Funerals during the 1994 cholera epidemic in Guinea-Bissau, 

West Africa: The need for disinfection of bodies of persons 

dying of cholera

The 1994 cholera epidemic in Guinea-Bissau resulted in 15878 reported cases and 306 deaths. Early in the epidemic, although the health ministry mandated that the bodies of persons dying of cholera be disinfected, outbreaks occurred in several villages following funerals in the region of Biombo. To determine the influence of disinfection and funeral activities on cholera transmission, we analysed surveillance data and conducted a case-control study following a funeral. The attack rate during the week following funerals was higher in villages where bodies were not disinfected (risk ratio = 2·6, 95% confidence interval [CI] 1·9–3·8). Cholera was strongly associated with eating at a funeral with a non-disinfected corpse (odds ratio [OR] = 14·5, 95% CI 0·9–786) and with touching (i.e., transporting, washing) the body (OR = 36·2, 95% CI 2·6–1769). During cholera epidemics, in addition to other cholera prevention activities, health officials should inform community leaders about the risk of cholera transmission during funerals, meals should not be served at funerals, and bodies of persons dying of cholera should be disinfected.

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A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer

Scientific Reports ◽

10.1038/s41598-021-95955-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mariem Hajji-Louati ◽

Emilie Cordina-Duverger ◽

Nasser Laouali ◽

Francesca-Romana Mancini ◽

Pascal Guénel

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Odds Ratio ◽

Hormone Receptors ◽

Case Control Study ◽

Breast Cancer Subtype ◽

Case Control ◽

Tumor Subtype ◽

Control Study

AbstractDietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of diet and breast cancer risk in a case–control study in France including 872 breast cancer cases and 966 population controls. All women completed a food frequency questionnaire that was used to compute a Dietary Inflammatory Index (DII) based on the inflammatory weight of 33 dietary components. The DII ranged from a median of − 3.22 in the lowest quartile (anti-inflammatory) to + 2.96 in the highest quartile (pro-inflammatory). The odds ratio contrasting quartile 4 to quartile 1 was 1.31 (95% CI 1.00, 1.73; p-trend = 0.02). Slightly higher odds ratios were observed in post-menopausal women, particularly those with body mass index > 25 kg/m2 (odds ratio 1.62; 95% CI 0.92, 2.83; p-trend = 0.02), and among ever smokers (odds ratio 1.71; 95% CI 1.11, 2.65; p-trend 0.01). The analyses by breast cancer subtype showed that the DII was associated with breast tumors that expressed either the estrogen (ER) or progesterone (PR) hormone receptors or the Human Epidermal Growth Factor Receptor-2 (HER2), but no association was seen for the triple negative breast tumor subtype. Our results add further evidence that a pro-inflammatory diet is associated with breast cancer risk with possible effect variation according to tumor subtype.

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Plasma acylcarnitines and risk of lower-extremity functional impairment in older adults: a nested case–control study

Scientific Reports ◽

10.1038/s41598-021-82912-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Francisco Félix Caballero ◽

Ellen A. Struijk ◽

Alberto Lana ◽

Antonio Buño ◽

Fernando Rodríguez-Artalejo ◽

...

Keyword(s):

Older Adults ◽

Confidence Interval ◽

Lower Extremity ◽

Functional Impairment ◽

Odds Ratio ◽

Case Control Study ◽

Case Control ◽

Community Dwelling ◽

Control Study ◽

Long Chain

AbstractElevated concentrations of acylcarnitines have been associated with higher risk of obesity, type 2 diabetes and cardiovascular disease. The aim of the present study was to assess the association between L-carnitine and acylcarnitine profiles, and 2-year risk of incident lower-extremity functional impairment (LEFI). This case–control study is nested in the Seniors-ENRICA cohort of community-dwelling older adults, which included 43 incident cases of LEFI and 86 age- and sex- matched controls. LEFI was assessed with the Short Physical Performance Battery. Plasma L-carnitine and 28 acylcarnitine species were measured. After adjusting for potential confounders, medium-chain acylcarnitines levels were associated with 2-year incidence of LEFI [odds ratio per 1-SD increase: 1.69; 95% confidence interval: 1.08, 2.64; p = 0.02]. Similar results were observed for long-chain acylcarnitines [odds ratio per 1-SD increase: 1.70; 95% confidence interval: 1.03, 2.80; p = 0.04]. Stratified analyses showed a stronger association between medium- and long-chain acylcarnitines and incidence of LEFI among those with body mass index and energy intake below the median value. In conclusion, higher plasma concentrations of medium- and long-chain acylcarnitines were associated with higher risk of LEFI. Given the role of these molecules on mitochondrial transport of fatty acids, our results suggest that bioenergetics dysbalance contributes to LEFI.

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Parental risk factors for congenital diaphragmatic hernia – a large German case-control study

BMC Pediatrics ◽

10.1186/s12887-021-02748-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Felicitas Schulz ◽

Ekkehart Jenetzky ◽

Nadine Zwink ◽

Charlotte Bendixen ◽

Florian Kipfmueller ◽

...

Keyword(s):

Risk Factors ◽

Confidence Interval ◽

Environmental Risk ◽

Odds Ratio ◽

Alcohol Intake ◽

Case Control Study ◽

Case Control ◽

Parental Risk Factors ◽

Healthy Control ◽

Control Study

Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH.

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745 Risk Factors of Incident Renal Stones in Indian Population: A Hospital-Based Case-Control Study

British Journal of Surgery ◽

10.1093/bjs/znab134.573 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

S Singh ◽

S Gupta ◽

T S Mishra ◽

B D Banerjee ◽

T Sharma ◽

...

Keyword(s):

Risk Factors ◽

Heavy Metals ◽

Case Control Study ◽

Dietary Habits ◽

Renal Stones ◽

Tertiary Hospital ◽

Case Control ◽

The Body ◽

Increased Risk ◽

Control Study

Abstract Introduction Nephrolithiasis is pathological calcification in the excretory passages of the body and is prevalent among 7.6% of Indians. We aimed to study the various risk factors associated with renal stones from India. Method It was a hospital-based case-control study conducted over 18 months in a tertiary hospital in Delhi. Cases were defined as patients with renal stones diagnosed on the basis of history and radiological examination. Controls were similar to cases in all respects except for the diagnosis and selected from the hospital. A total of 18 risk factors, including age, gender, heavy metals, stress, metabolic factors, alcohol intake, dietary habits, co-morbidities, etc. were assessed. Logistic regression analysis was performed to calculate the strength of the risk associations. Results In the analysis of 60 cases and controls, we found 6 times, 5.5 times, and 2.4 times increased odds of renal stones in patients with increased arsenic, cadmium, and lead concentrations in blood, respectively. Similarly, there are 3 times increased odds of renal stones in patients suffering from stress. Conclusions Exposure to smoke, occupation dust, and contaminated water may lead to an increased ingestion/inhalation of heavy metals like cadmium, arsenic, and predisposing people to an increased risk of renal stones.

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Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

Neonatology ◽

10.1159/000512020 ◽

2020 ◽

pp. 1-7

Author(s):

Tobias Hengartner ◽

Mark Adams ◽

Riccardo E. Pfister ◽

Diane Snyers ◽

Jane McDougall ◽

...

Keyword(s):

Retinopathy Of Prematurity ◽

Odds Ratio ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Same Sex ◽

Live Births ◽

Adjusted Logistic Regression ◽

Control Study

Aim: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. Methods: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group). Results: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020–1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566–3.998) numbers were associated with ROP development. Conclusions: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.

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Risk Factors for Measles Vaccine Failure Among Immunized Students

PEDIATRICS ◽

10.1542/peds.76.4.518 ◽

1985 ◽

Vol 76 (4) ◽

pp. 518-523

Author(s):

Harry F. Hull ◽

Jean M. Montes ◽

Patricia C. Hays ◽

Robert L. Lucero

Keyword(s):

Risk Factors ◽

School System ◽

Odds Ratio ◽

Case Control Study ◽

Case Control ◽

Measles Vaccine ◽

Vaccine Failure ◽

Control Study

An outbreak of measles occurred in a municipal school system which had reported 98% of students immunized against measles. A case-control study was conducted to determine reasons for vaccine failure Vaccine failure was associated with immunizations that could not be documented in the provider's records. Among children with provider-documented immunization, vaccine failure was associated with vaccination at 12 to 14 months of age with an odds ratio of 4.73. Among children vaccinated at 15 months or older, vaccine failure was not associated with time elapsed since vaccination. Studies should be conducted to determine whether unreliable immunization records are a more widespread problem. Further consideration should be given to routine revaccination of children previously vaccinated at 12 to 14 months of age.

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Risk Factors for Herpes Zoster Infection in Patients With Chronic Kidney Disease: A Case-control Study

10.21203/rs.3.rs-252260/v1 ◽

2021 ◽

Author(s):

Qiao Wang ◽

Jiahui Ma ◽

Zhenxing Li ◽

Zhi Li ◽

Dong Huang ◽

...

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Herpes Zoster ◽

Kidney Disease ◽

Odds Ratio ◽

Case Control Study ◽

Immunosuppressive Agents ◽

Tertiary Hospital ◽

Case Control ◽

Control Study

Abstract Background: Chronic kidney disease (CKD) increases the susceptibility to the infection of herpes zoster (HZ). Less is known about the risk factors of HZ in CKD patients.Methods and Participants: This is a case-control study. CKD patients diagnosed with HZ infection between January 2015 and October 2020 in a tertiary hospital were identified. One age- and gender- matched control was paired for each case, matched to the date of initial HZ diagnose. The uni- and multivariate analysis were used to evaluate the risk factors for development of HZ in CKD patients.Results: Forty-six HZ patients and controls were identified. In general, about 80% (72 out of 92) patients were classified at end-stage renal disease (ESRD, CKD Ⅳ to Ⅴ). Multivariate analyses revealed that immunosuppressive agents (odds ratio: 12.50, 95% CI: 1.53-102.26, P=0.021) and dialysis (odds ratio: 3.33, 95% CI: 1.13-9.78, P=0.029) were independent risk factors of HZ in patient with CKD. Conclusion: Immunosuppressive medication and dialysis were associated with HZ infection in CKD. Further guideline may highlight the necessity of zoster vaccine for patients with CKD, who undertake immunosuppressive or dialysis treatment.

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Hubungan Riwayat Cidera Lutut Terhadap Pasien Yang Berpotensi Osteoarthritis Lutut Di Puskesmas Dinoyo Kota Malang

Jurnal Fisioterapi dan Rehabilitasi ◽

10.33660/jfrwhs.v3i1.31 ◽

2019 ◽

Vol 3 (1) ◽

pp. 20-29

Author(s):

Safun Rahmanto ◽

Khaiyatul Aisyah

Keyword(s):

Random Sampling ◽

Odds Ratio ◽

Case Control Study ◽

Simple Random Sampling ◽

Case Control ◽

Chi Square ◽

Ligament Sprain ◽

Control Study

ABSTRAK Latar belakang : Osteoartritis merupakan salah satu penyakit degenerative yang ditandai dengan hilangnya tulang rawan articular dan terjadi peradangan sinovial yang menyebabkan kekakuan sendi, nyeri dan kehilangan mobilitas sendi. Ada banyak faktor risiko osteoarthritis lutut, salah satunya adalah riwayat cidera lutut. Cidera lutut menurunkan kestabilan sendi lutut pada bantalan beban tubuh. Cidera lutut meningkatkan risiko osteoarthritis pada area kontak tibiofemoral dan tekanan pada cidera meniscal, sehingga menyebabkan unstabil sendi berupa ligament sprain dan lesi pada chondral atau dengan mengganggu sistem neuromuskular. Individu dengan riwayat trauma sendi 3-6 kali lebih berpotensi terjadinya osteoarthritis lutut. Dalam 5 tahun cedera, lutut mengalami perubahan struktural seperti, perubahan komposisi tulang rawan, dan perubahan pada struktur ulang. Tujuan Penelitian : Menganalisis hubungan antara riwayat cidera lutut terhadap pasien yang berpotensi osteoarthritis lutut di Puskesmas Dinoyo Kota Malang. etode Penelitian : Desain penelitian menggunakan Case Control Study dengan jumlah sampel 120 responden di Puskesmas Dinoyo Kota Malang yang diambil dengan metode Simple Random Sampling. Pengambilan data untuk mengetahui riwayat cidera lutut dinilai dengan kuesioner OA Risk C dan wawancara mendalam. Potensi adanya osteoarthritis lutut dinilai menggunakan pemeriksaan fisik, skala jette dan data sekunder dari Puskesmas Dinoyo Kota Malang. Hasil : Hasil penelitian dengan uji Chi-Square terhadap Riwayat cidera lutut dikaitkan dengan osteoarthritis lutut dalam penelitian ini didapatkan nilai signifikan lebih kecil dari alpha 5% (0,00 < 0,05) dengan Odds Ratio [OR= 5,82 (95% CI 2,54-13,35)]. Kesimpulan : Terdapat hubungan yang signifikan antara riwayat cidera lutut terhadap pasien yang berpotensi osteoarthritis lutut di Puskesmas Dinoyo Kota Malang dan orang yang memiliki riwayat cidera lutut berpeluang 5 kali lebih besar menderita osteoarthritis lutut daripada orang yang tidak memiliki riwayat cidera lutut.

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Association between anxiety symptoms and atrial fibrillation in a community cohort of Chinese older adults: a case-control study

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02278-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zhu-Xia Shen ◽

Yu-Min Sun ◽

Hui-Hui Gu ◽

Yan Zhang ◽

Zhi-Wen Shen ◽

...

Keyword(s):

Atrial Fibrillation ◽

Older Adults ◽

Heart Disease ◽

Odds Ratio ◽

Case Control Study ◽

Case Control ◽

Anxiety Symptoms ◽

Control Group ◽

Community Based ◽

Control Study

Abstract Background The association between anxiety and atrial fibrillation (AF) remains unclear. Moreover, this association has rarely been studied in Chinese individuals aged 60 years or older. This study investigated the association between anxiety and AF in a community-based case-control study of older adult residents in urban China. Methods The cases and controls were from a community-based study conducted in the Jingansi community in Shanghai, China, between January 2010 and December 2012. A total of 3622 residents aged 60 years or older without severe vision, hearing, or speaking impairments were eligible to participate in the physical examinations and questionnaire survey. AF was assessed based on a previous physician’s diagnosis, electrocardiogram, ambulatory electrocardiogram, or echocardiogram. Anxiety was evaluated using the Zung Self-Rating Anxiety Scale (ZSAS). Using the AF group as a reference, the control group consisted of randomly selected age- and sex-matched individuals in a 1:5 ratio (case:control = 1:5). The association between anxiety and AF in the AF group and the multifactor-matched control group was explored using logistic regression. Results In the AF and control groups, after adjusting for a history of coronary heart disease, valvular heart disease, hypertension, stroke, hyperlipidemia, and diabetes, as well as depression score, ZSAS scores (odds ratio 1.07; 95% confidence interval 1.02–1.12; p = 0.003), and anxiety symptoms (odds ratio 3.94; 95% confidence interval 1.06–14.70; p = 0.041) were associated with AF. Conclusions Anxiety symptoms were associated with AF in a Chinese older population. This suggests that older adults who have anxiety symptoms may need psychological intervention or treatment in daily life and care.

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Abstract WP369: Long Sleep Duration as a Risk Factor for Intracerebral Hemorrhage: a Nationwide, Multicenter Case-control Study

Stroke ◽

10.1161/str.47.suppl_1.wp369 ◽

2016 ◽

Vol 47 (suppl_1) ◽

Author(s):

Tae Jung Kim ◽

Chi Kyung Kim ◽

Yerim Kim ◽

Han-Gil Jeong ◽

Kiwoong Nam ◽

...

Keyword(s):

Risk Factor ◽

Confidence Interval ◽

Intracerebral Hemorrhage ◽

Sleep Duration ◽

Odds Ratio ◽

Case Control Study ◽

Case Control ◽

Stroke Incidence ◽

Long Sleep ◽

Control Study

Introduction: Sleep duration has been regarded as a potential risk factor for cardiovascular disease and stroke. Short sleep duration is linked with higher stroke incidence, and mortality. Moreover, and paradoxically, long sleep duration is also reported to be positively associated with stroke incidence. However, the impact of sleep duration on the intracerebral hemorrhage (ICH) risk remains unclear. Hypothesis: We assessed the relationship between sleep duration and the risk of ICH. Methods: We performed a nationwide, multicenter matched case-control study to investigate the risk factors for hemorrhagic stroke, using patients from 33 hospitals in Korea. We enrolled a total of 490 patients with ICH and 980 age- and sex-matched controls. We obtained information regarding sleep, sociodemographic factors, lifestyle, and medical history before ICH onset, using qualified structured questionnaires. Sleep duration was categorized as ≤5, 6, 7, 8, and ≥9 hours. We chose sleep duration of 7 h as the reference duration. Results: The included patients were mostly male (58.2%) with a mean age of 57 years. The number of subjects with long sleep duration, more than 8 h, was significantly greater in the ICH group than in the control group (≥8 h, 30.4% vs. 22.6%, P = 0.002). Compared to 7 h, long sleep duration participants tended to be older, be more hypertensive, and be more likely to have blue collar jobs, lower education levels, and poorer marital status (i.e., unmarried or divorced/separated). After controlling for confounding factors, we found that longer sleep duration was independently associated with the risk of ICH in a dose-response manner (8 h: Odds ratio, 1.44; confidence interval, 1.01-2.07; ≥9 h: Odds ratio, 2.60; confidence interval, 1.50–4.49). Conclusions: In conclusion, our study suggested that long sleep duration is positively related to ICH risk in a dose-dependent manner. In this context, our data might suggest that sleep duration is a modifiable risk factor for ICH.

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