be developed to absorb energy with high efficiency from photons of certain frequency ranges. The ability to understand specific diseases such as osteogenesis imperfecta based upon such fundamental analyses has been demonstrated by ASME member Sandra Shefelbine of Imperial College London in collaboration with the Buehler group. The tools of nanotechnology have enabled mechanical engineers to engineer the beginnings of an entirely new generation of cures and therapies, and this article has discussed just a sample. In order to serve as a forum for discussion of these advances ASME is recommissioning the Journal of Nanotechnology in Engineering and Medicine.

Slow sand filtration pre-treatment with alum is efficient, but is it effective?

2013 ◽  
Vol 3 (2) ◽  
pp. 106-111 ◽  
Author(s):  
C. C. Dorea
Keyword(s):  
Process Control ◽  
High Efficiency ◽  
Sand Filters ◽  
Sand Filter ◽  
Limited Effectiveness ◽  
Scale Field ◽  
Slow Sand Filter ◽  
High Turbidity ◽  
Pre Treatment ◽  
Run Lengths

Enhancing the performance of slow sand filter pre-treatment with alum (i.e. direct or contact filtration) has been proposed as an alternative to overcome limitations of conventional gravel (roughing) pre-filtration. Experimental results revealed high turbidity reduction efficiencies in alum-dosed pre-filtration. However, due to the alum coagulation, the nature of the particulates in the pre-treatment effluent changed and had a potential to shorten the downstream slow sand filter run lengths by approximately 50% under the conditions tested. Hence, depending on the effluent turbidity levels the effectiveness of the alum-dosed pre-treatment could be compromised, despite its high efficiency. Relatively low turbidity levels (&lt;2 NTU) were needed to minimise excessive headloss development in alum-dosed filters. However, the necessary resources to achieve such process control may not be available in developing country contexts. Furthermore, full-scale field experiences indicated the limited effectiveness of alum dosing prior to slow sand filters and the difficulties in maintaining an adequate chemical dosing in under-resourced settings.

scholarly journals Systematic Evaluation of Light-Activatable Biohybrids for Anti-Glioma Photodynamic Therapy

2019 ◽  
Vol 8 (9) ◽  
pp. 1269 ◽  
Author(s):  
Inglut ◽  
Baglo ◽  
Liang ◽  
Cheema ◽  
Stabile ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Systematic Evaluation ◽  
Therapeutic Effects ◽  
End Effects ◽  
Fundamental Understanding ◽  
Effective Use ◽  
Oxygen Yield ◽  
New Generation

Photosensitizing biomolecules (PSBM) represent a new generation of light-absorbing compounds with improved optical and physicochemical properties for biomedical applications. Despite numerous advances in lipid-, polymer-, and protein-based PSBMs, their effective use requires a fundamental understanding of how macromolecular structure influences the physicochemical and biological properties of the photosensitizer. Here, we prepared and characterized three well-defined PSBMs based on a clinically used photosensitizer, benzoporphyrin derivative (BPD). The PSBMs include 16:0 lysophosphocholine-BPD (16:0 Lyso PC-BPD), distearoyl-phosphoethanolamine-polyethylene-glycol-BPD (DSPE-PEG-BPD), and anti-EGFR cetuximab-BPD (Cet-BPD). In two glioma cell lines, DSPE-PEG-BPD exhibited the highest singlet oxygen yield but was the least phototoxic due to low cellular uptake. The 16:0 Lyso PC-BPD was most efficient in promoting cellular uptake but redirected BPD’s subcellular localization from mitochondria to lysosomes. At 24 h after incubation, proteolyzed Cet-BPD was localized to mitochondria and effectively disrupted the mitochondrial membrane potential upon light activation. Our results revealed the variable trafficking and end effects of PSBMs, providing valuable insights into methods of PSBM evaluation, as well as strategies to select PSBMs based on subcellular targets and cytotoxic mechanisms. We demonstrated that biologically informed combinations of PSBMs to target lysosomes and mitochondria, concurrently, may lead to enhanced therapeutic effects against gliomas.

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