Pediatric Nephrotic Syndrome; Clinical Characteristics and Nutritional Status

Nephrotic syndrome (NS), is the most common chronic renal disorder in children, with multifactorial risk factors and complex etiology. Therefore, the aim of the present study was to determine the age and gender distribution and also determine the clinical characteristics and nutritional status of pediatric nephrotic syndrome. A total of 75 patients with nephrotic syndrome series were selected through semi-constructed questionnaires. The age of our subjects ranged between 1-18 years. Body weight and height were extracted from patient files or self-reported to calculate BMI percentile. Laboratory tests such as blood glucose, lipid profile vitamin D, and HbA1C were included. All samples were analyzed through either mean ±SEM or Chi-square for determining significant differences. The present study showed that 75 patients were diagnosed as nephrotic syndrome. The average age of patients was 9 years old and the age which showed significance was 6-10 years (p=0.04). In comparison to females, males were highly significant (p=0.000). Blood biochemistry showed low levels of total protein, albumin, hemoglobin, HCT, MCV, WBC, (gran %), calcium and sodium, and high levels for lymphocyte (mid %), urea, creatinine, ESR, potassium, hematuria, serum cholesterol, TG and VLDL. All patients were diagnosed as idiopathic nephrotic syndrome. Low birth weight showed significant increase in nephrotic diseases (p<0.05). Nutritional indices showed high body weight status with more junk and nutritious foods consumed among nephrotic patients. The present study revealed that nephrotic syndrome significantly increased in males (p<0.05) and male to female ratio 2.6:1. It also showed that the age groups between 6-10 years are more prone to suffer from a nephrotic disease (p<0.05). A history of low birth weight in infants or child family ranking were shown to be risk factors contributing to nephrotic disease (p=0.000).

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Prevalence of low birth weight and its association with maternal body weight status in selected countries in Africa: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2017-020410 ◽

2018 ◽

Vol 8 (8) ◽

pp. e020410 ◽

Cited By ~ 12

Author(s):

Zhifei He ◽

Ghose Bishwajit ◽

Sanni Yaya ◽

Zhaohui Cheng ◽

Dongsheng Zou ◽

...

Keyword(s):

Body Weight ◽

Birth Weight ◽

Low Birth Weight ◽

Burkina Faso ◽

Weight Status ◽

Cross Sectional Study ◽

Normal Weight ◽

Childbearing Age ◽

Maternal Body ◽

Cross Sectional

ObjectivesThe present study aimed to estimate the prevalence of low birth weight (LBW), and to investigate the association between maternal body weight measured in terms of body mass index (BMI) and birth weight in selected countries in Africa.SettingUrban and rural household in Burkina Faso, Ghana, Malawi, Senegal and Uganda.ParticipantsMothers (n=11 418) aged between 15 and 49 years with a history of childbirth in the last 5 years.ResultsThe prevalence of LBW in Burkina Faso, Ghana, Malawi, Senegal and Uganda was, respectively, 13.4%, 10.2%, 12.1%, 15.7% and 10%. Compared with women who are of normal weight, underweight mothers had a higher likelihood of giving birth to LBW babies in all countries except Ghana. However, the association between maternal BMI and birth weight was found to be statistically significant for Senegal only (OR=1.961 (95% CI 1.259 to 3.055)).ConclusionUnderweight mothers in Senegal share a greater risk of having LBW babies compared with their normal-weight counterparts. Programmes targeting to address infant mortality should focus on promoting nutritional status among women of childbearing age. Longitudinal studies are required to better elucidate the causal nature of the relationship between maternal underweight and LBW.

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Risk factors for relapse in pediatric nephrotic syndrome

Paediatrica Indonesiana ◽

10.14238/pi58.5.2018.238-41 ◽

2018 ◽

Vol 58 (5) ◽

pp. 238-41 ◽

Cited By ~ 1

Author(s):

Husein Albar ◽

Fadel Bilondatu ◽

Dasril Daud

Keyword(s):

Risk Factors ◽

Nephrotic Syndrome ◽

Risk Factor ◽

Nutritional Status ◽

Significant Risk ◽

Significant Risk Factor ◽

Chi Square ◽

Female Ratio ◽

High Relapse Rate ◽

Potential Risk Factors

Background Nephrotic syndrome (NS) is the most common kidney disease in children and is characterized by edema, massive proteinuria, hypoalbuminemia, and hyperlipidemia. High relapse rate remains a major problem in the management of this syndrome. Objective To identify risk factors for relapse in pediatric nephrotic syndrome. Methods This study was carried out in the Wahidin Sudirohusodo Teaching Hospital in Makassar, South Sulawesi, Indonesia, from January to August 2017 using complete medical records of children diagnosed with NS. Subjects were divided into 2 groups: 1) relapsed NS or 2) non-relapsed NS. The following potential risk factors for relapse were analyzed using Chi-square test: age, sex, nutritional status, hypertension, serum creatinine level, and infection at the time of established diagnosis of NS. Results A total of 142 children with NS who fulfilled the inclusion criteria aged 1.4 to 17.5 years were included in the study. Subjects were mostly boys (66.2%), with a male: female ratio of 1.95:1. The relapsed NS group had 80 cases (56.3%) and the non-relapsed NS group had 62 cases (43.7%). Statistical analysis revealed that nutritional status was a significant risk factor for relapse in pediatric nephrotic syndrome (P<0.05). Conclusion Nutritional status is an independent risk factor for relapse in pediatric nephrotic syndrome.

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STATUS GIZI AWAL KEHAMILAN DAN PERTAMBAHAN BERAT BADAN IBU HAMIL KAITANNYA DENGAN BBLR

Jurnal Gizi dan Pangan ◽

10.25182/jgp.2009.4.1.8-12 ◽

2009 ◽

Vol 4 (1) ◽

pp. 8

Author(s):

Yongky Yongky ◽

Hardinsyah Hardinsyah ◽

Gulardi Gulardi ◽

Marhamah Marhamah

Keyword(s):

Body Weight ◽

Birth Weight ◽

Low Birth Weight ◽

Nutritional Status ◽

Pregnant Women ◽

Early Pregnancy ◽

Economic Status ◽

First Trimester ◽

Font Size ◽

Socio Economic Status

The objectives of this research were to analyze nutritional status of pregnant women in Jakarta Timur and Bekasi and the accretion of body weight and its relationship with low birth weight. As many as 638 pregnant women had been followed since first examination until delivery. At the first trimester, most of pregnant women (53.8%) were categorized as normal nutritional status (BMI 19.8-26); underweight (BMI <19.8) 40%; and overweight (BMI > 26.01) 6.2%. The accretion of pregnant women body weight was relatively higher in high socio-economic status rather than low socio-economic status. The prevalence of low birth weight was higher among mothers from low socio-economic status. It is important for pregnant women to pay attention on her nutritional status in the early pregnancy and the accretion of body weight.

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Risk factors and clinical characteristics for bronchopulmonary dysplasia associated pulmonary hypertension in very-low-birth-weight infants

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02330-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Junfang Sun ◽

Bowen Weng ◽

Xiaoyue Zhang ◽

Xiaoyun Chu ◽

Cheng Cai

Keyword(s):

Risk Factors ◽

Pulmonary Hypertension ◽

Birth Weight ◽

Low Birth Weight ◽

Bronchopulmonary Dysplasia ◽

Clinical Characteristics ◽

Very Low Birth Weight ◽

Low Birth Weight Infants ◽

Average Birth Weight ◽

Specific Risk

Abstract Background Pulmonary hypertension (PH) is a common complication of bronchopulmonary dysplasia (BPD) in very-low-birth-weight infants (VLBWIs). Although recent studies have increased awareness that PH contributes significantly to the high morbidity and mortality of BPD, the risk factors and clinical characteristics for PH in VLBWIs are little known. Objectives To investigate the risk factors and clinical characteristics for BPD-associated pulmonary hypertension (BPD-PH) in VLBWIs. Methods A retrospective case–control observational study of VLBWIs with BPD admitted to a neonatal intensive care unit (NICU) over 4 years. According to echocardiograms confirming elevated pulmonary artery pressure after 28 days after birth, we divided BPD infants into PH group (n = 18) and non-PH group (n = 65). We compared pre- and postnatal characteristics between VLBWIs with or without PH. Multivariable logistic regression analysis was conducted with backward selection. Results A total of 83 infants with BPD were divided into PH group (n = 18) or non-PH group (n = 65). The average birth weight of the infants with BPD was 1078.1 g. Compared with those infants of the non-PH group, the birth weight of BPD-PH infants was significantly lower (968.1 ± 187.7 vs. 1108.5 ± 185.8, P = 0.006). Infants in the PH group had a higher incidence of patent ductus arteriosus (PDA) and underwent longer durations of oxygen therapy and mechanical ventilation compared to those in the non-PH group. In all subjects, birth weight (OR 0.995; 95% CI 0.991–0.999; P = 0.025) and PDA (OR 13.355; 95% CI 2.950–60.469; P = 0.001) were found to be specific risk factors for BPD-PH in this cohort. Conclusions The study shows PDA and birth weight are specific risk factors for BPD-PH in VLBWIs.

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Nutritional status and concomitant factors of stunting among pre-school children in Malda, India: A micro-level study using a multilevel approach

BMC Public Health ◽

10.1186/s12889-021-11704-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Rayhan Sk ◽

Anuradha Banerjee ◽

Md Juel Rana

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Nutritional Status ◽

School Children ◽

Birth Interval ◽

Health Workers ◽

Child Growth ◽

Micro Level ◽

Childhood Stunting

Abstract Background Malnutrition was the main cause of death among children below 5 years in every state of India in 2017. Despite several flagship programmes and schemes implemented by the Government of India, the latest edition of the Global Nutrition Report 2018 addressed that India tops in the number of stunted children, which is a matter of concern. Thus, a micro-level study was designed to know the level of nutritional status and to study this by various disaggregate levels, as well as to examine the risk factors of stunting among pre-school children aged 36–59 months in Malda. Method A primary cross-sectional quantitative survey was conducted using structured questionnaires following a multi-stage, stratified simple random sampling procedure in 2018. A sum of 731 mothers with at least one eligible child aged 36–59 months were the study participants. Anthropometric measures of children were collected following the WHO child growth standard. Children were classified as stunted, wasted, and underweight if their HAZ, WHZ, and WAZ scores, respectively, were less than −2SD. The random intercept multilevel logistic regression model has been employed to estimate the effects of possible risk factors on childhood stunting. Results The prevalence of stunting in the study area is 40% among children aged 36–59 months, which is a very high prevalence as per the WHO’s cut-off values (≥40%) for public health significance. Results of the multilevel analysis revealed that preceding birth interval, low birth weight, duration of breastfeeding, mother’s age at birth, mother’s education, and occupation are the associated risk factors of stunting. Among them, low birth weight (OR 2.22, 95% CI: 1.44–3.41) and bidi worker as mothers’ occupation (OR 1.92, 95% CI: 1.18–3.12) are the most influencing factors of stunting. Further, about 14 and 86% variation in stunting lie at community and child/household level, respectively. Conclusion Special attention needs to be placed on the modifiable risk factors of childhood stunting. Policy interventions should direct community health workers to encourage women as well as their male partners to increase birth interval using various family planning practices, provide extra care for low birth weight baby, that can help to reduce childhood stunting.

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Risk factors for low birth weight in a rural community in southern Brazil

Jornal de Pediatria ◽

10.2223/jped.645 ◽

1996 ◽

Vol 72 (6) ◽

pp. 369-373 ◽

Cited By ~ 4

Author(s):

Ricardo Halpern ◽

Earl S. Schaefer ◽

Airton S. Pereira ◽

Ernesto M. Arnt ◽

Jandira Pureza Valente Bezerra ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Rural Community ◽

Southern Brazil

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Intraventricular haemorrhage in a Ugandan cohort of low birth weight neonates: the IVHU study

BMC Pediatrics ◽

10.1186/s12887-020-02464-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

R. MacLeod ◽

J. N. Paulson ◽

N. Okalany ◽

F. Okello ◽

L. Acom ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Intraventricular Haemorrhage ◽

Sub Saharan Africa ◽

Cranial Ultrasound ◽

High Grade ◽

Odds Ratios ◽

Antenatal Steroids ◽

Eastern Uganda

Abstract Background Globally, 15 million neonates are born prematurely every year, over half in low income countries (LICs). Premature and low birth weight neonates have a higher risk of intraventricular haemorrhage (IVH). There are minimal data regarding IVH in sub-Saharan Africa. This study aimed to examine the incidence, severity and timing of and modifiable risk factors for IVH amongst low-birth-weight neonates in Uganda. Methods This is a prospective cohort study of neonates with birthweights of ≤2000 g admitted to a neonatal unit (NU) in a regional referral hospital in eastern Uganda. Maternal data were collected from interviews and medical records. Neonates had cranial ultrasound (cUS) scans on the day of recruitment and days 3, 7 and 28 after birth. Risk factors were tabulated and are presented alongside odds ratios (ORs) and adjusted odds ratios (aORs) for IVH incidence. Outcomes included incidence, timing and severity of IVH and 28-day survival. Results Overall, 120 neonates were recruited. IVH was reported in 34.2% of neonates; 19.2% had low grade (Papile grades 1–2) and 15% had high grade (Papile grades 3–4). Almost all IVH (90.2%) occurred by day 7, including 88.9% of high grade IVH. Of those with known outcomes, 70.4% (81/115) were alive on day 28 and survival was not associated with IVH. We found that vaginal delivery, gestational age (GA) < 32 weeks and resuscitation in the NU increased the odds of IVH. Of the 6 neonates who received 2 doses of antenatal steroids, none had IVH. Conclusion In this resource limited NU in eastern Uganda, more than a third of neonates born weighing ≤2000 g had an IVH and the majority of these occurred by day 7. We found that vaginal birth, earlier gestation and need for resuscitation after admission to the NU increased the risk of IVH. This study had a high rate of SGA neonates and the risk factors and relationship of these factors with IVH in this setting needs further investigation. The role of antenatal steroids in the prevention of IVH in LICs also needs urgent exploration.

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Prevalence, Risk Factors, and Short-Term Outcomes of Full-Term Low Birth Weight Infants Born at a Tertiary Academic Center: A Prospective Case–Control Study

American Journal of Perinatology ◽

10.1055/s-0040-1722599 ◽

2021 ◽

Author(s):

Heidi K. Al-Wassia ◽

Shahd K. Baarimah ◽

Asmaa H. Mohammedsaleh ◽

Manal O. Alsulami ◽

Ragad S. Abbas ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Case Control Study ◽

Case Control ◽

Adverse Outcomes ◽

Chromosomal Anomalies ◽

Short Term ◽

Term Infants ◽

Control Study

Objective Low birth weight (LBW) infants (<2,500 g) continued to be a global health problem because of the associated short- and long-term adverse outcomes. The study aimed to determine the prevalence, risk factors, and short-term outcomes of term LBW infants Study Design A prospective and case–control study. All infants born consecutively from September 1, 2018 to August 31, 2019 were included. Cases, term LBW infants, were 1:1 matched to controls, appropriate for gestational age (AGA) term infants. Major congenital or chromosomal anomalies and multiple pregnancies were excluded. Results The prevalence of term LBW in the studied period was 4.8%. Mothers of term LBW infants had significantly lower body mass index (p = 0.05), gained less weight (p = 0.01), had a history of previous LBW (p = 0.01), and lower monthly income (p = 0.04) compared with mothers of term AGA infants even after adjustment for confounders. A nonsignificant higher number of term LBW infants needed NICU admission, while their need for phototherapy was deemed significant. Conclusion We identified nutritional and socioeconomic maternal factors that are significantly associated with LBW infants and should be targeted during antenatal visits to improve neonatal outcomes. Key Points

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Frequency, risk factors and materno-foetal outcomes among cases of Placenta previa at a tertiary care hospital: a two year study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20192165 ◽

2019 ◽

Vol 8 (6) ◽

pp. 2240

Author(s):

Pamulaparthi Bindu Reddy ◽

Gurram Swetha Reddy

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Tertiary Care Hospital ◽

Placenta Previa ◽

Tertiary Care ◽

Previous History ◽

Morbidity And Mortality ◽

Care Hospital ◽

Early Date

Background: Placenta previa refers to the presence of placental tissue that extends over the internal cervical os. Placenta previa is linked to maternal hypovolemia, anaemia, and long hospital stay and with prematurity, low birth weight, low APGAR score in newborn. So it is very important to identify the condition at an early date to warn the condition thereby reducing the maternal and foetal morbidity and mortality. The present study was aimed to estimate the prevalence of PP, its associated predisposing risk factors and maternal morbidity, mortality and the perinatal outcome.Methods: A prospective observational study for two years was conducted at a tertiary care hospital. Pregnant mothers with >28 weeks of age with H/o ante partum haemorrhage were screened for placenta previa, confirmed by ultra sonography and included in the study. Clinical history, obstetric examination was done and followed up till the delivery. Maternal and foetal outcomes were recorded. Data analyzed by using SPSS version 20.Results: 1.4% incidence of PP was noted, mean age of group was 29.17±1.6 years. Age group of 21-30 years, multiparity Gravida 2-4, previous history of caesarean section and less number of ante natal checkups were significant risk factors and LSCS was most common outcome. Prematurity, low birth weight and APGAR <7 score for 1 minute was common foetal outcomes.Conclusions: Our study strongly suggests foetal surveillance programmes in cases of placenta previa. Measures should be made to bring awareness about PP, in urban slums and to increase medical checkups regularly. Making USG mandatory during every ANC and referral of cases of PP to tertiary care centres would definitely reduce the chances of morbidity and mortality.

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Diet Quality Is Associated with a High Newborn Size and Reduction in the Risk of Low Birth Weight and Small for Gestational Age in a Group of Mexican Pregnant Women: An Observational Study

Nutrients ◽

10.3390/nu13061853 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1853

Author(s):

María A. Reyes-López. ◽

Carla P. González-Leyva ◽

Ameyalli M. Rodríguez-Cano ◽

Carolina Rodríguez-Hernández ◽

Eloisa Colin-Ramírez ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Nutritional Status ◽

Diet Quality ◽

Gestational Age ◽

Small For Gestational Age ◽

Mexican Women ◽

High Quality ◽

Quality Diet ◽

Newborn Size

A high-quality diet during pregnancy may have positive effects on fetal growth and nutritional status at birth, and it may modify the risk of developing chronic diseases later in life. The aim of this study was to evaluate the association between diet quality and newborn nutritional status in a group of pregnant Mexican women. As part of the ongoing Mexican prospective cohort study, OBESO, we studied 226 healthy pregnant women. We adapted the Alternated Healthy Eating Index-2010 for pregnancy (AHEI-10P). The association between maternal diet and newborn nutritional status was investigated by multiple linear regression and logistic regression models. We applied three 24-h recalls during the second half of gestation. As the AHEI-10P score improved by 5 units, the birth weight and length increased (β = 74.8 ± 35.0 g and β = 0.3 ± 0.4 cm, respectively, p < 0.05). Similarly, the risk of low birth weight (LBW) and small for gestational age (SGA) decreased (OR: 0.47, 95%CI: 0.27–0.82 and OR: 0.55, 95%CI: 0.36–0.85, respectively). In women without preeclampsia and/or GDM, the risk of stunting decreased as the diet quality score increased (+5 units) (OR: 0.62, 95%IC: 0.40–0.96). A high-quality diet during pregnancy was associated with a higher newborn size and a reduced risk of LBW and SGA in this group of pregnant Mexican women.

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