scholarly journals Prevalence of Dermatophytosis in Badaun, Uttar Pradesh, India

2020 ◽  
pp. 71-76
Author(s):  
Pankaj Saxena ◽  
Neeraj Dholia
Keyword(s):  
Fungal Infection ◽  
Fungal Infections ◽  
Uttar Pradesh ◽  
Age Group ◽  
Tropical Countries ◽  
Group 16 ◽  
Diagnostic Centre

Dermatophytoses is a superficial fungal infection of tissues having keratin. The responsible fugus are dermatophytes. The infection is usually designated as ring worm or “tinea”. It is observed worldwide with higher prevalence in tropical countries and areas due to high rates of humidity, moisture and high sweating in summer. Recurrent dermatophytosis is a challenge for dermatologists in India and constituted 9.3% of all patients of dermatophytosis. The present study is conducted to reveal the prevalence of dermatophytosis in patients attended in the Maheshwari Hospital and Diagnostic Centre in Badaun. A survey was done for a period of one and half year. The samlples were obtained from Maheshwari Hospital and Diagnostic Centre, Badaun, Uttar Pradesh. A total of 300 patients were included in the study. Physical observation, KOH test, Microscopy and culture tests were performed for screening and confirmation of various fungal infections. Clinically the prevalence of dermatophytosis was 60% that was observed more in males. Patients with age group 16–30 and 31–40 years were more affected.

scholarly journals Frequency of fungal infections in nasal polypi.

2019 ◽  
Vol 26 (12) ◽  
pp. 2231-2234
Author(s):  
Uzma Aslam ◽  
Nausheen Henna ◽  
Aman-ur- Rehman ◽  
Saniyah Ali ◽  
Shireen Hamid ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Fungal Infections ◽  
Inflammatory Cells ◽  
Cross Sectional Study ◽  
Age Group ◽  
Cross Sectional ◽  
Nasal Polypi ◽  
Margin Of Error ◽  
Study Setting ◽  
Formalin Fixed

Objectives: Determine the frequency of fungal infections in nasal polypi. Study Design: Cross sectional study. Setting: Histopathology Department at Shaikh Zayed Hospital Lahore. Period: Six months from 12/2/2015 to 12/8/2015. Material & Methods: Two hundred surgical resections/biopsies using 95% confidence level, with 7% margin of error were collected. Formalin fixed specimens of patients of both genders and 10- 60 years of age with nasal polyps received after surgical procedure in department of ENT. Grossing and processing was done. Hematoxyin & Eosin stained sections were examined by two consultant Histopathologists independently. The presence of fungal hyphae was confirmed by PAS and Silver stains. The study was approved by College of Physicians & Surgeons Pakistan. All the data was entered and analyzed by using SPSS version 20. Results: Out of 200 patients all the patients showed the prescence of inflammatory cells in polyps (100%) with predominantly eosinophils in their submucosa (82%). Fungus was present in 48 cases (24%) most of them were in the age group of 42-57 years (13%) and 31(15.5%) patients having BMI <30 and 17(8.5%) having BMI >30 were positive for fungus.30 cases were of Aspergillus (62.5%) and rest 8 were of Mucor (37.5%). The fungus positive cases were more in males (13.5%). 160 of the cases were of unilateral polyps (80%) and 40 were of bilateral polypi (20%). Only 8% of the patients having diabetes had fungal infection. Conclusion: Hence, the frequency of fungal infection in nasal polypi is low with Aspergillus being the commonest pathogen affecting males predominantly.

scholarly journals Correlation of diabetes with mycotic infections: a pilot study

2021 ◽  
Vol 8 (4) ◽  
pp. 1671
Author(s):  
Manish Munjal ◽  
Naveen Mittal ◽  
Ekta Bansal ◽  
Shubham Munjal ◽  
Devambika Mehta ◽  
...  
Keyword(s):  
Pilot Study ◽  
Prospective Study ◽  
Fungal Infection ◽  
Paranasal Sinuses ◽  
Fungal Infections ◽  
Fungal Species ◽  
Age Group ◽  
Medical College ◽  
High Incidence ◽  
Mycotic Infections

Background: The immuno-compromised individuals have a high Incidence of fungal infections of the nose and the paranasal sinuses. There is a variation in the fungal species that manifest in different subset of individuals. The species and the susceptible individuals were studied in the Punjab population, to suggest measures to attain a better outcome.Methods: 50 subjects treated for paranasal fungal infection by rhinology division of the oto-rhino-laryngology services, Dayanand Medical College and hospital, Ludhiana, were analysed. The prospective study was carried out in a period of one and a half year (June 2009 to December 2010).Results: Mycotic infections was predominantly noted in the age group  51-60 years  i.e. in 14 patients (28%) followed by 41-50 years, 13 cases (26%). There were 29 (58%) of males and 21 (42%) females with a male:female ratio of 1.4:1. Amongst 50 patients with mycotic infection, 19 (38%) were diabetic. All 15 (100%) patients with zygomycosis had underlying diabetes while only 4 (21%) with aspergillosis were diabetic.Conclusions: Zygomycosis occurs usually in diabetics, while in aspergillosis the underlying morbidity may or may not be diabetes. Timely medical treatment is essential to check diabetes and species identification to select the appropriate antifungal medication. 

Impact Of Modernization Among College Students In Prayagraj District, Uttar Pradesh

2019 ◽  
Vol 5 (4) ◽  
pp. 21-26
Author(s):  
Purvi Nishad ◽  
Anjali Mathur ◽  
Anshu ◽  
Nisha Chacko
Keyword(s):  
College Students ◽  
Uttar Pradesh ◽  
Age Group ◽  
Adolescent Boys ◽  
The Impact

The present study was to assess the impact of modernization among the college students across gender, socio cultural settings and socio economic groups among adolescent boys and girls in the age group of 17 to 21 year.

scholarly journals The Prediction and Prognosis of Fungal Infection in Lung Transplant Recipients—A Retrospective Cohort Study in South Korea

2021 ◽  
Vol 7 (8) ◽  
pp. 639
Author(s):  
Yae-Jee Baek ◽  
Yun-Suk Cho ◽  
Moo-Hyun Kim ◽  
Jong-Hoon Hyun ◽  
Yu-Jin Sohn ◽  
...  
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Fungal Infection ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Lung Transplant ◽  
Fungal Infections ◽  
Transplant Recipients ◽  
Tertiary Center ◽  
Lung Transplant Recipients

(1) Background: Lung transplant recipients (LTRs) are at substantial risk of invasive fungal disease (IFD), although no consensus has been reached on the use of antifungal agents (AFAs) after lung transplantation (LTx). This study aimed to assess the risk factors and prognosis of fungal infection after LTx in a single tertiary center in South Korea. (2) Methods: The study population included all patients who underwent LTx between January 2012 and July 2019 at a tertiary hospital. It was a retrospective cohort study. Culture, bronchoscopy, and laboratory findings were reviewed during episodes of infection. (3) Results: Fungus-positive respiratory samples were predominant in the first 90 days and the overall cumulative incidence of Candida spp. was approximately three times higher than that of Aspergillus spp. In the setting of itraconazole administration for 6 months post-LTx, C. glabrata accounted for 36.5% of all Candida-positive respiratory samples. Underlying connective tissue disease-associated interstitial lung disease, use of AFAs before LTx, a longer length of hospital stay after LTx, and old age were associated with developing a fungal infection after LTx. IFD and fungal infection treatment failure significantly increased overall mortality. Host factors, antifungal drug resistance, and misdiagnosis of non-Aspergillus molds could attribute to the breakthrough fungal infections. (4) Conclusions: Careful bronchoscopy, prompt fungus culture, and appropriate use of antifungal therapies are recommended during the first year after LTx.

scholarly journals Estimated Burden of Fungal Infections in Oman

2020 ◽  
Vol 7 (1) ◽  
pp. 5
Author(s):  
Abdullah M. S. Al-Hatmi ◽  
Mohammed A. Al-Shuhoumi ◽  
David W. Denning
Keyword(s):  
Fungal Infection ◽  
Fungal Infections ◽  
Epidemiological Studies ◽  
Vaginal Candidiasis ◽  
Skin Infections ◽  
Opportunistic Pathogens ◽  
Fungal Rhinosinusitis ◽  
Populations At Risk ◽  
Different Populations ◽  
Underlying Pathology

For many years, fungi have emerged as significant and frequent opportunistic pathogens and nosocomial infections in many different populations at risk. Fungal infections include disease that varies from superficial to disseminated infections which are often fatal. No fungal disease is reportable in Oman. Many cases are admitted with underlying pathology, and fungal infection is often not documented. The burden of fungal infections in Oman is still unknown. Using disease frequencies from heterogeneous and robust data sources, we provide an estimation of the incidence and prevalence of Oman’s fungal diseases. An estimated 79,520 people in Oman are affected by a serious fungal infection each year, 1.7% of the population, not including fungal skin infections, chronic fungal rhinosinusitis or otitis externa. These figures are dominated by vaginal candidiasis, followed by allergic respiratory disease (fungal asthma). An estimated 244 patients develop invasive aspergillosis and at least 230 candidemia annually (5.4 and 5.0 per 100,000). Only culture and microscopy are currently available for diagnosis, so case detection is suboptimal. Uncertainty surrounds these figures that trigger the need for urgent local epidemiological studies with more sensitive diagnostics.

scholarly journals Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections

2021 ◽  
Author(s):  
Alyaa A. Albadr ◽  
Ismaiel A. Tekko ◽  
Lalitkumar K. Vora ◽  
Ahlam A. Ali ◽  
Garry Laverty ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Amphotericin B ◽  
Fungal Infections ◽  
Fungal Growth ◽  
Significant Inhibition ◽  
Corneal Tissue ◽  
Biodegradable Poly ◽  
Invasive Method ◽  
Poorly Soluble ◽  
Microneedle Patch

AbstractChronic fungal infection of the cornea could lead to blindness if not treated properly. Topical amphotericin B (AMP-B) is considered the first treatment of choice for ocular fungal infection. However, factors related to its poor solubility and penetration through intact cornea lead to poor bioavailability. Microneedles (MNs) are emerging as a minimally invasive method to enhance ocular drug delivery. This study aims to investigate the potential use of biodegradable poly(vinylpyrrolidone) (PVP) and hyaluronic acid (HA)–based rapidly dissolving MNs for delivery of AMP-B to treat fungal infection. The data obtained illustrates PVP/HA MN arrays’ reproducibility, good mechanical strength, and faster dissolution with 100% drug recovery. Multiphoton microscopic results revealed that MNs successfully penetrate the corneal tissue and enhance AMP-B permeation through corneal layers. Furthermore, PVP/HA MN arrays showed high solubility. Both PVP and HA successfully decreased AMP-B cytotoxicity when compared to free drug. More interestingly, the biocompatible MN formulations preserved the antifungal activity of AMP-B, as demonstrated by significant inhibition of fungal growth. Therefore, this study shows the feasibility of ocular delivery of the poorly soluble AMP-B using a fast-dissolving MN patch. Graphical abstract

Fungal infection after endothelial keratoplasty: association with hypothermic corneal storage

2018 ◽  
Vol 103 (10) ◽  
pp. 1487-1490 ◽  
Author(s):  
Nicola Lau ◽  
Aida Hajjar Sesé ◽  
Victor A Augustin ◽  
Geert Kuit ◽  
Mark R Wilkins ◽  
...  
Keyword(s):  
Organ Culture ◽  
Fungal Infection ◽  
Fungal Infections ◽  
Case Definition ◽  
Endothelial Keratoplasty ◽  
Donor Tissue ◽  
Purpureocillium Lilacinum ◽  
Eye Banks ◽  
The Usa ◽  
Host Cornea

PurposeTo compare the incidence of fungal infection after endothelial keratoplasty (EK) when donor tissue had been stored in hypothermic medium or organ culture.MethodsWe describe the clinical features of 10 cases of fungal infection (keratitis or endophthalmitis) following EK identified at three European centres. Case definition was the culture of fungus or a positive PCR from the host cornea or anterior chamber after EK. A survey of the incidence of infection after EK was conducted by the European Eye Bank Association. The main outcome measure was the number of cases in which donor tissue had been stored in hypothermic medium compared with organ culture.ResultsThe 10 cases occurred between 2014 and 2017. All donor corneas had been stored in hypothermic medium sourced from three US eye banks. Three pairs of mate corneas caused infections in six recipients. Candida spp were identified from nine cases, with one isolate of Purpureocillium lilacinum. Data on 16 862 corneas supplied for EK were available from 16 European eye banks for the 5-year period from 2012. There were 17 reported cases of infection, of which 15 (88%) were fungal infections and 14 (82%) were Candida spp. Fungal infection was reported from 3 of 14 476 (0.02%) corneas supplied in organ culture compared with 12 of 2386 (0.50%) corneas supplied in hypothermic medium (p<0.0001). The incidence of infection after hypothermic storage was similar for material sourced from Europe (0.52%) or the USA (0.61%).ConclusionsInfection after EK is strongly associated with Candida spp. The possible explanations for the higher incidence of infection when tissue is stored in hypothermic medium are discussed.

scholarly journals Effect of Prophylactic Antifungal Protocols on the Prognosis of Liver Transplantation: A Propensity Score Matching and Multistate Model Approach

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Yi-Chan Chen ◽  
Ting-Shuo Huang ◽  
Yu-Chao Wang ◽  
Chih-Hsien Cheng ◽  
Chen-Fang Lee ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Propensity Score ◽  
Fungal Infection ◽  
Propensity Score Matching ◽  
Fungal Infections ◽  
Transition Probability ◽  
Antifungal Prophylaxis ◽  
Chang Gung Memorial Hospital ◽  
Multistate Model ◽  
End Stage

Background. Whether routine antifungal prophylaxis decreases posttransplantation fungal infections in patients receiving orthotopic liver transplantation (OLT) remains unclear. This study aimed to determine the effectiveness of antifungal prophylaxis for patients receiving OLT.Patients and Methods. This is a retrospective analysis of a database at Chang Gung Memorial Hospital. We have been administering routine antibiotic and prophylactic antifungal regimens to recipients with high model for end-stage liver disease scores (>20) since 2009. After propensity score matching, 402 patients were enrolled. We conducted a multistate model to analyze the cumulative hazards, probability of fungal infections, and risk factors.Results. The cumulative hazards and transition probability of “transplantation to fungal infection” were lower in the prophylaxis group. The incidence rate of fungal infection after OLT decreased from 18.9% to 11.4% (p=0.052); overall mortality improved from 40.8% to 23.4% (p<0.001). In the “transplantation to fungal infection” transition, prophylaxis was significantly associated with reduced hazards for fungal infection (hazard ratio: 0.57, 95% confidence interval: 0.34–0.96,p=0.033). Massive ascites, cadaver transplantation, and older age were significantly associated with higher risks for mortality.Conclusion. Prophylactic antifungal regimens in high-risk recipients might decrease the incidence of posttransplant fungal infections.

scholarly journals Histopathological Pattern of Fungal Infections Seen in Usmanu Danfodiyo University Teaching Hospital Sokoto from 2014 To 2018

2020 ◽  
pp. 30-37
Author(s):  
M. O. Mohammed ◽  
M. Sirajo ◽  
O. O. Okechi ◽  
A. T. Muhammad ◽  
R. I. Tsamiya ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Fungal Infection ◽  
Teaching Hospital ◽  
Fungal Infections ◽  
University Teaching ◽  
Report Cards ◽  
Referral Centre ◽  
Subcutaneous Mycosis ◽  
Common Manifestation ◽  
Ethical Clearance

Introduction: Fungal infection is a common manifestation in this part of the country and worldwide. It is essential to define the epidemiology of fungal infection in a particular environment. Aim: This study aims to analyze the diagnosis of fungal infection carried out in patients attending the histopathology department (UDUTH) Sokoto from 2014 to 2018. Method: This study is a retrospective study of all fungal infection biopsies carried out from 2014 – 2019 in Usmanu Danfodiyo University Teaching Hospital, Sokoto, northwestern Nigeria, a referral centre for the neighbouring northern states Kebbi and Zamfara. Ethical clearance was obtained from the ethical committee of UDUTH, data was collected from histological report cards and analyze manually. Some tissue blocks of the case were retrieved to confirm the diagnosis. A total of 66 requests for fungal diagnosis were received from January 2014 to December 2018, which represent about 0.7% of the total biopsies received over the study period. Result: Out of the 66 of request for fungal diagnosis 32(48.5%) were fungal positive. Subcutaneous mycosis was the most frequent fungal infection with a frequency of 18(56.25%). Males were more frequently affected than females with the frequencies of 18(56.25%) and 14 (43.75%) respectively.

scholarly journals Epidemiological characterization of dermatophytes at a tertiary care hospital in Eastern Uttar Pradesh, India

2019 ◽  
Author(s):  
Ankur Kumar ◽  
Vandana Upadhyay ◽  
Amresh K. Singh ◽  
Jayesh Pandey
Keyword(s):  
Low Socioeconomic Status ◽  
Fungal Infections ◽  
Tertiary Care ◽  
Uttar Pradesh ◽  
Common Species ◽  
Personal Hygiene ◽  
Clinical Samples ◽  
Care Hospital ◽  
Direct Microscopic Examination ◽  
Superficial Mycosis

Background and Purpose: Superficial mycosis is more prevalent in tropical and subtropical countries, such as India. Regarding this, the present study was conducted to determine the epidemiology of superficial mycosis and identify the most common dermatophytic species in this region. Materials and Methods: For the purpose of the study, a total of 220 skin scraping, nail, and hair root specimens were collected. Direct microscopic examination was performed using potassium hydroxide mount. Additionally, the samples were inoculated onto Sabouraud dextrose agar (SDA) and dermatophyte test medium (DTM). The fungal colony of each isolates was stained with lactophenol cotton blue mount, and observed under microscope for species identification. Results: Out of 220 isolates, 172 samples, obtained from 108 males 64 females, were positive for skin fungal infections by either KOH mount or culture. Furthermore, 113 isolates were identified as dermatophytes, while 59 samples were found to be non-dermatophytes. Among the dermatophytes isolated from different clinical samples, Trichophyton verrucosum (42/113, 38%) was the most common species, and Tinea corporis was the most common infection (36.2%). Conclusion: As the findings indicated, dermatophytes had an isolation rate of 78%, which is higher than normal. This can be due to the fact that the majority of the patients were from a rural background (71.7%) with a low socioeconomic status and poor personal hygiene who were exposed to climatic changes.

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