Hydroxychloroquine: does prophylaxis work?

Background: Healthcare workers are front line workers in management of SARS-CoV-2 pandemic. The higher risk of acquiring the infection due to increased contact and exposures has prompted multiple risk mitigation strategies. To assess the role of hydroxychloroquine pre-exposure prophylaxis in prevention of SARS-CoV-2 infection amongst HCWs.Methods: This retrospective cohort study assessed the effect of HCQS prophylaxis amongst HCWs in a tertiary care hospital in the north-eastern part of India. All HCWs, involved in management of SARS-CoV-2 were enrolled. The subjects were retrospectively divided in two groups on HCQ prophylaxis. Group I (51.8%, n=116) taking HCQ prophylaxis and group II (48.2%, n=108) not taking the prophylaxis. The demographic characteristics, use of PPE, HCQ prophylaxis and side effect profile were noted. Results: Of the whole cohort, 22.8% (n=51) subjects tested positive. In group I (n=116), 24 subjects (20.7%) tested positive, whereas in Group II (n=108), 27 subjects (25.0%) tested positive. Further analysis of the incidence of SARS-CoV-2 infection amongst the two groups demonstrated that the although the rate of infection was lower (20.7% vs 25%) in Group I as compared to group II [X2 (1, N=224)=0.371, p=0.5] but it was statistically insignificant.Conclusions: Our study involving HCWs, does not show a statistically significant reduction in the incidence of infection with pre-exposure prophylaxis. Based on our findings and published literature, a prophylaxis of HCQS against the SARS-CoV-2 infection cannot be recommended.

COVID-19 AGENT-BASED MODEL: AN EPIDEMIOLOGICAL SIMULATOR APPLIED IN VACCINATION SCENARIOS FOR QUEZON CITY, PHILIPPINES

COVID-19 vaccines are rolling out in the Philippines but the supply remains limited; there is a need to optimize the distribution. In this study, we developed a COVID-19 agent-based model for Quezon City, a COVID-19 hotspot in the country. This model, in conjunction with a multi-objective linear programming model for equitable vaccine distribution, was then used to simulate four vaccination scenarios. Experiments were conducted with the front-line workers always added to the groups: mobile workers, elderly and low-income. Main results are: prioritizing the mobile workers minimizes infections the most (by 4.34%), while prioritizing the low-income groups minimizes deaths the most (by 1.93%). These results demonstrate that protecting the population with the most interactions (mobile workers) effectively reduces future infections. On the other hand, protecting the most vulnerable population (low income and elderly) decreases the likelihood of death. These results may guide the policy-makers in Quezon City.

Survival Analysis of Symptomatic COVID-19 in Phuentsholing Municipality, Bhutan

COVID-19 is a disease that is caused by a highly transmissible and pathogenic novel coronavirus: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). All of the COVID-19 positive cases in Bhutanese travellers returning via the Phuentsholing point of entry, the local population, and Indian nationals were isolated in the Phuentsholing COVID-19 isolation ward, Bhutan. This study aimed to identify the risk factors for developing symptoms among COVID-19 positive patients in this ward. A retrospective cohort study was conducted using the data regarding COVID-19 positive cases in the Phuentsholing COVID-19 isolation ward from 28 May 2020 to 31 May 2021. The Cox proportional hazards regression model was used to identify the risk factors of developing COVID-19 symptoms. There were 521 patients in the study; 368 (70.6%) were males and 153 (29.4%) were females. The mean age was 32 years (with a range of 1–78 years), and 290 (56.0%) reported at least one symptom. The median length of isolation was eight days (with a range of 3–48 days). The common symptoms were: cough (162, 31.0%), fever (135, 26.0%), and headache (101, 19.0%). In the multivariable Cox regression, vaccinated patients were 77.0% (p = 0.047) less likely to develop symptoms compared to those who were not vaccinated. The front line workers and the mini-dry port (MDP) workers were 15 (p = 0.031) and 41 (p < 0.001) times more likely to be symptomatic compared to returning travellers. The young and economically active population group was most commonly affected by COVID-19. The presence of risk factors, such as being front line workers, MDP workers, or not being vaccinated against COVID-19, meant that patients had a higher probability of developing symptoms of COVID-19.

Scalable, effective, and rapid decontamination of SARS-CoV-2 contaminated N95 respirators using germicidal ultraviolet C (UVC) irradiation device

Particulate respirators such as N95s are an essential component of personal protective equipment (PPE) for front-line workers. This study describes a rapid and effective UVC irradiation system that would facilitate the safe re-use of N95 respirators and provides supporting information for deploying UVC for decontamination of SARS-CoV-2 during the COVID-19 pandemic. To assess the inactivation potential of the proposed UVC germicidal device as a function of time by using 3 M 8211-N95 particulate respirators inoculated with SARS-CoV-2. A germicidal UVC device to deliver tailored UVC dose was developed and test coupons (2.5 cm2) of the 3 M-N95 respirator were inoculated with 106 plaque-forming units (PFU) of SARS-CoV-2 and were UV irradiated. Different exposure times were tested (0–164 s) by fixing the distance between the lamp and the test coupon to 15.2 cm while providing an exposure of at least 5.43 mWcm−2. Primary measure of outcome was titration of infectious virus recovered from virus-inoculated respirator test coupons after UVC exposure. Other measures included the method validation of the irradiation protocol, using lentiviruses (biosafety level-2 agent) and establishment of the germicidal UVC exposure protocol. An average of 4.38 × 103 PFU ml−1 (SD 772.68) was recovered from untreated test coupons while 4.44 × 102 PFU ml−1 (SD 203.67), 4.00 × 102 PFU ml−1 (SD 115.47), 1.56 × 102 PFU ml−1 (SD 76.98) and 4.44 × 101 PFU ml−1 (SD 76.98) was recovered in exposures 2, 6, 18 and 54 s per side respectively. The germicidal device output and positioning was monitored and a minimum output of 5.43 mW cm−2 was maintained. Infectious SARS-CoV-2 was not detected by plaque assays (minimal level of detection is 67 PFU ml−1) on N95 respirator test coupons when irradiated for 120 s per side or longer suggesting 3.5 log reduction in 240 s of irradiation, 1.3 J cm−2. A scalable germicidal UVC device to deliver tailored UVC dose for rapid decontamination of SARS-CoV-2 was developed. UVC germicidal irradiation of N95 test coupons inoculated with SARS-CoV-2 for 120 s per side resulted in 3.5 log reduction of virus. These data support the reuse of N95 particle-filtrate apparatus upon irradiation with UVC and supports use of UVC-based decontamination of SARS-CoV-2 during the COVID-19 pandemic.

Evaluation of facemask associated acne/ “Maskne” among health care workers and non-health care workers of India during COVID-19 pandemic-A cross-sectional study

“MASK-NE”-Mask associated Acne, is a common form of acne during COVID-19 pandemic. It is type of acne mechanica seen when external factor occludes the skin, leads to irritation, inflammation and starts/aggravates all grades of acne.We conducted a cross-sectional study among 773 participants, using a Self-administered, aim oriented, questionnaire which includes demographic data, acne related history, type and duration of wearing mask & other mask related skin problems in COVID-19 pandemic during 15 October to 15December,2020.: Among 773 participants, age ranged 18-45 years with mean 30.69 (SD: 61.30) and M:F was 1:1.78. After starting of Pandemic, occurrence of new development of mask associated Acne/ Maskne was higher among Health Care Workers (HCW) (34.98%) as compared to non- Health Care Workers (non-HCWs) (17.36%). Moreover, more number of HCWs had aggravation of their pre-existing acne and/or development of new of acne during pandemic (81.2%) than non-HCWs (61%). Wearing N95 type of mask showed the highest aggravation (82%) of Maskne as compare to wearing Surgical mask (75.5%) and wearing cloth (cotton) mask (65.6%).Wearing a face mask for 4 to 8 hours/day and &#62;8 hours/day showed increase in the aggravation of Maskne as compared to wearing a facemask &#60;4 hrs/day.Though wearing face masks can be the best strategy against COVID-19 infection, HAZARD OF THIS SAFETY is not negligible especially in front-line workers-doctors, nurses, pharmacist, policemen, hospital staff who are at higher risk due to several factors including type of mask use, duration of mask use etc.

Older adults’ philanthropic crafting of face masks during COVID-19

During the early months of the COVID-19 pandemic, people of all ages began sewing fabric face masks. Organized through separate grassroots movements, oftentimes using social media platforms, people pooled their resources to make masks for front line workers and others in desperate need. While some people sold these face masks, many participated in philanthropic crafting, donating them to hospitals and other health care centres. Older adults were identified early on as being particularly vulnerable to the effects of the virus, and so their response to mitigate the impacts of the pandemic through crafting was salient. This study investigated the experience of philanthropic hand crafting by older adults who were living through the COVID-19 pandemic. Twenty-seven older adults of age 60–87 who sewed masks for others were interviewed. A comprehensive data analysis of these interviews yielded 39 descriptive codes that were collapsed into eight themes: emotions, engagement, meaning, relationships, accomplishment, intellect, moral values and agency. One finding was that there were psychological, relational and existential benefits for the crafters. Making masks allowed participants to help other people, and it gave the participants a feeling of value, worthiness and purpose. Additionally, participants felt more in control in a chaotic world as they made masks to protect themselves, their loved ones, as well as strangers. The philanthropic crafting enhanced older adults’ well-being in many ways, and lessons learned from this study could be extended into ‘normal times’. For example, more older adults would be able to participate in craft-based philanthropy if they had access to the tools and materials. They would be more motivated if they received thank you notes and pictures of the recipients using their handmade gifts, and if they could express their creativity more. Finally, creating a physical or virtual community for older adults around craft philanthropy would help older adults feel more connected to and supported by their peers, and the community at large.

Effect of lockdown due to COVID-19 pandemic on lipid profile of Indian male population

<p class="abstract"><strong>Background:</strong> SARS-COV-2 pandemic is one of the biggest health challenges for modern era and this type of pandemic was never witnessed in recent past. To control the pandemic various measures were taken by various authorities like lockdown and shutdown. This study was meant to find the effect of this new way of social isolation during lockdown on Indian male population.</p><p class="abstract"><strong>Methods:</strong> The study was conducted in IMS and SUM hospital, Bhubaneswar, Odisha. Those having routine blood check-up before lockdown in the hospital were again re-evaluated for their lipid profile after lockdown. Only male between age group of 20 to 59 included in the study who were mostly confined to home during lockdown. Female, front line workers and people already having deranged lipid profile were excluded from the study.</p><p class="abstract"><strong>Results:</strong> It was found that there are significant variations in the triglyceride and cholesterol level in men before and after lockdown whereas the level of HDL did not show any significant variation.</p><p class="abstract"><strong>Conclusions:</strong> From above study it may be concluded that though lockdown is somehow able to control the rapid spread of the virus but it has negative effect on the lipid profile and indirectly cardiovascular health of a man.</p>

How Do Police Officers Perceive the Challenges Posed by Covid-19: A Qualitative Case Study from Jammu Region in India

Police is an agency characterized by multi-functionality, to handle civic problems and to fight crime like robbery, murder, etc. As they are among the first ones to respond to an emergency, they have been classified as public safety personnel (PSP) such as medical officials and firefighters. The police personnel struggle hard to handle issues related to law enforcement functions, which consumes the bulk of their time. This paper discusses the main challenges faced by J & K Police officials (In incharge Police posts, Station House Officers and newly recruited Sub-Inspectors) posted in the Jammu region, during COVID-19. Such a study was needed due to the unanticipated situation created by COVID-19 and the unprecedented scale to which it affected people in general and front-line workers in particular. A qualitative approach has been used to present findings. Results show that during COVID-19, J & K police personnel have pursued their day-to-day activities quite zealously. Even if they do not have a day off and cannot celebrate festivals like other people, they are contented with whatever they have been able to do for society at large. Their families are supportive and do understand the toughness of their job, though at times, their preoccupation with a 24 × 7 job puts their personal relations at stake. They have efficient coping strategies. Despite experiencing physical and mental fatigue, they consider serving the nation as their prime duty. Health issues are common, but ignored by them. However, handling the public and keeping them indoors has been the biggest challenge faced by them. Many of them have reported the arrogance of the public, including the educated people, when asked for maintaining social distance and the reasons for coming out. This experience, coupled with extra efforts to be made by them in a crisis situation disheartens them.