scholarly journals ANTIANXIETY EFFECT OF ETHANOLIC EXTRACT OF LEAVES OF TYLOPHORA INDICA IN WISTAR ALBINO RATS

2013 ◽  
Vol 4 (1) ◽  
pp. 127-129 ◽  
Author(s):  
Shyamjith Manikkoth ◽  
R Chandrashekar ◽  
S N Rao
Keyword(s):  
Ethanolic Extract ◽  
Albino Rats ◽  
Tylophora Indica ◽  
Wistar Albino Rats

scholarly journals Pharmacological evidence for the anticonvulsant activity of Tylophora indica in experimental animal models

2017 ◽  
Vol 6 (4) ◽  
pp. 750 ◽  
Author(s):  
Hafis TK ◽  
Shyamjith Manikkoth ◽  
Melinda Sequeira ◽  
Roopa P. Nayak
Keyword(s):  
Hind Limb ◽  
Drug Effects ◽  
Anticonvulsant Drug ◽  
Ethanolic Extract ◽  
Therapeutic Index ◽  
Albino Rats ◽  
Anticonvulsant Effect ◽  
Tylophora Indica ◽  
High Therapeutic Index ◽  
Wistar Albino Rats

Background: Epilepsy is a common neurological disorder. The antiepileptic drugs currently used are unable to manage seizures effectively and are associated with numerous adverse drug effects. Hence, there is a necessity of a newer anticonvulsant drug with high therapeutic index profile. The objective of this pre-clinical research was to investigate the role of Tylophora indica on Maximal electric shock [MES] and Pentylene tetrazole [PTZ] provoked convulsions in Wistar albino rats.Methods: 36 Wistar albino rats were used for this study, after obtaining ethical clearance. The ethanolic extract of the leaves of Tylophora indica [TIEE] (100 mg/kg, p.o) was used to screen the anticonvulsant effect on MES and PTZ provoked convulsions in Wistar albino rats. In MES seizures, inhibition of the tonic hind limb extension and in PTZ seizures, extent of convulsions was noted.Results: TIEE (100 mg/kg, p.o) significantly (p<0.001) blocked the hind limb extension due to MES. The same dose also significantly (p<0.001) lessened the extent of convulsions induced by PTZ.Conclusions: The data suggests that the ethanolic extract of Tylophora indica leaves produce its anticonvulsant effect via different mechanisms since it prevented the hind limb extension induced by MES and decreased the duration of convulsions produced by PTZ.

scholarly journals Protective Effect of Ethanolic Extract ofTabernaemontana divaricata(L.) R. Br. against DEN and Fe NTA Induced Liver Necrosis in Wistar Albino Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Kannappan Poornima ◽  
Palanisamy Chella Perumal ◽  
Velliyur Kanniappan Gopalakrishnan
Keyword(s):  
Ethanolic Extract ◽  
Treated Group ◽  
Hepatic Necrosis ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Protective Effects ◽  
Liver Necrosis ◽  
Standard Drug ◽  
Tabernaemontana Divaricata ◽  
Wistar Albino Rats

This study is an attempt to evaluate the hepatoprotective activity ofTabernaemontana divaricataagainst DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant ofTabernaemontana divaricataat doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated with the carcinogen DEN and Fe NTA. In simultaneously treated animals, the plant extract significantly decreased the levels of uric acid, bilirubin, AST, ALT, and ALP in serum and increased the levels of liver marker enzymes in liver. Treatment with the extracts resulted in a significant increase in the levels of antioxidants accompanied by a marked reduction in the levels of malondialdehyde when compared to DEN and Fe NTA treated group. When compared with 200 mg/kg bw rats, 400 mg/kg bw rats and 5-fluorouracil treated rats showed better results in all the parameters. The histopathological studies confirmed the protective effects of extract against DEN and Fe NTA induced liver necrosis. Thus, it could be concluded that the use ofTabernaemontana divaricataextract in the treatment of carcinogen induced hepatic necrosis.

scholarly journals Ameliorative effect of Cubeba Officinalis dried fruits against Tacrolimus induced nephrotoxicity in Wistar albino rats

2020 ◽  
Vol 11 (1) ◽  
pp. 596-602
Author(s):  
Suman S ◽  
Hayagreeva Dinakar Y ◽  
Suhas reddy P V ◽  
Sai Sudha Yadav B ◽  
Venkateshwar Reddy V
Keyword(s):  
Ethanolic Extract ◽  
Albino Rats ◽  
Local Market ◽  
Sodium Potassium ◽  
Dried Fruits ◽  
Main Adverse Effect ◽  
Ameliorative Effect ◽  
Nephroprotective Activity ◽  
Wistar Albino Rats ◽  
Histopathological Studies

Cubeba Officinalis is traditionally effective in the treatment of various kidney ailments, and the main adverse effect of tacrolimus is nephrotoxicity. There is no documented evidence about the ameliorative potential of Cubeba Officinalis in tacrolimus induced nephrotoxicity. The main endeavor of the study was to determine the nephroprotective activity of ethanolic extract of Cubeba Officinalis dried fruits against tacrolimus induced nephrotoxicity in Wistar albino rats. The Cubeba Officinalis dried fruits were collected from the local market, and Male albino rats weighing 200-250 g were used for the study. The dose of is lower 200mg/kg, higher dose 400 mg/kg of test drug (EECO) was used, and silymarin is used as the standard at the dose of 20 mg/kg. The animals were divided into five groups, six animals each, which is started prior to oral administration of tacrolimus and continued with the fourteen days tacrolimus treatment. After the whole period of study, the rats were sacrificed, and histopathological studies and biochemical estimations were carried out. The BUN values  were decreased from 33.60±3.84 in nephrotoxic rats to 28.27±2.48 (200mg/kg) and 20.70±0.81 (400mg/kg),creatinine levels from 1.645±0.21 to 0.926±0.19 (200mg/kg) and 0.638±0.07(400 mg/kg),uric acid levels from 1.822±0.249 to 1.092±0.306 (200 mg/kg) and 0.806±0.181 (400 mg/kg) sodium, potassium and chloride levels from 1.607± 0.091, 2.548± 0.293 and 259.8±6.42 to 1.302± 0.169 , 1.023±0.174 and 134.7±9.138 (200mg/kg of EECO) and 0.586±0.092 , 0.831±0.174 and 130.2±2.29 (400mg/kg of EECO). The Ethanolic extract of cubeba officinalis was found to be effective in treating the nephrotoxicity in tacrolimus induced nephrotoxicity.

scholarly journals Antibacterial, Antioxidant and Anti-Inflammatory Potential of the Different Extracts of Holoptelia Integrifolia

2019 ◽  
Vol 9 (2) ◽  
pp. 5234-5240
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Inflammatory Activity ◽  
Diffusion Method ◽  
Albino Rats ◽  
Nitric Oxide Radical ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

Medicinal plants are play significant impact in the personal medicine for most of the people all over the world as an alternative live saving medicines and most of their medicinal properties are well known for anticancer activity. The different extracts of Holoptelea integrifolia (H.integrifolia) leaves, stem bark and fruits were studied as a potent natural source of antimicrobial, antioxidant and wound healing potential. This work was carried out to evaluate antimicrobial, antioxidant and anti-inflammatory activity of different extracts of H.integrifolia. The antimicrobial activity of the H.integrifolia ethanolic extract was studied against five fungal and bacterial strains by utilizing the agar well diffusion method and MIC. Among several strain, the ethanolic extract of fruit has shown higher antimicrobial inhibition zone as 9.25-16 mm compare to other two extracts of stem and leaves as 10- 13.25 mm and 6-10.2 mm respectively. The antioxidant activities for different extract were also determined by DPPH free radical assay, Hydroxyl Radical Scavenging and Nitric Oxide Radical Scavenging Activity method. The anti-inflammatory activity also estimated basedon formalin induced paw edema method on Wistar albino rats. The different extracts of leaves, stem bark and fruit parts of Holoptelea integrifolia were estimated for in vivo anti-inflammatory activity against the animal model of female Wistar albino rats. The results of anti-inflammatory activity revealed that the Ethanol extracts showed vital and dose-dependent anti-inflammatory effects. Our findings revealed that aerial parts of H.integrifolia contais potential antimicrobial, antioxidant and anti-inflammatory compounds, which expose the medicinal potential of the selected plant could be a significant drug candidates against microbial, oxidative and inflammation-related pathological processes as a future alternative medicine.

Evaluation of Toxicity and Antidiabetic Activity of Ethanolic Extract of Flowers of Moringa Oleifera Against Dexamethasone Induced Hyperglycemia in Albino WistarRats

2020 ◽  
Vol 2 (29) ◽  
pp. 72-83
Author(s):  
Sourabh Jain Neha Jain
Keyword(s):  
Insulin Resistance ◽  
Oral Administration ◽  
Moringa Oleifera ◽  
Ethanolic Extract ◽  
Serum Glucose ◽  
The Body ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Antidiabetic Effect ◽  
Wistar Albino Rats

Abstract-Diabetes is a defect in the ability of the body to convert glucose (sugar) to energy. Glucose is the main source of energy in our body. When food is digested it is metabolized into fats, proteins, or carbohydrates. Glucose is then transferred to the blood and is used by the cells for energy production. To investigate the antidiabetic effect ethanolic extracts of flowers of Moringa oleifera against dexamethasone induced insulin resistance in wistar albino rats. To study the antidiabetic effect, flowers ofMoringaoleiferawerecollectedandauthenticated, extracted and investigated for acute toxicity and dexamethasone induced hyperglcemia. The animals treated with EEMOF at a dose of 100mg/kg and 200mg/kg prevented the development ofhyperglycemia,hypercholesteremiaandhypertriglyceridemia in dexamethasone induced insulin resistance models. Oral administration of Moringa Oleifera 100mg/kg and 200mg/kg reduces serum glucose, triglyceride, total cholesterols and LDLconcentration and improve the concentration of HDLin dexamethasone administered rats. The lignin Moringa Oleifera showed significant anti-diabetic effect in rats after oral administration. The present study demonstrated that Moringa Oleifera could be useful in Management of diabetes associated with abnormalities in lipid profiles. Further study need to isolate, identify the active compounds and find out thepossiblemechanismofactions.

scholarly journals Pharmacological Investigation of the Wound Healing Activity of Cestrum nocturnum (L.) Ointment in Wistar Albino Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Hemant Kumar Nagar ◽  
Amit Kumar Srivastava ◽  
Rajnish Srivastava ◽  
Madan Lal Kurmi ◽  
Harinarayan Singh Chandel ◽  
...  
Keyword(s):  
Wound Healing ◽  
Ethanolic Extract ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Albino Rats ◽  
Healing Effect ◽  
Wound Model ◽  
Wound Healing Effect ◽  
Wistar Albino Rats

Objectives. The present study was aimed at investigating the wound healing effect of ethanolic extract of Cestrum nocturnum (L.) leaves (EECN) using excision and incision wound model. Methods. Wistar albino rats were divided into five groups each consisting of six animals; group I (left untreated) considered as control, group II (ointment base treated) considered as negative control, group III treated with 5% (w/w) povidone iodine ointment (Intadine USP), which served as standard, group IV treated with EECN 2% (w/w) ointment, and group V treated with EECN 5% (w/w) ointment were considered as test groups. All the treatments were given once daily. The wound healing effect was assessed by percentage wound contraction, epithelialization period, and histoarchitecture studies in excision wound model while breaking strength and hydroxyproline content in the incision wound model. Result. Different concentration of EECN (2% and 5% w/w) ointment promoted the wound healing activity significantly in both the models studied. The high rate of wound contraction (P<0.001), decrease in the period for epithelialization (P<0.01), high skin breaking strength (P<0.001), and elevated hydroxyproline content were observed in animal treated with EECN ointments when compared to the control and negative control group of animals. Histopathological studies of the EECN ointments treated groups also revealed the effectiveness in improved wound healing. Conclusions. Ethanolic extract of Cestrum nocturnum (EECN) leaves possesses a concentration dependent wound healing effect.

scholarly journals Ameliorative effect of Albizzia procera leaves extract against experimentally induced gastric ulcer models in Wistar albino rats

2021 ◽  
Vol 13 (1) ◽  
pp. 308-315
Author(s):  
Vivek Srivastava ◽  
Santosh Kumar Verma ◽  
Neha Mathur ◽  
Kapil Kumar Goel
Keyword(s):  
Gastric Ulcer ◽  
Ethanolic Extract ◽  
Gastric Fluid ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Traditional Medicines ◽  
Pylorus Ligation ◽  
Ameliorative Effect ◽  
Wistar Albino Rats ◽  
Experimentally Induced

Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively.  Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing its pH (p<0.0001). The occupancy of different phytoconstituents in the extract, such as flavonoids and tannins were identified that may be responsible for its gastro-protective activity. All these results provide a basis explaining the antiulcer ability of A. procera being useful in the management of gastric ulcers.

scholarly journals Ethanolic Extract of Syzygium cumini Causes Toxic Effects on Ethanol-induced Liver and Kidney Damage in Albino Wistar Rats: A Biochemical and Histological Study

2022 ◽  
Vol 16 (1) ◽  
pp. 63-72
Author(s):  
Abba Aji Manu ◽  
◽  
Bello Muhammad Musa ◽  
Martha Orendu Oche Attah ◽  
Helga Ishaya Bedan ◽  
...  
Keyword(s):  
Histological Study ◽  
Kidney Tissue ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Syzygium Cumini ◽  
Tissue Samples ◽  
Inflammatory Conditions ◽  
Therapeutic Value ◽  
Liver And Kidney ◽  
Wistar Albino Rats

Background: The therapeutic value of Syzygium cumini (S. cumini) has been documented in traditional medicine for the treatment of many diseases and ailments. Various preparations of this plant have been made and used especially for liver inflammatory conditions in livestock. Further, many liver diseases in humans are inflammatory conditions, which are caused by alcohol intake. This study sought to examine the effect of S. cumini on ethanol-induced hepatotoxicity in Wistar albino rats. Methods: Twenty-five rats were divided into five groups of five rats each. The first group was control and the other four were administered ethanol at varying doses to induce liver and kidney damages. Two doses of the S. cumini extract were administered at a concentration of 200 mg/kg or 400 mg/kg. Silymarin was administered to the last group at 10 mg/kg. The liver and kidney tissue samples were collected and preserved for histological analyses and the rat sera were analyzed for the associated biochemical biomarkers. Results: Histopathological analyses revealed pyknotic nuclei and distortion in the arrangement of the hepatocytes in extract-treated groups. The kidney tissue samples showed signs of interstitial bleeding and aggregation of lymphocytes in the peri-glomerular areas. The analyses of the biochemical parameters revealed that there were significant increases in the aspartate aminotransferase (AST), alanine transaminase (ALT), Urea and creatinine in the sera of the groups treated with the extract compared to those of the controls (P<0.05). Conclusion: The S. cumini extract caused elevation of serum hepatic and renal biomarkers at 400 mg/kg and did not have a hepatoprotective effect.

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