The human microbiota and infection prevention

2019 ◽  
Vol 40 (05) ◽  
pp. 585-589 ◽  
Author(s):  
R. Araos ◽  
Erika M.C. D’Agata
Keyword(s):  
Human Physiology ◽  
Infection Prevention ◽  
Human Microbiome ◽  
Human Microbiota ◽  
Disease States ◽  
Published Evidence ◽  
Methodological Principles ◽  
The Impact

AbstractThe human microbiome participates in numerous aspects of human physiology and disease states. Recently, studies have begun to explore the role of the microbiome in colonization, infection and transmission of pathogens. This review provides a summary of the methodological principles used in microbiome studies and the published evidence of the impact of microbiome dysbiosis in infection prevention.

scholarly journals Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota

2017 ◽  
Author(s):  
Sean M. Kearney ◽  
Sean M. Gibbons ◽  
Mathilde Poyet ◽  
Thomas Gurry ◽  
Kevin Bullock ◽  
...  
Keyword(s):  
Dietary Fatty Acids ◽  
Resistant Bacteria ◽  
Human Gut ◽  
Environmental Signals ◽  
Human Microbiota ◽  
Disease States ◽  
Culture Independent ◽  
Health And Disease ◽  
Over Time

AbstractEndospore-formers in the human microbiota are well adapted for host-to-host transmission, and an emerging consensus points to their role in determining health and disease states in the gut. The human gut, more than any other environment, encourages the maintenance of endospore formation, with recent culture-based work suggesting that over 50% of genera in the microbiome carry genes attributed to this trait. However, there has been limited work on the ecological role of endospores and other stress-resistant cellular states in the human gut. In fact, there is no data to indicate whether organisms with the genetic potential to form endospores actually form endosporesin situand how sporulation varies across individuals and over time. Here, we applied a culture-independent protocol to enrich for endospores and other stress-resistant cells in human feces to identify variation in these states across people and within an individual over time. We see that cells with resistant states are more likely than those without to be shared among multiple individuals, which suggests that these resistant states are particularly adapted for cross-host dissemination. Furthermore, we use untargeted fecal metabolomics in 24 individuals and within a person over time to show that these organisms respond to shared environmental signals, and in particular, dietary fatty acids, that likely mediate colonization of recently disturbed human guts.

scholarly journals Peritoneal Microbiome in End-Stage Renal Disease Patients and the Impact of Peritoneal Dialysis Therapy

2020 ◽  
Vol 8 (2) ◽  
pp. 173
Author(s):  
Liliana Simões-Silva ◽  
Ricardo Araujo ◽  
Manuel Pestana ◽  
Isabel Soares-Silva ◽  
Benedita Sampaio-Maia
Keyword(s):  
Peritoneal Dialysis ◽  
Human Microbiome ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Peritoneal Tissue ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Impact

Factors influencing the occurrence of peritoneal dialysis (PD)-related infections are still far from fully understood. Recent studies described the existence of specific microbiomes in body sites previously considered microbiome-free, unravelling new microbial pathways in the human body. In the present study, we analyzed the peritoneum of end-stage kidney disease (ESKD) patients to determine if they harbored a specific microbiome and if it is altered in patients on PD therapy. We conducted a cross-sectional study where the peritoneal microbiomes from ESKD patients with intact peritoneal cavities (ESKD non-PD, n = 11) and ESKD patients undergoing PD therapy (ESKD PD, n = 9) were analyzed with a 16S rRNA approach. Peritoneal tissue of ESKD patients contained characteristically low-abundance microbiomes dominated by Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes. Patients undergoing PD therapy presented lower species richness, with dominance by the Pseudomonadaceae and Prevotelaceae families. This study provides the first characterization of the peritoneal microbiome in ESKD patients, bringing new insight to the human microbiome. Additionally, PD therapy may induce changes in this unique microbiome. The clinical relevance of these observations should be further explored to uncover the role of the peritoneal microbiome as a key element in the onset or aggravation of infection in ESKD patients, especially those undergoing PD.

scholarly journals Unity of bowel-lung axis and the role of beneficial microbiota in anti-infectious protection

2021 ◽  
Vol 4 (4) ◽  
pp. 355-361
Author(s):  
T.E. Taranushenko ◽  
Keyword(s):  
Immune Responses ◽  
Respiratory Infections ◽  
Human Microbiome ◽  
Human Microbiome Project ◽  
Medical Community ◽  
Mucosal Inflammation ◽  
Potential Interactions ◽  
The Impact ◽  
And Child Health

NIH Human Microbiome Project determined particular attention of the worldwide medical community to the study of the human microbiome and the assessment of the impact of symbiont microorganisms in the development of various (not only gastrointestinal) disorders. Potential interactions between the bowel and lungs (bowel-lung axis) via microbiota that allow for the possible involvement of microorganisms in the development of respiratory diseases are actively debated. This paper reviews studies on the pattern of interactions between bowel and lungs in infectious diseases associated with mucosal inflammation. The association between gut microbiota and the protective barrier of the respiratory tract based on known mechanisms and novel data derived from recent studies on SARS-CoV-2 is discussed. The relevance of beneficial bacteria (symbionts) in local and systemic immune responses, their disease-modifying and, eventually, therapeutic strategymodifying properties, the ability to be a resource of preventive medicine and an orchestrating tool for infections are addressed. Practitioners’ difficulties with probiotics in preventive and treatment schedules for various conditions are highlighted. Finally, the use of probiotics in children with respiratory infections and COVID-19 is uncovered. KEYWORDS: microbiota, microbiome, probiotics, children, mucosal immunity, Bifidobacterium. FOR CITATION: Taranushenko T.E. Unity of bowel-lung axis and the role of beneficial microbiota in anti-infectious protection. Russian Journal of Woman and Child Health. 2021;4(4):355–361 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4-355-361.

scholarly journals The Role of Microbiome in Cancer Cell Stimulation and Therapy

2021 ◽  
pp. 97-115
Author(s):  
Shahira Hassoubah
Keyword(s):  
Immune Response ◽  
Human Microbiome ◽  
Future Research ◽  
Published Data ◽  
Disease States ◽  
Life Threatening ◽  
Indigenous Microbiota ◽  
Symbiotic Microbiota ◽  
Insight Into

In recent times, the microbiome has been increasingly recognized as having a hand in various disease states that include cancer as a part. Our commensal and symbiotic microbiota, in addition to pathogens with oncogenesis features, have tumor-suppressive characteristics. Our nutrition and other environmental influences can modulate some microbial species representatives within our digestive system and other systems. The microbiota has recently shown a two-way link to cancer immunotherapy for both the prognosis and the therapeutic aspects. Preclinical results indicated that microbiota modification could be transformed into a novel technique to improve cancer therapy's effectiveness. This article aimed to review recent development in our understanding of the microbiome and its relationship to cancer cells and discuss how the microbiome stimulates cancer and its clinical and therapeutic applications. Such information was selected and extracted from the PubMed, Web of Science, and Google Scholar databases for published data from 2000 to 2020 using relevant keywords containing a combination of terms, including the microbiome, cancer, immune response, immune response, and microbiota. Finally, we concluded that studying the human microbiome is necessary because it provides a thorough understanding of humans' interaction and their indigenous microbiota. The microbiome provides useful insight into future research studies to optimize these species to fight life-threatening diseases such as cancer and has rendered the microbiome a successful cancer treatment strategy.

Introduction to Public Health in Pharmacy

2018 ◽  
Keyword(s):  
Public Health ◽  
Population Health ◽  
Pharmacy Practice ◽  
The United States ◽  
Pharmacy Education ◽  
Health Care Outcomes ◽  
Disease States ◽  
Care Outcomes ◽  
The Impact

The need for texts that blend the areas of pharmacy and public health has continued to expand. Introduction to Public Health in Pharmacy (second edition), builds upon the Center for the Advancement of Pharmacy Education (CAPE) Educational Outcomes report, which emphasizes public health in the domains of Foundational Knowledge and Essentials of Pharmacy Practice and Care, focusing on both patient and population health care outcomes. This second edition has (a) a strong pharmacy-relevant emphasis on the foundations of public health in pharmacy and (b) an increased emphasis on the impact of pharmacy on disease states important in public health and pharmacy in the United States and internationally. This text can be adopted for pharmacy and public health courses but would also be a valuable resource to those teaching therapeutics, patient care, disease prevention, and community engagement. In addition, it is an invaluable resource and handbook for practitioners. The focus is on the role of pharmacy in population health.

scholarly journals The Impact of Diet on Microbiota Evolution and Human Health. Is Diet an Adequate Tool for Microbiota Modulation?

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1654
Author(s):  
Laura Moles ◽  
David Otaegui
Keyword(s):  
Human Health ◽  
Human Evolution ◽  
Human Microbiome ◽  
Microbiota Composition ◽  
Dietary Changes ◽  
Human Microbiota ◽  
Factors Influencing ◽  
Complex Ecosystem ◽  
Dietary Strategies ◽  
The Impact

The human microbiome is emerging as an interesting field in research into the prevention of health problems and recovery from illness in humans. The complex ecosystem formed by the microbiota is continuously interacting with its host and the environment. Diet could be assumed to be one of the most prominent factors influencing the microbiota composition. Nevertheless, and in spite of numerous strategies proposed to modulate the human microbiota through dietary means, guidelines to achieve this goal have yet to be established. This review assesses the correlation between social and dietary changes over the course of human evolution and the adaptation of the human microbiota to those changes. In addition, it discusses the main dietary strategies for modulating the microbiota and the difficulties of putting them properly into practice.

scholarly journals A review of clothing microbiology: the history of clothing and the role of microbes in textiles

2021 ◽  
Vol 17 (1) ◽  
pp. 20200700
Author(s):  
Deaja Sanders ◽  
Amy Grunden ◽  
Robert R. Dunn
Keyword(s):  
Environmental Impacts ◽  
Human Microbiome ◽  
Environmental Application ◽  
The Future ◽  
History Of ◽  
The Impact

Humans have worn clothing for thousands of years, and since its invention, clothing has evolved from its simple utilitarian function for survival to become an integral part of society. While much consideration has been given to the broad environmental impacts of the textile and laundering industries, little is known about the impact wearing clothing has had on the human microbiome, particularly that of the skin, despite our long history with clothing. This review discusses the history of clothing and the evolution of textiles, what is and is not known about microbial persistence on and degradation of various fibres, and what opportunities for the industrial and environmental application of clothing microbiology exist for the future.

Computational methodology for predicting the landscape of the human–microbial interactome region level influence

2015 ◽  
Vol 13 (05) ◽  
pp. 1550023 ◽  
Author(s):  
Edgar D. Coelho ◽  
André M. Santiago ◽  
Joel P. Arrais ◽  
José Luís Oliveira
Keyword(s):  
Protein Interactions ◽  
Close Association ◽  
Human Microbiome ◽  
Estimation Algorithm ◽  
Protein Protein Interactions ◽  
Disease States ◽  
Pathway Data ◽  
Human Proteins ◽  
Computational Methodology ◽  
The Impact

Microbial communities thrive in close association among themselves and with the host, establishing protein–protein interactions (PPIs) with the latter, and thus being able to benefit (positively impact) or disturb (negatively impact) biological events in the host. Despite major collaborative efforts to sequence the Human microbiome, there is still a great lack of understanding their impact. We propose a computational methodology to predict the impact of microbial proteins in human biological events, taking into account the abundance of each microbial protein and its relation to all other microbial and human proteins. This alternative methodology is centered on an improved impact estimation algorithm that integrates PPIs between human and microbial proteins with Reactome pathway data. This methodology was applied to study the impact of 24 microbial phyla over different cellular events, within 10 different human microbiomes. The results obtained confirm findings already described in the literature and explore new ones. We believe the Human microbiome can no longer be ignored as not only is there enough evidence correlating microbiome alterations and disease states, but also the return to healthy states once these alterations are reversed.

scholarly journals From Structure to Function: the Ecology of Host-Associated Microbial Communities

2010 ◽  
Vol 74 (3) ◽  
pp. 453-476 ◽  
Author(s):  
Courtney J. Robinson ◽  
Brendan J. M. Bohannan ◽  
Vincent B. Young
Keyword(s):  
Community Structure ◽  
Microbial Communities ◽  
Human Microbiome ◽  
Structure And Function ◽  
Future Directions ◽  
Human Microbiota ◽  
Health And Disease ◽  
Indigenous Microbiota ◽  
And Function

SUMMARY In the past several years, we have witnessed an increased interest in understanding the structure and function of the indigenous microbiota that inhabits the human body. It is hoped that this will yield novel insight into the role of these complex microbial communities in human health and disease. What is less appreciated is that this recent activity owes a great deal to the pioneering efforts of microbial ecologists who have been studying communities in non-host-associated environments. Interactions between environmental microbiologists and human microbiota researchers have already contributed to advances in our understanding of the human microbiome. We review the work that has led to these recent advances and illustrate some of the possible future directions for continued collaboration between these groups of researchers. We discuss how the application of ecological theory to the human-associated microbiota can lead us past descriptions of community structure and toward an understanding of the functions of the human microbiota. Such an approach may lead to a shift in the prevention and treatment of human diseases that involves conservation or restoration of the normal community structure and function of the host-associated microbiota.

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