Василіянське чернецтво перемишльської єпархії: просопографічні характеристики (1739–1783 роки)

W artykule autor zaprezentował wyniki badań prozopograficznych nad bazylianami z eparchii przemyskiej z klasztorów działających w latach 1739–1783. Omówione zostały pochodzenie, wykształcenie świeckie, wiek, etapy formacji duchowej i intelektualnej, mobilność, obowiązki monastyczne i kościelne członków badanej grupy. Do artykułu dołączono materiał statystyczno-pomocniczy Basilians of the Przemyśl Eparchy in 1739–1783. A Prosopographic Description The article stresses the importance of prosopographic studies on the characteristics of the monasticism of the Basilians (Basilian Fathers) of the Przemyśl eparchy (the origin, secular education, age, stages of spiritual and intellectual formation, mobility, monastic and church duties). The paper defines the source base of the studies (catalogues of monasteries and monks, the manuscript catalog of the biographies of Basilian monasticism). The text presents a survey of the achievements of Ukrainian and Polish church historiography with regards to the issues of prosopographic studies, and investigates the dynamics of the Basilian monasteries and their inhabitants in the context of the entry of the ascetic communities in the Przemyśl diocese into the monastic Province of the Holy Protection of the Mother of God›s Order of St. Basil the Great. The author traces the process of reorganization of monastic centers in the Przemyśl diocese in the second half of the 18th century and specifies the consequences of the closedown of small monasteries. Attention is drawn to the numerical and qualitative composition of the monastic Przemyśl Province as of 1783. The paper defines the prospective direction of further research: to find and edit the catalogues of the manuscripts of monasticism. Appended to the article is the statistical and auxiliary material: Appendix I. Dynamics of the number of Basilian monasteries and numerical strength of monasticism in the Przemyśl diocese (1739–1783); Appendix II. A Report on the personal composition of the Basilian monasteries in the Chełm diocese, which became part of the monastic Przemyśl Province on 23 July 1783; Appendix III. A Comparative table of the number of monks as of 12 June 1783.

Graphene Oxide Accelerate Diabetic Wound Repair by Inhibiting Apoptosis of Ad-MSCs via Linc00324/miR-7977/STK4 Pathway

BackgroundGraphene oxide (GO) has been proven in many studies to promote the proliferation and differentiation of a variety of stem cells, but its effect on the apoptosis of adipose-derived mesenchymal stem cells (Ad-MSCs) is still unclear. Apoptosis is one of the most important factors in the treatment of diabetic wounds by stem cells. Therefore, we explored its therapeutic effect on diabetic wounds by studying the effect of GO on the apoptosis of Ad-MSCs.MethodsqRT-PCR was used to detect the expression of lncRNAs, miRNAs and mRNAs in Ad-MSCs. RNA immunoprecipitation (RIP), RNA pull-down and luciferase assays were used to detect the interaction of the specific lncRNA, miRNA and mRNA. The effects of Linc00324 on Ad-MSCs cells apoptosis were explored by flow cytometer, TUNEL assay and Western blot. Diabetic wound was established to explore the function of Linc00324 on Ad-MSCs repairing ability in vivo.ResultsGO inhibited the apoptosis of Ad-MSCs caused by high glucose, and Linc00324 was one of the factors contributing to its effect. In terms of mechanism, RIP and RNA-Pull-down confirmed Linc00324 could directly interact with miR-7977, and then acted as a miRNA sponge to regulate the expression of miR-7977 target gene STK4 (MST1) and downstream signaling pathways. In addition, GO reduced the apoptosis of Ad-MSCs in wounds and promoted wound healing. ConclusionsOverall, this study highlights that GO maybe a superior auxiliary material for Ad-MSCs to repair diabetic wounds via Linc00324/miR-7977/STK4 pathway.

MATERIAL SCHEDULING TO PROVIDE MANUFACTURING IN MACHINE INDUSTRY

The article describes an approach to the material scheduling to provide manufacturing by machinery designers. The approach is based on the statistics of material consumption over the last periods and on manufacturing sequence. The article considers information technology alternatives of production reserve planning. The authors propose the model of material support based on a time series analysis. They describe a study scheme and a database structure for calculating by the model developed. The algorithm steps of data analysis, modeling of time series and resulted VS test values comparison are described in details. The article defines an experimental calculation to test the model validity and diagrams to compare the time series of the main and auxiliary material sample pieces. The programmed calculations are given as an additional module for interactive web resource and are implemented through T-SQL.

Remizov's myth in the structure of Yaroslavl text

The purpose of the article is to consider an important scientific historical and literary issue: the place of A. M. Remizov, an outstanding representative of Russian neorealism, in the structure of the so-called Yaroslavl text. For the first time Remizov's auteur myth is inscribed into the structure of a local text, to which type the Yaroslavl text belongs. This literary phenomenon is presented in the context of studying the author's individuality along the lines common to Russian prose: the enrichment of content, the search for new narrative and artistic forms. The following objectives of the work were also dealt with in the context of contemporary studies of the first half of the XX century Russian literature: to clarify the definitions of the Yaroslavl text and the Remizov myth; to determine the biographical, narrative, historical and literary contours of the latter; to identify and establish the place of archetypes and motives in this myth; and, finally, to incorporate myth into the conceptual space of the Yaroslavl text. The most significant results of the work are the following: the historical-literary and personal-biographical components of the Remizov myth are described; the role of folklore, literary motives and archetypes in the system of motives and images of Remizov's prose is established; the latter are shown in the context of his creative evolution. Remizov's auteur myth is integrated into the historical and literary space of the Yaroslavl text. Some observations are made on the philosophy, aesthetics, and poetics of Remizov's prose and the expressiveness of his writings. Diaries and documents are taken into account as a full-fledged link in the writer's legacy; the attitude to them as secondary, auxiliary material has been overcome. The approaches used in the work led to an original view of the writer’s skills and allowed to break the existing opinions about Remizov's type of artistic thinking. The article evaluates the artistic merits of some of the well-known works in a new way, clarifies the writer's position, shows its connection with mythology and folklore, with the functions of the components of external and internal forms. Remizov's skill is analyzed in the context of neo-mythologism and word-making relevant to the Russian prose of the XX century. Thus, scientific understanding of the complex phenomena in Russian literature of the first third of the XX century have been enriched.

Gender related topics in the European parliament election campaigns of the Italian populist parties in 2019: ideas reflection in the media and social network

The author studies how gender related topics are presented in the Italian populist parties and the populist political leader’s discourse. Based on the qualitative and quantitative content analysis of the texts of the representatives of political parties in the media and their posts on their Facebook page, as well as the texts of political programs of political parties that participated in the elections to the European Parliament in 2019, the main gender themes of contemporary Italian society are highlighted. The second part of the paper is devoted the analysis of women representation in the parties’ election lists for the European Parliament elections. The aim of the paper is to identify how gender topics are reflected in the speeches of politicians and political programs of the parties, to determine the relevance of this topic. The empirical basis of the study are the text units (comments, articles, posts in the social media), and the texts of political programs of Italian populist political parties. According to the article gender topics are usually integrated in the themes of economy development and financial support for different groups of the population. However, the gender related themes are not dominant in the discourse of Italian populists. The established populist parties cover gender issues much less than parties-newcomers. The reason of presence of women in the lists of candidates mainly is a legal requirement, but not a public need. The research results can be used as an auxiliary material in the study of the key peculiarities of Italian populism.

Toxicodynamics of Chlorpyrifos and “Ivin” Combined Action under Prolonged Admission

The combined action of pesticides is one of the problems of toxicology, because in comparison to individual active substances, their mixtures can increase toxicity and delayed action effects, which is a risk to human health. It is known that plant growth regulators (PGR) when applied together with pesticides help to reduce the quantitative rates of pesticides applied, the accumulation of pesticides and heavy metals in plants, reduce the acute toxicity of xenobiotics. The combined effect of the prolonged admission of PGRs and pesticides is an unexplored area, and it is an important issue in preventive toxicology. The Aim of the Research. Determination of the nature of toxic effects of Chlorpyrifos and “Ivin” combined action at subchronic oral admission. Materials and Methods. Chlorpyrifos and PGR “Ivin” (2.6-dimethyl-N-pyridine oxide) combined action was studied on male Wistar Han rats. Substances were administered orally, via a feeding tube for 13 weeks; Chlorpyrifos was administered in the form of an aqueous emulsion with an auxiliary material OP-10 at a dose of 5 mg/kg (1/15 LD50), “Ivin” — in the form of an aqueous solution at a dose of 13 mg/kg and 0.013 mg/kg (1/100 and 1/100000 LD50 respectively), the control group of rats was given water with an auxiliary material OP-10. Signs of intoxication were recorded, body weight was measured in 4, 9 and 13 weeks, biochemical indicators of blood serum were determined (the activity of ALT and AST enzymes and alkaline phosphatase; the content of crude protein, urea, cholesterol, triglycerides and glucose were determined using kits of reagents by BioSystems (Spain); cholinesterase (ChE) activity in serum, red blood cells and brain tissue was determined with the use of methodology by Hesrtin S. using a kit of reagents produced by LLC NPP Filisit-Diagnostics (Ukraine). Results. No clinical signs of intoxication were detected in the experimental groups of rats. Under the isolated use of Chlorpyrifos a significant decrease in body weight, ChE inhibition activity in all bio substrates, with the greatest effect in the brain (by 48.8%); increase (after 9 and 13 weeks) in the activity of ALT and AST by 26.7–32.6%, 12.5–12.0%; a slight but a significant increase in the level of urea and glucose in blood serum to 17.3% and 17.6 %, respectively was detected. Under the combined action of Chlorpyrifos and “Ivin” in specified doses the body weight of rats was at control level, decrease of ChE activity was observed in all biological substrates and was at nearly the same level with the isolated use of Chlorpyrifos. There was a tendency towards the decline in ChE inhibition activity in brain tissue, and under the combined action of Chlorpyrifos with “Ivin” at higher doses after 4 weeks this effect was a significant (22.15%, p < 0.05). Conclusions. Chlorpyrifos under the isolated oral admission for 13 weeks has a weak hepatotoxic effect, as evidenced by the increase in cytolysis enzymes and urea levels in serum and causes a moderate anticholinesterase effect. “Ivin” under combined with Chlorpyrifos admission to the organism eliminates the hepatotoxic effects of Chlorpyrifos and reduces its anticholinergic effects in brain, which contributes to a less severe intoxication. Key Words: Chlorpyrifos, Ivin, hepatotoxic effect, anticholinesterase effect.

Kildare rebellion (1534-1535) in the Annals of the Four Masters

One of the most important Irish historical sources, which are the Annals of the Four Masters, written in the modern period, provide us with unusually valuable information about the history of the Emerald Island. In addition to data from the ancient or medieval periods, it also contains material from the difficult 16th and 17th centuries for Ireland, when it came under the yoke of English Protestants, who were initially represented by the Tudors and then by the Stuart dynasty. The Annals of the Four Masters also witnesses the resistance of the Irish, both those from Hiberno Normans and Gaelic Irish, to the demands of new authorities, including the rejection of Catholicism and total submission to the power of the kings of England. One such attempt, although unsuccessful, was the Kildare rebellion undertaken by Silken Thomas Earl of Kildare in the late 1630s. The laconic nature of Annales’ accounts, as well as the omission by this source of many important data, makes it an auxiliary material related to military history in the case of the Kildare rebellion. This is interesting because, in the context of later revolts that broke out in Ireland against the authority of the Tudors or Stuarts, in the era of further conquest of the island, this source is very valuable research material in this field.

THEORETICAL RESEARCH OF THE RECIPE OF SUPPLEMENTARY MATERIAL OF TECHNOLOGICAL PURPOSE FOR ENSURING ECOLOGICAL BEZ-PEPYKHYRA VYROPYRA

In the manufacture (repair) of products of transport pipeline systems, auxiliary materials are widely used, which play the role of lubricants, cooling, cleaning and other substances. Special requirements are imposed on the composition of such substances, which are developed in accordance with the technological instructions, since they are, as a rule, chemically active, surfactants of organic and inorganic origin. Therefore, not only the quality of processing of structural elements of transport pipeline systems, but also the environmental safety of the techno-logical process of their manufacture (repair) depends on the composition and mass fraction of ingredients in these substances. Of particular importance in solving problems on this problem belongs to the theory of predicting the formation of the composition of effective auxiliary materials, assessed by technological, economic, sanitary and hygienic and other indicators that are directly related to the formulation of these materials. The theoretical foundations and methods for creating auxiliary materials for technological purposes in the practice of specialized enterprises are implemented using the example of a simplified technological scheme. Ac-cording to this scheme, the action of each source of deviations (errors in the composition of the auxiliary material) is evaluated separately, and the other sources are “off,” that is, the principle of superposition is implemented. For a qualitative reflection of the technological uniformity of any two constituent ingredients in terms of their influ-ence coefficients, the concept of "intersection" is used, and all possible intersections between pairs of constituents form a square matrix of intersections of dimensions. The level of effective homogeneity, which predetermines the quality of the auxiliary material for technological purposes, depends on two groups of indicators that equally affect this effective homogeneity. Thus, any variant of the formulation of an auxiliary material consisting of groups of constituents with the maximum level of objective closure always corresponds to a certain variant of an ordered series of ingredients. Keywords: auxiliary material, transport pipeline systems, error, quality, reliability, environmental safety, manufacturing, repair.

TECHNOLOGICAL ASPECTS OF ASSESSMENT OF RELIABILITY, QUALITY AND ENVIRONMENTAL SAFETY OF SUPPLEMENTARY MATERIAL FOR MANUFACTURE OF TRANSPORT PIPELINES

When carrying out finishing (finishing and lapping) operations necessary for the manufacture (repair) of products of transport pipeline systems, special attention is paid to the auxiliary materials necessary for the imple-mentation of this technological process. The basis of these materials are chemically active, surfactant, flammable and explosive substances of organic and inorganic origin, developed according to a certain recipe in a strict combination of ingredients and with high requirements for quality output. During the implementation of the technological process of manufacturing or repair of products of transport pipeline systems, the auxiliary material is often considered as a kind of random process that has a certain impact on the environmental safety of these systems. This material for technological purposes is characterized by a num-ber of indicators that do not have numerical values, but to interpret them it is necessary to build a system of logi-cal and analytically related relationships, taking into account the required formulation of auxiliary material. In practice, these indicators of the material represent some criterion (criteria), which in the n-dimensional space can be represented as a vector of the technological state of the auxiliary material on the basis of its integrated evalua-tion. At present, a general scheme of work on the automated design of the formulation of auxiliary material based on the aggregate design method has been developed. The task of this method is to give the developed auxiliary material the maximum potential energy, as well as to increase its shelf life and reduce the risk of environmental impact. In addition, there are certain requirements for the ingredients of the material, and the formulation of the auxiliary material is based on the use of such ingredients that would ensure the reliability, quality and environ-mental safety of the operation of transport pipelines. Keywords: pipe fittings, transport piping systems, auxiliary material, recipe, quality, reliability, environmen-tal safety.