Overnight fasting affects avoidance learning and relief

Prolonged fasting influences threat and reward processing, two fundamental systems underpinning adaptive behaviors. In animals, overnight fasting sensitizes the mesolimbic-dopaminergic activity governing avoidance, reward, and fear-extinction learning. Despite evidence that overnight fasting may also affect reward and fear learning in humans, effects on human avoidance learning have not been studied yet. Here, we examined the effects of 16h-overnight fasting on instrumental avoidance and relief from threat omission. To this end, 50 healthy women were randomly assigned to a fasting (N=25) or a re-feeding group (N=25) and performed an Avoidance-Relief Task. We found that fasting decreases unnecessary avoidance during signaled safety; this effect was mediated via a reduction in relief pleasantness during signaled absence of threat. A fasting-induced reduction in relief was also found during fear extinction learning. We conclude that fasting optimizes avoidance and safety learning. Future studies should test whether these effects also hold for anxious individuals.

3D Brownian Motion Thin Film Fluid spraying nanoparticles impact of Convective Heat Phenomena over Stretchable Rotating Surface: Numerical Computation

The purpose of this research is to examine thin-film nanomaterial movement in three dimensions over a stretchable rotating inclined surface. Similarity variables are used to transform fundamental systems of equations into a set of First-order Differential Equations. The Runge-Kutta Fourth Order approach is utilized for numerical purpose solution. Variable thickness., Unsteadiness parameter., Prandtl number., Schmidt number., Brownian-motion parameter., and Thermophoretic parameter have all been seen to have an impact. Physically and statistically, the indispensable terms namely Nusselt as well as Sherwood numbers are also investigated. As the dimensionless factor \(S\) grows, the temperature field decreases. The momentum boundary layer is cooled when the parameter \(S\) is improved, and the opposite effect is observed for Nusselt number. A greater Schmidt number Sc reduces the Sherwood number by increasing the kinematic viscosity as well as Concentration of the chemical species. Further, the RK4 method is also validated with the HAM approach. Furthermore, we verified the acquired results by establishing a comparison with previous literature, and we discovered an outstanding match, confirming the accuracy of the current communication.

Effect of Different Preservation Time of Chilled Semen on the Fertility of Field Indigenous Ewes

Background: Artificial insemination (AI), among all the fundamental systems of animal breeding, has proved to be the best and efficient method for the rapid improvement of livestock for maximum use of superior genetic merit of males on numerous dams. The frozen AI in sheep is, to date, not fulfilling the farmer’s need. Therefore, the present study aimed to determine the pregnancy rate in indigenous ewes with chilled semen preserved at different hours. Methods: Semen was collected from three indigenous rams using an artificial vagina and evaluated for its quality both in the fresh and chilled stage at 12 h, 24 h and 48 h before insemination. Trans-cervical insemination was performed in PGF2α synchronized ewes. Pregnancy was confirmed by ultrasonography at 50-60 days of gestation. Result: The motility, viability and normal sperm values of chilled semen decreased significantly (p less than 0.01) with increasing the duration of preservation. However, the quality of chilled semen was acceptable level for insemination. The pregnancy rate was significantly varied (p less than 0.01) and the higher pregnancy rate (64.28%) was achieved when AI was performed using semen stored at 4oC for 12 h than 24 h (58.33%) and 48 h (50%), respectively. Therefore, increased the duration of preservation time of different chilling process negatively affect the semen quality and the pregnancy rates.

A Vision for Resilient Urban Futures

A fundamental systems approach is essential to advancing our understanding of how to address critical challenges caused by the intersection of urbanization and climate change. The social–ecological–technological systems (SETS) conceptual framework brings forward a systems perspective that considers the reality of cities as complex systems and provides a baseline for developing a science of, and practice for, cities. Given the urgency of issues we collectively face to improve livability, justice, sustainability, and resilience in cities, bringing a systems approach to resilience planning and policymaking is critical, as is development of positive visions and scenarios that can provide more realistic and systemic solutions. We provide a vision for more resilient urban futures that learns from coproduced scenario development work in nine US and Latin American cities in the URExSRN. We find that developing an urban systems science that can provide actionable knowledge for decision-making is an emerging, and much needed, transdisciplinary research agenda. It will require true boundary-crossing to bring the knowledge, skills, tools, and ideas together in ways that can help achieve the normative goals and visions we have for our shared urban future.

A review of COVID-19: A summary of the epidemic in Wuhan and other local areas in China

COVID-19 is a new kind of coronavirus that was found in 2019 and it has swept the world until now. Reviewing it and discovering the problem is what we must do. In this scenario, the influence of COVID-19 on the world, and especially in China since it is the country where COVID-19 first outbreak, has been thoroughly reviewed. The main point of this paper is to identify the epidemiological information of COVID-19 and to review typical cities that are most influenced by COVID-19, such as Wuhan, Dalian, and Shijiazhuang. Moreover, discovering and comparing the characteristics and regulations according to different periods have also been carefully performed. With the understanding of the infection of COVID-19, the bright future in which prevention and control measures of nosocomial infection are improved is surely within reach. Furthermore, the psychological construction and management in fundamental systems require more attention.

Flow Cytometry: From Experimental Design to Its Application in the Diagnosis and Monitoring of Respiratory Diseases

Recent advances in the field of flow cytometry (FCM) have highlighted the importance of incorporating it as a basic analysis tool in laboratories. FCM not only allows the identification of cell subpopulations by detecting the expression of molecules in the cell membrane or cytoplasm, but it can also quantify and identify soluble molecules. The proper functioning of the FCM requires six fundamental systems, from those related to the transport of events to the systems dedicated to the analysis of information. In this review, we have identified the main considerations that every FCM user must know for an optimal antibody panel design, the quality systems that must govern the FCM protocols to guarantee reproducible results in research or clinical laboratories. Finally, we have introduced the current evidence that highlights the relevance of FCM in the investigation and clinical diagnosis of respiratory diseases, establishing important advances in the basic and clinical study of diseases as old as Tuberculosis along with the recent proposals for the monitoring and classification of patients infected with the new SARS-CoV2 virus.

Evaluation Criteria for Evaluating Transformation: Implications for the Coronavirus Pandemic and the Global Climate Emergency

Fundamental systems transformations are needed to address the global emergency brought on by climate change and related global trends, including the COVID-19 pandemic, which, together, pose existential threats to the future of humanity. Transformation has become the clarion call on the global stage. Evaluating transformation requires criteria. The revised Organization for Economic Cooperation and Development/Development Assistance Committee criteria are adequate for business as usual summative and accountability evaluations but are inadequate for addressing major systems transformations. Six criteria for evaluating transformations are offered, discussed, and illustrated by applying them to the pandemic and the Global Alliance for the Future of Food. The suggested criteria illustrate possibilities. The criteria for judging any intervention should be developed in the context of and aligned with the purpose of a specific evaluation and information needs of primary intended users. This article concludes that the greatest danger for evaluators in times of turbulence is not the turbulence—it is to act with yesterday’s criteria.

Experimental Discovery of the Particle Properties of Gravity and Gravitons by Theoretical Investigation of the Bent Point of Space Time

As, it is known having more challenged on the wave or particle nature of light, from the theory of Newton to proof of its being wave by Huygens and also Young’s Double-slit experiment, more important ,Maxwell equations, all showed the nature of being wave of the light till Heinrich Hertz discovered photoelectric phenomenon and after that Einstein talked about the mathematic and quantum characteristics of this phenomenon, his explanations about this phenomenon showed failure of the characteristic of being wave of light in photoelectric explanation so double wave- particle characteristic failed in the scientific society. We all know that many of mass and energy fundamental systems have the same double characteristic of the light. The Photoelectric is the action of light and matter interactions that can prove the double light- particle nature because of inability of being wave principals of the light. Another one of the nature fundamental forces which many believed on its double wave- particle nature is gravity. In this essay we try to interpret the inability of wave nature of gravity in explanation of dark matter and we will see how the concept of invisible masses of the matter is the only action of the graviton interaction and proof of existence of constituent packs of gravity energy i.e. gravitons. Discovering this innovation is wonderful.

Complex Formation Between Zinc(II) and Alkyl-N-iminodiacetic Acids in Aqueous Solution and Solid State

Removal of metal compounds from wastewater using processes where metals can be removed and valuable chemicals recycled is of significant industrial importance. Chelating surfactants are an interesting group of chemicals to be used in such applications. Carboxylated polyamines are a promising group to be used in such processes. To apply carboxylated polyamines as chelating surfactants, detailed knowledge of the solution chemistry, including complex formation, kinetics and structures of pure fundamental systems, is required. In this study zinc(II) alkyl-N-iminodiacetate systems with varying length of the alkyl chain have been studied. Acidic and stability constants have been studied by potentiometry, and the structures of both solids and aqueous solutions have been determined by EXAFS. Zinc(II) forms two strong complexes with alkyl-N-iminodiacetates in aqueous solution. In an attempt to determine the acidic constants of these complexes, the deprotonation of the nitrogen atom in the complex bound ligands, it was observed that this reaction is very slow and no accurate values could be obtained. The bis(alkyl-N-iminodiacetato)zincate(II) complexes take, however, up two protons in the pH region 3–7, which means that this complex is approximately singly protonated in the pH region 3–7 and doubly protonated at pH < 3. The bis(n-hexyl-N-iminodiacetato)zincate(II) complex at pH = 13 has a distorted octahedral configuration with four short strong Zn–O bonds at 2.08(1) Å, while the Zn–N bonds are weaker at much longer distance, 2.28(2) Å. Similar configurations are also found in most reported structures of zinc(II) complexes with carboxylated amines/polyamines. The singly protonated complex seems to be five-coordinate, with four Zn–O bond distances at ca. 2.03 Å, and a single Zn–N bond distance in the range 2.15–2.25 Å. The relationship between the structure of the protonated bis(n-hexyl-N-iminodiacetato)zincate(II) complex and the slow kinetics in the region pH = 3–7 are discussed.

The impact of climate change on water and energy security

The interdependent fundamental systems, water and energy, face abundant challenges, one of which is climate change, which is expected to aggravate water and energy securities. The hydropower industry's benefits have led to its development and growth around the world. Nonetheless, climate change is expected to disturb the future performance of hydropower plants. This study looks at the Seimareh Hydropower Plant to assess the potential vulnerability of hydropower plants to climate change. Results indicate that climate change will affect the area's hydrological variables and suggest an increase in temperatures and decrease in precipitation during a 30-year future period (2040–2069). It is predicted that Seimareh Dam's inflow will decrease by between 5.2% and 13.4% in the same period. These hydrological changes will affect the Seimareh plant's performance: current predictions are that the total energy produced will decrease by between 8.4% and 16.3%. This research indicates the necessity of considering climate change impacts in designing and maintaining hydraulic structures to reach their optimal performance.