Internal Standard an Important Analyte Use in Drug Analysis by Liquid Chromatography Mass Spectrometry- An Article

Internal standard is an external compound which is mixed with targeted analytical solution and matrix as a constant concentration and use for preparing calibration standard curve by using ratio of analyte area and internal standard area with analyte concentration and internal standard concentration. This calibration curve used for quantification of unknown concentration of anlayte of interest. This article provide necessary information about internal standard like its selection procedure, characterization, types and response factor , to all analyst who are connected with drug analysis. This article is more important and I think first article which focuses a clear idea about internal standard use in drug analysis.

Crude Extract of Terminalia Chebula Fruit Effect on Gastro Intestinal Disorders Using Different Animal Models

Terminalia chebula is an ancient medicinal herb. it is also known as Haritaki, Yellow myrobalan, Chebulic myrobalan, Yellow myrobalan, and Terminalia chebulabe longs to Combretaceae family is a major Ayurvedic medicine that is native to South Asia, predominantly from India. Apart from Ayurveda, it is commonly used in Unani and Homeopathic medicine systems. Because of the broad variety of pharmacological activities connected with the biologically active constitutents found throughout this herb, it is included in conventional medicine. The fruit contains main pharmacological activities such as Hepatoprotective activity, Cytoprotective activity Cardioprotective activity, Antidiabetic and renoprotective activity, Antibacterial activity, Antifungal activity, Antiviral activity, Antiprotozoal activity, Anti-inflammatory and anti-arthritic activity, antioxidant and free radical scavenging activity, Anticarcinogenic activity, Antimutagenic, radioprotective and Chemopreventive activity, Hypolipidemic and hypocholesterolemic activity, Adaptogenic and anti anaphylactic activities, Gastrointestinal motility improving and anti-ulcerogenic activity, Antispasmodic activity, Wound healing activity, Anticaries activity, Immunomodulatory activity any many are reported with scientific evidence. All these ancient applications of Terminalia chebula as home remedies have been confirmed in preclinical trials. The current evidence on the effect of Terminalia chebula intake or consumption on gastrointestinal disorders and diseases is scientifically based on preclinical and clinical trials. All these ancient applications of Terminalia chebula as home remedies have been confirmed in preclinical trials. The current evidence on the effect of Terminalia chebula intake or consumption on gastrointestinal disorders and diseases is scientifically based on preclinical and clinical trials. Study indicates different dosage of Terminalia chebula is effective to get relief from gastrointestinal troubles. Due to less number of gastrointestinal studies, there is no scientific report to consume a specific amount of dose. To prove that Terminalia chebula and its standard extracts are effective as a gastroprotective agent, more comprehensive preclinical and clinical trials are required. To reliably evaluate the appropriate dosages for specific disorders and preparation of extract of Terminalia chebula fruit in prospective human trials procedures, dose-finding preclinical studies should be conducted. There is an evident need for more patient and physician education concerning specific therapies, legislation to regulate the quality of pharmaceutical preparations, and, in particular, more clinical and pre-clinical trials to determine the value and safety of such medicaments in digestive and other disorders.

Modernization of the Catalyst Composition for the Synthesis of Acrylic Acid Nitrile in Aqueous and Non-Aqueous Media

The effect of the components of the catalyst solution for the hydrocyanation of acetylene on the activity and selectivity of the process under liquid-phase conditions has been studied. The introduction of ZnSO 4 and ZnO additives into the shop catalyst did not give a positive effect under these conditions. Studies of catalysts in non-aqueous media lead to an increase in their activity and selectivity in comparison with aqueous media. It has been shown that the composition of the CuCl - NMP - DMF catalyst is characterized by high activity (up to 32 g / l.h.) and selectivity (83-90%), i.e. the activity of this composition is almost twice as high as compared to the water-based ones (12-18 g l.h.).

Case Report: The Influence of Endometrial Suturing on the Risk of Subsequent Infertility

There are global rise in the rate of Caesarean sections (CS) during the last 25 years has coincided with an increase in the number of couples seeking help for secondary infertility.[1,2] There have been attempts to examine the link between these two conditions, and available data confirm an association between CS and infertility. The relationship is complex, however, involving more than a simple patho‐physiological association. There may be a voluntary component to the causal relationship between CS and infertility, which is best explored using qualitative methods. We argue that CS does cause infertility, but the mechanism could be social/psychological rather than pathological. CS was associated with a 15% lesser chance of conception than vaginal birth during 3 years of subsequent follow-up, whether or not women were trying to conceive.[3]

Development and Evaluation of Nanoparticles Based Topical Gel Containing Antifungal Drug Fluconazole

The objective of this work was to prepare Fluconazole nanoparticles, and then incorporated into the freshly prepared gel for transdermal delivery, reducing the oral side effects of the drug and forenhancing stability. Fluconazole is commonly used antifungal agents for the treatment of local and systemic fungal infections. In this study Fluconazole nanoparticles was prepared by using Eudragit RL 100 by nanoprecipitation method with different drugs to polymer (1:1, 1:2 and 1:3) and stabilizer (Poloxamer 188) ratios (0.5%, 0.75% and 1%) and evaluated for various parameters. Drug-excipients compatibility was performed by FTIR study. The particle size, polydispersity index, Zeta potential, % Entrapment efficiency and % drug content of all the formulations were found in the range of 16.8 to 48.9nm, 0.229 to 0.558, -11.6 to -26.6 mv, 28.41% to 95.78% and 59% to 97.38%. From SEM studies it was revealed that Fluconazole nanoparticles particles are spherical in shape and without any agglomeration. From the in-vitro drug release study, it was revealed that sustained release of same formulation last up to 12 hours. From the stability study, it was revealed that the F5 formulation was stable at 40°C ± 2°C /75% ± 5%RH and 4°C. The optimised formulation F5 was selected to prepare Fluconazole loaded nanoparticles based topical gels using different concentration of Carbopol 934 and 940 and characterized for pH, spreadability, drug content, viscosity and in-vitro drug diffusion. Among the five formulations, G5 was selected as the best formulation. The pH of all formulations was found near to the skin pH value. The in-vitrodiffusion study of Fluconazole gel (G5) showed 94.75%. The optimized formulation G5 was checked for mechanism and kinetics of drug release. It is found it following Zero order release and non-Fickian mechanism. The selected Gel formulation G5 was found to be stable at 40°C ± 2°C /75% ± 5%RH and 4°C, it is clear that the formulation did not undergo any chemical changes found more stable at room temperature

Relative Impact and Analysis of Composition of Goat Milk by Stall-Feeding System and Rearing with Grazing System of Goats

In many regions of the world, goat milk and its milk products have played a major role in economic viability, particularly in developing countries like India. In terms of getting milk products high in minerals and other protein, the importance of free grazing still prevails and is preferred over stall feeding, but both ways are good in general. With the importance of the above in mind, an approach has been taken in the current study to compare the yield of milk from goats using a stall-feeding system and a free grazing system. Our findings show that milk minerals such as Calcium, Potassium, Magnesium, and Sodium are higher in stall-feeding goat systems than in free grazing systems because stall-feeding provides a computed ration – Minerals, Common salt, mineral mixture, concentrate feeding, feed additives, and feed supplement. As a result, milk minerals are higher in stall-feeding goat systems than in free grazing goat systems. Lactose levels are higher in stall-feeding systems than in open grazing systems because leguminous feeds like as lucerne and bersim grasses, as well as green forages, are used. Because they graze freely in the environment and consume various types of feeds, fat percentage is higher in the free grazing system of goats than in the stall-feeding system. Since stall-feeding systems provide feed supplement and concentrate feeding, fat soluble vitamins are higher in stall-feeding systems than in free grazing systems, which is why fat-soluble vitamins are higher in stall-feeding systems of goats.

Analyzing Marketing Strategy of Milk and Dairy Products Launch Plan for New Variety of Milk

The authors conducted a survey in Nagpur to analyse the marketing strategy for liquid milk and the new product launch plan for a new variety of special milk. He has focused on marketing strategies used by major liquid milk players in the market like differentiation strategy, low pricing strategy, and focus group strategy, and we've also figured out how to break into a new market segment with a new liquid milk variety. Based on our observations, we're trying to collect information from 350 tea vendors in Nagpur. We also collected data from major milk marketing players, whose names are not to be revealed, so we have annotated A, B, C, D, E, and others. The current study focuses on emphasising the importance of a launch plan strategy for new milk and dairy products.

Stachybotrys Chartarum Secondary Metabolots of Poisonic Microzoquary

Filtered culture fluids of the Stachybotrys chartarum strain were exhaustively extracted with ethyl acetate. The iso lated red residue was subjected to column chro matography (silica gel) with gradient elution, resulting in 2 different fractions. Fraction 1-2 consisted of a crystalline material that showed the same parameters of 1H and 13C as the parameters of staxibotrilaktam and staxibotrilaktam А, a derivative of driman's sesquiterpenoid. The structure proposed for this compound was based on spectroscopic data and no indication of the configuration of stereogenic carbon atoms was obtained. The fungus was produced mainly stachybotrys fully characterized derived sesquiterpenoid of drimana.

Impact of Strengthening and Proprioceptive Exercises on Balance and Activities of Daily Living (ADLS) In Knee Osteoarthritis Patients from West Delhi, Indianpopulation

Background: Knee osteoarthritis (OA)is a chronic joint disease, primarily occurring in aged population. Rehabilitation of knee osteoarthritis aims to reduce pain and disability by strengthening, raising endurance, range of motion, proprioception and improving aerobic fitness. Aim and Objectives: This study aimed to analyse and compare the impact of strengthening and proprioceptive exercises on balance and activities of daily living in knee OAin population of west Delhi, India. Material & Methods- Thirty OA patients were enrolled from Khetarpal hospital, Delhi, after taking ethical approval and informed consent. A study was explained to subjects and data was obtained as per proforma. Age of patients ranged from 50-80 years. Diagnosis was established based on radiological examination shown in the knee joint X-ray. Statistical analysis was performed by using SPSS software (Version 26). Results- Patients treated with the strengthening and proprioceptive exercises showed t-value on Berg balance scale(BBS)as -16.12 and 13.15 respectively, and the parameter of Knee Injury and Osteoarthritis Outcome Score (KOOS) showed -13.21 and 13.481 respectively, were statistically significant. Conclusion-The study groups showed, both the exercises helped reduce pain and improved the balance of daily-based activities. Furthermore, both the groups showed a significant improvement in BBS and KOOS scales.

A Seer Evaluation on Pravala Garbha Pottali with its Characterization

Pottali kalpanas are the distinctive preparations among Rasayogas, used to treat various disease conditions. It stands in the highest place among the Murchita Parada yogas because of its bonding nature as well as its efficacy. These preparations are famous for its unique method of preparation, quick administration and easy mode of transport. Usage of Pottali kalpas dates back 12th century A.D and about 87 different Pottali preparations are available in Rasagranthas. Putapaka, Gandhaka dravapaka, Kaparda/Shankha purana and Bhavana are the different methods of Pottali kalpana preparations. Gandhakadrava paka is the special method came into existence in 13th century for Soushthava sampadna (to allure patients by its colour). Garbha Pottalis come under Gandhaka Drava paka method where dhatu paka is done in garbha (midst) of Gandhaka Drava. Pravala garbha Pottali is one such rare formulation from Pottali rahasya of Rasayogasagara, which contains Sudhavarga dravyas along with Parada. Here, this study was taken to know the importance of Gandhakadrava paka and Paka parinama with respect to Pravalagarbha Pottali and studied pharmaceutically and analytically (XRD).