scholarly journals From Tissue Repair to Tissue Regeneration

2019 ◽  
Author(s):  
Aragona Salvatore Emanuele ◽  
Mereghetti Giada ◽  
Ferrari Alessio ◽  
Giorgio Ciprandi
Keyword(s):  
Tissue Regeneration ◽  
Tissue Repair

scholarly journals Pain sensing neurons promote tissue regeneration in adult mice

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Lise Rabiller ◽  
Elodie Labit ◽  
Christophe Guissard ◽  
Silveric Gilardi ◽  
Bruno P. Guiard ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
Animal Species ◽  
Loss Of Function ◽  
Nociceptive Neurons ◽  
Regulatory Processes ◽  
Adult Mice ◽  
Calcitonin Gene ◽  
Lower Vertebrates

AbstractTissue repair after injury in adult mammals, usually results in scarring and loss of function in contrast to lower vertebrates such as the newt and zebrafish that regenerate. Understanding the regulatory processes that guide the outcome of tissue repair is therefore a concerning challenge for regenerative medicine. In multiple regenerative animal species, the nerve dependence of regeneration is well established, but the nature of the innervation required for tissue regeneration remains largely undefined. Using our model of induced adipose tissue regeneration in adult mice, we demonstrate here that nociceptive nerves promote regeneration and their removal impairs tissue regeneration. We also show that blocking the receptor for the nociceptive neuropeptide calcitonin gene-related peptide (CGRP) inhibits regeneration, whereas CGRP administration induces regeneration. These findings reveal that peptidergic nociceptive neurons are required for adult mice tissue regeneration.

Overview: Autologous Peripheral Blood Mononuclear Cells

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Petrungaro A ◽  
◽  
Scudo F ◽  
Quartarone E ◽  
◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Tissue Repair ◽  
Mononuclear Cells ◽  
Mononuclear Phagocyte ◽  
Tendon Tissue ◽  
Central Importance ◽  
Peripheral Blood Mononuclear ◽  
Avant Garde ◽  
Blood Mononuclear Cells ◽  
A Cell

The implant of autologous mononuclear cells is an avant-garde method based on the use of a cell population within our body to regenerate tissues that have been damaged by various pathological events. The biological assumption is the richness and complexity of biochemical and cellular phenomena inherent in both organism response to damage and tissue regeneration. The key role is played by the mononuclear phagocyte system which regulates and modulates the activity of mesenchymal stem cells capable of differentiating and providing tissue repair. This system does not only have a traditional “scavenger” function within the immune system, but it is also of central importance in the modulation and activation of the response to tissue damage, be it traumatic, surgical, or degenerative. In this review we summarize the main features of this method and the most common uses in clinical practice where the interest is growing considering both the powerful, rapid and documented regenerative response of the various “target” tissues: vascular, cartilage, bone, muscle and tendon tissue.

scholarly journals A review of protein adsorption on bioceramics

2012 ◽  
Vol 2 (3) ◽  
pp. 259-277 ◽  
Author(s):  
Kefeng Wang ◽  
Changchun Zhou ◽  
Youliang Hong ◽  
Xingdong Zhang
Keyword(s):  
Tissue Regeneration ◽  
Protein Interactions ◽  
Tissue Repair ◽  
Cellular Response ◽  
Biological Activities ◽  
Biological Mechanisms ◽  
Hard Tissue ◽  
Coated Layer ◽  
Sense And Respond

Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic–protein interactions.

Bioactive glasses in wound healing: hope or hype?

2017 ◽  
Vol 5 (31) ◽  
pp. 6167-6174 ◽  
Author(s):  
Shiva Naseri ◽  
William C. Lepry ◽  
Showan N. Nazhat
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
Great Promise ◽  
Mineralized Tissue ◽  
Bioactive Glasses ◽  
Soft Tissue Repair ◽  
Potential Applications

Bioactive glasses have long been investigated in mineralized tissue regeneration, but recently their potential applications in soft tissue repair, and in particular wound healing, have demonstrated great promise.

GMP-Conform Generation and Cultivation of Unrestricted Somatic Stems Cells (USSC) from Cord Blood Using the SEPAX©-Separation Method a Closed Culture System Applying Cell Stacks.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 1211-1211 ◽  
Author(s):  
Teja F. Radke ◽  
Anja Buchheiser ◽  
Aurélie Lefort ◽  
Mahtab Maleki ◽  
Peter Wernet ◽  
...  
Keyword(s):  
Cord Blood ◽  
Tissue Regeneration ◽  
Closed System ◽  
Tissue Repair ◽  
Mononuclear Cells ◽  
Calf Serum ◽  
Processing System ◽  
Population Doubling ◽  
Differentiation Potential ◽  
Laboratory Conditions

Abstract Generation and characterization of unrestricted somatic stem cells (USSC) from cord blood (CB) was described by our group and has been well established under laboratory conditions [Koegler et al 2004, 2005 and 2006; Sensken et al 2007]. Due to their proliferative and differentiation capacity, USSCs are an interesting candidate for the future development of cellular therapy for tissue repair and tissue regeneration as well as a supportive cell layer to support hematopoietic reconstitution. Since generation and expansion under GMP-grade conditions is mandatory for use in clinical application, the automated cell processing system Sepax (BIOSAFE) with the CS900 separation kit was used for mononuclear cell separation and the subsequent generation of the USSC colonies in the presence of 30% GMP-grade fetal calf serum (Perbio), low-glucose DMEM-medium/10-7M dexamethasone. Expansion of USSC was performed in a closed system (Macopharma) applying cell stacks (Costar Corning). Results achieved so far indicate that the generation frequency and quality of generated USSC under GMP conditions are equal or even superior (45%) to manual generation under laboratory conditions (43%). 20 cord-blood units (mean volume 88,5 +− 15,8 ml; mean number of mononuclear cells 3,1 +−0,6 *108 MNC) have been processed, resulting in 9 USSC-colony formations and lines within 14–28 days. Growth kinetics is equal to the previously established USSC-lines (∼36–48 h / population doubling). Analysis of the immunophenotype as well as the differentiation potential towards the mesenchymal, neural and endodermal lineages also showed no difference to those lines generated manually using Ficoll-separation and normal cell culture flasks (Costar Corning T225). The closed system applied here is perfectly suitable to ensure safe and easy handling of the USSC, including seeding, trypsination and harvesting. In combination with the cell stack system (1, 2, 5 and 10 layers), cell amounts of more than 1.0×109 USSC can be achieved within 4 passages. These USSC products were temperature controlled cryopreserved in the presence of 10% DMSO, HSA and dextran. USSC can be thawed and further expanded in clinical grade quality. On the basis of their pluripotency and expansion under GMP-conditions into large quantities, these USSC from cord blood, when pretested for infectious agents and matched for the major transplantation antigens, may serve as a universal allogeneic stem cell source for tissue repair and tissue regeneration.

scholarly journals Evaluation of success and/or failure of endodontic treatment in non-vital teeth performed at the School of Dentistry at the Universidad del Valle. Case series

2017 ◽  
Vol 22 (2) ◽  
pp. 13-19
Author(s):  
Luis Ochoa ◽  
Stevan Moreno ◽  
David Piarpuzán ◽  
Patricia Rodríguez ◽  
Adriana Herrera ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Tissue Repair ◽  
Tooth Loss ◽  
Case Series ◽  
Dental Students ◽  
Endodontic Treatment ◽  
Necrotic Tissue ◽  
The Third ◽  
Biofilm Removal ◽  
School Of Dentistry

Introduction: The endodontic treatment in non-vital teeth is directed to the elimination of the infection through the biofilm removal biomechanics and remnants of necrotic tissue, in order to eliminate infection and generate periapical tissue repair. Objective: To determine the success or failure of endodontic treatment in non-vital teeth performed by dental students under supervision. Materials and methods: In this article 3 clinical cases of patients undergoing endodontic procedures with non-vital pulps track 4 and 6 years are presented. Results: Two of the 3 cases show a process of incomplete periapical tissue regeneration at the time of observation. The third case shows a process of subsequent periodontal disease to endodontics leading to tooth loss. Conclusions: Is necessary to conduct a study with a sample size calculated to determine what percentage of success and failure of endodontic treatment in non-vital teeth, performed by undergraduate dental students under supervision, and to determine those factors that directly influence both outcomes.

scholarly journals Regenerative Immunology: Pushing Biomaterials Beyond Tissue Repair

2020 ◽  
pp. 1-2
Author(s):  
Judite Novais Barbosa ◽  
Judite Novais Barbosa
Keyword(s):  
Immune System ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
Short Review ◽  
Tissue Repair And Regeneration

In this short review, we discuss how the paradigm in the development of new biomaterials has shifted over the last years and the growing idea that the immune system is of key importance in an effective tissue repair and regeneration. The immune system is currently considered crucial for tissue regeneration, leading to the emerging concept of Regenerative Immunology.

Sulfated Polysaccharides from Macroalgae for Bone Tissue Regeneration

2019 ◽  
Vol 25 (11) ◽  
pp. 1200-1209 ◽  
Author(s):  
Jayachandran Venkatesan ◽  
Sukumaran Anil ◽  
Sneha Rao ◽  
Ira Bhatnagar ◽  
Se-Kwon Kim
Keyword(s):  
Bone Tissue ◽  
Bioactive Compounds ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
Biomedical Applications ◽  
Stem Cell Differentiation ◽  
Bone Tissue Regeneration ◽  
Sulfated Polysaccharides ◽  
Tissue Repair And Regeneration ◽  
Pharmaceutical Industries

Background: Utilization of macroalgae has gained much attention in the field of pharmaceuticals, nutraceuticals, food and bioenergy. Macroalgae has been widely consumed in Asian countries as food from ancient days and proved that it has potential bioactive compounds which are responsible for its nutritional properties. Macroalgae consists of a diverse range of bioactive compounds including proteins, lipids, pigments, polysaccharides, etc. Polysaccharides from macroalgae have been utilized in food industries as gelling agents and drug excipients in the pharmaceutical industries owing to their biocompatibility and gel forming properties. Exploration of macroalgae derived sulfated polysaccharides in biomedical applications is increasing recently. Method: In the current review, we have provided information of three different sulfated polysaccharides such as carrageenan, fucoidan and ulvan and their isolation procedure (enzymatic precipitation, microwave assisted method, and enzymatic hydrolysis method), structural details, and their biomedical applications exclusively for bone tissue repair and regeneration. Results: From the scientific results on sulfated polysaccharides from macroalgae, we conclude that sulfated polysaccharides have exceptional properties in terms of hydrogel-forming ability, scaffold formation, and mimicking the extracellular matrix, increasing alkaline phosphatase activity, enhancement of biomineralization ability and stem cell differentiation for bone tissue regeneration. Conclusion: Overall, sulfated polysaccharides from macroalgae may be promising biomaterials in bone tissue repair and regeneration.

scholarly journals Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Aleksandra Klimczak ◽  
Urszula Kozlowska
Keyword(s):  
Progenitor Cells ◽  
Tissue Regeneration ◽  
Stromal Cells ◽  
Tissue Repair ◽  
Current Knowledge ◽  
Local Environment ◽  
Tissue Homeostasis ◽  
Differentiation Potential ◽  
Multiple Cells ◽  
Stromal Stem Cells

Multipotent mesenchymal stromal/stem cells (MSCs) reside in many human organs and comprise heterogeneous population of cells with self-renewal ability. These cells can be isolated from different tissues, and their morphology, immunophenotype, and differentiation potential are dependent on their tissue of origin. Each organ contains specific population of stromal cells which maintain regeneration process of the tissue where they reside, but some of them have much more wide plasticity and differentiate into multiple cells lineage. MSCs isolated from adult human tissues are ideal candidates for tissue regeneration and tissue engineering. However, MSCs do not only contribute to structurally tissue repair but also MSC possess strong immunomodulatory and anti-inflammatory properties and may influence in tissue repair by modulation of local environment. This paper is presenting an overview of the current knowledge of biology of tissue-resident mesenchymal stromal and progenitor cells (originated from bone marrow, liver, skeletal muscle, skin, heart, and lung) associated with tissue regeneration and tissue homeostasis.

Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine – a new paradigm for tissue repair

2018 ◽  
Vol 6 (1) ◽  
pp. 60-78 ◽  
Author(s):  
I. M. Bjørge ◽  
S. Y. Kim ◽  
J. F. Mano ◽  
B. Kalionis ◽  
W. Chrzanowski
Keyword(s):  
Regenerative Medicine ◽  
Extracellular Vesicles ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
New Paradigm ◽  
Ribonucleic Acids ◽  
Biological Signals

Extracellular vesicles are highly specialized messengers that deliver vital biological signals including ribonucleic acids – key modulators in tissue regeneration.

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