PENGARUH BALUTAN BASAH OLIVE OIL TERHADAP PROSES PENYEMBUHAN LUKA BAKAR DERAJAT II PADA TIKUS PUTIH (RATTUS NORVEGICUS)

Luka bakar yang sering terjadi dan banyak ditemukan adalah luka bakar derajat II. Tumbuhan alam yang berkhasiat obat telah banyak dikenal oleh masyarakat Indonesia sejak lama. Salah satu tanaman alam yang mengandung banyak khasiat adalah olive oil. Olive oil memiliki kandungan senyawa penting dalam penyembuhkan luka antara lain oleochantal, sterol, fenol, squalen, vitamin C, E dan K yang dapat berperan mempercepat proses penyembuhan luka. Kandungan vitamin A dan vitamin E telah diketahui sebagai vitamin yang dapat membantu dalam proses penyembuhan luka. Penelitian ini menggunakan olive oil yang di buat dalam bentuk balutan basah untuk perawatan luka bakar derajat II pada tikus putih. Penelitian ini menggunakan metode true experiment dengan desain posttest only control design. Penelitian ini dilaksanakan pada bulan Maret 2020. Sampel penelitian adalah 20 kelompok perlakuan (tikus putih yang diberikan balutan basah olive oil) dan 20 kelompok kontrol tikus putih. Dengan teknik random sampling. Data diolah dengan SPSS menggunakan uji Mann Whitney. Hasil penelitian di dapatka P-value 0,00 < α (0,05) yang berarti adanya pengaruh Perawatan Luka Bakar Derajat II Dengan Balutan Basah Olive Oil Pada Tikus Putih (Rattus Norvegicus). Diharapkan dengan pemanfaatan bahan alam untuk kepentingan sehari-hari dapat meminimalkan efek samping dari penggunaan bahan kimia yang sering digunakan oleh masyarakat saat ini. Kata Kunci: Luka Bakar Derajat II, Olive Oil, Tikus Putih (Rattus Norvegicus) Abstract Burns that often occur and are commonly found are second-degree burns. Natural medicinal plants have been widely known by the people of Indonesia for a long time. One of the natural plants that contain many benefits is olive oil. Olive oil has important compounds in wound healing including oleochantal, sterol, phenol, squalen, vitamins C, E and K which can play a role in accelerating the wound healing process. The content of vitamin A and vitamin E has been known as a vitamin that can help in the wound healing process. This study used olive oil which is made in the form of a wet dressing for the treatment of second-degree burns in white rats. This study used the true experiment method with the posttest only control design. The research was conducted in March 2020. The study sample was 20 treatment groups (white rats given wet olive oil dressing) and 20 control groups of white rats. With random sampling technique. Data were processed with SPSS using the Mann Whitney test. The results of the study obtained a P-value of 0.00 <α (0.05), which means that there is an influence of Grade II Burn Treatment with Olive Oil Wet Wrap on White Rat (Rattus Norvegicus). It is expected that the use of natural materials for daily use can minimize the side effects of the use of chemicals that are often used by the community today. Keywords: Grade II Burns, Olive Oil, White Rat (Rattus Norvegicus)

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EFEKTIVITAS PEMBERIAN EKSTRAK JAHE MERAH (ZINGIBER OFFICINALE) TERHADAP JUMLAH SEL FIBROBLAS DALAM PROSES PENYEMBUHAN ULKUS PADA MUKOSA MULUT TIKUS PUTIH JANTAN (RATTUS NORVEGICUS)

ODONTO Dental Journal ◽

10.30659/odj.3.2.98-104 ◽

2016 ◽

Vol 3 (2) ◽

pp. 98

Author(s):

Prima Agusmawanti

Keyword(s):

Wound Healing ◽

Oral Mucosa ◽

Rattus Norvegicus ◽

Healing Process ◽

White Male ◽

Zingiber Officinale ◽

Male Rats ◽

Wound Healing Process ◽

P Value ◽

Red Ginger

Background: In the wound healing process there are a variety of processes, including the most important are fibroplasia process that has a very important role in the wound healing process. Red ginger (Zingiber officinale) contains active ingredients include a mixture of components of essential oils and resins that oleoresin which has anti-inflammatory effects. The aim is determine the effect of red ginger extract against the number of fibroblasts in healing ulcers on the oral mucosa white male rats (Rattus norvegicus)Method: Samples using 24 male rats 2-3 months of age and body weight of 120-200 grams. Mandibular labial mucosa injured mice using H2O2 solution for 2x1 days. The samples were divided into 4 groups, where each group each of 4individuals: group 1 without any treatment, group 2 was treated application ginger gel extract 4%, group 3 was given treatment application ginger gel extract 8% and group 4 treated with applications aloclair gel. On the fourth day after the injury,the rats were decapitated, then do making preparations for histology to count the number of fibroblast cells.Result: The results Oneway ANOVA p value <0.05 and post Hoc Test LSD p value <0.05 which means that the extract of red ginger significantly affects the number of fibroblast cells and between groups have significant differencesConclusion: Extract red ginger gel is effective against the number of fibroblasts in healing ulcers on the oral mucosa white male rats.

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COMPARISON OF THE EFFECTIVENESS OF GIVING BINAHONG LEAF (Anredera cordifolia (Ten) Steenis) AND PAPAYA LEAF (Carica papaya) ON SKIN WOUND HEALING IN WHITE RAT (Rattus novergicus)

Journal Widya Medika Junior ◽

10.33508/jwmj.v3i2.3181 ◽

2021 ◽

Vol 3 (2) ◽

pp. 78-85

Author(s):

Givenchy Winarjo ◽

◽

Fransiscus Arifin ◽

Dave Oenarta ◽

◽

...

Keyword(s):

Wound Healing ◽

Leaf Extract ◽

Healing Process ◽

Control Group ◽

Wound Healing Process ◽

P Value ◽

World Population ◽

White Rats ◽

Significant Difference ◽

The World

Introduction: The incidence of acute and chronic injuries increases every year. Most injuries in the world population, as many as 48%, are caused by trauma or surgery. the highest incidence of wounds in the world based on the etiology was from surgery, which was 110.30 million cases. One of the handlings of wounds on the skin can be done by giving herbal medicines, which can be easily accessed by the public, such as binahong leaves and papaya leaves. Purpose: To analyze the effectiveness of giving 40% binahong leaf extract cream and 40% papaya leaf extract cream on the wound distance in the white rat wound healing process. Method: this study is an experimental study with post-test only control group design approach. The sampling technique used in this study was a random sampling method where the number of samples was calculated using the Federer formula, with a total sample of 28 white rats. The distance of the wound was measured using a micrometer. Results: Twenty-eight wound distance on rats were measured as subjects of the study and then treated with binahong leaf extract cream and papaya leaf extract cream, then the wound distance of each treatment was measured using a micrometer. According to the results, 40% binahong leaf extract cream and 40% papaya leaf extract cream showed better effectiveness in reducing the wound distance of white rat incision than the negative control group (cream base) and positive control group (gentamicin ointment). According to the Mann Whitney test comparing the P1 group (40% binahong leaf extract cream) and P2 (40% papaya leaf extract cream), p-value >0.05, which is 0.543, which means that P1 has no significant mean difference with P2. Conclusion: There was no significant difference in effectiveness between the treatment of 40% binahong leaf extract cream and 40% papaya leaf extract cream.

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Gambaran Makroskopis Persembuhan Luka Mukosa Buccal Tikus Putih (Rattus norvegicus) Pascapemberian Policresulen

ARSHI Veterinary Letters ◽

10.29244/avl.4.3.57-58 ◽

2021 ◽

Vol 4 (3) ◽

pp. 57-58

Author(s):

Tri Isyani Tunggadewi ◽

Tony Wahyudi ◽

Aisyah Alviatus Shofwan ◽

Anggri Azhari Khoerunnisa ◽

Huda Salahudin Darusman

Keyword(s):

Wound Healing ◽

Rattus Norvegicus ◽

Healing Process ◽

Mucosal Injury ◽

Control Group ◽

Wound Healing Process ◽

Treatment Groups ◽

White Rats ◽

Biopsy Punch ◽

Macroscopic Observation

This study aimed to investigate the effect of policresulen treatment with various concentrations on the wound healing in buccal mucosa of white rats (Rattus norvegicus) through macroscopically observation. The number of 54 rats were divided into six treatment groups policresulen with concentration of 36%, 10%, 5%, 1%, 0.3% and one control group. The buccal mucosal injury was made with a 0.5 cm biopsy punch. The treatment of mucosal injury was conducted by dropped policresulen on the 2nd day until the 5th day after the injury. Macroscopic observation under a stereo micro-scope was conducted on the wound diameter, redness, swelling, and necrose. The results showed that wound healing was influenced significantly with concentration of the policresulen. The best healing was shown on lowest concentration marked which has lowest size of the wound diameter (0.50 ± 0.00 cm), the lowest tissue redness (0.00 ± 0.00), lowest final swelling at a concentration of 0.3%. Clinical evaluation of wound tissue necrose parameters which were seen to be most severe at 10% policresulen administration followed by 36% concentration and the least necrose shown on policresulen administration 0.3%. Therefore, based on macroscopic images with parameters of wound diameter, redness, swelling, and necrose suggested that policresulen used for wound healing process are at a concentration of 0.3%.

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HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

Jurnal Penelitian Keperawatan Medik ◽

10.36656/jpkm.v2i1.187 ◽

2019 ◽

Vol 2 (1) ◽

pp. 14-17

Author(s):

Nurul Aini Siagian ◽

Syafira Nusaibah ◽

Andayani Boang Manalu

Keyword(s):

Wound Healing ◽

Healing Process ◽

Early Mobilization ◽

Sectio Caesarea ◽

Wound Healing Process ◽

P Value ◽

Cross Sectional ◽

Care Services ◽

Healing Wound ◽

Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

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Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

Jurnal Kesehatan Panrita Husada ◽

10.37362/jkph.v2i1.147 ◽

2017 ◽

Vol 2 (1) ◽

pp. 20-28

Author(s):

Fitriani ◽

Tenriwati

Keyword(s):

Wound Healing ◽

Nutritional Status ◽

Healing Process ◽

Data Retrieval ◽

Observational Research ◽

Wound Healing Process ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

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PENGARUH MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST SECTIO CAESAREA

Jurnal IPTEKS Terapan ◽

10.22216/jit.2017.v11i1.661 ◽

2017 ◽

Vol 11 (1) ◽

pp. 109

Author(s):

Reni Heryani ◽

Ardenny Denny

Keyword(s):

Wound Healing ◽

Placenta Previa ◽

Healing Process ◽

Early Mobilization ◽

Sectio Caesarea ◽

Uterine Action ◽

Wound Healing Process ◽

P Value ◽

Post Test ◽

Development Goals

ABSTRAK Salah satu tujuan pembangunan era Millenium Development goals (MDG’s) 2015 adalah perbaikan kesehatan maternal. Salah satu cara di dalam persalinan atau mengeluarkan bayi secara patologis yaitu dengan sectio caesarea. Menurut statistik 3.509 kasus sectio caesarea, indikasi terbanyak adalah disproporsi cephalo pelvik (21%), sedangkan indikasi lain adalah gawat janin (14%), plasenta previa (11%), pernah sectio caesarea (11%), incoordinate uterine action (9%), preeklamsi dan hipertensi (7%). Penelitian ini menggunakan desain penelitian Quasy Experiment dengan post test only with control. Hasil penelitian menunjukkan bahwa umumnya responden memiliki umur tidak berisiko terhadap tindakan operasi yati sebanyak 15 orang (75%), sebagian responden pertama kali dilakukan operasi caesarea yaitu sebanyak 10 orang (50,0%), sebagian responden mengalami penyembuhan luka yang normal yaitu sebanyak 13 orang (65,0%), dan sebagian responden responden melakukan mobilisasi dini yaitu sebanyak 14 orang (70,0%). Secara statistik terdapat pengaruh mobilisasi dini terhadap penyembuhan luka post sectio caesarea di RSUD Arifin Achmad Pekanbaru (p value = 0.007). Disarankan bagi respnden dapat meningkatkan kesadarannya dalam meningkatkan derajat kesehatan melalui latihan mobilisasi dini untuk mempercepat proses penyembuhan luka akibat operasi. Kata Kunci : sectio caesarea, mobilisasi, penyembuhan luka ABSTRACT One of the goals of development era of Millennium Development Goals (MDG's) in 2015 is the improvement of maternal health. One way in the delivery or the baby out with the pathological ie sectio caesarea. According to 3509 statistics compiled case sectio caesarea, an indication of cephalo pelvic disproportion is the highest (21%), while the other is an indication of fetal distress (14%), placenta previa (11%), never sectio caesarea (11%), incoordinate uterine action (9%), preeclampsia and hypertension (7%). This study research design quasy Experiment with post test only with control. The results showed that respondents generally have a lifespan of no risk for surgery yati many as 15 people (75%), the majority of respondents were first performed caesarea operation as many as 10 people (50.0%), the majority of respondents experienced a normal wound healing as many as 13 people (65.0%), and the majority of respondents respondents did early mobilization as many as 14 people (70.0%). There is a statistically significant relationship between early mobilization on wound healing post sectio caesarea (p value = 0.007). Suggested for respnden can increase awareness in improving health status through early mobilization exercises to accelerate the wound healing process as a result of the operation. Keywords: sectio caesarea, mobilization, wound healing

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EFEKTIFITAS ANTARA PERAWATAN LUKA DENGAN MENGGUNAKAN NaCl 0,9% DAN BETADIN TERHADAP PROSES PENYEMBUHAN LUKA POST OPERASI

Jurnal Kesehatan ◽

10.38165/jk.v7i1.120 ◽

2020 ◽

Vol 7 (1) ◽

pp. 782-788

Author(s):

Sri Lestari ◽

Kunidah Kunidah

Keyword(s):

Wound Healing ◽

Wound Care ◽

Healing Process ◽

Care Patient ◽

Sectio Caesarea ◽

Wound Healing Process ◽

P Value ◽

Purposive Sampling ◽

Healing Wound ◽

Post Operation

Penyembuhan luka merupakan suatu proses yang kompleks karena berbagai kegiatan bio-seluler, bio-kimia terjadi berkesinambungan. Sifat penyembuhan pada semua luka sama, dengan variasinya bergantung pada lokasi, keparahan, dan luasnya cedera. Tujuan penelitian ini untuk mengetahui efektifitas antara perawatan luka menggunakan NaCl 0,9% dengan betadin terhadap proses penyembuhan luka post operasi pada pasien sectio caesarea. Penelitian ini merupakan jenis penelitian Quaisy Experimen. Dengan populasi seluruh pasien perawatan luka post operasi sectio caesarea yaitu 26, dan menggunakan teknik sampel purposive sampling dengan jumlah 13 responden setiap kelompok. Penelitian ini dilakukan di Rumah Sakit Ciremai Kota Cirebon. Hasil penelitian ini adalah perawatan luka post operasi sectio caesarea menggunakan NaCl 0,9% sebanyak 13 responden dengan proses penyembuhan luka ≤ 3 hari di dapatkan rata-rata 7,07. Dan hasil bivariate menunjukkan bahwa ada perbedaan antara efektifitas proses penyembuhan luka pada perawatan luka pasien post operasi sectio caesarea menggunakan NaCl 0,9% dengan nilai p value = 0,000 < (a=0,05).Kata kunci : Proses penyembuhan luka, perawatan luka, NaCl 0,9%, Betadin ABSTRACTWound healing is a complex process because of the various activies of bio-chemical, bio-cell occurs continuosly. Wound healing properties on the all the same, with variations depending on the location, saverity, and the extent of the injury. The purpose of this reseach was to determine the effectiveness of wound care using NaCl 0,9 % with using betadin to wound healing process post operation on patients sectio caesarea. This research is a kind of the quaisy experimental. With a population of whole patients wound care post operatition sectio caesarea which is 26, and using the tecnique of purposive sampling with a total of 13 respondents per-group. The research was conducted at the ciremai hospital of cirebon city.The results of this research are wound care post operation sectio caesarea using NaCl 0,9% as much 13 respondents with the healing process of wound ≤ 3 days obtained of average 7,07. Bivariate and result showed the there is between the effectiveness of the process of wound healing in wound care patient post operation sectio caesarea using NaCl 0,9% with a value p = 0,000 < (a=0,05).Keywords : The process of wound healing, wound care, NaCl 0,9%, betadin

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16. Healing Process Of Burns (Vulnus combustion) Degrees IIB Using Mixed Leaf (Spondias dulcis F.) Fresh And Dry With Vaselin In Rats (Rattus Norvegicus)

Jurnal Medika Veterinaria ◽

10.21157/j.med.vet..v13i1.4310 ◽

2019 ◽

Vol 13 (1) ◽

pp. 114-124

Author(s):

Ummu Balqis ◽

Mirna Safrani Fauzi ◽

Zuhrawati NA ◽

Nazaruddin Nazaruddin ◽

Razali Daud ◽

...

Keyword(s):

Rattus Norvegicus ◽

Inflammatory Cell ◽

Healing Process ◽

Inflammatory Cells ◽

Inflammatory Cell Infiltration ◽

Cell Infiltration ◽

Treatment Groups ◽

White Rats ◽

Grade Ii ◽

Hematoxylin And Eosin

The aims of this research was looked to determine the healing process of burns Grade II B using a mixture of fresh and dried leaf kedondong with vaseline white rats (Rattus norvegicus). Animals used were 18 rats. This study was designed using three treatment groups namely (KI) vaseline, (KII) mixture of crushed leaves and fresh kedondong (KIII) mixture of crushed dried leaves kedondong and each two replications. Burns made on the backs of mice and the treatments are done twice a day for 21 days.Observation research parameter is the description of macroscopic and microscopic observed at day 7, 14, and 21 in the skin tissue with hematoxylin and eosin staining. The observation of macroscopic studies showed that the formation of a reddish color, presence of edema, and loss of the fastest consecutive scab is KI, KIII, and KII, while the formation of a scab fastest respectively KIII, KI and KII. The observation of histopathology showed on day 7, KI, KII and KIII found inflammatory cell infiltration, hemorrhage and edema with the spread of many.on the 14th day of KI and KII infiltration of inflammatory cells and their udema much, whereas KIII inflammatory cell infiltration decreased, and hyperemia increase, on the 21st day KI, KII and KII inflammatory cell infiltration, hyperemia and hemorrhage spread with a little, but KI and KII oedemanya still being spread. Based on the results of this study concluded that KIII accelerate the healing process of burns on rats

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Effect of Red Fruit Oil Soap (Pandanus Conoideus Lam.) as Wound Cleansing on Wound Healing and the Number of Bacterial Colonies among Grade II Diabetic Ulcer Patients at Griya Wound Care Clinic Kudus, Indonesia

GHMJ (Global Health Management Journal) ◽

10.35898/ghmj-32268 ◽

2019 ◽

Vol 3 (2) ◽

pp. 55

Author(s):

Hevny Kartika Dewi ◽

Mardiyono Mardiyono ◽

Diyah Fatmasari ◽

Sudirman Sudirman ◽

Djenta Saha

Keyword(s):

Wound Healing ◽

Healing Process ◽

Intervention Group ◽

Control Group ◽

Wound Healing Process ◽

Nacl Solution ◽

Diabetic Ulcer ◽

Grade Ii ◽

The Mean ◽

Fruit Oil

Background: Diabetic ulcer is an open wound on the skin layer to the dermis due to hyperglycemia and neuropathy. This condition often causes infection and becomes an inhibitor in the wound healing process. Red fruit oil soap can be used as an alternative cleansing to reduce the number of bacterial colonies and accelerate the wound healing process.Aims: This present study aimed to observe the effect of red fruit oil soap in the cleansing process to reduce the number of bacterial colonies and the wound healing process in grade II Diabetic ulcer patientsMethods: This is a quasi-experimental study with the pre-test post-test non-equivalent control group design. Wound cleansing in the intervention group used 0.9% NaCl solution and red fruit oil soap with a pH of 5.74, while the wound cleansing in the control group used 0.9% NaCl solution. Bacterial colonies were assessed and the type of bacteria was observed by the swab method. The wound healing was assessed with Bates-Jensen Wound Assessment Tool (BWAT) instrument for 14 days with observations every 3 days. Analysis test used Mann Whitney and Repeated Measure ANOVA.Results: There was no difference in the mean of the number of bacterial colonies between the wounds that were cleansed with 0.9% NaCl solution and red fruit oil soap and the wounds which were cleansed by using 0.9% NaCl solution (p> 0.05). The mean of the number of colonies in the intervention group until the 14th day reduced by 3.14x106 and in the control group was reduced h 1.40x106. There was a significant decrease in the wound healing scores in each group, in each assessment for 14 days.Conclusion: This study found that the wound cleansing using red fruit oil soap and 0.9% NaCl solution could reduce the number of bacterial colonies on the wound surface and accelerate the wound healing process among patients with grade II diabetic ulcer.

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